Ferroptosis inhibition by lysosome-dependent catabolism of extracellular protein.

[1]  Wilhelm Palm,et al.  Direct control of lysosomal catabolic activity by mTORC1 through regulation of V-ATPase assembly , 2022, Nature Communications.

[2]  J. Minna,et al.  Author Correction: Targeting de novo lipogenesis and the Lands cycle induces ferroptosis in KRAS-mutant lung cancer , 2022, Nature communications.

[3]  Kellen L. Olszewski,et al.  A targetable CoQ-FSP1 axis drives ferroptosis- and radiation-resistance in KEAP1 inactive lung cancers , 2022, Nature Communications.

[4]  Yu Rim Lee,et al.  Macropinocytosis is an alternative pathway of cysteine acquisition and mitigates sorafenib-induced ferroptosis in hepatocellular carcinoma , 2022, Journal of experimental & clinical cancer research : CR.

[5]  N. Perrimon,et al.  Lysosomal cystine mobilization shapes the response of TORC1 and tissue growth to fasting , 2022, Science.

[6]  S. Dixon,et al.  Nucleotide biosynthesis links glutathione metabolism to ferroptosis sensitivity , 2021, Life Science Alliance.

[7]  D. Sabatini,et al.  GCN2 adapts protein synthesis to scavenging-dependent growth. , 2021, Cell systems.

[8]  S. Dixon,et al.  Understanding the role of cysteine in ferroptosis: progress & paradoxes , 2021, The FEBS journal.

[9]  J. Pouysségur,et al.  A Cystine-Cysteine Intercellular Shuttle Prevents Ferroptosis in xCTKO Pancreatic Ductal Adenocarcinoma Cells , 2021, Cancers.

[10]  S. Dixon,et al.  A Compendium of Kinetic Modulatory Profiles Identifies Ferroptosis Regulators , 2021, Nature Chemical Biology.

[11]  B. Stockwell,et al.  Ferroptosis: mechanisms, biology and role in disease , 2021, Nature Reviews Molecular Cell Biology.

[12]  S. Dixon,et al.  Quantification of drug-induced fractional killing using high-throughput microscopy , 2021, STAR protocols.

[13]  L. Zhuang,et al.  Cystine transporter SLC7A11/xCT in cancer: ferroptosis, nutrient dependency, and cancer therapy , 2020, Protein & Cell.

[14]  Stephen A. Sastra,et al.  Cysteine depletion induces pancreatic tumor ferroptosis in mice , 2020, Science.

[15]  A. Edinger,et al.  Macropinocytosis confers resistance to therapies targeting cancer anabolism , 2020, Nature Communications.

[16]  C. Thompson,et al.  Transsulfuration Activity Can Support Cell Growth upon Extracellular Cysteine Limitation. , 2019, Cell metabolism.

[17]  Edward W. Tate,et al.  FSP1 is a glutathione-independent ferroptosis suppressor , 2019, Nature.

[18]  J. Olzmann,et al.  The CoQ oxidoreductase FSP1 acts in parallel to GPX4 to inhibit ferroptosis , 2019, Nature.

[19]  Yijuan Zhang,et al.  Macropinocytosis in Cancer: A Complex Signaling Network. , 2019, Trends in cancer.

[20]  B. Stockwell,et al.  Imidazole Ketone Erastin Induces Ferroptosis and Slows Tumor Growth in a Mouse Lymphoma Model. , 2019, Cell chemical biology.

[21]  G. DeNicola,et al.  The Non-Essential Amino Acid Cysteine Becomes Essential for Tumor Proliferation and Survival , 2019, Cancers.

[22]  A. Chinnaiyan,et al.  CD8+ T cells regulate tumor ferroptosis during cancer immunotherapy , 2019, Nature.

[23]  M. Murphy,et al.  Mechanistic basis for impaired ferroptosis in cells expressing the African-centric S47 variant of p53 , 2019, Proceedings of the National Academy of Sciences.

[24]  J. Olzmann,et al.  Exogenous Monounsaturated Fatty Acids Promote a Ferroptosis-Resistant Cell State. , 2019, Cell chemical biology.

[25]  Wilhelm Palm Metabolic functions of macropinocytosis , 2018, Philosophical Transactions of the Royal Society B.

[26]  M. V. Vander Heiden,et al.  Quantification of microenvironmental metabolites in murine cancers reveals determinants of tumor nutrient availability , 2018, bioRxiv.

[27]  S. Dixon,et al.  p53 Suppresses Metabolic Stress-Induced Ferroptosis in Cancer Cells. , 2018, Cell reports.

[28]  A. Walch,et al.  Selenium Utilization by GPX4 Is Required to Prevent Hydroperoxide-Induced Ferroptosis , 2017, Cell.

[29]  Tricia T. Nguyen,et al.  PTEN Deficiency and AMPK Activation Promote Nutrient Scavenging and Anabolism in Prostate Cancer Cells. , 2018, Cancer discovery.

[30]  Inge M. N. Wortel,et al.  Surviving Stress: Modulation of ATF4-Mediated Stress Responses in Normal and Malignant Cells , 2017, Trends in Endocrinology & Metabolism.

[31]  Gregory A. Wyant,et al.  Lysosomal metabolomics reveals V-ATPase- and mTOR-dependent regulation of amino acid efflux from lysosomes , 2017, Science.

[32]  Gregory A. Wyant,et al.  mTORC1 Activator SLC38A9 Is Required to Efflux Essential Amino Acids from Lysosomes and Use Protein as a Nutrient , 2017, Cell.

[33]  J. Rabinowitz,et al.  mTOR Inhibition Restores Amino Acid Balance in Cells Dependent on Catabolism of Extracellular Protein. , 2017, Molecular cell.

