An integrative review of nonobvious puzzles of cellular and molecular cardiooncology

[1]  D. Day,et al.  Immune Checkpoint Inhibitor Therapy in Oncology , 2022, JACC. CardioOncology.

[2]  J. Rhee,et al.  Beyond cardiomyocytes: Cellular diversity in the heart's response to exercise , 2022, Journal of sport and health science.

[3]  G. Calin,et al.  Hormonal therapies up-regulate MANF and overcome female susceptibility to immune checkpoint inhibitor myocarditis , 2022, Science Translational Medicine.

[4]  Xiaoyan Zhao,et al.  Resveratrol alleviated 5-FU-induced cardiotoxicity by attenuating GPX4 dependent ferroptosis. , 2022, The Journal of nutritional biochemistry.

[5]  Zhao-hui Pei,et al.  Empagliflozin attenuates trastuzumab-induced cardiotoxicity through suppression of DNA damage and ferroptosis. , 2022, Life sciences.

[6]  Fan Yang,et al.  Therapeutic overexpression of miR-92a-2-5p ameliorated cardiomyocyte oxidative stress injury in the development of diabetic cardiomyopathy , 2022, Cellular & Molecular Biology Letters.

[7]  A. Oliveira‐Brett,et al.  Electrochemistry of chemotherapeutic alkylating agents and their interaction with DNA. , 2022, Journal of pharmaceutical and biomedical analysis.

[8]  A. Vallakati,et al.  Carfilzomib-induced Cardiotoxicity: An Analysis of the FDA Adverse Event Reporting System (FAERS) , 2022, Journal of the Saudi Heart Association.

[9]  L. Lerman,et al.  Cellular senescence: the good, the bad and the unknown , 2022, Nature Reviews Nephrology.

[10]  W. Akamatsu,et al.  Involvement of kallikrein‐PAR2‐proinflammatory pathway in severe trastuzumab‐induced cardiotoxicity , 2022, Cancer science.

[11]  Natalia Frankowska,et al.  Proteolysis dysfunction in the process of aging and age-related diseases , 2022, Frontiers in Aging.

[12]  D. Jindatip,et al.  Curcumin reduces blood-nerve barrier abnormalities and cytotoxicity to endothelial cells and pericytes induced by cisplatin. , 2022, Folia morphologica.

[13]  A. Crijns,et al.  Association Between Cardiac Radiation Exposure and the Risk of Arrhythmia in Breast Cancer Patients Treated With Radiotherapy: A Case–Control Study , 2022, Frontiers in Oncology.

[14]  B. Lakkakula,et al.  Biomarkers of Oxidative Stress Tethered to Cardiovascular Diseases , 2022, Oxidative medicine and cellular longevity.

[15]  Xiao-hang Liu,et al.  PD-1 inhibitor induces myocarditis by reducing regulatory T cells, activating inflammatory responses, promoting myocardial apoptosis and autophagy. , 2022, Cytokine.

[16]  Zhiru Li,et al.  Comparing the efficacy and safety of cisplatin and other platinum-based chemotherapies in locally advanced nasopharyngeal carcinoma: a systematic review and meta-analysis , 2022, BMC cancer.

[17]  Hui-Ching Cheng,et al.  Quercetin Mitigates Cisplatin-Induced Oxidative Damage and Apoptosis in Cardiomyocytes through Nrf2/HO-1 Signaling Pathway. , 2022, The American journal of Chinese medicine.

[18]  M. Shabani,et al.  Protective Effect of Curcumin, Chrysin and Thymoquinone Injection on Trastuzumab-Induced Cardiotoxicity via Mitochondrial Protection , 2022, Cardiovascular Toxicology.

[19]  W. Cubała,et al.  Commentary concerning treatment of depression in patients with heart failure according to 2021 ESC Guidelines on cardiovascular disease prevention in clinical practice. , 2022, European journal of preventive cardiology.

[20]  J. Sanger,et al.  Inhibitors of the ubiquitin proteasome system block myofibril assembly in cardiomyocytes derived from chick embryos and human pluripotent stem cells , 2022, Cytoskeleton.

[21]  G. Pelosi,et al.  An Olive Oil Mill Wastewater Extract Improves Chemotherapeutic Activity Against Breast Cancer Cells While Protecting From Cardiotoxicity , 2022, Frontiers in Cardiovascular Medicine.

[22]  T. Chou,et al.  Far‐infrared radiation alleviates cisplatin‐induced vascular damage and impaired circulation via activation of HIF‐1α , 2022, Cancer science.

[23]  Naoko Ohtani.  The roles and mechanisms of senescence-associated secretory phenotype (SASP): can it be controlled by senolysis? , 2022, Inflammation and Regeneration.

[24]  Chia-Yang Li,et al.  Proteasome Inhibitors Decrease the Viability of Pulmonary Arterial Smooth Muscle Cells by Restoring Mitofusin-2 Expression under Hypoxic Conditions , 2022, Biomedicines.

[25]  L. Brunham,et al.  RARG S427L attenuates the DNA repair response to doxorubicin in induced pluripotent stem cell-derived cardiomyocytes , 2022, Stem cell reports.

[26]  Jeonghun Yeom,et al.  Radiation‐induced C‐reactive protein triggers apoptosis of vascular smooth muscle cells through ROS interfering with the STAT3/Ref‐1 complex , 2022, Journal of cellular and molecular medicine.

[27]  Q. Kong,et al.  Why Senescent Cells Are Resistant to Apoptosis: An Insight for Senolytic Development , 2022, Frontiers in Cell and Developmental Biology.

[28]  Jiong Cai,et al.  Acetylation of Atp5f1c Mediates Cardiomyocyte Senescence via Metabolic Dysfunction in Radiation-Induced Heart Damage , 2022, Oxidative medicine and cellular longevity.

[29]  Jack D. Crouch,et al.  Epigenetic Regulation of Cellular Senescence , 2022, Cells.

[30]  D. Jindatip,et al.  Cisplatin-induced alterations in the blood-nerve barrier: effects of combination of vitamin B1, B6 and B12. , 2022, Folia morphologica.

[31]  Hongjuan You,et al.  The interaction of canonical Wnt/β-catenin signaling with protein lysine acetylation , 2022, Cellular & Molecular Biology Letters.

[32]  Hongjuan You,et al.  The interaction of canonical Wnt/β-catenin signaling with protein lysine acetylation , 2022, Cellular & molecular biology letters.

[33]  Xiaoyan Zhao,et al.  ROS and iron homeostasis dependent ferroptosis play a vital role in 5-Fluorouracil induced cardiotoxicity in vitro and in vivo. , 2022, Toxicology.

[34]  L. Scorrano,et al.  Transient Exposure of Endothelial Cells to Doxorubicin Leads to Long-Lasting Vascular Endothelial Growth Factor Receptor 2 Downregulation , 2022, Cells.

[35]  Jiayi Chen,et al.  Trastuzumab aggravates radiation induced cardiotoxicity in mice. , 2022, American journal of cancer research.

[36]  M. Knapik-Czajka,et al.  The influence of 5-fluorouracil on the α-ketoglutarate dehydrogenase complex in rat's cardiac muscle - a preliminary study. , 2022, Folia medica Cracoviensia.

[37]  L. Mitrofanova,et al.  Myocardial PD-L1 Expression in Patients With Ischemic and Non-ischemic Heart Failure , 2022, Frontiers in Cardiovascular Medicine.

[38]  E. Duplus,et al.  Inflammation, Oxidative Stress, Senescence in Atherosclerosis: Thioredoxine-1 as an Emerging Therapeutic Target , 2021, International journal of molecular sciences.

[39]  Manasa Reddy Gummi,et al.  Stressor-Induced “Inflammaging” of Vascular Smooth Muscle Cells via Nlrp3-Mediated Pro-inflammatory Auto-Loop , 2021, Frontiers in Cardiovascular Medicine.

[40]  K. Salaita,et al.  Carfilzomib Treatment Causes Molecular and Functional Alterations of Human Induced Pluripotent Stem Cell–Derived Cardiomyocytes , 2021, Journal of the American Heart Association.

[41]  P. Guns,et al.  Doxorubicin Impairs Smooth Muscle Cell Contraction: Novel Insights in Vascular Toxicity , 2021, International Journal of Molecular Sciences.

[42]  J. Duarte,et al.  Role of Inflammation and Redox Status on Doxorubicin-Induced Cardiotoxicity in Infant and Adult CD-1 Male Mice , 2021, Biomolecules.

[43]  J. Vicente,et al.  Microtubule Targeting Agents in Disease: Classic Drugs, Novel Roles , 2021, Cancers.

[44]  Xiaojia Wang,et al.  Cardiotoxicity of Epidermal Growth Factor Receptor 2-Targeted Drugs for Breast Cancer , 2021, Frontiers in Pharmacology.

[45]  Liping Wei,et al.  Dynamic observation of 5-fluorouracil-induced myocardial injury and mitochondrial autophagy in aging rats , 2021, Experimental and therapeutic medicine.

[46]  Jiong Cai,et al.  Radiation-induced dysfunction of energy metabolism in the heart results in the fibrosis of cardiac tissues , 2021, Molecular medicine reports.

[47]  Jin-fang Xu,et al.  Cardiovascular Toxicity of Carfilzomib: The Real-World Evidence Based on the Adverse Event Reporting System Database of the FDA, the United States , 2021, Frontiers in Cardiovascular Medicine.

[48]  M. Mureşan,et al.  Comparative Study of the Pharmacological Properties and Biological Effects of Polygonum aviculare L. herba Extract-Entrapped Liposomes versus Quercetin-Entrapped Liposomes on Doxorubicin-Induced Toxicity on HUVECs , 2021, Pharmaceutics.

[49]  S. Rimpelová,et al.  Vincristine in Combination Therapy of Cancer: Emerging Trends in Clinics , 2021, Biology.

[50]  I. V. Van Gelder,et al.  2021 ESC Guidelines on cardiovascular disease prevention in clinical practice. , 2021, European heart journal.

[51]  S. Miyagawa,et al.  Elimination of residual undifferentiated induced pluripotent stem cells (iPSCs) using irradiation for safe clinical applications of iPSC-derived cardiomyocytes. , 2021, Biochemical and biophysical research communications.

[52]  J. Cochicho,et al.  A Case Report of an Emergency Hypertensive Episode During Trastuzumab Therapy , 2021, Cureus.

[53]  Ling He,et al.  Transcriptional activation of ENPP2 by FoxO4 protects cardiomyocytes from doxorubicin-induced toxicity , 2021, Molecular medicine reports.

[54]  S. Matoba,et al.  Cellular senescence promotes endothelial activation through epigenetic alteration, and consequently accelerates atherosclerosis , 2021, Scientific Reports.

[55]  P. Ellis,et al.  Pertuzumab Cardiotoxicity in Patients With HER2-Positive Cancer: A Systematic Review and Meta-analysis , 2021, CJC open.

[56]  J. Durand,et al.  Immune checkpoint inhibitor myocarditis: elucidating the spectrum of disease through endomyocardial biopsy , 2021, European journal of heart failure.

[57]  A. Palmisano,et al.  Imaging side effects and complications of chemotherapy and radiation therapy: a pictorial review from head to toe , 2021, Insights into Imaging.

[58]  Zubair I Shah,et al.  Vitamin D3 attenuates doxorubicin-induced senescence of human aortic endothelial cells by upregulation of IL-10 via the pAMPKα/Sirt1/Foxo3a signaling pathway , 2021, PloS one.

[59]  F. Fieschi,et al.  NADPH Oxidases (NOX): An Overview from Discovery, Molecular Mechanisms to Physiology and Pathology , 2021, Antioxidants.

[60]  S. Francis,et al.  Frataxin and endothelial cell senescence in pulmonary hypertension. , 2021, The Journal of clinical investigation.

[61]  O. Inanami,et al.  DNA damage response in vascular endothelial senescence: Implication for radiation-induced cardiovascular diseases , 2021, Journal of radiation research.

[62]  Nageswaran Sivalingam,et al.  A comprehensive review on time-tested anticancer drug doxorubicin. , 2021, Life sciences.

