Metalloproteinase inhibition reduces lung injury and improves survival after cecal ligation and puncture in rats.

[1]  T. Salo,et al.  A combination of a chemically modified doxycycline and a bisphosphonate synergistically inhibits endotoxin-induced periodontal breakdown in rats. , 2001, Journal of periodontology.

[2]  J. T. Saari,et al.  Augmented metalloproteinase activity and acute lung injury in copper-deficient rats. , 2001, American journal of physiology. Lung cellular and molecular physiology.

[3]  G. Nieman,et al.  Metalloproteinase inhibition prevents acute respiratory distress syndrome. , 2001, The Journal of surgical research.

[4]  D. Madtes,et al.  Selective induction of tissue inhibitor of metalloproteinase-1 in bleomycin-induced pulmonary fibrosis. , 2001, American journal of respiratory cell and molecular biology.

[5]  T. Salo,et al.  Association of trypsin-2 with activation of gelatinase B and collagenase-2 in human bronchoalveolar lavage fluid in vivo , 2001, Annals of medicine.

[6]  M. Heinzelmann,et al.  Heparin binding protein increases survival in murine fecal peritonitis , 2000, Critical care medicine.

[7]  R. Guo,et al.  Time-dependent inhibition of immune complex-induced lung injury by catalase: relationship to alterations in macrophage and neutrophil matrix metalloproteinase elaboration. , 2000, Free radical biology & medicine.

[8]  S. Nakao,et al.  Delayed neutrophil elastase inhibition prevents subsequent progression of acute lung injury induced by endotoxin inhalation in hamsters. , 2000, American journal of respiratory and critical care medicine.

[9]  N. Sakata,et al.  Evaluating the role of inducible nitric oxide synthase using a novel and selective inducible nitric oxide synthase inhibitor in septic lung injury produced by cecal ligation and puncture. , 2000, American journal of respiratory and critical care medicine.

[10]  A. Usui,et al.  Protective effects of ONO-5046*Na, a specific neutrophil elastase inhibitor, on postperfusion lung injury. , 1999, The Annals of thoracic surgery.

[11]  I. Chaudry Sepsis: lessons learned in the last century and future directions. , 1999, Archives of surgery.

[12]  C. Finck,et al.  Matrix metalloproteinase inhibitor prevents acute lung injury after cardiopulmonary bypass. , 1999, Circulation.

[13]  T. Fukuoka,et al.  Low-dose intramuscular polymyxin B improves survival of septic rats. , 1999, Shock.

[14]  L. Golub,et al.  Pharmacologic suppression of experimental abdominal aortic aneurysms: acomparison of doxycycline and four chemically modified tetracyclines. , 1998, Journal of vascular surgery.

[15]  T. Salo,et al.  Inhibition of MMP Synthesis by Doxycycline and Chemically Modified Tetracyclines (CMTs) in Human Endothelial Cells , 1998, Advances in dental research.

[16]  G. Miserocchi,et al.  Involvement of lung interstitial proteoglycans in development of hydraulic- and elastase-induced edema. , 1998, American journal of physiology. Lung cellular and molecular physiology.

[17]  D. Carden,et al.  Neutrophil elastase promotes lung microvascular injury and proteolysis of endothelial cadherins. , 1998, American journal of physiology. Heart and circulatory physiology.

[18]  E. Deitch ANIMAL MODELS OF SEPSIS AND SHOCK: A REVIEW AND LESSONS LEARNED , 1998, Shock.

[19]  U. Bergmann,et al.  Activation of Type IV Procollagenases by Human Tumor-associated Trypsin-2* , 1997, The Journal of Biological Chemistry.

[20]  J. Whitsett,et al.  Alterations of the endogenous surfactant system in septic adult rats. , 1997, American journal of respiratory and critical care medicine.

[21]  G. Bernard,et al.  The effects of ibuprofen on the physiology and survival of patients with sepsis. The Ibuprofen in Sepsis Study Group. , 1997, The New England journal of medicine.

