The cytochromes P-448--a unique family of enzymes involved in chemical toxicity and carcinogenesis.

[1]  J. Miller,et al.  Major role of hepatic sulfotransferase activity in the metabolic activation, DNA adduct formation, and carcinogenicity of 1'-hydroxy-2',3'-dehydroestragole in infant male C57BL/6J x C3H/HeJ F1 mice. , 1985, Cancer research.

[2]  D. Waxman,et al.  Regulation of rat hepatic cytochrome P-450: age-dependent expression, hormonal imprinting, and xenobiotic inducibility of sex-specific isoenzymes. , 1985, Biochemistry.

[3]  F. Guengerich,et al.  Metabolic oxidation of carcinogenic arylamines by rat, dog, and human hepatic microsomes and by purified flavin-containing and cytochrome P-450 monooxygenases. , 1985, Cancer research.

[4]  K. Mann,et al.  Thrombin-catalyzed activation of single chain bovine factor V. , 1979, The Journal of biological chemistry.

[5]  M. Noshiro,et al.  Immunochemical study on the role of different types of microsomal cytochrome P-450 in mutagenesis by chemical carcinogens. , 1980, Cancer research.

[6]  M. J. Coon,et al.  Comparison of six rabbit liver cytochrome P-450 isozymes in formation of a reactive metabolite of acetaminophen. , 1983, Biochemical and biophysical research communications.

[7]  F. Kadlubar,et al.  Prostaglandin endoperoxide synthetase-mediated metabolism of carcinogenic aromatic amines and their binding to DNA and protein. , 1982, Biochemical and biophysical research communications.

[8]  D. Nebert,et al.  Cytochrome P450 gene expression and regulation , 1985 .

[9]  J. Goldstein,et al.  Purification and characterization of a second form of hepatic cytochrome P-448 from rats treated with a pure polychlorinated biphenyl isomer. , 1982, The Journal of biological chemistry.

[10]  H. Ohkawa,et al.  Characterization of three forms of cytochrome P-450 isolated from liver microsomes of rats treated with 3-methylcholanthrene. , 1984, Journal of biochemistry.

[11]  M. Boyd,et al.  Effects of phenobarbital and 3-methylcholanthrene on the in vivo distribution, metabolism and covalent binding of 4-ipomeanol in the rat; implications for target organ toxicity. , 1982, Biochemical pharmacology.

[12]  H. Strobel,et al.  Multiple forms of cytochrome P-450 in liver microsomes from beta-naphthoflavone-pretreated rats. Separation, purification, and characterization of five forms. , 1982, The Journal of biological chemistry.

[13]  T. Kamataki,et al.  Metabolic activation of glutamic acid pyrolysis products, 2-amino-6-methyldipyrido[1,2-a:3',2'-d]imidazole and 2-amino-dipyrido[1,2-a:3',2'-d]imidazole, by purified cytochrome P-450. , 1981, Chemico-biological interactions.

[14]  O. Hankinson,et al.  Effects of cytochrome P1-450 inducers on the cell-surface receptors for epidermal growth factor, phorbol 12,13-dibutyrate, or insulin of cultured mouse hepatoma cells. , 1983, The Journal of biological chemistry.

[15]  H. Murakami,et al.  Nucleotide sequence of a full-length cDNA coding for 3-methylcholanthrene-induced rat liver cytochrome P-450MC. , 1984, Nucleic acids research.

[16]  J. Mester,et al.  Oncogenes homologous to steroid receptors? , 1985, Nature.

[17]  S. Paik,et al.  Oxidative activation and inactivation of the carcinogen 2-acetylaminofluorene by various purified cytochromes P-450 from 3-methylcholanthrene pretreated rats. , 1984, Toxicology letters.

[18]  D. Jerina,et al.  Arene oxides: a new aspect of drug metabolism. , 1974, Science.

[19]  H. Bonkovsky,et al.  Inhibition of uroporphyrinogen decarboxylase by halogenated biphenyls in chick hepatocyte cultures. Essential role for induction of cytochrome P-448. , 1984, The Biochemical journal.

[20]  F. Guengerich,et al.  Purification and characterization of microsomal cytochrome P-450s. , 1982, Xenobiotica; the fate of foreign compounds in biological systems.

