The chlorococcalean alga Chlorella in animal nutrition: a review

Unicellular freshwater microalgae of the genus Chlorella are characterised by a relative ease of cultivation, high productivity and high content of proteins and other valuable components. However, the alga is too expensive to use widely as a protein supplement in animal feed. Nevertheless, in many experiments, it was found that even a very low, economically acceptable addition of Chlorella biomass to animal feed can positively influence growth and performance. This is due to the presence of pigments, antioxidants, provitamins, vitamins and a growth substance known as the Chlorella Growth Factor (CGF), which can stimulate or enhance the immune system, increase feed intake and utilisation and promote reproduction; the use of Chlorella biomass might therefore increase the value of animal products for human consumption. Significant results were also achieved in the use of Chlorella biomass as a carrier of organically bound selenium and iodine that play a substantial role in the thyroid hormone regulation in an organism.

[1]  D. Rotkovská,et al.  Amelioration of radiation damage to haemopoiesis by Ivastimul, given after irradiation to mice protected by peroral cystamine. , 1992, Folia biologica.

[2]  B. Wooten,et al.  Consumption of 2 and 4 egg yolks/d for 5 wk increases macular pigment concentrations in older adults with low macular pigment taking cholesterol-lowering statins. , 2009, The American journal of clinical nutrition.

[3]  Peter F Surai,et al.  Selenium in poultry nutrition. , 2008 .

[4]  P. Janczyk,et al.  Nutritional value of Chlorella vulgaris: Effects of ultrasonication and electroporation on digestibility in rats , 2007 .

[5]  P. Janczyk,et al.  Microbial community composition of the crop and ceca contents of laying hens fed diets supplemented with Chlorella vulgaris. , 2009, Poultry science.

[6]  J. Doucha,et al.  Influence of processing parameters on disintegration of Chlorella cells in various types of homogenizers , 2008, Applied Microbiology and Biotechnology.

[7]  R. J. Shields Algae for Aquaculture and Animal Feeds by , 2012 .

[8]  C. Posten,et al.  Second Generation Biofuels: High-Efficiency Microalgae for Biodiesel Production , 2008, BioEnergy Research.

[9]  J. H. Kim,et al.  Effect of various forms of dietary Chlorella supplementation on growth performance, immune characteristics, and intestinal microflora population of broiler chickens , 2013 .

[10]  S. Resnikoff,et al.  Global data on visual impairment in the year 2002. , 2004, Bulletin of the World Health Organization.

[11]  A. Lane,et al.  Synthesis and structure characterization of selenium metabolites , 1998 .

[12]  B. Lipstein,et al.  The nutritional value of algae for poultry. Dried chlorella in layer diets , 1980 .

[13]  C. Bincoletto,et al.  Chlorella vulgaris treatment ameliorates the suppressive effects of single and repeated stressors on hematopoiesis , 2013, Brain, Behavior, and Immunity.

[14]  Microalgae for aquaculture: microalgae production for aquaculture. , 2007 .

[15]  D. Mahan,et al.  Effect of inorganic or organic selenium at two dietary levels on reproductive performance and tissue selenium concentrations in first-parity gilts and their progeny. , 1996, Journal of animal science.

[16]  B. An,et al.  The Dietary Effects of Fermented Chlorella vulgaris (CBT®) on Production Performance, Liver Lipids and Intestinal Microflora in Laying Hens , 2011, Asian-Australasian journal of animal sciences.

[17]  M. Svoboda,et al.  Effect of Organic Selenium from Se-enriched Alga ( Chlorella spp.) on Selenium Transfer from Sows to Their Progeny , 2009 .

[18]  M. Sporn,et al.  Can dietary beta-carotene materially reduce human cancer rates? , 1981, Nature.

[19]  K. Lum,et al.  Nonruminant Nutrition Symposium: Potential of defatted microalgae from the biofuel industry as an ingredient to replace corn and soybean meal in swine and poultry diets. , 2014, Journal of animal science.

[20]  V. Guiard,et al.  Effect of feed supplementation with Chlorella vulgaris powder on mice reproduction. , 2006 .

[21]  Michael A. Borowitzka,et al.  Microalgae for aquaculture: Opportunities and constraints , 1997, Journal of Applied Phycology.

[22]  J. Pickova,et al.  Fatty acid and carotenoid composition of egg yolk as an effect of microalgae addition to feed formula for laying hens , 2006 .

[23]  A. Richmond,et al.  CRC Handbook of microalgal mass culture , 1986 .

[24]  J. Doucha,et al.  Production of Chlorella biomass enriched by selenium and its use in animal nutrition: a review , 2009, Applied Microbiology and Biotechnology.

[25]  J. Doucha,et al.  Outdoor open thin-layer microalgal photobioreactor: potential productivity , 2009, Journal of Applied Phycology.

[26]  Peter F Surai Selenium in poultry nutrition 1. Antioxidant properties, deficiency and toxicity , 2002 .

[27]  M. Rayman,et al.  The importance of selenium to human health , 2000, The Lancet.

[28]  E. Becker Micro-algae as a source of protein. , 2007, Biotechnology advances.

[29]  G. Z. Justo,et al.  EFFECTS OF THE GREEN ALGAE CHLORELLA VULGARIS ON THE RESPONSE OF THE HOST HEMATOPOIETIC SYSTEM TO INTRAPERITONEAL EHRLICH ASCITES TUMOR TRANSPLANTATION IN MICE , 2001, Immunopharmacology and immunotoxicology.

