Over 300 Radiation Caries Papers: Reflections From the Rearview Mirror

Radiation caries (RC) is an aggressive oral toxicity in head and neck cancer survivors, which develops 6 to 12 months after head and neck radiotherapy. It initially affects the tooth cervical/incisal surfaces, and if not promptly diagnosed/managed, progresses to dental crown amputation and risk of osteoradionecrosis. It results from a multidimensional cluster of treatment-induced oral symptoms, including hyposalivation, dietary changes, and oral hygiene impairment. Although recognized as a frequent complication of radiotherapy and extensively assessed by a myriad of retrospective, in vitro, and in situ studies, RC patients are still orphans of clinically validated methods for risk prediction, prevention, and treatment of early lesions. This review provides a historical overview of science-based concepts regarding RC pathogenesis and treatment, emphasizing the growing demand for interventional clinical studies (randomized trials).

[1]  T. Brandão,et al.  AWARENESS OF THE RISK OF RADIATION-RELATED CARIES IN HEAD AND NECK CANCER PATIENTS: A SURVEY OF PHYSICIANS, DENTISTS, AND PATIENTS , 2022, Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology.

[2]  M. Martins,et al.  Head and neck radiotherapy effects on the dental pulp vitality and response to sensitivity tests. A systematic review with meta-analysis. , 2022, International endodontic journal.

[3]  B. Schmidt,et al.  Tooth failure post-radiotherapy in head and neck cancer. , 2021, International journal of radiation oncology, biology, physics.

[4]  Mehran Azimbagirad,et al.  Prediction of Radiation-Related Dental Caries Through PyRadiomics Features and Artificial Neural Network on Panoramic Radiography , 2021, Journal of Digital Imaging.

[5]  T. Brandão,et al.  Impact of radiation on tooth loss in patients with head and neck cancer: a retrospective dosimetric-based study. , 2021, Oral surgery, oral medicine, oral pathology and oral radiology.

[6]  A. Prado-Ribeiro,et al.  Awareness of the risk of radiation-related caries in patients with head and neck cancer: A survey of physicians, dentists, and patients. , 2021, Oral surgery, oral medicine, oral pathology and oral radiology.

[7]  Xuedong Zhou,et al.  Synonymous point mutation of gtfB gene caused by therapeutic X-rays exposure reduced the biofilm formation and cariogenic abilities of Streptococcus mutans , 2021, Cell & bioscience.

[8]  A. Prado-Ribeiro,et al.  Are intraoral stents effective in reducing oral toxicities caused by radiotherapy? A systematic review and meta-analysis. , 2021, The Journal of prosthetic dentistry.

[9]  A. Prado-Ribeiro,et al.  Impact of head and neck radiotherapy on the longevity of dental adhesive restorations: A systematic review and meta-analysis. , 2021, The Journal of prosthetic dentistry.

[10]  E. Gogineni,et al.  Dental radiation dosimetric maps from intensity‐modulated radiation therapy planning for head and neck cancers , 2021, Head & neck.

[11]  Zheng Li,et al.  Oral pH value predicts the incidence of radiotherapy related caries in nasopharyngeal carcinoma patients , 2020, Scientific Reports.

[12]  M. Glogauer,et al.  The DMFS160: A new index for measuring post-radiation caries. , 2020, Oral oncology.

[13]  A. Prado-Ribeiro,et al.  Radiation-related caries: current diagnostic, prognostic, and management paradigms. , 2020, Oral surgery, oral medicine, oral pathology and oral radiology.

[14]  D. Fernandes,et al.  The impact of an educational video about radiotherapy and its toxicities in head and neck cancer patients. Evaluation of patients' understanding, anxiety, depression, and quality of life. , 2020, Oral oncology.

[15]  M. McGurk,et al.  Presenting pre-radiotherapy dental status of head and neck cancer patients in the novel radiation era , 2020, British Dental Journal.

[16]  Öztun Temelli,et al.  The effect of different doses of radiation on the morphogical, mechanical and chemical properties of the primary and permanent teeth—an in vitro study , 2020 .