[63]  J. Klimas,et al.  Vildagliptin improves vascular smooth muscle relaxation and decreases cellular senescence in the aorta of doxorubicin-treated rats. , 2021, Vascular pharmacology.

[64]  M. Aschner,et al.  Anti-inflammatory effects of thymoquinone and its protective effects against several diseases. , 2021, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.

[65]  Liusheng Li,et al.  Statins use and the prognosis of colorectal cancer: a meta-analysis. , 2021, Clinics and research in hepatology and gastroenterology.

[66]  M. Dimopoulos,et al.  Carfilzomib-induced endothelial dysfunction, recovery of proteasome activity, and prediction of cardiovascular complications: a prospective study , 2021, Leukemia.

[67]  S. Pepe,et al.  Molecules and Mechanisms to Overcome Oxidative Stress Inducing Cardiovascular Disease in Cancer Patients , 2021, Life.

[68]  B. Stockwell,et al.  Ferroptosis: mechanisms, biology and role in disease , 2021, Nature Reviews Molecular Cell Biology.

[69]  Peng Zhang,et al.  Dexrazoxane ameliorates radiation-induced heart disease in a rat model. , 2021, Aging.

[70]  Syu-Ichi Kanno,et al.  The mRNA expression of Il6 and Pdcd1 are predictive and protective factors for doxorubicin-induced cardiotoxicity , 2020, Molecular medicine reports.

[71]  K. Satoh,et al.  Involvement of Circadian Clock Gene BMAL1 in Doxorubicin-Induced Inflammation in Vascular Smooth Muscle Cells , 2021, Pharmacology & Pharmacy.

[72]  M. Emdin,et al.  Oxidative stress and inflammation: determinants of anthracycline cardiotoxicity and possible therapeutic targets , 2020, Heart Failure Reviews.

[73]  ESC / EAS Guidelines for the Treatment of Dyslipidemias: Lipid Modification to Reduce Cardiovascular Risk , 2020, Digital Doctor.

[74]  Jing Wang,et al.  A genetic mouse model recapitulates immune checkpoint inhibitor-associated myocarditis and supports a mechanism-based therapeutic intervention. , 2020, Cancer discovery.

[75]  K. Skonieczna-Żydecka,et al.  Antioxidant Potential of Curcumin—A Meta-Analysis of Randomized Clinical Trials , 2020, Antioxidants.

[76]  J. Wippermann,et al.  Delicate Role of PD-L1/PD-1 Axis in Blood Vessel Inflammatory Diseases: Current Insight and Future Significance , 2020, International journal of molecular sciences.

[77]  G. Botti,et al.  Evidences of CTLA-4 and PD-1 Blocking Agents-Induced Cardiotoxicity in Cellular and Preclinical Models , 2020, Journal of personalized medicine.

[78]  Arjun K. Ghosh,et al.  Hypertensive Cardiotoxicity in Cancer Treatment—Systematic Analysis of Adjunct, Conventional Chemotherapy, and Novel Therapies—Epidemiology, Incidence, and Pathophysiology , 2020, Journal of clinical medicine.

[79]  H. El-Abhar,et al.  Activated ROCK/Akt/eNOS and ET-1/ERK pathways in 5-fluorouracil-induced cardiotoxicity: modulation by simvastatin , 2020, Scientific Reports.

[80]  A. Cohen-Solal,et al.  Cardiovascular Toxicity Related to Cancer Treatment: A Pragmatic Approach to the American and European Cardio‐Oncology Guidelines , 2020, Journal of the American Heart Association.

[81]  Xiang Song,et al.  Role of GPX4-Mediated Ferroptosis in the Sensitivity of Triple Negative Breast Cancer Cells to Gefitinib , 2020, Frontiers in Oncology.

[82]  E. Lutgens,et al.  Antibody-Mediated Inhibition of CTLA4 Aggravates Atherosclerotic Plaque Inflammation and Progression in Hyperlipidemic Mice , 2020, Cells.

[83]  Dezhi Ren,et al.  Yangxin granules alleviate doxorubicin-induced cardiotoxicity by suppressing oxidative stress and apoptosis mediated by AKT/GSK3β/β-catenin signaling , 2020, The Journal of international medical research.

[84]  M. Dimopoulos,et al.  Investigating the Vascular Toxicity Outcomes of the Irreversible Proteasome Inhibitor Carfilzomib , 2020, International journal of molecular sciences.

[85]  M. Hashizume,et al.  Sodium thiosulfate prevents doxorubicin-induced DNA damage and apoptosis in cardiomyocytes in mice. , 2020, Life sciences.

[86]  Wenyu Li,et al.  Antibiotics for cancer treatment: A double-edged sword , 2020, Journal of Cancer.

[87]  C. Mummery,et al.  Uncoupling DNA damage from chromatin damage to detoxify doxorubicin , 2020, Proceedings of the National Academy of Sciences.

[88]  Y. Xin,et al.  Radiation‐induced myocardial fibrosis: Mechanisms underlying its pathogenesis and therapeutic strategies , 2020, Journal of cellular and molecular medicine.

[89]  Qiaojun He,et al.  A Comprehensive Review of Clinical Cardiotoxicity Incidence of FDA-Approved Small-Molecule Kinase Inhibitors , 2020, Frontiers in Pharmacology.

[90]  M. Gertz,et al.  Proteasome Inhibitor-Related Cardiotoxicity: Mechanisms, Diagnosis, and Management , 2020, Current Oncology Reports.

[91]  A. García-Herrera,et al.  Complement as the enabler of carfilzomib‐induced thrombotic microangiopathy , 2020, British journal of haematology.

[92]  Xiaoqiang Tang,et al.  Cardiomyocyte Senescence and Cellular Communications Within Myocardial Microenvironments , 2020, Frontiers in Endocrinology.

[93]  A. Salimi,et al.  Chrysin ameliorates aluminum phosphide‐induced oxidative stress and mitochondrial damages in rat cardiomyocytes and isolated mitochondria , 2020, Environmental toxicology.

[94]  M. Krzakowski,et al.  Cardiovascular Complications of Systemic Therapy in Non-Small-Cell Lung Cancer , 2020, Journal of clinical medicine.

[95]  J. Herrmann.  Adverse cardiac effects of cancer therapies: cardiotoxicity and arrhythmia , 2020, Nature Reviews Cardiology.

[96]  T. Shiga,et al.  Cardiotoxicities of 5-Fluorouracil and Other Fluoropyrimidines , 2020, Current Treatment Options in Oncology.

[97]  C. Cipolla,et al.  Cardiotoxicity of Anthracyclines , 2020, Frontiers in Cardiovascular Medicine.

[98]  W. D. De Vos,et al.  Rosiglitazone Protects Endothelial Cells From Irradiation-Induced Mitochondrial Dysfunction , 2020, Frontiers in Pharmacology.

[99]  A. Borczuk,et al.  Histopathologic Characterization of Myocarditis Associated With Immune Checkpoint Inhibitor Therapy. , 2020, Archives of pathology & laboratory medicine.

[100]  M. Camera,et al.  Repurposing of drugs approved for cardiovascular diseases: opportunity or mirage? , 2020, Biochemical pharmacology.

[101]  Yang Ruan,et al.  Dexrazoxane Protects Cardiomyocyte from Doxorubicin-Induced Apoptosis by Modulating miR-17-5p , 2020, BioMed research international.

[102]  Yuchen Ge,et al.  SIRT1 and aging related signaling pathways , 2020, Mechanisms of Ageing and Development.

[103]  W. Roos,et al.  Anticancer drug and ionizing radiation-induced DNA damage differently influences transcription activity and DDR-related stress responses of an endothelial monolayer. , 2020, Biochimica et biophysica acta. Molecular cell research.

[104]  H. Ogawa,et al.  Regulatory mechanisms of ryanodine receptor/Ca2+ release channel revealed by recent advancements in structural studies , 2020, Journal of Muscle Research and Cell Motility.

[105]  K. Satoh,et al.  The role of circadian clock gene BMAL1 in vascular proliferation. , 2020, European journal of pharmacology.

[106]  T. Pasqua,et al.  Cardiac damage in anthracyclines therapy: focus on oxidative stress and inflammation. , 2020, Antioxidants & redox signaling.

[107]  S. Fu,et al.  Kaempferol attenuated cisplatin-induced cardiac injury via inhibiting STING/NF-κB-mediated inflammation. , 2020, American journal of translational research.

[108]  M. Karaağaç,et al.  Pazopanib-induced fatal heart failure in a patient with unresectable soft tissue sarcoma and review of literature , 2020, Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners.

[109]  H. Mirzaei,et al.  Evaluation of antitumor effects of aspirin and LGK974 drugs on cellular signaling pathways, cell cycle and apoptosis in colorectal cancer cell lines compared to oxaliplatin drug , 2020, Fundamental & clinical pharmacology.

[110]  M. He,et al.  Doxorubicin Induces Endotheliotoxicity and Mitochondrial Dysfunction via ROS/eNOS/NO Pathway , 2020, Frontiers in Pharmacology.

[111]  A. Prats,et al.  Paclitaxel induces lymphatic endothelial cells autophagy to promote metastasis , 2019, Cell Death & Disease.

[112]  Jiyan Liu,et al.  Immune Checkpoint Inhibitor-Associated Cardiotoxicity: Current Understanding on Its Mechanism, Diagnosis and Management , 2019, Front. Pharmacol..

[113]  P. Kubatka,et al.  Paclitaxel’s Mechanistic and Clinical Effects on Breast Cancer , 2019, Biomolecules.

[114]  H. Overkleeft,et al.  Carfilzomib Induces Cardiotoxicity Via ß5/ß2-Specific Proteasome Subunit Inhibition Pattern , 2019, Blood.

[115]  A. Pelosi,et al.  Early morphological changes in cardiac mitochondria after subcutaneous administration of trastuzumab in rabbits: possible prevention with oral selenium supplementation. , 2019, Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology.

[116]  Sheng-Nan Wu,et al.  High Effectiveness in Actions of Carfilzomib on Delayed-Rectifier K+ Current and on Spontaneous Action Potentials , 2019, Front. Pharmacol..

[117]  M. Marra,et al.  Dietary Quercetin and Kaempferol: Bioavailability and Potential Cardiovascular-Related Bioactivity in Humans , 2019, Nutrients.

[118]  S. Toppo,et al.  Insight into the mechanism of ferroptosis inhibition by ferrostatin-1 , 2019, Redox biology.

[119]  J. Stone,et al.  Immune checkpoint inhibitor associated myocarditis occurs in both high-grade and low-grade forms , 2019, Modern Pathology.

[120]  Li Zhao.  Protective effects of trimetazidine and coenzyme Q10 on cisplatin-induced cardiotoxicity by alleviating oxidative stress and mitochondrial dysfunction , 2019, Anatolian journal of cardiology.

[121]  K. Seong,et al.  Cellular Stress Responses in Radiotherapy , 2019, Cells.

[122]  K. Bhaskaran,et al.  Medium and long-term risks of specific cardiovascular diseases in survivors of 20 adult cancers: a population-based cohort study using multiple linked UK electronic health records databases , 2019, The Lancet.

[123]  Ahmedin Jemal,et al.  Cancer treatment and survivorship statistics, 2019 , 2019, CA: a cancer journal for clinicians.

[124]  M. Sabatine,et al.  2019 ESC/EAS Guidelines for the management of dyslipidaemias: lipid modification to reduce cardiovascular risk. , 2019, European heart journal.

[125]  V. Zharov,et al.  Doxorubicin Activates Ryanodine Receptors in Rat Lymphatic Muscle Cells to Attenuate Rhythmic Contractions and Lymph Flow , 2019, The Journal of Pharmacology and Experimental Therapeutics.

[126]  H. Nader,et al.  Heparan sulfate proteoglycans as trastuzumab targets in anoikis‐resistant endothelial cells , 2019, Journal of cellular biochemistry.

[127]  J. Ge,et al.  Lysine acetyltransferases and lysine deacetylases as targets for cardiovascular disease , 2019, Nature Reviews Cardiology.

[128]  Jennifer E Liu,et al.  Cardiotoxicity of HER2-targeted therapies. , 2019, Current opinion in cardiology.