[30]  C. Barrow,et al.  Immunostimulatory principles from Chlorella pyrenoidosa--part 1: isolation and biological assessment in vitro. , 2007, Phytomedicine : international journal of phytotherapy and phytopharmacology.

[31]  K. Tanaka,et al.  A novel glycoprotein obtained from Chlorella vulgaris strain CK22 shows antimetastatic immunopotentiation , 1998, Cancer Immunology, Immunotherapy.

[32]  M L He,et al.  Supplementation of algae to the diet of pigs: a new possibility to improve the iodine content in the meat. , 2002, Journal of animal physiology and animal nutrition.

[33]  A. Wendel Selenium in Biology and Medicine , 1989, Springer Berlin Heidelberg.

[34]  J. Doucha,et al.  Utilization of flue gas for cultivation of microalgae Chlorella sp.) in an outdoor open thin-layer photobioreactor , 2005, Journal of Applied Phycology.

[35]  E. Becker Microalgae: Biotechnology and Microbiology , 1994 .

[36]  M. Sager Selenium in agriculture, food, and nutrition , 2006 .

[37]  David E. Leiva-Candia Second generation biofuels from microbial oil , 2014 .

[38]  H. Iwamoto,et al.  Industrial Production of Microalgal Cell‐Mass and Secondary Products ‐ Major Industrial Species: Chlorella , 2007 .

[39]  A. K. Calgarotto,et al.  Chlorella vulgaris restores bone marrow cellularity and cytokine production in lead-exposed mice. , 2011, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

[40]  D. Mahan Effect of organic and inorganic selenium sources and levels on sow colostrum and milk selenium content. , 2000, Journal of animal science.

[41]  S. Lim,et al.  Effect of Fermented Chlorella Supplementation on Growth Performance, Nutrient Digestibility, Blood Characteristics, Fecal Microbial and Fecal Noxious Gas Content in Growing Pigs , 2012, Asian-Australasian journal of animal sciences.

[42]  Y. Chisti Biodiesel from microalgae. , 2007, Biotechnology advances.

[43]  A. Ben‐Amotz,et al.  Inhibition by beta-carotene-rich algae Dunaliella of spontaneous mammary tumourigenesis in mice. , 1989, Anticancer research.

[44]  A. Muller-Feuga,et al.  Microalgae for aquaculture: the current global situation and future trends. , 2013 .

[45]  S. Ševčíková,et al.  Dietary selenium increases vitamin E contents of egg yolk and chicken meat , 2008, British poultry science.

[46]  Arnaud Muller-Feuga,et al.  The role of microalgae in aquaculture: situation and trends , 2000, Journal of Applied Phycology.

[47]  L. Gouveia,et al.  Use ofChlorella vulgarisin Rainbow Trout,Oncorhynchus mykiss, Diets to Enhance Muscle Pigmentation , 1997 .

[48]  Peter F Surai Selenium in poultry nutrition 2. Reproduction, egg and meat quality and practical applications , 2002 .

[49]  D. Mahan,et al.  Long-term effects of dietary organic and inorganic selenium sources and levels on reproducing sows and their progeny. , 2004, Journal of animal science.

[50]  D. Mahan,et al.  Evaluating the efficacy of selenium-enriched yeast and sodium selenite on tissue selenium retention and serum glutathione peroxidase activity in grower and finisher swine. , 1996, Journal of animal science.

[51]  J. Doucha,et al.  High Density Outdoor Microalgal Culture , 2014 .

[52]  Xuewu Zhang,et al.  Biodiesel Production by Microalgal Biotechnology , 2018, Renewable Energy.

[53]  M. Svoboda,et al.  Efficacy of Se-enriched Alga Chlorella spp. and Se-enriched Yeast on Tissue Selenium Retention and Carcass Characteristics in Finisher Pigs , 2009 .

[54]  L. Gouveia,et al.  Colouring ornamental fish (Cyprinus carpio and Carassius auratus) with microalgal biomass , 2003 .

[55]  T. Goodwin Metabolism, Nutrition, and Function of Carotenoids , 1986 .

[56]  F. Dolberg,et al.  Algae in animal production , 1995 .

[57]  W. Becker Microalgae for aquaculture: the nutritional value of microalgae for aquaculture. , 2007 .

[58]  R. J. Shields,et al.  Algae for Aquaculture and Animal Feeds , 2012 .

[59]  Y. Yoshikai,et al.  Accelerated restoration of the leukocyte number and augmented resistance against Escherichia coli in cyclophosphamide-treated rats orally administered with a hot water extract of Chlorella vulgaris. , 1990, International journal of immunopharmacology.

[60]  C. Cobbett,et al.  Phytochelatins and metallothioneins: roles in heavy metal detoxification and homeostasis. , 2002, Annual review of plant biology.

[61]  V. Zamrazil,et al.  Correlations between parameters of body selenium status and peripheral thyroid parameters in the low selenium region. , 1995, The Analyst.

[62]  D. Rotkovská,et al.  Radioprotection of hemopoiesis conferred by aqueous extract from chlorococcal algae (Ivastimul) administered to mice before irradiation. , 1990, Experimental hematology.