[21]  M. J. Coon,et al.  Metabolism of nitrosamines by purified rabbit liver cytochrome P-450 isozymes. , 1985, Cancer research.

[22]  K. Bock,et al.  Purification of Rat-Liver Microsomal UDP-glucuronyltransferase , 1979 .

[23]  R. Tukey,et al.  Regulation of mouse cytochrome P3-450 by the Ah receptor. Studies with a P3-450 cDNA clone. , 1984, Biochemistry.

[24]  J. Depierre,et al.  Metabolism of 2-acetylaminofluorene by eight different forms of cytochrome P-450 isolated from rat liver. , 1985, Carcinogenesis.

[25]  P. Thomas,et al.  Monoclonal antibodies distinguish among isozymes of the cytochrome P-450b subfamily. , 1985, Archives of biochemistry and biophysics.

[26]  P. Albro,et al.  Interactions between xenobiotics that increase or decrease the levels of cytochrome P-450 isozymes in rabbit lung and liver. , 1983, The Journal of biological chemistry.

[27]  H. Glatt,et al.  Inactivation of a diol-epoxide and a K-region epoxide with high efficiency by glutathione transferase X. , 1983, Cancer research.

[28]  D. Nebert.  Genetic differences in the induction of monooxygenase activities by polycyclic aromatic compounds , 1979 .

[29]  A. Kumar,et al.  Cloned cytochrome P-450 cDNA. Nucleotide sequence and homology to multiple phenobarbital-induced mRNA species. , 1983, The Journal of biological chemistry.

[30]  O. Gotoh,et al.  Complete nucleotide sequence of a methylcholanthrene-inducible cytochrome P-450 (P-450d) gene in the rat. , 1985, The Journal of biological chemistry.

[31]  S. Safe,et al.  Immunochemical quantitation of cytochrome P-450 isozymes and epoxide hydrolase in liver microsomes from polychlorinated or polybrominated biphenyl-treated rats. A study of structure-activity relationships. , 1983, The Journal of biological chemistry.

[32]  R. Tukey,et al.  Cloning and isolation of human cytochrome P-450 cDNAs homologous to dioxin-inducible rabbit mRNAs encoding P-450 4 and P-450 6. , 1985, DNA.

[33]  J. Schenkman,et al.  Isolation and comparison of four cytochrome P-450 enzymes from phenobarbital-induced rat liver: three forms possessing identical NH2-terminal sequences. , 1985, Pharmacology.

[34]  K. Dus.  Insights into the active site of the cytochrome P-450 haemoprotein family--a unifying concept based on structural considerations. , 1982, Xenobiotica; the fate of foreign compounds in biological systems.

[35]  P. Thomas,et al.  Regio- and stereoselective metabolism of two C19 steroids by five highly purified and reconstituted rat hepatic cytochrome P-450 isozymes. , 1983, The Journal of biological chemistry.

[36]  F. Oesch,et al.  Effects of the modulation of epoxide hydrolase activity on the binding of benzo[a]pyrene metabolites to DNA in the intact nuclei. , 1983, Carcinogenesis.

[37]  C. Ioannides,et al.  Activation of benzo(a)pyrene and 2-acetamidofluorene to mutagens by microsomal preparations from different animal species: role of cytochrome P-450 and P-448. , 1981, Xenobiotica; the fate of foreign compounds in biological systems.

[38]  E. Bresnick,et al.  Multiple, immunoidentical forms of phenobarbital-induced rat liver cytochromes P-450 are encoded by different mRNAs. , 1982, The Journal of biological chemistry.

[39]  T. Kamataki,et al.  Activation and inactivation of a variety of mutagenic compounds by the reconstituted system containing highly purified preparations of cytochrome P-450 from rat liver , 1985 .

[40]  D. Jerina.  Drug Metabolism Concepts , 1977 .

[41]  D. Nebert,et al.  Comparison of the flanking regions and introns of the mouse 2,3,7,8-tetrachlorodibenzo-p-dioxin-inducible cytochrome P1-450 and P3-450 genes. , 1985, The Journal of biological chemistry.

[42]  L. King,et al.  Role of epidermal growth factor in carcinogenesis. , 1986, Cancer research.