[129]  A. Malykhina,et al.  Doxorubicin induces detrusor smooth muscle impairments through myosin dysregulation, leading to a risk of lower urinary tract dysfunction. , 2019, American journal of physiology. Renal physiology.

[130]  M. Bennett,et al.  Vascular smooth muscle cells in atherosclerosis , 2019, Nature Reviews Cardiology.

[131]  A. Ihsan,et al.  Chitosan oligosaccharides prevent doxorubicin-induced oxidative stress and cardiac apoptosis through activating p38 and JNK MAPK mediated Nrf2/ARE pathway. , 2019, Chemico-biological interactions.

[132]  Joe Z. Zhang,et al.  Human-Induced Pluripotent Stem Cell Model of Trastuzumab-Induced Cardiac Dysfunction in Patients With Breast Cancer. , 2019, Circulation.

[133]  E. Biskup,et al.  Anthracycline-induced cardiotoxicity in the chemotherapy treatment of breast cancer: Preventive strategies and treatment , 2019, Molecular and clinical oncology.

[134]  Shuai Jiang,et al.  Mitochondrial electron transport chain, ROS generation and uncoupling (Review) , 2019, International journal of molecular medicine.

[135]  E. Lipson,et al.  Cardiovascular toxicities associated with immune checkpoint inhibitors , 2019, Cardiovascular research.

[136]  V. De Feo,et al.  Wheat phenolics suppress doxorubicin-induced cardiotoxicity via inhibition of oxidative stress, MAP kinase activation, NF-κB pathway, PI3K/Akt/mTOR impairment, and cardiac apoptosis. , 2019, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

[137]  R. Lage,et al.  Omentin protects H9c2 cells against docetaxel cardiotoxicity , 2019, PloS one.

[138]  M. Dimopoulos,et al.  Molecular mechanisms of carfilzomib-induced cardiotoxicity in mice and the emerging cardioprotective role of metformin. , 2019, Blood.

[139]  F. Gao,et al.  Ferroptosis as a target for protection against cardiomyopathy , 2019, Proceedings of the National Academy of Sciences.

[140]  B. Liu,et al.  Effects of paclitaxel intervention on pulmonary vascular remodeling in rats with pulmonary hypertension , 2018, Experimental and therapeutic medicine.

[141]  M. Sperandio,et al.  Priming anti-tumor immunity by radiotherapy: Dying tumor cell-derived DAMPs trigger endothelial cell activation and recruitment of myeloid cells , 2018, Oncoimmunology.

[142]  W. Aronow,et al.  Cardiotoxicity of cancer chemotherapy in clinical practice , 2018, Hospital practice.

[143]  Yameng Cui,et al.  Tongmai Yangxin pills anti-oxidative stress alleviates cisplatin-induced cardiotoxicity: Network pharmacology analysis and experimental evidence. , 2018, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.

[144]  D. Mei,et al.  Cisplatin-induced cardiotoxicity with midrange ejection fraction , 2018, Medicine.

[145]  Y. Ge,et al.  The suppressive effect of co-inhibiting PD-1 and CTLA-4 expression on H22 hepatomas in mice , 2018, Cellular & Molecular Biology Letters.

[146]  Wei-Liang Xue,et al.  Schisandrin B Attenuates Inflammation in LPS-Induced Sepsis Through miR-17-5p Downregulating TLR4 , 2018, Inflammation.

[147]  Z. Oltvai,et al.  Statin drugs to reduce breast cancer recurrence and mortality , 2018, Breast Cancer Research.

[148]  A. Aerts,et al.  Pathological effects of ionizing radiation: endothelial activation and dysfunction , 2018, Cellular and Molecular Life Sciences.

[149]  Daniel M. Johnson,et al.  Arrhythmogenic Mechanisms in Heart Failure: Linking β-Adrenergic Stimulation, Stretch, and Calcium , 2018, Front. Physiol..

[150]  R. Ramer,et al.  The antiangiogenic action of cisplatin on endothelial cells is mediated through the release of tissue inhibitor of matrix metalloproteinases-1 from lung cancer cells , 2018, Oncotarget.

[151]  J. Larkin,et al.  Immune checkpoint inhibitors and cardiovascular toxicity. , 2018, The Lancet. Oncology.

[152]  Laura S. Shankman,et al.  Irradiation abolishes smooth muscle investment into vascular lesions in specific vascular beds. , 2018, JCI insight.

[153]  C. Peng,et al.  Overview of MicroRNA Biogenesis, Mechanisms of Actions, and Circulation , 2018, Front. Endocrinol..

[154]  G. Tse,et al.  Uncoupling Protein 2 in Cardiovascular Health and Disease , 2018, Front. Physiol..

[155]  Wen-Jie Guo,et al.  The effects of beta-blocker use on cancer prognosis: a meta-analysis based on 319,006 patients , 2018, OncoTargets and therapy.

[156]  J. Abe,et al.  Radiation-Induced Endothelial Vascular Injury , 2018, JACC. Basic to translational science.

[157]  A. Bertolotti,et al.  Regulation of proteasome assembly and activity in health and disease , 2018, Nature Reviews Molecular Cell Biology.

[158]  H. Goldschmidt,et al.  Cardiovascular adverse events in modern myeloma therapy – Incidence and risks. A review from the European Myeloma Network (EMN) and Italian Society of Arterial Hypertension (SIIA) , 2018, Haematologica.

[159]  T. Beiert,et al.  Impact of Ionizing Radiation on Electrophysiological Behavior of Human-induced Ipsc-derived Cardiomyocytes on Multielectrode Arrays , 2018, Health physics.

[160]  A. Grothey,et al.  5-fluorouracil and cardiotoxicity: a review , 2018, Therapeutic advances in medical oncology.

[161]  Jian-Min Luo,et al.  Microvesicles shed from bortezomib-treated or lenalidomide-treated human myeloma cells inhibit angiogenesis in vitro. , 2018, Oncology reports.

[162]  Yvonne E. Moussa,et al.  The side effects of platinum-based chemotherapy drugs: a review for chemists. , 2018, Dalton transactions.

[163]  J. Symerský,et al.  High-resolution cryo-EM analysis of the yeast ATP synthase in a lipid membrane , 2018, Science.

[164]  A. Cheng,et al.  The HER2 inhibitor lapatinib potentiates doxorubicin-induced cardiotoxicity through iNOS signaling , 2018, Theranostics.

[165]  N. Meydan,et al.  Arterial Stiffness in Breast Cancer Patients Treated with Anthracycline and Trastuzumab-Based Regimens , 2018, Cardiology research and practice.

[166]  V. Murray,et al.  The Interaction of the Metallo-Glycopeptide Anti-Tumour Drug Bleomycin with DNA , 2018, International journal of molecular sciences.

[167]  M. Aglietta,et al.  Fluoropyrimidine-induced cardiotoxicity. , 2018, Critical reviews in oncology/hematology.

[168]  Yu-qi Fan,et al.  Resveratrol suppresses doxorubicin‐induced cardiotoxicity by disrupting E2F1 mediated autophagy inhibition and apoptosis promotion , 2018, Biochemical pharmacology.

[169]  E. Chen,et al.  Hepatocyte-secreted DPP4 in obesity promotes adipose inflammation and insulin resistance , 2018, Nature.

[170]  Dae Hyun Lee,et al.  Cardiovascular Complications of Multiple Myeloma Treatment: Evaluation, Management, and Prevention , 2018, Current Treatment Options in Cardiovascular Medicine.

[171]  O. Inanami,et al.  Ataxia-Telangiectasia Mutated (ATM) Kinase Regulates eNOS Expression and Modulates Radiosensitivity in Endothelial Cells Exposed to Ionizing Radiation , 2018, Radiation Research.

[172]  R. Touyz,et al.  Vascular smooth muscle contraction in hypertension , 2018, Cardiovascular research.

[173]  K. J. Grande-Allen,et al.  Radiation-Induced Cardiovascular Disease: Mechanisms and Importance of Linear Energy Transfer , 2018, Front. Cardiovasc. Med..

[174]  W. Hwang,et al.  Carfilzomib-Associated Cardiovascular Adverse Events: A Systematic Review and Meta-analysis , 2017, JAMA oncology.

[175]  N. Mohan,et al.  Type IIB DNA topoisomerase is downregulated by trastuzumab and doxorubicin to synergize cardiotoxicity , 2017, Oncotarget.

[176]  H. Duan,et al.  Cyanidin ameliorates cisplatin-induced cardiotoxicity via inhibition of ROS-mediated apoptosis , 2017, Experimental and therapeutic medicine.

[177]  W. Frishman,et al.  Cardiovascular Complications of Proteasome Inhibitors Used in Multiple Myeloma , 2017, Cardiology in review.

[178]  M. Dimopoulos,et al.  Cardio-oncology: A Focus on Cardiotoxicity. , 2017, European cardiology.

[179]  S. Sollott,et al.  Mitochondrial membrane potential. , 2017, Analytical biochemistry.

[180]  Donato Cappetta,et al.  Doxorubicin targets multiple players: A new view of an old problem , 2018, Pharmacological research.

[181]  G. Seebohm,et al.  Cardiogenic programming of human pluripotent stem cells by dose-controlled activation of EOMES , 2018, Nature Communications.

[182]  C. Annunziata,et al.  Proteasome inhibitors: structure and function. , 2017, Seminars in oncology.

[183]  E. Yeh,et al.  Cardiovascular Complications of Cancer Therapy: Best Practices in Diagnosis, Prevention, and Management: Part 2. , 2017, Journal of the American College of Cardiology.

[184]  A. Ballestrero,et al.  5‐fluorouracil causes endothelial cell senescence: potential protective role of glucagon‐like peptide 1 , 2017, British journal of pharmacology.

[185]  E. Füchtbauer,et al.  Diverse cellular architecture of atherosclerotic plaque derives from clonal expansion of a few medial SMCs. , 2017, JCI insight.

[186]  D. Bonaduce,et al.  Cardiotoxicity of immune checkpoint inhibitors , 2017, ESMO Open.

[187]  Jianyi(Jay) Zhang,et al.  Effect of densely ionizing radiation on cardiomyocyte differentiation from human‐induced pluripotent stem cells , 2017, Physiological reports.

[188]  C. Nunes,et al.  A biophysical approach to daunorubicin interaction with model membranes: relevance for the drug's biological activity , 2017, Journal of The Royal Society Interface.

[189]  Norihiko Takeda,et al.  The Roles of Hypoxia Signaling in the Pathogenesis of Cardiovascular Diseases , 2017, Journal of atherosclerosis and thrombosis.

[190]  A. Bitto,et al.  Oxidative Stress: Harms and Benefits for Human Health , 2017, Oxidative medicine and cellular longevity.

[191]  E. Johnston,et al.  Transforming growth factor beta-1 (TGF-β1) stimulates collagen synthesis in cultured rainbow trout cardiac fibroblasts , 2017, Journal of Experimental Biology.

[192]  F. Paris,et al.  Ionizing radiation induces long‐term senescence in endothelial cells through mitochondrial respiratory complex II dysfunction and superoxide generation , 2017, Free radical biology & medicine.

[193]  J. Radhakrishnan,et al.  Capillary leak syndrome: etiologies, pathophysiology, and management. , 2017, Kidney international.

[194]  R. Henning,et al.  Proteostasis in cardiac health and disease , 2017, Nature Reviews Cardiology.

[195]  M. H. Osman,et al.  Cardiac glycosides use and the risk and mortality of cancer; systematic review and meta-analysis of observational studies , 2017, PloS one.

[196]  R. Knight,et al.  Spasmogenic Effects of the Proteasome Inhibitor Carfilzomib on Coronary Resistance, Vascular Tone and Reactivity , 2017, EBioMedicine.

[197]  R. Abalo,et al.  Characterization of Cardiovascular Alterations Induced by Different Chronic Cisplatin Treatments , 2017, Front. Pharmacol..

[198]  Guixue Wang,et al.  Cytotoxic effects of docetaxel as a candidate drug of drug-eluting stent on human umbilical vein endothelial cells and the signaling pathway of cell migration inhibition, adhesion delay and shape change , 2017, Regenerative biomaterials.