[22]  C. Delacourt,et al.  Gelatinases in epithelial lining fluid of patients with adult respiratory distress syndrome. , 1997, The American journal of physiology.

[23]  P. Suter,et al.  Matrix metalloproteinases and TIMP in acute respiratory distress syndrome. , 1996, American journal of respiratory and critical care medicine.

[24]  A. Sauaia,et al.  Early neutrophil sequestration after injury: a pathogenic mechanism for multiple organ failure. , 1995, The Journal of trauma.

[25]  D. Steedman,et al.  Plasma elastase levels and the development of the adult respiratory distress syndrome. , 1995, American journal of respiratory and critical care medicine.

[26]  S. Nasraway,et al.  Efficacy and safety of monoclonal antibody to human tumor necrosis factor alpha in patients with sepsis syndrome. A randomized, controlled, double-blind, multicenter clinical trial. TNF-alpha MAb Sepsis Study Group. , 1995, JAMA.

[27]  G. Koch,et al.  Efficacy and Safety of Monoclonal Antibody to Human Tumor Necrosis Factor α in Patients With Sepsis Syndrome: A Randomized, Controlled, Double-blind, Multicenter Clinical Trial , 1995 .

[28]  T. Honda,et al.  Effects of ONO-5046, a specific neutrophil elastase inhibitor, on endotoxin-induced lung injury in sheep. , 1994, Journal of applied physiology.

[29]  T. Salo,et al.  Effects of Tetracyclines on Neutrophil, Gingival, and Salivary Collagenases , 1994, Annals of the New York Academy of Sciences.

[30]  H. Nakagawa,et al.  Protective effect of recombinant neutrophil elastase inhibitor (R-020) on sepsis-induced organ injury in rat , 1994, Inflammation.

[31]  S. Opal,et al.  Recombinant human interleukin 1 receptor antagonist in the treatment of patients with sepsis syndrome. Results from a randomized, double-blind, placebo-controlled trial. Phase III rhIL-1ra Sepsis Syndrome Study Group. , 1994, JAMA.

[32]  R. F. Johnston,et al.  Recombinant Human Interleukin 1 Receptor Antagonist in the Treatment of Patients With Sepsis Syndrome: Results From a Randomized, Double-blind, Placebo-Controlled Trial , 1994 .

[33]  A S Slutsky,et al.  Induction of the heat shock response reduces mortality rate and organ damage in a sepsis‐induced acute lung injury model , 1994, Critical care medicine.

[34]  C. Delacourt,et al.  Matrix metalloproteinase and elastase activities in LPS-induced acute lung injury in guinea pigs. , 1994, The American journal of physiology.

[35]  M. Lamy,et al.  The American-European Consensus Conference on ARDS. Definitions, mechanisms, relevant outcomes, and clinical trial coordination. , 1994, American journal of respiratory and critical care medicine.

[36]  A. Ishizaka,et al.  Serum concentration of 7S collagen and prognosis in patients with the adult respiratory distress syndrome. , 1994, Thorax.

[37]  J. Snapper,et al.  Neutrophil elastase inhibitors, SC-37698 and SC-39026, reduce endotoxin-induced lung dysfunction in awake sheep. , 1993, The American review of respiratory disease.

[38]  A. Fowler,et al.  Role of the neutrophil in adult respiratory distress syndrome , 1993, The British journal of surgery.

[39]  J. Norton,et al.  Recombinant interleukin-1 receptor antagonist (IL-1ra): effective therapy against gram-negative sepsis in rats. , 1992, Surgery.

[40]  Y. Kondoh,et al.  Platelet‐activating factor in bronchoalveolar lavage fluid of patients with adult respiratory distress syndrome , 1992, Clinical and experimental pharmacology & physiology.

[41]  E. Moore,et al.  Endotoxin after gut ischemia/reperfusion causes irreversible lung injury. , 1992, The Journal of surgical research.