[43]  T. Kamataki,et al.  Microsomal activation of 2-amino-3-methylimidazo[4,5-f]quinoline, a pyrolysate of sardine and beef extracts, to a mutagenic intermediate. , 1983, Cancer research.

[44]  T. Cresteil,et al.  Immunological and enzymatic comparison of hepatic cytochrome P-450 fractions from phenobarbital-, 3-methylcholanthrene-, beta-naphthoflavone- and 2,3,7,8- tetrachlorodibenzo-p-dioxin-treated rats. , 1983, Biochemical pharmacology.

[45]  H. Yonekawa,et al.  Participation of the microsomal electron transport system in mutagenic activation of 4-dimethylaminoazobenzene, 4-methylaminoazobenzene and their 3'-methyl-derivatives. , 1982, Biochemical and biophysical research communications.

[46]  I. Weinstein,et al.  Glucocorticoids and benzo(a)pyrene have opposing effects on EGF receptor binding , 1981, Nature.

[47]  B. Hales,et al.  Effects of phenobarbital and beta-naphthoflavone on the activation of cyclophosphamide to mutagenic metabolites in vitro by liver and kidney from male and female rats. , 1980, Biochemical pharmacology.

[48]  D. Nebert,et al.  Isosafrole-induced cytochrome P2-450 in DBA/2N mouse liver. Characterization and genetic control of induction. , 1984, The Journal of biological chemistry.

[49]  P. Thomas,et al.  Use of monoclonal antibody probes against rat hepatic cytochromes P-450c and P-450d to detect immunochemically related isozymes in liver microsomes from different species. , 1984, Archives of biochemistry and biophysics.

[50]  K. Zukowski,et al.  Glucuronidation of carcinogenic arylamine metabolites by rat liver microsomes. , 1985, Biochemical pharmacology.

[51]  H. A. Masson,et al.  The role of highly purified cytochrome P-450 isozymes in the activation of 4-aminobiphenyl to mutagenic products in the Ames test. , 1983, Carcinogenesis.

[52]  C. Ioannides,et al.  The metabolic activation of 2-naphthylamine to mutagens in the Ames test. , 1986, Anticancer research.

[53]  J. Miller,et al.  Sulfuric acid esters as major ultimate electrophilic and hepatocarcinogenic metabolites of 4-aminoazobenzene and its N-methyl derivatives in infant male C57BL/6J x C3H/HeJ F1 (B6C3F1) mice. , 1986, Carcinogenesis.

[54]  P. Thomas,et al.  Preparation of monospecific antibodies against two forms of rat liver cytochrome P-450 and quantitation of these antigens in microsomes. , 1979, Archives of biochemistry and biophysics.

[55]  Eric F. Johnson,et al.  The role of cytochrome P-450 forms in 2-aminoanthracene and benz[α]pyrene mutagenesis , 1979 .

[56]  K. Holm,et al.  Regioselectivity of hydroxylation of prostaglandins by liver microsomes supported by NADPH versus H2O2 in methylcholanthrene-treated and control rats: formation of novel prostaglandin metabolites. , 1985, Archives of biochemistry and biophysics.

[57]  C. Ioannides,et al.  Studies on the substrate-binding sites of liver microsomal cytochrome P-448. , 1982, The Biochemical journal.

[58]  F. Guengerich,et al.  An immunohistochemical study on the localization and distributions of phenobarbital- and 3-methylcholanthrene-inducible cytochromes P-450 within the livers of untreated rats. , 1981, The Journal of biological chemistry.

[59]  F. Oesch,et al.  Characterization, localization and regulation of a novel phenobarbital-inducible form of cytochrome P450, compared with three further P450-isoenzymes, NADPH P450-reductase, glutathione transferases and microsomal epoxide hydrolase. , 1984, Carcinogenesis.

[60]  H. Gelboin.  Carcinogens, drugs, and cytochromes P-450. , 1983, The New England journal of medicine.

[61]  P. Iversen,et al.  Gene structure and nucleotide sequence for rat cytochrome P-450c. , 1985, Archives of biochemistry and biophysics.

[62]  A. Y. Lu,et al.  Role of Purified Cytochrome P-448 and Epoxide Hydrase in the Activation and Detoxification of Benzo[a]pyrene , 1977 .