[199]  M. Hennig,et al.  Platelets subvert T cell immunity against cancer via GARP-TGFβ axis , 2017, Science Immunology.

[200]  W. Aronow,et al.  Cardiac Complications of Cancer Therapy: Pathophysiology, Identification, Prevention, Treatment, and Future Directions , 2017, Current Cardiology Reports.

[201]  A. Lyon,et al.  Proteasome Inhibitors as a Potential Cause of Heart Failure. , 2017, Heart failure clinics.

[202]  J. Gamble,et al.  Ionizing radiation reduces ADAM10 expression in brain microvascular endothelial cells undergoing stress-induced senescence , 2017, Aging.

[203]  B. Offersen,et al.  Short and long term radiation induced cardiovascular disease in patients with cancer , 2017, Clinical cardiology.

[204]  David Cameron,et al.  11 years' follow-up of trastuzumab after adjuvant chemotherapy in HER2-positive early breast cancer: final analysis of the HERceptin Adjuvant (HERA) trial , 2017, The Lancet.

[205]  Jianhua Yao,et al.  Cardiac cell proliferation is not necessary for exercise‐induced cardiac growth but required for its protection against ischaemia/reperfusion injury , 2017, Journal of cellular and molecular medicine.

[206]  Baolin Zhang,et al.  Doxorubicin induces cardiotoxicity through upregulation of death receptors mediated apoptosis in cardiomyocytes , 2017, Scientific Reports.

[207]  M. Koizumi,et al.  Irradiation strongly reduces tumorigenesis of human induced pluripotent stem cells , 2017, Journal of radiation research.

[208]  Weimin Cai,et al.  Do renin–angiotensin system inhibitors influence the recurrence, metastasis, and survival in cancer patients? , 2017, Medicine.

[209]  D. Pascual-Figal,et al.  Doxorubicin-induced oxidative stress: The protective effect of nicorandil on HL-1 cardiomyocytes , 2017, PloS one.

[210]  D. Serie,et al.  The antineoplastic drug, trastuzumab, dysregulates metabolism in iPSC-derived cardiomyocytes , 2017, Clinical and Translational Medicine.

[211]  B. Hasinoff,et al.  Molecular Mechanisms of the Cardiotoxicity of the Proteasomal-Targeted Drugs Bortezomib and Carfilzomib , 2017, Cardiovascular Toxicology.

[212]  Tri M Phan,et al.  Unlocking Aspirin's Chemopreventive Activity: Role of Irreversibly Inhibiting Platelet Cyclooxygenase-1 , 2016, Cancer Prevention Research.

[213]  K. Schäfer,et al.  Endothelial cell senescence and thrombosis: Ageing clots. , 2016, Thrombosis research.

[214]  I. Miinalainen,et al.  VEGF-B gene therapy inhibits doxorubicin-induced cardiotoxicity by endothelial protection , 2016, Proceedings of the National Academy of Sciences.

[215]  C. Conover,et al.  Senescent intimal foam cells are deleterious at all stages of atherosclerosis , 2016, Science.

[216]  C. Rombouts,et al.  Cardiovascular diseases related to ionizing radiation: The risk of low-dose exposure (Review) , 2016, International journal of molecular medicine.

[217]  Vagheesh M. Narasimhan,et al.  Extensive Proliferation of a Subset of Differentiated, yet Plastic, Medial Vascular Smooth Muscle Cells Contributes to Neointimal Formation in Mouse Injury and Atherosclerosis Models , 2016, Circulation research.

[218]  Junichi Ishida,et al.  Repurposing of approved cardiovascular drugs , 2016, Journal of Translational Medicine.

[219]  K. Fukino,et al.  Acute Myocardial Infarction Caused by Thrombotic Microangiopathy Complicated With Myelodysplastic Syndrome. , 2016, International heart journal.

[220]  C. Nieder,et al.  Palliative Radiotherapy in Cancer Patients with Increased Serum C-Reactive Protein Level. , 2016, In vivo.

[221]  M. Hayden,et al.  Recommendations for genetic testing to reduce the incidence of anthracycline‐induced cardiotoxicity , 2016, British journal of clinical pharmacology.

[222]  Emma L. Wilkinson,et al.  Cardiotoxic drugs Herceptin and doxorubicin inhibit cardiac microvascular endothelial cell barrier formation resulting in increased drug permeability , 2016, Biology Open.

[223]  Luke A. Gilbert,et al.  A senescence secretory switch mediated by PI3K/AKT/mTOR activation controls chemoprotective endothelial secretory responses , 2016, Genes & development.

[224]  R. Lightowlers,et al.  The process of mammalian mitochondrial protein synthesis , 2016, Cell and Tissue Research.

[225]  Haiyang Tang,et al.  Bortezomib alleviates experimental pulmonary hypertension by regulating intracellular calcium homeostasis in PASMCs. , 2016, American journal of physiology. Cell physiology.

[226]  B. Hasinoff,et al.  Molecular Mechanisms of the Cardiotoxicity of the Proteasomal-Targeted Drugs Bortezomib and Carfilzomib , 2016, Cardiovascular Toxicology.

[227]  M. Boerma,et al.  Ionizing Radiation-Induced Endothelial Cell Senescence and Cardiovascular Diseases , 2016, Radiation Research.

[228]  G. Mercuro,et al.  Pathophysiology of cardiotoxicity induced by nonanthracycline chemotherapy , 2016, Journal of cardiovascular medicine.

[229]  E. Yang,et al.  Fluoropyrimidine-Induced Cardiotoxicity: Manifestations, Mechanisms, and Management , 2016, Current Oncology Reports.

[230]  Laura S. Shankman,et al.  Activation of the ESC pluripotency factor OCT4 in smooth muscle cells is atheroprotective , 2016, Nature Medicine.

[231]  N. Mohan,et al.  Trastuzumab, but Not Pertuzumab, Dysregulates HER2 Signaling to Mediate Inhibition of Autophagy and Increase in Reactive Oxygen Species Production in Human Cardiomyocytes , 2016, Molecular Cancer Therapeutics.

[232]  C. Grines,et al.  Vascular Toxicities of Cancer Therapies: The Old and the New – An Evolving Avenue , 2016, Circulation.

[233]  D. Sawyer,et al.  Cardio-Oncology: An Update on Cardiotoxicity of Cancer-Related Treatment. , 2016, Circulation research.

[234]  Herman I. May,et al.  Doxorubicin Blocks Cardiomyocyte Autophagic Flux by Inhibiting Lysosome Acidification , 2016, Circulation.

[235]  D. Pascual-Figal,et al.  Early oxidative damage induced by doxorubicin: Source of production, protection by GKT137831 and effect on Ca(2+) transporters in HL-1 cardiomyocytes. , 2016, Archives of biochemistry and biophysics.

[236]  Saijun Fan,et al.  Ionizing Radiation Induces HMGB1 Cytoplasmic Translocation and Extracellular Release. , 2016, Guo ji fang she yi xue he yi xue za zhi = International journal of radiation medicine and nuclear medicine.

[237]  H. Malekinejad,et al.  Cardioprotective effect of royal jelly on paclitaxel-induced cardio-toxicity in rats , 2016, Iranian journal of basic medical sciences.

[238]  Jae-Hoon Jeong,et al.  XIAP-associating factor 1, a transcriptional target of BRD7, contributes to endothelial cell senescence , 2016, Oncotarget.

[239]  Daowen Wang,et al.  miR-320a mediates doxorubicin-induced cardiotoxicity by targeting VEGF signal pathway , 2016, Aging.

[240]  C. Barisione,et al.  Testosterone Antagonizes Doxorubicin‐Induced Senescence of Cardiomyocytes , 2016, Journal of the American Heart Association.

[241]  Zhenyu Yang,et al.  Taxol prevents myocardial ischemia-reperfusion injury by inducing JNK-mediated HO-1 expression , 2015, Pharmaceutical biology.

[242]  B. Ebert,et al.  The novel mechanism of lenalidomide activity. , 2015, Blood.

[243]  Oliver Sawodny,et al.  Impairment of energy metabolism in cardiomyocytes caused by 5-FU catabolites can be compensated by administration of amino acids , 2015, 2015 37th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC).

[244]  P. Ascenzi,et al.  Hsp90: A New Player in DNA Repair? , 2015, Biomolecules.

[245]  Tammy J. Toney-Butler.  Physiology, Thromboxane A2 , 2015 .

[246]  M. Fenech,et al.  Persistent γH2AX: A promising molecular marker of DNA damage and aging. , 2015, Mutation research. Reviews in mutation research.

[247]  M. Valsecchi.  Combined Nivolumab and Ipilimumab or Monotherapy in Untreated Melanoma. , 2015, The New England journal of medicine.

[248]  T. Kondo,et al.  Roles of ROS and PKC-βII in ionizing radiation-induced eNOS activation in human vascular endothelial cells. , 2015, Vascular pharmacology.

[249]  A. Zimna,et al.  Hypoxia-Inducible Factor-1 in Physiological and Pathophysiological Angiogenesis: Applications and Therapies , 2015, BioMed research international.

[250]  R. Morimoto,et al.  The biology of proteostasis in aging and disease. , 2015, Annual review of biochemistry.

[251]  L. Rochette,et al.  Anthracyclines/trastuzumab: new aspects of cardiotoxicity and molecular mechanisms. , 2015, Trends in pharmacological sciences.

[252]  Patrick M. McLendon,et al.  Proteotoxicity and cardiac dysfunction. , 2015, Circulation research.

[253]  Laura S. Shankman,et al.  KLF4 Dependent Phenotypic Modulation of SMCs Plays a Key Role in Atherosclerotic Plaque Pathogenesis , 2015, Nature Medicine.

[254]  W. Land.  The Role of Damage-Associated Molecular Patterns (DAMPs) in Human Diseases: Part II: DAMPs as diagnostics, prognostics and therapeutics in clinical medicine. , 2015, Sultan Qaboos University medical journal.

[255]  Xin Wang,et al.  Taxol stabilizes gap junctions and reduces ischemic ventricular arrhythmias in rats in vivo. , 2015, Molecular medicine reports.

[256]  W. Kwiatek,et al.  Comparative endothelial profiling of doxorubicin and daunorubicin in cultured endothelial cells. , 2015, Toxicology in vitro : an international journal published in association with BIBRA.

[257]  M. Schlumbrecht,et al.  Cisplatin-induced bradycardia and the importance of the QT interval , 2015, Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners.

[258]  坂田 公正.  Roles of ROS and PKC-β II in ionizing radiation-induced eNOS activation in human vascular endothelial cells , 2015 .

[259]  J. Kostis,et al.  Radiation-Induced Heart Disease: Pathologic Abnormalities and Putative Mechanisms , 2015, Front. Oncol..

[260]  D. Noonan,et al.  Effects of 5-Fluorouracil on Morphology, Cell Cycle, Proliferation, Apoptosis, Autophagy and ROS Production in Endothelial Cells and Cardiomyocytes , 2015, PloS one.

[261]  J. Pourahmad,et al.  A comparison of cardiomyocyte cytotoxic mechanisms for 5-fluorouracil and its pro-drug capecitabine , 2015, Xenobiotica; the fate of foreign compounds in biological systems.

[262]  T. Kondo,et al.  Activation of eNOS in endothelial cells exposed to ionizing radiation involves components of the DNA damage response pathway. , 2015, Biochemical and biophysical research communications.

[263]  Takako Sasaki,et al.  Perlecan deficiency causes endothelial dysfunction by reducing the expression of endothelial nitric oxide synthase , 2015, Physiological reports.

[264]  Gang Wu,et al.  NEMO Modulates Radiation-Induced Endothelial Senescence of Human Umbilical Veins Through NF-κB Signal Pathway , 2015, Radiation research.

[265]  A. Rodríguez-Sinovas,et al.  Microtubule stabilization with paclitaxel does not protect against infarction in isolated rat hearts , 2015, Experimental physiology.

[266]  T. Haddad,et al.  New-onset heart failure in association with severe hypertension during trastuzumab therapy. , 2014, Mayo Clinic proceedings.

