Effects of oncogenic mutations in Smoothened and Patched can be reversed by cyclopamine

[1]  R. Hesketh,et al.  Lines of communication , 2002, Journal of Cell Science.

[2]  J. Gibbs.  Mechanism-based target identification and drug discovery in cancer research. , 2000, Science.

[3]  Philip A Beachy,et al.  Hedgehog-Regulated Processing of Gli3 Produces an Anterior/Posterior Repressor Gradient in the Developing Vertebrate Limb , 2000, Cell.

[4]  T. Steck,et al.  Regulation of endoplasmic reticulum cholesterol by plasma membrane cholesterol. , 1999, Journal of lipid research.

[5]  P. Beachy,et al.  Sonic hedgehog protein signals not as a hydrolytic enzyme but as an apparent ligand for patched. , 1999, Proceedings of the National Academy of Sciences of the United States of America.

[6]  Philip A Beachy,et al.  Nuclear Trafficking of Cubitus interruptus in the Transcriptional Regulation of Hedgehog Target Gene Expression , 1999, Cell.

[7]  L. Wojnowski,et al.  The patched signaling pathway in tumorigenesis and development: lessons from animal models , 1999, Journal of Molecular Medicine.

[8]  Konrad Basler,et al.  Hedgehog Controls Limb Development by Regulating the Activities of Distinct Transcriptional Activator and Repressor Forms of Cubitus interruptus , 1999, Cell.

[9]  F. Sauvage,et al.  Sonic hedgehog signaling by the Patched–Smoothened receptor complex , 1999, Current Biology.

[10]  M. Scott,et al.  Hedgehog and Patched in Neural Development and Disease , 1998, Neuron.

[11]  R. Kapur,et al.  The teratogenic Veratrum alkaloid cyclopamine inhibits sonic hedgehog signal transduction. , 1998, Development.

[12]  P. Ingham,et al.  Transducing Hedgehog: the story so far , 1998, The EMBO journal.

[13]  P. Beachy,et al.  Teratogen-mediated inhibition of target tissue response to Shh signaling. , 1998, Science.

[14]  C. Ambrose,et al.  Identification of a Palmitic Acid-modified Form of Human Sonic hedgehog* , 1998, The Journal of Biological Chemistry.

[15]  M. Wolter,et al.  Missense mutations in SMOH in sporadic basal cell carcinomas of the skin and primitive neuroectodermal tumors of the central nervous system. , 1998, Cancer research.

[16]  Q. Gu,et al.  Activating Smoothened mutations in sporadic basal-cell carcinoma , 1998, Nature.

[17]  M. Scott,et al.  Altered neural cell fates and medulloblastoma in mouse patched mutants. , 1997, Science.

[18]  T. Kornberg,et al.  Proteolysis That Is Inhibited by Hedgehog Targets Cubitus interruptus Protein to the Nucleus and Converts It to a Repressor , 1997, Cell.

[19]  T Pietsch,et al.  Medulloblastomas of the desmoplastic variant carry mutations of the human homologue of Drosophila patched. , 1997, Cancer research.

[20]  M. Nakafuku,et al.  A binding site for Gli proteins is essential for HNF-3beta floor plate enhancer activity in transgenics and can respond to Shh in vitro. , 1997, Development.

[21]  H. Bourne,et al.  How receptors talk to trimeric G proteins. , 1997, Current opinion in cell biology.

[22]  C. James,et al.  Sporadic medulloblastomas contain PTCH mutations. , 1997, Cancer research.

[23]  A. Saul,et al.  Macromolecular transport in malaria--does the duct exist? , 1997, European journal of cell biology.

[24]  P. Beachy,et al.  Cyclopia and defective axial patterning in mice lacking Sonic hedgehog gene function , 1996, Nature.

[25]  R. Myers,et al.  Human Homolog of patched, a Candidate Gene for the Basal Cell Nevus Syndrome , 1996, Science.

[26]  Michael Dean,et al.  Mutations of the Human Homolog of Drosophila patched in the Nevoid Basal Cell Carcinoma Syndrome , 1996, Cell.

[27]  D. Ferguson,et al.  Parasite-regulated membrane transport processes and metabolic control in malaria-infected erythrocytes. , 1995, The Biochemical journal.

[28]  T. Kenakin,et al.  Physiological effects of inverse agonists in transgenic mice with myocardial overexpression of the β2-adrenoceptor , 1995, Nature.

[29]  W. Trager,et al.  Human malaria parasites in continuous culture. , 1976, Science.

[30]  V. Freedman,et al.  Tumorigenicity of virus-transformed cells in nude mice is correlated specifically with anchorage independent growth in vitro. , 1975, Proceedings of the National Academy of Sciences of the United States of America.

[31]  R. Keeler.  Teratogenic compounds of Veratrum californicum (Durand). 13. Structure of muldamine. , 1971, Steroids.

[32]  R. Keeler,et al.  Teratogenic compounds of Veratrum californicum (Durand). V. Comparison of cyclopian effects of steroidal alkaloids from the plant and structurally related compounds from other sources. , 1968, Teratology.

[33]  D. E. Goldman.  POTENTIAL, IMPEDANCE, AND RECTIFICATION IN MEMBRANES , 1943, The Journal of general physiology.

[34]  P. Beachy,et al.  Multiple roles of cholesterol in hedgehog protein biogenesis and signaling. , 1997, Cold Spring Harbor symposia on quantitative biology.