Localized tissue destruction by high-intensity focused ultrasound.

Rat liver and rabbit liver and kidney were exposed to focused ultrasound of 312 w/sq cm (rat) and 900 w/sq cm (rabbit) by direct application of the ultrasound transducer to the surface of the organ exposed. A discrete, narrow, cylindrical zone of tissue necrosis to a depth of approximately 2 cm could be induced in the tissue exposed to the ultrasound. Lesions thus produced were well tolerated and tended to be resorbed over a period of several weeks without evidence of hemorrhage, infection, or adverse systemic effect. In rabbit liver, a linear zone of necorsis was induced by linear movement of the transducer. Development of the use of local high-intensity ultrasound may broaden the clinical scope of thermal destruction of cancer beyond that accomplished by electrocoagulation or cryosurgery.

[1]  W. Whitmore.  The treatment of bladder tumors. , 1969, The Surgical clinics of North America.

[2]  C. Linke,et al.  Localized heating of tissue by electric and nonelectric means. , 1967, Investigative urology.

[3]  A. Gage.  Cryosurgery for oral and pharyngeal carcinoma. , 1969, American journal of surgery.

[4]  O. Saphir,et al.  Immunologic resistance to carcinoma produced by electrocoagulation. , 1965, Surgery, gynecology & obstetrics.

[5]  R. Marcove,et al.  Cryosurgery in the treatment of solitary or multiple bone metastases from renal cell carcinoma. , 1972, The Journal of urology.

[6]  A. Roberts,et al.  Effect of marked hyperthermia upon the canine bladder. , 1972, The Journal of urology.

[7]  P. P. Lele,et al.  An analysis of lesion development in the brain and in plastics by high-intensity focused ultrasound at low-megahertz frequencies. , 1972, The Journal of the Acoustical Society of America.

[8]  D. Chrzan,et al.  The early histologic changes following electrocoagulation. , 1961, The Journal of urology.

[9]  Cryosurgery of malignant neoplasms of the head and neck. , 1972, JAMA.

[10]  Ketcham As,et al.  Comparison of tumor immunity after complete excision, cryonecrosis, and in the presence of persistent tumor. , 1970 .

[11]  A. Ketcham,et al.  Requisites for successful cryogenic surgery of cancer. , 1971, Archives of surgery.

[12]  G. Crile.  Heat as an adjunct to the treatment of cancer; experimental studies. , 1961, Cleveland Clinic quarterly.

[13]  F Dunn,et al.  Frequency dependence of thresholds for ultrasonic production of thermal lesions in tissue. , 1973, The Journal of the Acoustical Society of America.

[14]  W. A. Soanes,et al.  Remission of metastatic lesions following cryosurgery in prostatic cancer: immunologic considerations. , 1970, The Journal of urology.

[15]  C. Linke,et al.  Effects of microwaves on normal tissues. , 1962, The Journal of urology.

[16]  W. B. Patterson,et al.  Electrocoagulation vs excision: comparison of degree of immunity engendered by treatment of induced tumors in syngeneic mice. , 1972, Surgical forum.

[17]  J B Pond,et al.  The role of heat in the production of ultrasonic focal lesions. , 1970, The Journal of the Acoustical Society of America.

[18]  G. Crile,et al.  The role of electrocoagulation in the treatment of carcinoma of the rectum. , 1972, Surgery, gynecology & obstetrics.

[19]  W J FRY,et al.  Fundamental neurological research and human neurosurgery using intense ultrasound. , 1960, IRE transactions on medical electronics.

[20]  C. Heidelberger,et al.  Selective heat sensitivity of cancer cells. Biochemical and clinical studies , 1967 .

[21]  F Dunn,et al.  Ultrasonic threshold dosages for the mammalian central nervous system. , 1971, IEEE transactions on bio-medical engineering.