[267]  M. Najafi,et al.  The Mechanisms of Radiation-Induced Bystander Effect , 2014, Journal of biomedical physics & engineering.

[268]  G. Monteiro,et al.  Carboplatin: molecular mechanisms of action associated with chemoresistance , 2014 .

[269]  L. Wojnowski,et al.  Dexrazoxane may prevent doxorubicin-induced DNA damage via depleting both Topoisomerase II isoforms , 2014, BMC Cancer.

[270]  F. Walter,et al.  Low Dose Cranial Irradiation-Induced Cerebrovascular Damage Is Reversible in Mice , 2014, PloS one.

[271]  S. Shan,et al.  Effects of cisplatin on the contractile function of thoracic aorta of Sprague-Dawley rats. , 2014, Biomedical reports.

[272]  Jin Han,et al.  Different effects of prolonged β-adrenergic stimulation on heart and cerebral artery , 2014, Integrative medicine research.

[273]  P. Tchounwou,et al.  Cisplatin in cancer therapy: molecular mechanisms of action. , 2014, European journal of pharmacology.

[274]  L. Jones,et al.  Unravelling the causes of reduced peak oxygen consumption in patients with cancer: complex, timely, and necessary. , 2014, Journal of the American College of Cardiology.

[275]  V. Giguère,et al.  ERBB2 Deficiency Alters an E2F-1-Dependent Adaptive Stress Response and Leads to Cardiac Dysfunction , 2014, Molecular and Cellular Biology.

[276]  B. Weaver,et al.  How Taxol/paclitaxel kills cancer cells , 2014, Molecular biology of the cell.

[277]  K. Vistisen,et al.  A systematic review of the pathophysiology of 5-fluorouracil-induced cardiotoxicity , 2014, BMC Pharmacology and Toxicology.

[278]  K. Raj,et al.  Premature aging induced by radiation exhibits pro-atherosclerotic effects mediated by epigenetic activation of CD44 expression , 2014, Aging cell.

[279]  B. Lilly.  We have contact: endothelial cell-smooth muscle cell interactions. , 2014, Physiology.

[280]  M. F. Khan,et al.  Gemcitabine-induced cardiomyopathy: a case report and review of the literature , 2014, Journal of Medical Case Reports.

[281]  Joshua J. Neumiller.  Empagliflozin: a new sodium-glucose co-transporter 2 (SGLT2) inhibitor for the treatment of type 2 diabetes , 2014, Drugs in context.

[282]  F. d’Adda di Fagagna,et al.  Irreparable telomeric DNA damage and persistent DDR signalling as a shared causative mechanism of cellular senescence and ageing , 2014, Current opinion in genetics & development.

[283]  Joseph A. Hill,et al.  Cardiomyocyte autophagy and cancer chemotherapy. , 2014, Journal of molecular and cellular cardiology.

[284]  Rachel V. Stankowski,et al.  Cardiovascular toxicity associated with adjuvant trastuzumab therapy: prevalence, patient characteristics, and risk factors , 2014, Therapeutic advances in drug safety.

[285]  R. Mutharasan,et al.  Cardiotoxicity of doxorubicin is mediated through mitochondrial iron accumulation. , 2014, The Journal of clinical investigation.

[286]  C. Mandarim-de-Lacerda,et al.  Apoptosis induction of cardiomyocytes and subsequent fibrosis after irradiation and neoadjuvant chemotherapy , 2014, International journal of radiation biology.

[287]  Kyu Jin Choi,et al.  Characterization of DNA damage-induced cellular senescence by ionizing radiation in endothelial cells , 2014, International journal of radiation biology.

[288]  P. Vejpongsa,et al.  Topoisomerase 2β: A Promising Molecular Target for Primary Prevention of Anthracycline‐Induced Cardiotoxicity , 2013, Clinical pharmacology and therapeutics.

[289]  J. Dudka,et al.  Effect of hypoxia on toxicity induced by anticancer agents in cardiomyocyte culture. , 2014 .

[290]  C. Rao,et al.  The role of inflammation in colon cancer. , 2014, Advances in experimental medicine and biology.

[291]  Wei Wang 王 伟,et al.  Different responses of cell cycle between rat vascular smooth muscle cells and vascular endothelial cells to paclitaxel , 2014, Journal of Huazhong University of Science and Technology [Medical Sciences].

[292]  Zhaohua Zhang,et al.  The effect of PS-341 on pulmonary vascular remodeling in high blood flow-induced pulmonary hypertension. , 2014, International journal of molecular medicine.

[293]  S. Lippard,et al.  Understanding and improving platinum anticancer drugs--phenanthriplatin. , 2014, Anticancer research.

[294]  Zhaohua Zhang,et al.  Proteasome inhibitor PS-341 attenuates flow-induced pulmonary arterial hypertension , 2014, Clinical and Experimental Medicine.

[295]  Kirsten Vistisen,et al.  Cardiotoxicity in cancer patients treated with 5-fluorouracil or capecitabine: a systematic review of incidence, manifestations and predisposing factors. , 2013, Cancer treatment reviews.

[296]  D. Sosnowska,et al.  Ionizing radiation promotes the acquisition of a senescence‐associated secretory phenotype and impairs angiogenic capacity in cerebromicrovascular endothelial cells: role of increased DNA damage and decreased DNA repair capacity in microvascular radiosens (665.3) , 2013, The journals of gerontology. Series A, Biological sciences and medical sciences.

[297]  Z. Korwek,et al.  A comparison of replicative senescence and doxorubicin-induced premature senescence of vascular smooth muscle cells isolated from human aorta , 2013, Biogerontology.

[298]  Z. Korwek,et al.  A comparison of replicative senescence and doxorubicin-induced premature senescence of vascular smooth muscle cells isolated from human aorta , 2013, Biogerontology.

[299]  N. Mohan,et al.  Trastuzumab Alters the Expression of Genes Essential for Cardiac Function and Induces Ultrastructural Changes of Cardiomyocytes in Mice , 2013, PloS one.

[300]  R. Day,et al.  Inhibition of IGF-1R Prevents Ionizing Radiation-Induced Primary Endothelial Cell Senescence , 2013, PloS one.

[301]  Yuan Shen,et al.  Bortezomib induces apoptosis of endometrial cancer cells through microRNA‐17‐5p by targeting p21 , 2013, Cell biology international.

[302]  F. Stewart,et al.  Understanding radiation-induced cardiovascular damage and strategies for intervention. , 2013, Clinical oncology (Royal College of Radiologists (Great Britain)).

[303]  A. Shah,et al.  Ionizing radiation regulates cardiac Ca handling via increased ROS and activated CaMKII , 2013, Basic Research in Cardiology.

[304]  R. Day,et al.  X-irradiation induces ER stress, apoptosis, and senescence in pulmonary artery endothelial cells , 2013, International journal of radiation biology.

[305]  K. Zeng,et al.  Statins are associated with reduced risk of gastric cancer: A meta-analysis , 2013, European Journal of Clinical Pharmacology.

[306]  M. Murad,et al.  Statins are associated with reduced risk of esophageal cancer, particularly in patients with Barrett's esophagus: a systematic review and meta-analysis. , 2013, Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association.

[307]  G. D. De Keulenaer,et al.  Cardiotoxicity associated with cancer therapy: Pathophysiology and prevention , 2013 .

[308]  G. Biondi-Zoccai,et al.  Comparative Cardiac Toxicity of Anthracyclines In Vitro and In Vivo in the Mouse , 2013, PloS one.

[309]  J. Moslehi.  The cardiovascular perils of cancer survivorship. , 2013, The New England journal of medicine.

[310]  Cam Patterson,et al.  Proteotoxicity and cardiac dysfunction--Alzheimer's disease of the heart? , 2013, The New England journal of medicine.

[311]  T. Hei,et al.  Mitochondrial alteration in malignantly transformed human small airway epithelial cells induced by α‐particles , 2013, International journal of cancer.

[312]  Edouard I Azzam,et al.  Ionizing radiation-induced metabolic oxidative stress and prolonged cell injury. , 2012, Cancer letters.

[313]  H. Haller,et al.  Urokinase Receptor Mediates Doxorubicin-Induced Vascular Smooth Muscle Cell Senescence via Proteasomal Degradation of TRF2 , 2012, Journal of Vascular Research.

[314]  Z. Tahergorabi,et al.  A Review on Angiogenesis and Its Assays , 2012, Iranian journal of basic medical sciences.

[315]  E. Yeh,et al.  Identification of the molecular basis of doxorubicin-induced cardiotoxicity , 2012, Nature Medicine.

[316]  F. A. Stewart.  Mechanisms and dose-response relationships for radiation-induced cardiovascular disease , 2012, Annals of the ICRP.

[317]  C. Barisione,et al.  Inhibition of Doxorubicin-Induced Senescence by PPARδ Activation Agonists in Cardiac Muscle Cells: Cooperation between PPARδ and Bcl6 , 2012, PloS one.

[318]  L. Young,et al.  AMP-Activated Protein Kinase Regulation and Biological Actions in the Heart , 2012, Circulation research.

[319]  M. Marra,et al.  5-Fluorouracil induces apoptosis in rat cardiocytes through intracellular oxidative stress , 2012, Journal of experimental & clinical cancer research : CR.

[320]  L. Bertrand,et al.  AMP-activated Protein Kinase in the Control of Cardiac Metabolism and Remodeling , 2012, Current Heart Failure Reports.

[321]  Sudeep Gupta,et al.  Acute non-ST elevation myocardial infarction following paclitaxel administration for ovarian carcinoma: a case report and review of literature. , 2012, Journal of cancer research and therapeutics.

[322]  H. Okano,et al.  Epigenetic regulation of cancer stem cell genes in triple-negative breast cancer. , 2012, The American journal of pathology.

[323]  R. Carvajal,et al.  Unstable angina associated with cisplatin and carboplatin in a patient with advanced melanoma. , 2012, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[324]  C. Koning,et al.  High risk of symptomatic cardiac events in childhood cancer survivors. , 2012, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[325]  S. Jakob,et al.  Cancer therapy modulates VEGF signaling and viability in adult rat cardiac microvascular endothelial cells and cardiomyocytes. , 2012, Journal of molecular and cellular cardiology.

[326]  A. Salminen,et al.  Emerging role of NF-κB signaling in the induction of senescence-associated secretory phenotype (SASP). , 2012, Cellular signalling.

[327]  Caicun Zhou.  Multi-targeted tyrosine kinase inhibitors for the treatment of non-small cell lung cancer: an era of individualized therapy. , 2012, Translational Lung Cancer Research.

[328]  R. Mutharasan,et al.  Disruption of ATP-binding cassette B8 in mice leads to cardiomyopathy through a decrease in mitochondrial iron export , 2012, Proceedings of the National Academy of Sciences.

[329]  D. Häussinger,et al.  Cardiotoxicity of the Antiprolif erative Compound Fluorouracil , 1999, Drugs.

[330]  Toshihiko Suzuki,et al.  Paclitaxel-induced endothelial dysfunction in living rats is prevented by nicorandil via reduction of oxidative stress. , 2012, Journal of pharmacological sciences.

[331]  S. Novo,et al.  Timely Recognition of Cardiovascular Toxicity by Anticancer Agents: A Common Objective of the Pharmacologist, Oncologist and Cardiologist , 2012, Cardiovascular Toxicology.

[332]  Lincoln D. Stein,et al.  Alterations in tumor necrosis factor signaling pathways are associated with cytotoxicity and resistance to taxanes: a study in isogenic resistant tumor cells , 2012, Breast Cancer Research.

[333]  K. Dieckmann,et al.  Evidence for acute vascular toxicity of cisplatin-based chemotherapy in patients with germ cell tumour. , 2011, Anticancer research.

[334]  R. Langer,et al.  In vivo prevention of arterial restenosis with paclitaxel-encapsulated targeted lipid–polymeric nanoparticles , 2011, Proceedings of the National Academy of Sciences.

[335]  I. Afanas’ev.  ROS and RNS Signaling in Heart Disorders: Could Antioxidant Treatment Be Successful? , 2011, Oxidative medicine and cellular longevity.