[63]  F. Guengerich,et al.  Noncoordinate regulation of the mRNAs encoding cytochromes P-450BNF/MC-B and P-450ISF/BNF-G. , 1986, Archives of biochemistry and biophysics.

[64]  B. Paigen,et al.  Effect of 3-methylcholanthrene on atherosclerosis in two congenic strains of mice with different susceptibilities to methylcholanthrene-induced tumors. , 1986, Cancer research.

[65]  D. Jerina,et al.  Metabolic activation of dibenzo(a,h)anthracene and its dihydrodiols to bacterial mutagens. , 1978, Cancer research.

[66]  J. Goldstein,et al.  Induction of specific cytochrome P-450 isozymes by methylenedioxyphenyl compounds and antagonism by 3-methylcholanthrene. , 1985, Archives of biochemistry and biophysics.

[67]  C. Ioannides,et al.  Induction of rat hepatic mixed function oxidases by aromatic amines and its relationship to their bioactivation to mutagens. , 1986, Mutation research.

[68]  D. Parke,et al.  The stimulation of hydroxylation by carcinogenic and non-carcinogenic compounds. , 1966, Biochemical pharmacology.

[69]  A. Y. Lu,et al.  Comparison of cytochromes P-450 with high activity toward benzo[a]pyrene purified from liver microsomes of beta-naphthoflavone and 3-methylcholanthrene-pretreated rats. , 1982, Archives of biochemistry and biophysics.

[70]  J. Ghrayeb,et al.  Multiplicity strain differences, and topology of phenobarbital-induced cytochromes P-450 in rat liver microsomes. , 1982, Biochemistry.

[71]  P. Watkins,et al.  Identification of the cytochrome P-450 induced by macrolide antibiotics in rat liver as the glucocorticoid responsive cytochrome P-450p. , 1985, Biochemistry.

[72]  F G Walz,et al.  Polypeptide patterns of hepatic microsomes from Long-Evans rats treated with different xenobiotics. , 1982, Biochemistry.

[73]  C. Ioannides,et al.  Induction of cytochrome P-448 activity as exemplified by the O-deethylation of ethoxyresorufin. Effects of dose, sex, tissue and animal species. , 1986, Biochemical pharmacology.

[74]  M. J. Coon,et al.  Hydroxylation of prostaglandins by inducible isozymes of rabbit liver microsomal cytochrome P-450. Participation of cytochrome b5. , 1982, The Journal of biological chemistry.

[75]  T. Kamataki,et al.  N-hydroxylation of carcinogenic and mutagenic aromatic amines. , 1983, Environmental health perspectives.

[76]  B. Kemper,et al.  Isolation and sequence analysis of three cloned cDNAs for rabbit liver proteins that are related to rabbit cytochrome P-450 (form 2), the major phenobarbital-inducible form. , 1984, Biochemistry.

[77]  Watabe Tadashi,et al.  The carcinogen, 7-hydroxymethyl-12-methylbenz[a]anthracene, is activated and covalently binds to DNA via a sulphate ester. , 1985 .

[78]  P. Thomas,et al.  Regulation of three forms of cytochrome P-450 and epoxide hydrolase in rat liver microsomes. Effects of age, sex, and induction. , 1981, The Journal of biological chemistry.

[79]  C. Ioannides,et al.  The homogeneity of rat liver microsomal cytochrome P-448 activity and its role in the activation of benzo[a]pyrene to mutagens. , 1985, The International journal of biochemistry.

[80]  C. Ioannides,et al.  Determination of cytochrome P-448 activity in biological tissues. , 1984, The Biochemical journal.

[81]  N. Nomura,et al.  Similarity of protein encoded by the human c-erb-B-2 gene to epidermal growth factor receptor , 1986, Nature.

[82]  P. Seeburg,et al.  Tyrosine kinase receptor with extensive homology to EGF receptor shares chromosomal location with neu oncogene. , 1985, Science.

[83]  E. Zeiger,et al.  Specificity of rat liver cytochrome P-450 isozymes in the mutagenic activation of benzo[a]pyrene, aromatic amines and aflatoxin B1. , 1983, Carcinogenesis.

