Modulation of the mevalonate pathway and cell growth by pravastatin and d-limonene in a human hepatoma cell line (Hep G2).

[1]  K. Einarsson,et al.  Influence of pravastatin, a specific inhibitor of HMG-CoA reductase, on hepatic metabolism of cholesterol. , 1990, The New England journal of medicine.

[2]  M. Gould,et al.  Selective inhibition of isoprenylation of 21-26-kDa proteins by the anticarcinogen d-limonene and its metabolites. , 1991, The Journal of biological chemistry.

[3]  A. Kandutsch,et al.  Consequences of blocked sterol synthesis in cultured cells. DNA synthesis and membrane composition. , 1977, The Journal of biological chemistry.

[4]  M. Brown,et al.  Inhibition of cholesterol synthesis with compactin renders growth of cultured cells dependent on the low density lipoprotein receptor. , 1979, The Journal of biological chemistry.

[5]  P. Casey,et al.  p21ras is modified by a farnesyl isoprenoid. , 1989, Proceedings of the National Academy of Sciences of the United States of America.

[6]  M N Gould,et al.  Inhibition of DMBA-induced mammary cancer by the monoterpene d-limonene. , 1984, Carcinogenesis.

[7]  M. Kuroda,et al.  Competitive inhibition of 3-hydroxy-3-methylglutaryl coenzyme A reductase by ML-236A and ML-236B fungal metabolites, having hypocholesterolemic activity. , 2004, FEBS letters.

[8]  R. Ross,et al.  Relation of cholesterol and mevalonic acid to the cell cycle in smooth muscle and swiss 3T3 cells stimulated to divide by platelet-derived growth factor. , 1980, The Journal of biological chemistry.

[9]  J. S. Owen,et al.  Membrane lipid changes in erythrocytes, liver and kidney in acute and chronic experimental liver disease in rats. , 1987, Biochimica et biophysica acta.

[10]  R. Evans,et al.  Differential inhibitory effects of lovastatin on protein isoprenylation and sterol synthesis. , 1990, The Journal of biological chemistry.

[11]  M. Gould,et al.  Chemoprevention of mammary carcinogenesis by hydroxylated derivatives of d-limonene. , 1992, Carcinogenesis.

[12]  M. Lewis,et al.  Peptidomimetic inhibitors of Ras farnesylation and function in whole cells. , 1993, The Journal of biological chemistry.

[13]  R. Tanaka,et al.  Tissue-selective acute effects of inhibitors of 3-hydroxy-3-methylglutaryl coenzyme A reductase on cholesterol biosynthesis in lens. , 1989, Journal of lipid research.

[14]  L. Beck,et al.  Incorporation of a product of mevalonic acid metabolism into proteins of Chinese hamster ovary cell nuclei , 1988, The Journal of cell biology.

[15]  H. W. Chen,et al.  The activity of 3‐hydroxy‐3‐methylglutaryl coenzyme a reductase and the rate of sterol synthesis diminish in cultures with high cell density , 1981, Journal of cellular physiology.

[16]  A. Levinson,et al.  Benzodiazepine peptidomimetics: potent inhibitors of Ras farnesylation in animal cells. , 1993, Science.

[17]  S. Thorgeirsson,et al.  Characterization of a transforming N-ras gene in the human hepatoma cell line Hep G2: additional evidence for the importance of c-myc and ras cooperation in hepatocarcinogenesis. , 1990, Cancer research.

[18]  R. Defendini,et al.  Suppression of murine neuroblastoma growth in vivo by mevinolin, a competitive inhibitor of 3-hydroxy-3-methylglutaryl-coenzyme A reductase. , 1985, The Journal of clinical investigation.

[19]  D. Bilheimer,et al.  Regulatory role for hepatic low density lipoprotein receptors in vivo in the dog. , 1981, Proceedings of the National Academy of Sciences of the United States of America.

[20]  J. Glomset,et al.  Evidence for modification of lamin B by a product of mevalonic acid. , 1988, The Journal of biological chemistry.