[336]  D. Feldman,et al.  High incidence of thromboembolic events in patients treated with cisplatin-based chemotherapy: a large retrospective analysis. , 2011, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[337]  J. Weiss,et al.  Rb and p130 control cell cycle gene silencing to maintain the postmitotic phenotype in cardiac myocytes , 2011, The Journal of cell biology.

[338]  M. Kelliher,et al.  A Cytosolic ATM/NEMO/RIP1 Complex Recruits TAK1 To Mediate the NF-κB and p38 Mitogen-Activated Protein Kinase (MAPK)/MAPK-Activated Protein 2 Responses to DNA Damage , 2011, Molecular and Cellular Biology.

[339]  J. Auwerx,et al.  Regulation of PGC-1α, a nodal regulator of mitochondrial biogenesis. , 2011, The American journal of clinical nutrition.

[340]  D. Bers,et al.  Reactive Oxygen Species–Activated Ca/Calmodulin Kinase II&dgr; Is Required for Late INa Augmentation Leading to Cellular Na and Ca Overload , 2011, Circulation research.

[341]  S. Marx,et al.  Vascular smooth muscle cell proliferation in restenosis. , 2011, Circulation. Cardiovascular interventions.

[342]  J. Itskovitz‐Eldor,et al.  Molecular characterization and functional properties of cardiomyocytes derived from human inducible pluripotent stem cells , 2009, Journal of cellular and molecular medicine.

[343]  Y. Yun,et al.  Inhibitory effects of docetaxel on platelet-derived growth factor (PDGF)-BB-induced proliferation of vascular smooth muscle cells through blocking PDGF-receptor β phosphorylation. , 2011, Journal of pharmacological sciences.

[344]  A. Algra,et al.  Long-term effect of aspirin on colorectal cancer incidence and mortality: 20-year follow-up of five randomised trials , 2010, The Lancet.

[345]  Y. Liu,et al.  Taxol, a microtubule stabilizer, prevents atrial fibrillation in in vitro atrial fibrillation models using rabbit hearts. , 2010, Medical science monitor : international medical journal of experimental and clinical research.

[346]  B. Ehrlich,et al.  Paclitaxel accelerates spontaneous calcium oscillations in cardiomyocytes by interacting with NCS-1 and the InsP3R. , 2010, Journal of molecular and cellular cardiology.

[347]  G. Dittmar,et al.  A cytoplasmic ATM-TRAF6-cIAP1 module links nuclear DNA damage signaling to ubiquitin-mediated NF-κB activation. , 2010, Molecular cell.

[348]  D. Schadendorf,et al.  Improved survival with ipilimumab in patients with metastatic melanoma. , 2010, The New England journal of medicine.

[349]  H. Hsieh,et al.  Antiangiogenic activities and cisplatin-combined antitumor activities of BPR0L075. , 2010, Anticancer research.

[350]  I. Komuro,et al.  Inhibition of autophagy in the heart induces age-related cardiomyopathy , 2010, Autophagy.

[351]  V. Cornelius,et al.  Cardiotoxicity of anthracycline agents for the treatment of cancer: Systematic review and meta-analysis of randomised controlled trials , 2010, BMC Cancer.

[352]  N. Saijo,et al.  Bortezomib potentially inhibits cellular growth of vascular endothelial cells through suppression of G2/M transition , 2010, Cancer science.

[353]  Y. Liu,et al.  Taxol, a Microtubule Stabilizer, Improves Cardiac Contractile Function during Ischemia in vitro , 2010, Pharmacology.

[354]  S. Cross,et al.  Microvascular Endothelial Cell Responses in vitro and in vivo: Modulation by Zoledronic Acid and Paclitaxel? , 2010, Journal of Vascular Research.

[355]  M. Ferrarini,et al.  Bortezomib induces autophagic death in proliferating human endothelial cells. , 2010, Experimental cell research.

[356]  Jun Ren,et al.  Cisplatin compromises myocardial contractile function and mitochondrial ultrastructure: Role of endoplasmic reticulum stress , 2010, Clinical and experimental pharmacology & physiology.

[357]  I. Ivanova,et al.  Protein kinase C-dependent inhibition of BKCa current in rat aorta smooth muscle cells following γ-irradiation , 2010, International journal of radiation biology.

[358]  A. Abdollahi,et al.  MicroRNA expression after ionizing radiation in human endothelial cells , 2010, Radiation oncology.

[359]  Jun Ren,et al.  Microtubular stability affects cardiomyocyte glycolysis by HIF-1alpha expression and endonuclear aggregation during early stages of hypoxia. , 2010, American journal of physiology. Heart and circulatory physiology.

[360]  B. Tesfamariam,et al.  Paclitaxel Potentiates Inflammatory Cytokine-induced Prothrombotic Molecules in Endothelial Cells , 2010, Journal of cardiovascular pharmacology.

[361]  G. Mills,et al.  ATM signals to TSC2 in the cytoplasm to regulate mTORC1 in response to ROS , 2010, Proceedings of the National Academy of Sciences.

[362]  L. Thuesen,et al.  Late coronary stent thrombosis. , 2010, Minerva medica.

[363]  C. Brunelli,et al.  Sublethal Doses of an Anti-erbB2 Antibody Leads to Death by Apoptosis in Cardiomyocytes Sensitized by Low Prosenescent Doses of Epirubicin: The Protective Role of Dexrazoxane , 2010, Journal of Pharmacology and Experimental Therapeutics.

[364]  D. Mulrooney,et al.  Cardiac outcomes in a cohort of adult survivors of childhood and adolescent cancer: retrospective analysis of the Childhood Cancer Survivor Study cohort , 2009, BMJ : British Medical Journal.

[365]  C. Barisione,et al.  Doxorubicin induces senescence or apoptosis in rat neonatal cardiomyocytes by regulating the expression levels of the telomere binding factors 1 and 2. , 2009, American journal of physiology. Heart and circulatory physiology.

[366]  Satoru Kobayashi,et al.  Transcription Factor GATA4 Inhibits Doxorubicin-induced Autophagy and Cardiomyocyte Death* , 2009, The Journal of Biological Chemistry.

[367]  B. Shen,et al.  Doxorubicin-induced vasomotion and [Ca2+]i elevation in vascular smooth muscle cells from C57BL/6 mice , 2009, Acta Pharmacologica Sinica.

[368]  J. S. Janicki,et al.  Nrf2 Protects Against Maladaptive Cardiac Responses to Hemodynamic Stress , 2009, Arteriosclerosis, thrombosis, and vascular biology.

[369]  Y. Ouchi,et al.  Sirolimus and everolimus induce endothelial cellular senescence via sirtuin 1 down-regulation: therapeutic implication of cilostazol after drug-eluting stent implantation. , 2009, Journal of the American College of Cardiology.

[370]  E. Jiménez,et al.  Cisplatin Reduces Endothelial Cell Migration Via Regulation of Type 2-Matrix Metalloproteinase Activity , 2009, Cellular Physiology and Biochemistry.

[371]  Eun-sook Kim,et al.  Simvastatin and lovastatin inhibit breast cell invasion induced by H-Ras. , 2009, Oncology reports.

[372]  W. Mendenhall,et al.  The Influence of Intraarterial High-Dose Cisplatin With Concomitant Irradiation on Arterial Microanastomosis: An Experimental Study , 2009, American journal of clinical oncology.

[373]  D. Hershman,et al.  Anthracycline cardiotoxicity after breast cancer treatment. , 2009, Oncology.

[374]  D. Sawyer,et al.  The role of Neuregulin-1beta/ErbB signaling in the heart. , 2009, Experimental cell research.

[375]  R. Himes,et al.  Differences in Paclitaxel and Docetaxel Interactions with Tubulin Detected by Mutagenesis of Yeast Tubulin , 2008, ChemMedChem.

[376]  Xiaohong Wang,et al.  Heat Shock Protein 20 Interacting With Phosphorylated Akt Reduces Doxorubicin-Triggered Oxidative Stress and Cardiotoxicity , 2008, Circulation research.

[377]  Eleftherios P. Diamandis,et al.  Novel therapeutic applications of cardiac glycosides , 2008, Nature Reviews Drug Discovery.

[378]  Weiling Zhao,et al.  NADPH oxidase mediates radiation-induced oxidative stress in rat brain microvascular endothelial cells. , 2008, Free radical biology & medicine.

[379]  A. Sharpe,et al.  Programmed Death Ligand 1 Regulates a Critical Checkpoint for Autoimmune Myocarditis and Pneumonitis in MRL Mice1 , 2008, The Journal of Immunology.

[380]  T. Chiu,et al.  Pravastatin attenuates carboplatin-induced cardiotoxicity via inhibition of oxidative stress associated apoptosis , 2008, Apoptosis.

[381]  K. Hirao,et al.  Induction of premature senescence in cardiomyocytes by doxorubicin as a novel mechanism of myocardial damage , 2008, Aging cell.

[382]  O. Ogunwobi,et al.  Statins Inhibit Proliferation and Induce Apoptosis in Barrett's Esophageal Adenocarcinoma Cells , 2008, The American Journal of Gastroenterology.

[383]  G. Saretzki,et al.  Telomerase does not counteract telomere shortening but protects mitochondrial function under oxidative stress , 2008, Journal of Cell Science.

[384]  F. Schmidt.  Meta-Analysis , 2008 .

[385]  S. Lipshultz,et al.  Anthracycline associated cardiotoxicity in survivors of childhood cancer , 2007, Heart.

[386]  Janet L. Johnstone,et al.  Intracellular Protein Aggregation Is a Proximal Trigger of Cardiomyocyte Autophagy , 2008, Circulation.

[387]  P. Kyrle,et al.  Chemotherapy‐induced thrombin generation via procoagulant endothelial microparticles is independent of tissue factor activity , 2007, Journal of thrombosis and haemostasis : JTH.

[388]  G. Freeman,et al.  Endothelial Programmed Death-1 Ligand 1 (PD-L1) Regulates CD8+ T-Cell–Mediated Injury in the Heart , 2007, Circulation.

[389]  Jacek Jassem,et al.  Cardiovascular effects of breast cancer radiotherapy. , 2007, Cancer treatment reviews.

[390]  L. Rochette,et al.  Involvement of microtubules in the tolerance of cardiomyocytes to cold ischemia-reperfusion , 2007, Molecular and Cellular Biochemistry.

[391]  G. D. De Keulenaer,et al.  Role of Neuregulin-1/ErbB Signaling in Cardiovascular Physiology and Disease: Implications for Therapy of Heart Failure , 2007, Circulation.

[392]  Seung‐Jung Park,et al.  FcgammaRIIa mediates C-reactive protein-induced inflammatory responses of human vascular smooth muscle cells by activating NADPH oxidase 4. , 2007, Cardiovascular Research.

[393]  A. Geist,et al.  Dexrazoxane prevents doxorubicin‐induced long‐term cardiotoxicity and protects myocardial mitochondria from genetic and functional lesions in rats , 2007, British journal of pharmacology.

[394]  Michael Joner,et al.  Vascular Responses to Drug Eluting Stents: Importance of Delayed Healing , 2007, Arteriosclerosis, thrombosis, and vascular biology.

[395]  S. Demo,et al.  Antitumor activity of PR-171, a novel irreversible inhibitor of the proteasome. , 2007, Cancer research.

[396]  A. Curcio,et al.  Fludarabine prevents smooth muscle proliferation in vitro and neointimal hyperplasia in vivo through specific inhibition of STAT-1 activation. , 2007, American journal of physiology. Heart and circulatory physiology.

[397]  Yasushi Matsumura,et al.  The role of autophagy in cardiomyocytes in the basal state and in response to hemodynamic stress , 2007, Nature Medicine.

[398]  T. Suter,et al.  Pathophysiology and diagnosis of cancer drug induced cardiomyopathy , 2007, Cardiovascular Toxicology.

[399]  H. T. ter Keurs,et al.  Calcium and arrhythmogenesis. , 2007, Physiological reviews.

[400]  S. Pocock,et al.  Safety and efficacy of sirolimus- and paclitaxel-eluting coronary stents. , 2007, The New England journal of medicine.

[401]  K. Trott,et al.  Radiation-induced cardiovascular diseases: is the epidemiologic evidence compatible with the radiobiologic data? , 2007, International journal of radiation oncology, biology, physics.