[84]  C. Ioannides,et al.  Metabolic activation of 2-amino-3-methylimidazo(4,5-f)quinoline by hepatic preparations--contribution of the cytosolic fraction and its significance to strain differences. , 1986, Mutagenesis.

[85]  A. Y. Lu,et al.  Metabolism of benzo(a)pyrene and benzo (a)pyrene derivatives to mutagenic products by highly purified hepatic microsomal enzymes. , 1976, The Journal of biological chemistry.

[86]  C. Walsh,et al.  Phenobarbital-induced rat liver cytochrome P-450. Purification and characterization of two closely related isozymic forms. , 1982, The Journal of biological chemistry.

[87]  C. Kasper,et al.  Genetic polymorphisms for a phenobarbital-inducible cytochrome P-450 map to the Coh locus in mice. , 1983, The Journal of biological chemistry.

[88]  F. Guengerich,et al.  Regulation of cytochrome P-450. Immunochemical quantitation of eight isozymes in liver microsomes of rats treated with polybrominated biphenyl congeners. , 1983, The Journal of biological chemistry.

[89]  M. J. Coon,et al.  ω-1 and ω-2 hydroxylation of prostaglandins by rabbit hepatic microsomal cytochrome P-450 isozyme 6 , 1985 .

[90]  D. Lewis,et al.  Molecular dimensions of the substrate binding site of cytochrome P-448. , 1986, Biochemical pharmacology.

[91]  A. Y. Lu,et al.  Electroimmunochemical quantitation of cytochrome P-450, cytochrome P-448, and epoxide hydrolase in rat liver microsomes. , 1981, The Journal of biological chemistry.

[92]  T. Shires,et al.  Purification and characterization of a previously unreported form of cytochrome P-448 from the liver of 3-methylcholanthrene-pretreated rats. , 1986, The Biochemical journal.

[93]  D. Jerina,et al.  Metabolic activation of 3-methylcholanthrene and its metabolites to products mutagenic to bacterial and mammalian cells. , 1978, Cancer research.

[94]  L. Jones,et al.  Rapid purification of calsequestrin from cardiac and skeletal muscle sarcoplasmic reticulum vesicles by Ca2+-dependent elution from phenyl-sepharose. , 1983, The Journal of biological chemistry.

[95]  T. Kamataki,et al.  Comparative study on the metabolism of N-methyl-4-aminoazobenzene by two forms of cytochrome P-488. , 1985, Biochemical pharmacology.

[96]  D. Nebert,et al.  The murine Ah locus. Comparison of the complete cytochrome P1-450 and P3-450 cDNA nucleotide and amino acid sequences. , 1984, The Journal of biological chemistry.

[97]  U. Muller-eberhard,et al.  Identification of the major cytochrome P-450 form transplacentally induced in neonatal rabbits by 3,3,7,8-tetrachlorodibenzo-p-dioxin. , 1978, Journal of Biological Chemistry.

[98]  C. Ioannides,et al.  Interactions of safrole and isosafrole and their metabolites with cytochromes P-450. , 1985, Chemico-biological interactions.

[99]  T. Masuko,et al.  3-Methoxy-4-aminoazobenzene, a selective inducer for a high spin form of cytochrome P-448 in rat liver microsomes. , 1985, Biochemical and biophysical research communications.

[100]  C. Walsh,et al.  Cytochrome P-450 isozyme 1 from phenobarbital-induced rat liver: purification, characterization, and interactions with metyrapone and cytochrome b5. , 1983, Biochemistry.

[101]  C. Ioannides,et al.  Cytochrome P-448 and the activation of toxic chemicals and carcinogens. , 1984, Xenobiotica; the fate of foreign compounds in biological systems.

[102]  B. Carr,et al.  Binding of epidermal growth factor and insulin and the autophosphorylation of their receptors in experimental primary hepatocellular carcinomas. , 1986, Cancer research.

[103]  P. Thomas,et al.  Induction of two immunochemically related rat liver cytochrome P-450 isozymes, cytochromes P-450c and P-450d, by structurally diverse xenobiotics. , 1983, The Journal of biological chemistry.

[104]  G. Siest,et al.  Stereochemical heterogeneity of hepatic UDP-glucuronosyltransferase activity in rat liver microsomes. , 1981, Biochemical pharmacology.