Borderline ovarian tumors, fertility-sparing surgery and pregnancy outcome.

BACKGROUND Borderline ovarian tumors (BOTs) represent a type of epithelial tumors having a biologic intermediate behavior between clearly malignant and straight benign tumors. Most of BOTs interest women during fertile age, for which it is necessary to consider a fertility sparing surgery. AIM To evaluate the clinical aspects and pregnancy rate of women affected by borderline ovarian tumors who have undergone fertility sparing surgery. PATIENTS AND METHODS A study of 22 patients affected by BOTs who have been treated with a fertility sparing surgery was conducted between January 2005 and October 2011 at Sant'Andrea Hospital, "Sapienza" University of Rome. The patients' characteristics analyzed were: age, histological type, tumor size, adnexal surgery, pre-operative serum CA-125, diagnostic circumstances, number of patients who became pregnant and number of overall pregnancies. RESULTS Among the 22 patients treated with a fertility sparing surgery, only sixteen wanted to get pregnant. Eleven patents out of 16 accomplished it. The pregnancy rate was 68.7%. CONCLUSIONS Fertility sparing surgery can be considered a safe procedure for young women affected by borderline ovarian tumors.

[1]  P. Morice,et al.  Fertility and borderline ovarian tumor: a systematic review of conservative management, risk of recurrence and alternative options. , 2013, Human reproduction update.

[2]  L. Selvaggi,et al.  Borderline Epithelial Tumors of the Ovary , 2013 .

[3]  Jeong-Won Lee,et al.  Fertility-Sparing Surgery for Borderline Ovarian Tumors: Oncologic Safety and Reproductive Outcomes , 2011, International Journal of Gynecologic Cancer.

[4]  B. Yılmaz,et al.  Fertility outcome after conservative surgery for borderline ovarian tumors: a single center experience , 2011, Archives of Gynecology and Obstetrics.

[5]  Yong-Man Kim,et al.  Surgical management of borderline ovarian tumors: The role of fertility-sparing surgery. , 2009, Gynecologic oncology.

[6]  R. Barakat,et al.  Long-Term Survival After Fertility-Sparing Surgery for Epithelial Ovarian Cancer , 2009, International Journal of Gynecologic Cancer.

[7]  A. Gadducci,et al.  Management of borderline ovarian tumors: results of an Italian multicenter study. , 2006, Gynecologic oncology.

[8]  I. Shih,et al.  Serous borderline tumours of the ovary , 2005, Histopathology.

[9]  E. Daraï,et al.  Fertility after conservative treatment for borderline ovarian tumors: a French multicenter study. , 2005, Fertility and sterility.

[10]  S. Ankara.  Fertility and recurrence results of conservative surgery for borderline ovarian tumors , 2005 .

[11]  R. Kurman,et al.  Borderline ovarian tumors: key points and workshop summary. , 2004, Human pathology.

[12]  E. Trimble,et al.  Long-term survival and patterns of care in women with ovarian tumors of low malignant potential. , 2002, Gynecologic oncology.

[13]  C. Mangioni,et al.  Behavior of borderline tumors with particular interest to persistence, recurrence, and progression to invasive carcinoma: a prospective study. , 2001, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[14]  D. Bell.  Ovarian surface epithelial-stromal tumors. , 1991, Human pathology.

[15]  H. Kottmeier.  Classification and staging of malignant tumours in the female pelvis. , 1968, Acta obstetricia et gynecologica Scandinavica.