[402]  M. Benito,et al.  Negative regulation of Akt activity by p38alpha MAP kinase in cardiomyocytes involves membrane localization of PP2A through interaction with caveolin-1. , 2007, Cellular signalling.

[403]  M. Majetschak,et al.  Distribution and interrelationship of ubiquitin proteasome pathway component activities and ubiquitin pools in various porcine tissues. , 2007, Physiological research.

[404]  S. Manna,et al.  RETRACTED ARTICLE: Cardiac glycoside induces cell death via FasL by activating calcineurin and NF-AT, but apoptosis initially proceeds through activation of caspases , 2007, Apoptosis.

[405]  B. Kaina,et al.  Lovastatin protects human endothelial cells from the genotoxic and cytotoxic effects of the anticancer drugs doxorubicin and etoposide , 2006, British journal of pharmacology.

[406]  L. Ignarro,et al.  Endothelial cellular senescence is inhibited by nitric oxide: Implications in atherosclerosis associated with menopause and diabetes , 2006, Proceedings of the National Academy of Sciences.

[407]  So-Young Rah,et al.  Doxorubicin-induced reactive oxygen species generation and intracellular Ca2+increase are reciprocally modulated in rat cardiomyocytes , 2006, Experimental & Molecular Medicine.

[408]  Kevin C Oeffinger,et al.  Chronic health conditions in adult survivors of childhood cancer. , 2006, The New England journal of medicine.

[409]  J. Bourhis,et al.  Influence of endothelial cells on vascular smooth muscle cells phenotype after irradiation: implication in radiation-induced vascular damages. , 2006, The American journal of pathology.

[410]  Keith K. Fenrich,et al.  Protection of Human Vascular Smooth Muscle Cells From H2O2-Induced Apoptosis Through Functional Codependence Between HO-1 and AKT , 2006, Arteriosclerosis, thrombosis, and vascular biology.

[411]  R. Novak,et al.  DNA damage is an early event in doxorubicin-induced cardiac myocyte death. , 2006, American journal of physiology. Heart and circulatory physiology.

[412]  E. Schwartz,et al.  Taxotere-induced inhibition of human endothelial cell migration is a result of heat shock protein 90 degradation. , 2006, Cancer research.

[413]  Liz Y. Han,et al.  Chronic stress promotes tumor growth and angiogenesis in a mouse model of ovarian carcinoma , 2006, Nature Medicine.

[414]  U. Vischer,et al.  von Willebrand factor, endothelial dysfunction, and cardiovascular disease , 2006, Journal of thrombosis and haemostasis : JTH.

[415]  F. V. van Leeuwen,et al.  Long-term risk of cardiovascular disease in 5-year survivors of testicular cancer. , 2006, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[416]  Gil Bub,et al.  The kinetics of spontaneous calcium oscillations and arrhythmogenesis in the in vivo heart during ischemia/reperfusion. , 2006, Heart rhythm.

[417]  J. Sørensen,et al.  Risk factors and prevention of cardiotoxicity induced by 5-fluorouracil or capecitabine , 2006, Cancer Chemotherapy and Pharmacology.

[418]  M. Pfreundschuh,et al.  NAD(P)H Oxidase and Multidrug Resistance Protein Genetic Polymorphisms Are Associated With Doxorubicin-Induced Cardiotoxicity , 2005, Circulation.

[419]  B. Bewig,et al.  Symptoms and signs of an acute myocardial ischemia caused by chemotherapy with Paclitaxel (Taxol) in a patient with metastatic ovarian carcinoma. , 2005, European journal of medical research.

[420]  Jiaping Zhang,et al.  [An experimental study on the influence of hypoxia induction factor-1alpha on the glycolysis of the rat myocardial cell under hypoxic condition]. , 2005, Zhonghua shao shang za zhi = Zhonghua shaoshang zazhi = Chinese journal of burns.

[421]  C. Nahmias,et al.  Angiotensin receptors: a new role in cancer? , 2005, Trends in Endocrinology & Metabolism.

[422]  R. Moreland,et al.  Ionizing radiation alters myofilament calcium sensitivity in vascular smooth muscle: potential role of protein kinase C. , 2005, American journal of physiology. Regulatory, integrative and comparative physiology.

[423]  P. Ellis,et al.  Adjuvant trastuzumab for HER2-positive breast cancer , 2005, The Lancet.

[424]  R. Iozzo.  Basement membrane proteoglycans: from cellar to ceiling , 2005, Nature Reviews Molecular Cell Biology.

[425]  D. Richardson,et al.  Molecular Pharmacology of the Interaction of Anthracyclines with Iron , 2005, Molecular Pharmacology.

[426]  O. Carretero,et al.  Role of inducible nitric oxide synthase in cardiac function and remodeling in mice with heart failure due to myocardial infarction. , 2005, American journal of physiology. Heart and circulatory physiology.

[427]  H. Sheng,et al.  Prostaglandin E2 Stimulates the β-Catenin/T Cell Factor-dependent Transcription in Colon Cancer* , 2005, Journal of Biological Chemistry.

[428]  Robert W. Taylor,et al.  A mitochondrial cytochrome b mutation causing severe respiratory chain enzyme deficiency in humans and yeast , 2005, The FEBS journal.

[429]  A. Cheung,et al.  Different responses by cultured aortic and venous smooth muscle cells to gamma radiation. , 2005, Kidney international.

[430]  S. Strumiło.  Short-Term Regulation of the α-Ketoglutarate Dehydrogenase Complex by Energy-Linked and Some Other Effectors , 2005, Biochemistry (Moscow).

[431]  D. Kass,et al.  Oxidant stress from nitric oxide synthase-3 uncoupling stimulates cardiac pathologic remodeling from chronic pressure load. , 2005, The Journal of clinical investigation.

[432]  E. Pasquier,et al.  Antiangiogenic concentrations of paclitaxel induce an increase in microtubule dynamics in endothelial cells but not in cancer cells. , 2005, Cancer research.

[433]  P. Morandi,et al.  Cardiac toxicity of high-dose chemotherapy , 2005, Bone Marrow Transplantation.

[434]  Hiroyuki Ito,et al.  Vitamin E prevents endothelial injury associated with cisplatin injection into the superior mesenteric artery of rats , 2005, Heart and Vessels.

[435]  R. Hajjar,et al.  Inhibition of ErbB2 causes mitochondrial dysfunction in cardiomyocytes: implications for herceptin-induced cardiomyopathy. , 2004, Journal of the American College of Cardiology.

[436]  G. Howe,et al.  Analysis of the Mortality Experience amongst U.S. Nuclear Power Industry Workers after Chronic Low-Dose Exposure to Ionizing Radiation , 2004, Radiation research.

[437]  M. Isobe,et al.  Blockade of the Interaction Between PD-1 and PD-L1 Accelerates Graft Arterial Disease in Cardiac Allografts , 2004, Arteriosclerosis, thrombosis, and vascular biology.

[438]  E. Pasquier,et al.  Antiangiogenic activity of paclitaxel is associated with its cytostatic effect, mediated by the initiation but not completion of a mitochondrial apoptotic signaling pathway. , 2004, Molecular cancer therapeutics.

[439]  Wolfgang Schöber,et al.  The Effects of Paclitaxel on the Three Phases of Restenosis: Smooth Muscle Cell Proliferation, Migration, and Matrix Formation: An In Vitro Study , 2004, Investigative radiology.

[440]  E. Fleck,et al.  C-Reactive Protein Induces Apoptosis in Human Coronary Vascular Smooth Muscle Cells , 2004, Circulation.

[441]  Ruud P. M. Dings,et al.  Carboplatin selectively induces the VEGF stress response in endothelial cells: Potentiation of antitumor activity by combination treatment with antibody to VEGF , 2004, International journal of cancer.

[442]  L. Gianni,et al.  Anthracyclines: Molecular Advances and Pharmacologic Developments in Antitumor Activity and Cardiotoxicity , 2004, Pharmacological Reviews.

[443]  John M Sedivy,et al.  Telomere shortening triggers senescence of human cells through a pathway involving ATM, p53, and p21(CIP1), but not p16(INK4a). , 2004, Molecular cell.

[444]  G. LaMuraglia,et al.  Gamma-irradiation modulates vascular smooth muscle cell and extracellular matrix function: Implications for neointimal development. , 2004, Journal of vascular surgery.

[445]  W. Cefalu,et al.  Arterial heparan sulfate is negatively associated with hyperglycemia and atherosclerosis in diabetic monkeys , 2004, Cardiovascular diabetology.

[446]  Guido Kroemer,et al.  Cell death by mitotic catastrophe: a molecular definition , 2004, Oncogene.

[447]  W. Schmiegel,et al.  5-Fluorouracil induces arterial vasocontractions. , 2004, Annals of oncology : official journal of the European Society for Medical Oncology.

[448]  E. Folch-Puy,et al.  Oxygen Free Radicals and the Systemic Inflammatory Response , 2004, IUBMB life.

[449]  Henk-Jan Guchelaar,et al.  Cardiotoxicity of cytotoxic drugs. , 2004, Cancer treatment reviews.

[450]  A. Heldman,et al.  Inhibition of Restenosis With a Paclitaxel-Eluting, Polymer-Free Coronary Stent: The European evaLUation of pacliTaxel Eluting Stent (ELUTES) Trial , 2004, Circulation.

[451]  M. Benito,et al.  P38 alpha mitogen-activated protein kinase sensitizes cells to apoptosis induced by different stimuli. , 2003, Molecular biology of the cell.

[452]  Hyun Pyo Kim,et al.  Anti-inflammatory plant flavonoids and cellular action mechanisms. , 2004, Journal of pharmacological sciences.

[453]  B. Hasinoff,et al.  The oral iron chelator ICL670A (deferasirox) does not protect myocytes against doxorubicin. , 2003, Free radical biology & medicine.

[454]  Yoshimasa Tanaka,et al.  Autoantibodies against cardiac troponin I are responsible for dilated cardiomyopathy in PD-1-deficient mice , 2003, Nature Medicine.

[455]  A Bast,et al.  The new cardioprotector Monohydroxyethylrutoside protects against doxorubicin-induced inflammatory effects in vitro , 2003, British Journal of Cancer.

[456]  L. Constine,et al.  Radiation-associated cardiovascular disease: manifestations and management. , 2003, Seminars in radiation oncology.

[457]  Michael Bustin,et al.  Inflammation-promoting activity of HMGB1 on human microvascular endothelial cells. , 2003, Blood.

[458]  Jean-Luc Balligand,et al.  Irradiation-induced angiogenesis through the up-regulation of the nitric oxide pathway: implications for tumor radiotherapy. , 2003, Cancer research.

[459]  A. Gurney,et al.  Saline containing phosphatidylcholine liposomes possess the ability to restore endothelial function damaged resulting from gamma-irradiation. , 2002, Journal of physiology and pharmacology : an official journal of the Polish Physiological Society.

[460]  Edward L Schwartz,et al.  Inhibition of endothelial cell function in vitro and angiogenesis in vivo by docetaxel (Taxotere): association with impaired repositioning of the microtubule organizing center. , 2002, Molecular cancer therapeutics.

[461]  Ruediger C. Braun-Dullaeus,et al.  Vascular proliferation and atherosclerosis: New perspectives and therapeutic strategies , 2002, Nature Medicine.

[462]  D. Bers,et al.  Quantitative Assessment of the SR Ca2+ Leak-Load Relationship , 2002, Circulation research.

[463]  S. Rosenkranz,et al.  Alterations of β-adrenergic signaling and cardiac hypertrophy in transgenic mice overexpressing TGF-β1 , 2002 .

[464]  Robert Kiss,et al.  In vitro pharmacological characterizations of the anti-angiogenic and anti-tumor cell migration properties mediated by microtubule-affecting drugs, with special emphasis on the organization of the actin cytoskeleton. , 2002, International journal of oncology.

[465]  D. Sabatini,et al.  mTOR Interacts with Raptor to Form a Nutrient-Sensitive Complex that Signals to the Cell Growth Machinery , 2002, Cell.