[17]  Q. Gao,et al.  Effects of different anti-caries procedures on microhardness and micromorphology of irradiated permanent enamel. , 2020, Dental materials journal.

[18]  T. Brandão,et al.  Impact of Clustering Oral Symptoms in the Pathogenesis of Radiation Caries: A Systematic Review , 2020, Caries Research.

[19]  L. Chow.  Head and Neck Cancer. , 2020, The New England journal of medicine.

[20]  C. Cardwell,et al.  Dental caries following radiotherapy for head and neck cancer: A systematic review. , 2019, Oral oncology.

[21]  M. B. Gavião,et al.  The impact of radiation caries in the quality of life of head and neck cancer patients , 2019, Supportive Care in Cancer.

[22]  Xinlin Yu,et al.  Direct radiation-induced effects on dental hard tissue , 2019, Radiation oncology.

[23]  B. Paster,et al.  Caries-associated oral microbiome in head and neck cancer radiation patients: a longitudinal study , 2019, Journal of oral microbiology.

[24]  R. Palma-Dibb,et al.  Radiotherapy Activates and Protease Inhibitors Inactivate Matrix Metalloproteinases in the Dentinoenamel Junction of Permanent Teeth , 2018, Caries Research.

[25]  Pablo Agustin Vargas,et al.  Radiation-related caries assessment through the International Caries Detection and Assessment System and the Post-Radiation Dental Index. , 2017, Oral surgery, oral medicine, oral pathology and oral radiology.

[26]  M. Delgado-Rodríguez,et al.  Systematic review and meta-analysis. , 2017, Medicina intensiva.

[27]  T. Brandão,et al.  Impact of head and neck radiotherapy on the mechanical behavior of composite resins and adhesive systems: A systematic review. , 2017, Dental materials : official publication of the Academy of Dental Materials.

[28]  N. Heaivilin,et al.  Common oral complications of head and neck cancer radiation therapy: mucositis, infections, saliva change, fibrosis, sensory dysfunctions, dental caries, periodontal disease, and osteoradionecrosis , 2017, Cancer medicine.

[29]  Yong Wang,et al.  Stress analysis of irradiated human tooth enamel using finite element methods , 2017, Computer methods in biomechanics and biomedical engineering.

[30]  F. Setzer,et al.  Late Effects of Head and Neck Radiotherapy on Pulp Vitality Assessed by Pulse Oximetry. , 2016, Journal of endodontics.

[31]  T. Brandão,et al.  Micromorphology of the dental pulp is highly preserved in cancer patients who underwent head and neck radiotherapy. , 2014, Journal of endodontics.

[32]  N. R. Johnson,et al.  Dental management of patients irradiated for head and neck cancer. , 2014, Australian dental journal.

[33]  J. Thariat,et al.  Oral complications of cancer and cancer therapy , 2012, CA: a cancer journal for clinicians.

[34]  E. Mohammadi,et al.  Barriers and facilitators related to the implementation of a physiological track and trigger system: A systematic review of the qualitative evidence , 2017, International journal for quality in health care : journal of the International Society for Quality in Health Care.

[35]  F. Setzer,et al.  Pulp vitality in patients with intraoral and oropharyngeal malignant tumors undergoing radiation therapy assessed by pulse oximetry. , 2011, Journal of endodontics.

[36]  L. Z. Naves,et al.  Effect of Gamma Irradiation on Ultimate Tensile Strength of Enamel and Dentin , 2010, Journal of dental research.

[37]  K. Williams,et al.  Post-radiation dental index: development and reliability , 2008, Supportive Care in Cancer.

[38]  W. Hinkelbein,et al.  Radiation-related damage to dentition. , 2006, The Lancet. Oncology.

[39]  T. Brandão,et al.  Preservation of immunoexpression of type I collagen, BSP and BMP4 in the dentin-pulp complex of head and neck cancer patients after radiotherapy. , 2022, Brazilian oral research.

[40]  Maja O’Connor.  LONGITUDINAL STUDY , 2013 .

[41]  S. Taylor.  Head and neck cancer. , 1991, Cancer chemotherapy and biological response modifiers.