MEMS-based adaptive optics scanning laser ophthalmoscopy

We have developed a compact, robust adaptive optics (AO) scanning laser ophthalmoscope using a microelectromechanical (MEMS) deformable mirror (DM). Facilitated with a Shack-Hartmann wavefront sensor, the MEMS-DM-based AO operates a closed-loop modal wave aberration correction for the human eye and reduces wave aberrations in most eyes to below 0.1 μm rms. Lateral resolution is enhanced, and images reveal a clear cone mosaic near the foveal center. The significant increase in throughput allows for a confocal pinhole whose diameter is less than the Airy disc of the collection lens, thereby fully exploiting the axial resolution capabilities of the system.

[1]  T. Hebert,et al.  Adaptive optics scanning laser ophthalmoscopy. , 2002, Optics express.

[2]  B. Singer,et al.  Improvement in retinal image quality with dynamic correction of the eye's aberrations. , 2001, Optics express.

[3]  Krishnakumar Venkateswaran,et al.  Optical slicing of human retinal tissue in vivo with the adaptive optics scanning laser ophthalmoscope. , 2005, Applied optics.

[4]  Austin Roorda,et al.  Mechanism for Cone Reflectivity Revealed With Low Coherence AOSLO Imaging , 2005 .

[5]  R. Webb.  Confocal optical microscopy , 1996 .

[6]  Geunyoung Yoon,et al.  Use of a microelectromechanical mirror for adaptive optics in the human eye. , 2002, Optics letters.

[7]  R. Weinreb,et al.  Active optical depth resolution improvement of the laser tomographic scanner. , 1989, Applied optics.

[8]  Robert H. Webb,et al.  Scanning Laser Ophthalmoscope , 1981, IEEE Transactions on Biomedical Engineering.

[9]  P. Artal,et al.  Adaptive-optics ultrahigh-resolution optical coherence tomography. , 2004, Optics letters.

[10]  Thomas G. Bifano,et al.  Micromachined deformable mirrors for adaptive optics , 2002, SPIE Optics + Photonics.

[11]  F. Medeiros,et al.  Relationship of SITA and full-threshold standard perimetry to frequency-doubling technology perimetry in glaucoma. , 2005, Investigative ophthalmology & visual science.

[12]  Austin Roorda,et al.  Retinal motion estimation in adaptive optics scanning laser ophthalmoscopy. , 2006, Optics express.

[13]  Xin Hong,et al.  Requirements for segmented correctors for diffraction-limited performance in the human eye. , 2005, Optics express.

[14]  R. Webb,et al.  Confocal scanning laser ophthalmoscope. , 1987, Applied optics.

[15]  D R Williams,et al.  Supernormal vision and high-resolution retinal imaging through adaptive optics. , 1997, Journal of the Optical Society of America. A, Optics, image science, and vision.

[16]  I Iglesias,et al.  Closed-loop adaptive optics in the human eye. , 2001, Optics letters.

[17]  David Williams,et al.  The reflectance of single cones in the living human eye. , 2002, Investigative ophthalmology & visual science.