[466]  K. Robinson,et al.  Endovascular irradiation impairs vascular functional responses in noninjured pig coronary arteries. , 2002, Cardiovascular radiation medicine.

[467]  M. P. van den Berg,et al.  Evaluation of long term cardiotoxicity after epirubicin containing adjuvant chemotherapy and locoregional radiotherapy for breast cancer using various detection techniques , 2002, Heart.

[468]  P. Voûte,et al.  Frequency and risk factors of subclinical cardiotoxicity after anthracycline therapy in children: a systematic review. , 2002, Annals of oncology : official journal of the European Society for Medical Oncology.

[469]  I. Komuro,et al.  Endothelial Cell Senescence in Human Atherosclerosis: Role of Telomere in Endothelial Dysfunction , 2002, Circulation.

[470]  R. Bronson,et al.  Mutant Mouse Models Reveal the Relative Roles of E2F1 and E2F3 In Vivo , 2002, Molecular and Cellular Biology.

[471]  P. Voûte,et al.  Frequency and risk factors of anthracycline-induced clinical heart failure in children: a systematic review. , 2002, Annals of oncology : official journal of the European Society for Medical Oncology.

[472]  J. Redondo,et al.  Doxorubicin Induces Apoptosis and CD95 Gene Expression in Human Primary Endothelial Cells through a p53-dependent Mechanism* , 2002, The Journal of Biological Chemistry.

[473]  S. Rosenkranz,et al.  Alterations of beta-adrenergic signaling and cardiac hypertrophy in transgenic mice overexpressing TGF-beta(1). , 2002, American journal of physiology. Heart and circulatory physiology.

[474]  M. Cwikiel,et al.  Antithrombotic treatment in protection against thrombogenic effects of 5-fluorouracil on vascular endothelium: a scanning microscopy evaluation. , 2006, Scanning.

[475]  J. Joseph,et al.  Doxorubicin-induced Apoptosis Is Associated with Increased Transcription of Endothelial Nitric-oxide Synthase , 2001, The Journal of Biological Chemistry.

[476]  G. Minotti,et al.  Doxorubicin irreversibly inactivates iron regulatory proteins 1 and 2 in cardiomyocytes: evidence for distinct metabolic pathways and implications for iron-mediated cardiotoxicity of antitumor therapy. , 2001, Cancer research.

[477]  P. Tsao,et al.  eNOS Activity Is Reduced in Senescent Human Endothelial Cells: Preservation by hTERT Immortalization , 2001, Circulation research.

[478]  A. Zeiher,et al.  Aging Enhances the Sensitivity of Endothelial Cells Toward Apoptotic Stimuli: Important Role of Nitric Oxide , 2001, Circulation research.

[479]  R. Kumar,et al.  The role of HER2 in angiogenesis. , 2001, Seminars in oncology.

[480]  D. Rader,et al.  The adhesion receptor CD44 promotes atherosclerosis by mediating inflammatory cell recruitment and vascular cell activation. , 2001, The Journal of clinical investigation.

[481]  Zvi Fuks,et al.  Endothelial Apoptosis as the Primary Lesion Initiating Intestinal Radiation Damage in Mice , 2001, Science.

[482]  A. Orlandi,et al.  Phenotypic Heterogeneity Influences Apoptotic Susceptibility to Retinoic Acid and cis-Platinum of Rat Arterial Smooth Muscle Cells In Vitro: Implications for the Evolution of Experimental Intimal Thickening , 2001, Arteriosclerosis, thrombosis, and vascular biology.

[483]  P. Visser,et al.  Irradiated versus nonirradiated endothelial cells: effect on proliferation of vascular smooth muscle cells. , 2001, Journal of vascular and interventional radiology : JVIR.

[484]  A. Mailloux,et al.  Anticancer drugs induce necrosis of human endothelial cells involving both oncosis and apoptosis. , 2001, European journal of cell biology.

[485]  P. Delafontaine,et al.  Gamma-Irradiation Markedly Inhibits the Hydrated Collagen Gel Contraction by Arterial Smooth Muscle Cells , 2001, Journal of Investigative Medicine.

[486]  H. Yamawaki,et al.  Chronic vascular toxicity of doxorubicin in an organ‐cultured artery , 2001, British journal of pharmacology.

[487]  T. Fleming,et al.  Use of chemotherapy plus a monoclonal antibody against HER2 for metastatic breast cancer that overexpresses HER2. , 2001, The New England journal of medicine.

[488]  J. Shay,et al.  Putative telomere-independent mechanisms of replicative aging reflect inadequate growth conditions. , 2001, Genes & development.

[489]  D. Richardson,et al.  The cardioprotective effect of the iron chelator dexrazoxane (ICRF-187) on anthracycline-mediated cardiotoxicity , 2000, Redox report : communications in free radical research.

[490]  A. Zeiher,et al.  Nitric Oxide Activates Telomerase and Delays Endothelial Cell Senescence , 2000, Circulation research.

[491]  İ. Durak,et al.  Reduced antioxidant defense capacity in myocardial tissue from guinea pigs treated with 5-fluorouracil. , 2000, Journal of toxicology and environmental health. Part A.

[492]  M. Nahata,et al.  Cardiotoxicity of Chemotherapeutic Agents , 2000 .

[493]  D J van Veldhuisen,et al.  Cardiovascular morbidity in long-term survivors of metastatic testicular cancer. , 2000, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[494]  C. Gajdusek,et al.  Inhibition of Rat Smooth Muscle Proliferation by Radiation after Arterial Injury: Temporal Characteristics In Vivo and In Vitro , 2000, Radiation research.

[495]  M. Nahata,et al.  Cardiotoxicity of chemotherapeutic agents: incidence, treatment and prevention. , 2000, Drug safety.

[496]  G. LaMuraglia,et al.  Different effects of photodynamic therapy and gamma-irradiation on vascular smooth muscle cells and matrix : implications for inhibiting restenosis. , 1999, Arteriosclerosis, thrombosis, and vascular biology.

[497]  Y. Masuda,et al.  Induction of apoptosis by bufalin in human tumor cells is associated with a change of intracellular concentration of Na+ ions. , 1999, Journal of biochemistry.

[498]  P. Keegan,et al.  Cardiotoxicity associated with paclitaxel/trastuzumab combination therapy. , 1999, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[499]  D. Sawyer,et al.  Daunorubicin-induced apoptosis in rat cardiac myocytes is inhibited by dexrazoxane. , 1999, Circulation research.

[500]  K. Williams,et al.  Human Vascular Endothelial Cells Are a Rich and Regulatable Source of Secretory Sphingomyelinase , 1998, The Journal of Biological Chemistry.

[501]  G. Appendino,et al.  Differential effects of paclitaxel and derivatives on guinea pig isolated heart and papillary muscle. , 1998, The Journal of pharmacology and experimental therapeutics.

[502]  T. Yokoyama,et al.  Sarcoplasmic reticulum genes are selectively down-regulated in cardiomyopathy produced by doxorubicin in rabbits. , 1998, Journal of molecular and cellular cardiology.

[503]  K. Pritchard,et al.  Endothelial nitric oxide synthase-dependent superoxide generation from adriamycin. , 1997, Biochemistry.

[504]  R. Saura,et al.  A mechanism of cisplatin action: antineoplastic effect through inhibition of neovascularization. , 1997, The Kobe journal of medical sciences.

[505]  A. Küttner,et al.  Paclitaxel inhibits arterial smooth muscle cell proliferation and migration in vitro and in vivo using local drug delivery. , 1997, Circulation.

[506]  William L. Smith,et al.  Prostaglandin Endoperoxide H Synthases (Cyclooxygenases)-1 and −2* , 1996, The Journal of Biological Chemistry.

[507]  G. Viale,et al.  The microtubule-affecting drug paclitaxel has antiangiogenic activity. , 1996, Clinical cancer research : an official journal of the American Association for Cancer Research.

[508]  C. Gajdusek,et al.  Gamma radiation effect on vascular smooth muscle cells in culture. , 1996, International journal of radiation oncology, biology, physics.

[509]  R. Virmani,et al.  Apoptosis in myocytes in end-stage heart failure. , 1996, The New England journal of medicine.

[510]  M. Cwikiel,et al.  The influence of 5-fluorouracil and methotrexate on vascular endothelium. An experimental study using endothelial cells in the culture. , 1996, Annals of oncology : official journal of the European Society for Medical Oncology.

[511]  M. Thomas,et al.  Effects of doxorubicin, 4'-epirubicin, and antioxidant enzymes on the contractility of isolated cardiomyocytes. , 1996, Canadian journal of physiology and pharmacology.

[512]  D. Hallahan,et al.  E-selectin gene induction by ionizing radiation is independent of cytokine induction. , 1995, Biochemical and biophysical research communications.

[513]  J. Maier,et al.  Senescence-dependent regulation of type 1 plasminogen activator inhibitor in human vascular endothelial cells. , 1995, Experimental cell research.

[514]  A. Haimovitz-Friedman,et al.  Ionizing radiation acts on cellular membranes to generate ceramide and initiate apoptosis , 1994, The Journal of experimental medicine.

[515]  D. Keefe,et al.  Clinical Cardiotoxicity of 5‐Fluorouracil , 1993, Journal of clinical pharmacology.

[516]  M. Mosseri,et al.  In vitro evidence that myocardial ischemia resulting from 5-fluorouracil chemotherapy is due to protein kinase C-mediated vasoconstriction of vascular smooth muscle. , 1993, Cancer research.

[517]  K. Berbaum,et al.  Effect of antineoplastic agents on smooth muscle cell proliferation in vitro: implications for prevention of restenosis after transluminal angioplasty. , 1992, Journal of vascular and interventional radiology : JVIR.

[518]  E K Rowinsky,et al.  Cardiac disturbances during the administration of taxol. , 1991, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[519]  L. Toll,et al.  L-type cardiac calcium channels in doxorubicin cardiomyopathy in rats morphological, biochemical, and functional correlations. , 1991, The Journal of clinical investigation.

[520]  M. Reidy,et al.  Proliferation of smooth muscle cells at sites distant from vascular injury. , 1990, Arteriosclerosis.

[521]  O. Tokunaga,et al.  Atherosclerosis- and age-related multinucleated variant endothelial cells in primary culture from human aorta. , 1989, The American journal of pathology.

[522]  L F Watson,et al.  Colorectal cancer risk, chronic illnesses, operations and medications: case control results from the Melbourne Colorectal Cancer Study. 1988. , 2007, International journal of epidemiology.

[523]  J. Doroshow,et al.  Redox cycling of anthracyclines by cardiac mitochondria. I. Anthracycline radical formation by NADH dehydrogenase. , 1986, The Journal of biological chemistry.

[524]  J. Doroshow,et al.  Redox cycling of anthracyclines by cardiac mitochondria. II. Formation of superoxide anion, hydrogen peroxide, and hydroxyl radical. , 1986, The Journal of biological chemistry.

[525]  E. Rosen,et al.  Survival and repair of potentially lethal radiation damage in confluent vascular smooth muscle cell cultures. , 1986, Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology.

[526]  A. Antonov,et al.  Heterogeneity of endothelium in human aorta. A quantitative analysis by scanning electron microscopy. , 1984, Atherosclerosis.

[527]  R. Bonow,et al.  Prospective randomized study of the role of N‐acetyl cysteine in reversing doxorubicin‐induced cardiomyopathy , 1982, American journal of clinical oncology.

[528]  P. Caroni,et al.  The cardiotoxic antibiotic doxorubicin inhibits the Na+/Ca2+ exchange of dog heart sarcolemmal vesicles , 1981, FEBS letters.

[529]  E. Goormaghtigh,et al.  Evidence of a specific complex between adriamycin and negatively-charged phospholipids. , 1980, Biochimica et biophysica acta.

[530]  S. Imai,et al.  Cardiotoxic effects of 5-fluorouracil in the guinea pig. , 1980, Japanese journal of pharmacology.

[531]  I. Mccoll,et al.  Letter: 5-Fluorouracil and angina. , 1975, Lancet.

[532]  G. Burch,et al.  Effects of radiation on the human heart. An electron microscopic study. , 1968, Archives of internal medicine.