[21]  B. Roth,et al.  Hep-G2 cells and primary rat hepatocytes differ in their response to inhibitors of HMG-CoA reductase. , 1990, Biochemical and biophysical research communications.

[22]  M. Brown,et al.  Synthesis of ubiquinone and cholesterol in human fibroblasts: regulation of a branched pathway. , 1979, Archives of biochemistry and biophysics.

[23]  M. Brown,et al.  Regulation of plasma cholesterol by lipoprotein receptors. , 1981, Science.

[24]  K. J. Thorne,et al.  Synthesis of radioactive dolichol from (4S-3H)mevalonate in the regenerating rat liver. , 1974, Biochemical Journal.

[25]  W. Schafer,et al.  Genetic and pharmacological suppression of oncogenic mutations in ras genes of yeast and humans. , 1989, Science.

[26]  D. Goodman,et al.  Relationship between mevalonate and mitogenesis in human fibroblasts stimulated with platelet-derived growth factor. , 1984, The Journal of biological chemistry.

[27]  R Monaghan,et al.  Mevinolin: a highly potent competitive inhibitor of hydroxymethylglutaryl-coenzyme A reductase and a cholesterol-lowering agent. , 1980, Proceedings of the National Academy of Sciences of the United States of America.

[28]  Y. Matsuzawa,et al.  Increase in the active form of 3-hydroxy-3-methylglutaryl coenzyme A reductase in human hepatocellular carcinoma: possible mechanism for alteration of cholesterol biosynthesis. , 1990, Cancer research.

[29]  T. Chojnacki,et al.  Separation, quantitation and distribution of dolichol and dolichyl phosphate in rat and human tissues. , 1983, Biochimica et biophysica acta.

[30]  C C Howe,et al.  Human hepatocellular carcinoma cell lines secrete the major plasma proteins and hepatitis B surface antigen. , 1980, Science.

[31]  S. Edge,et al.  Characterization of a Human Hepatic Receptor for High Density Lipoproteins , 1985, Arteriosclerosis.

[32]  C. Marshall,et al.  All ras proteins are polyisoprenylated but only some are palmitoylated , 1989, Cell.

[33]  D. Lowy,et al.  Inhibition of cell growth by lovastatin is independent of ras function. , 1991, Cancer research.

[34]  M. Wiley,et al.  Essential role for mevalonate synthesis in DNA replication. , 1979, Proceedings of the National Academy of Sciences of the United States of America.

[35]  J. Goldstein,et al.  Regulation of the mevalonate pathway , 1990, Nature.

[36]  Catherine H. Wu,et al.  Activity and Regulation of Low Density Lipoprotein Receptors in a Human Hepatoblastoma Cell Line , 1984, Hepatology.

[37]  O. H. Lowry,et al.  Protein measurement with the Folin phenol reagent. , 1951, The Journal of biological chemistry.

[38]  W. Maltese Induction of differentiation in murine neuroblastoma cells by mevinolin, a competitive inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A reductase. , 1984, Biochemical and biophysical research communications.

[39]  F. Hemming,et al.  The characterization and stereochemistry of biosynthesis of dolichols in rat liver. , 1970, The Biochemical journal.

[40]  M. Brown,et al.  Familial hypercholesterolemia: defective binding of lipoproteins to cultured fibroblasts associated with impaired regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity. , 2009, Proceedings of the National Academy of Sciences of the United States of America.

[41]  J. Backer,et al.  Lovastatin blocks N-ras oncogene-induced neuronal differentiation. , 1990, Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research.

[42]  J. Gaylor Enzymes of Sterol Biosynthesis , 1974 .

[43]  Y. Tsujita,et al.  CS-514, a competitive inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A reductase: tissue-selective inhibition of sterol synthesis and hypolipidemic effect on various animal species. , 1986, Biochimica et biophysica acta.

[44]  S. Ranganathan,et al.  The role of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity in the regulation of ubiquinone synthesis in human fibroblasts. , 1980, The Journal of biological chemistry.