[42]  R. deShazo,et al.  Mechanisms of neutrophil damage to human alveolar extracellular matrix: the role of serine and metalloproteases. , 1992, The Journal of allergy and clinical immunology.

[43]  Y. Kondoh,et al.  7S collagen in bronchoalveolar lavage fluid of patients with adult respiratory distress syndrome. , 1992, Chest.

[44]  Jerome J. Schentag,et al.  A Controlled Clinical Trial of E5 Murine Monoclonal IgM Antibody to Endotoxin in the Treatment of Gram-Negative Sepsis , 1991 .

[45]  M. A. Martin,et al.  A controlled clinical trial of E5 murine monoclonal IgM antibody to endotoxin in the treatment of gram-negative sepsis. The XOMA Sepsis Study Group. , 1991, JAMA.

[46]  T. Petty Protease Mechanisms in the Pathogenesis of Acute Lung Injury , 1991, Annals of the New York Academy of Sciences.

[47]  C. Sprung,et al.  Treatment of gram-negative bacteremia and septic shock with HA-1A human monoclonal antibody against endotoxin. A randomized, double-blind, placebo-controlled trial. The HA-1A Sepsis Study Group. , 1991 .

[48]  A. Harken,et al.  Reversible lung neutrophil accumulation can cause lung injury by elastase-mediated mechanisms. , 1990, Surgery.

[49]  S. Weiss Tissue destruction by neutrophils. , 1989, The New England journal of medicine.

[50]  C. Haslett,et al.  Neutrophil-mediated injury to endothelial cells. Enhancement by endotoxin and essential role of neutrophil elastase. , 1986, The Journal of clinical investigation.

[51]  I. Chaudry,et al.  Evaluation of factors affecting mortality rate after sepsis in a murine cecal ligation and puncture model. , 1983, Surgery.

[52]  R. Rogers,et al.  Adult respiratory-distress syndrome: changing concepts of lung injury and repair. , 1982, The New England journal of medicine.

[53]  A. Fein,et al.  Elastolytic activity in pulmonary lavage fluid from patients with adult respiratory-distress syndrome. , 1981, The New England journal of medicine.

[54]  H. Carp,et al.  Lung injury induced by leukocytic proteases. , 1979, The American journal of pathology.

[55]  I. Chaudry,et al.  Effect of sepsis on tissue adenine nucleotide levels. , 1979, Surgery.

[56]  T L Petty,et al.  Acute respiratory distress in adults. , 1967, Lancet.

[57]  Thomas R. Riley,et al.  A Randomized Double-blind Placebo-controlled Trial , 2004 .

[58]  S. Weiss,et al.  Role of stromelysin 1 and gelatinase B in experimental acute lung injury. , 2001, American journal of respiratory cell and molecular biology.

[59]  A. Lentsch,et al.  Inhibition of NF-κB Activation and Augmentation of IκBβ by Secretory Leukocyte Protease Inhibitor during Lung Inflammation , 1999 .

[60]  S. Miyake,et al.  Effects of a neutrophil elastase inhibitor (ONO-5046) on acute pulmonary injury induced by tumor necrosis factor alpha (TNFalpha) and activated neutrophils in isolated perfused rabbit lungs. , 1998, American journal of respiratory and critical care medicine.

[61]  K. Iida,et al.  Higher concentrations of matrix metalloproteinases in bronchoalveolar lavage fluid of patients with adult respiratory distress syndrome. , 1997, American journal of respiratory and critical care medicine.

[62]  H. M. Lee,et al.  alpha 1-Proteinase inhibitor in gingival crevicular fluid of humans with adult periodontitis: serpinolytic inhibition by doxycycline. , 1997, Journal of periodontal research.

[63]  A. Ishizaka,et al.  Effect of a specific neutrophil elastase inhibitor, ONO-5046, on endotoxin-induced acute lung injury. , 1996, American journal of respiratory and critical care medicine.