Introduction of structural bioinformatics with respect to drug discovery

Abstract Drug discovery is an arduous, time consuming and expensive process requiring several years and a huge amount of funding. Identifying a potential drug target and suitable lead molecule for drug development are critical steps in the drug discovery process. Among the various methods available for the identification of new lead molecules, structural bioinformatics has a special place. Structural bioinformatics plays a vital role in target validation, active site identification, lead optimization, drug-likeness prediction and stability analysis. The structural bioinformatics helps in identifying and designing novel leads against a selected drug target that could be tested experimentally to check the impact on the biological system.

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