[34]  A. Letai,et al.  Cytoplasmic p53 couples oncogene-driven glucose metabolism to apoptosis and is a therapeutic target in glioblastoma , 2017, Nature Medicine.

[35]  Jill P. Mesirov,et al.  Dependency of a therapy-resistant state of cancer cells on a lipid peroxidase pathway , 2017, Nature.

[36]  Stuart L. Schreiber,et al.  Drug-tolerant persister cancer cells are vulnerable to GPX4 inhibition , 2017, Nature.

[37]  S. Dixon,et al.  Systematic Quantification of Population Cell Death Kinetics in Mammalian Cells. , 2017, Cell systems.

[38]  Carson C. Thoreen,et al.  mTORC1 Balances Cellular Amino Acid Supply with Demand for Protein Synthesis through Post-transcriptional Control of ATF4 , 2017, Cell reports.

[39]  Christine Unger,et al.  Comparison of cancer cells in 2D vs 3D culture reveals differences in AKT–mTOR–S6K signaling and drug responses , 2017, Journal of Cell Science.

[40]  G. Stephanopoulos,et al.  Direct evidence for cancer-cell-autonomous extracellular protein catabolism in pancreatic tumors , 2016, Nature Medicine.

[41]  G. Georgiou,et al.  Systemic depletion of serum l-Cyst(e)ine with an engineered human enzyme induces production of reactive oxygen species and suppresses tumor growth in mice , 2016, Nature medicine.

[42]  Christian M. Metallo,et al.  Reductive carboxylation supports redox homeostasis during anchorage-independent growth , 2016, Nature.

[43]  Matthias Mann,et al.  Plasma Proteome Profiling to Assess Human Health and Disease. , 2016, Cell systems.

[44]  B. Stockwell,et al.  Global Survey of Cell Death Mechanisms Reveals Metabolic Regulation of Ferroptosis , 2016, Nature chemical biology.

[45]  J. Dye,et al.  Cysteine Cathepsin Inhibitors as Anti-Ebola Agents. , 2016, ACS infectious diseases.

[46]  E. Lander,et al.  Identification and characterization of essential genes in the human genome , 2015, Science.

[47]  D. Tuveson,et al.  The Utilization of Extracellular Proteins as Nutrients Is Suppressed by mTORC1 , 2015, Cell.

[48]  K. Ross,et al.  Transcriptional control of autophagy–lysosome function drives pancreatic cancer metabolism , 2015, Nature.

[49]  M. V. Vander Heiden,et al.  Human pancreatic cancer tumors are nutrient poor and tumor cells actively scavenge extracellular protein. , 2015, Cancer research.

[50]  A. Walch,et al.  Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice , 2014, Nature Cell Biology.

[51]  Matthew E. Welsch,et al.  Pharmacological inhibition of cystine–glutamate exchange induces endoplasmic reticulum stress and ferroptosis , 2014, eLife.

[52]  Matthew E. Welsch,et al.  Regulation of Ferroptotic Cancer Cell Death by GPX4 , 2014, Cell.

[53]  Christian M. Metallo,et al.  Macropinocytosis of protein is an amino acid supply route in Ras-transformed cells , 2013, Nature.

[54]  Kevin W Eliceiri,et al.  NIH Image to ImageJ: 25 years of image analysis , 2012, Nature Methods.

[55]  M. R. Lamprecht,et al.  Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death , 2012, Cell.

[56]  Hanna Y. Irie,et al.  Antioxidant and oncogene rescue of metabolic defects caused by loss of matrix attachment , 2009, Nature.

[57]  Juergen Friedrich,et al.  Spheroid-based drug screen: considerations and practical approach , 2009, Nature Protocols.

[58]  Jeffrey R. Morgan,et al.  Mammalian Target of Rapamycin Contributes to the Acquired Apoptotic Resistance of Human Mesothelioma Multicellular Spheroids* , 2008, Journal of Biological Chemistry.

[59]  Satoru Takahashi,et al.  Redox Imbalance in Cystine/Glutamate Transporter-deficient Mice* , 2005, Journal of Biological Chemistry.

[60]  Dong Joon Kim,et al.  A rapid, simple measurement of human albumin in whole blood using a fluorescence immunoassay (I). , 2004, Clinica chimica acta; international journal of clinical chemistry.

[61]  S. Barnes,et al.  Sulfenic acid formation in human serum albumin by hydrogen peroxide and peroxynitrite. , 2003, Biochemistry.

[62]  W. Gahl,et al.  Cystinosis. , 2002, The New England journal of medicine.

[63]  A. Cantin,et al.  Albumin-mediated regulation of cellular glutathione and nuclear factor kappa B activation. , 2000, American journal of respiratory and critical care medicine.

[64]  T. Coelho-Sampaio,et al.  A novel methodology for the investigation of intracellular proteolytic processing in intact cells. , 1998, European journal of cell biology.

[65]  R. Stocker,et al.  Radical-induced chain oxidation of proteins and its inhibition by chain-breaking antioxidants. , 1993, The Biochemical journal.

[66]  S. Ohkuma,et al.  Effect of weak bases on the intralysosomal pH in mouse peritoneal macrophages , 1981, The Journal of cell biology.

[67]  G. L. Watkins,et al.  Standardization of immunochemical determinations of serum albumin. , 1981, Clinical chemistry.

[68]  K. Piez,et al.  The reversible binding of half-cystine residues to serum protein, and its bearing on the cystine requirement of cultured mammalian cells. , 1960, The Journal of biological chemistry.

[69]  H. Eagle,et al.  Amino acid metabolism in mammalian cell cultures. , 1959, Science.