论文信息 - STUDIES ON THE TREATMENT OF MALIGNANT TUMORS WITH FIBROBLAST-INHIBITING AGENT. IV. EFFECTS OF CHLOROQUINE ON MALIGNANT LYMPHOMAS.

STUDIES ON THE TREATMENT OF MALIGNANT TUMORS WITH FIBROBLAST-INHIBITING AGENT. IV. EFFECTS OF CHLOROQUINE ON MALIGNANT LYMPHOMAS.

Eleven cases of malignant lymphomas were treated with a fibroblast-inhibiting agent, chloroquine, and of these, one case of lymphosarcoma, two of acute and chronic lymphocytic leukemia, respectively, and two of giant follicle lymphoma showed regression of the enlarged lymph nodes and also of the enlarged spleen in some of the splenomegalic patients. In contrast, the drug proved ineffective in two cases of reticulum cell sarcoma and Hodgkin's disease, respectively. The side effects of the drug were minimal, and three of the 11 cases complained of nausea, anorexia or palpebral ptosis, which disappeared by decreasing the drug dosage or combining ATP preparation. The tissue culture study of biopsied lymph nodes from lymphocytic leukemia showed inhibition of the growth zone in a medium containing chloroquine indicating a possibility of the drug action not only upon the stromal tissue but also upon the parenchymal tumor cell.

I. Kimura | K. Hiraki

[1] H. Kodani. Studies on the Treatment of Malignant Tumors with Fibroblast-Inhibiting Agent , 1965 .

[2] I. Kimura,et al. STUDIES ON THE TREATMENT OF MALIGNANT TUMORS WITH FIBROBLAST-INHIBITING AGENT. 3. EFFECTS OF CHLOROQUINE ON HUMAN CANCERS. , 1964, Acta medicinae Okayama.

[3] H. Sunami,et al. The method of tissue culture (mainly of the bone marrow) and a simple method of observ-ing living tissue , 1956 .

[4] I. Kimura,et al. STUDIES ON THE TREATMENT OF MALIGNANT TUMORS WITH FIBROBLAST-INHIBITING AGENT. II. EFFECTS OF CHLOROQUINE ON ANIMAL TUMORS. , 1963, Acta medicinae Okayama.

[5] I. Kimura,et al. STUDIES ON THE TREATMENT OF MALIGNANT TUMORS WITH FIBROBLAST-INHIBITING AGENT. I. FIBROBLAST-INHIBITING ACTION OF CHLOROQUINE. , 1963, Acta medicinae Okayama.