Phytochemistry and Pharmacology of Zanthoxylum gilletii: A Review

Aim: Zanthoxylum gilletii is used in traditional medicine against several pains, namely urinary tract infections, malaria, lombargy, high blood pressure etc. Thus, the aim of this study was to review the literature on the traditionnal use, the phytochemical composition and the biological activities of the above-mentioned plant. Methodology: A literature review was conducted  based on the scientific results sourced from Science Direct, PubMed, Google Scholar, SciLEO and PubMed Central. The plant scientific name was used as a search keyword together with the following  words phytochemistry, pharmacology, bioactivity and pharmacognosia. Results: Z. gilletii extracts have shown antimicrobial, antifungal, antiparasitic and anticancer activities. Several compounds have been reported from different parts of the plant including alkaloids, amides, coumarins and essential oils and have shown interesting biological properties such as the antioxidant and  antimicrobial activities. However, there are, to date, several compounds whose biological activities are not known, especially that belonging to the  essential oil class. At the same time, there are also the activities observed but for which the responsible compounds are unknown. Conclusion: All parts of Z.gilletii are used in traditional medicine and  decoction is the most recommended method of preparation. Data from phytochemical studies are quite poor, especially on essential oils. 

[1]  B. Oumarou,et al.  Aqueous Extract of Fagara tessmannii Engl. (Rutaceae) Exhibits Antihypertensive Activity in NO Synthase Inhibitor-Induced Hypertensive Rats , 2020 .

[2]  Xiao-hui Chen,et al.  A Review on Classification and Biological Activities of Alkaloids from the Genus Zanthoxylum Species. , 2020, Mini reviews in medicinal chemistry.

[3]  Yasser Fakri Mustafa,et al.  Phytochemical, Antioxidant and Antitumor Studies of Coumarins Extracted from Granny Smith Apple Seeds by Different Methods , 2020 .

[4]  Bertin Mikolo Repellent Activity of Bark Extracts of Zanthoxylum heitzii Against the Malaria Vector Anopheles gambiae , 2019, Comparative study of M. oleifera and M. ovalifolia survival rates in Central Namibia.

[5]  G. McFadden,et al.  Anti-plasmodial Effects of Zanthoxylum zanthoxyloides , 2019, Planta Medica.

[6]  A. Shah,et al.  Butyrlycholine esterase inhibitory activity and effects of extracts (fruit, bark and leaf) from Zanthoxylum armatum DC in gut, airways and vascular smooth muscles , 2019, BMC Complementary and Alternative Medicine.

[7]  N. Sewald,et al.  A New Aromatic Amide from the Roots of Zanthoxylum tessmannii (Rutaceae) , 2019, Chemistry & biodiversity.

[8]  S. Limsuwan,et al.  New alkylamide from the stems of Zanthoxylum nitidum , 2019, Natural product research.

[9]  I. Okagu,et al.  Methanol extracts of Fagara zanthoxyloides leaves possess antimalarial effects and normalizes haematological and biochemical status of Plasmodium berghei-passaged mice , 2019, Pharmaceutical biology.

[10]  A. Das,et al.  Bioactivity studies on Zanthoxylum budrunga wall (Rutaceae) root bark , 2018, Clinical Phytoscience.

[11]  E. Velozo,et al.  In vitro antibacterial effects of Zanthoxylum tingoassuiba root bark extracts and two of its alkaloids against multiresistant Staphylococcus aureus , 2017 .

[12]  S. A. Saah,et al.  Phytochemical screening, antimicrobial and antioxidant properties of assorted Carica papaya leaves in Ghana , 2016 .

[13]  D. Koné,et al.  Étude ethnobotanique et évaluation in vitro de l’activité antifongique des extraits de l’écorce de Zanthoxylum gilletii (de Wild Waterman) sur deux souches phytopathogenes de Sclerotium rolfsii , 2016 .

[14]  Liang Zou,et al.  [Research progress on alkaloids constituents from Zanthoxylum and their pharmacological activities]. , 2015, Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica.

[15]  Z. Qin,et al.  [Comparative Study on Effects of Anti-contusion Injury, Analgesia and Anti-inflammation of Root and Stem of Zanthoxylum nitidum]. , 2015, Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials.

[16]  V. Kuete,et al.  Antibacterial activities of Fagara macrophylla, Canarium schweinfurthii, Myrianthus arboreus, Dischistocalyx grandifolius and Tragia benthamii against multi-drug resistant Gram-negative bacteria , 2015, SpringerPlus.

[17]  Y. Kuo,et al.  New Coumarin Derivatives and Other Constituents from the Stem Bark of Zanthoxylum avicennae: Effects on Neutrophil Pro-Inflammatory Responses , 2015, International journal of molecular sciences.

[18]  Jong Jin Bae,et al.  Antiviral effect of flavonol glycosides isolated from the leaf of Zanthoxylum piperitum on influenza virus , 2014, Journal of Microbiology.

[19]  J. Tabuti,et al.  Knowledge on plants used traditionally in the treatment of tuberculosis in Uganda. , 2014, Journal of ethnopharmacology.

[20]  M. WafulaRobert Phytochemical investigation of zanthoxylum gilletii (rutaceae) for antiplasmodial biomolecules , 2014 .

[21]  Gaya,et al.  Variation of alkaloids in the Kenyan Zanthoxylum gilletii (De Wild Waterman) , 2013 .

[22]  Ey,et al.  An overview on phytomedicinal approaches of Zanthoxylum armatum DC.: An important magical medicinal plant , 2013 .

[23]  A. Boye,et al.  Gastroprotective Effect and Safety Assessment of Zanthoxylum Zanthoxyloides (Lam) Waterm Root Bark Extract , 2012 .

[24]  A. Fongod,et al.  Ethnobotany survey and uses of plants in the Lewoh- Lebang communities in the Lebialem highlands, South West Region, Cameroon , 2012 .

[25]  S. Cuca,et al.  Zanthoxylum Genus as Potential Source of Bioactive Compounds , 2012 .

[26]  E. Ugwuja,et al.  EFFECTS OF ZANTHOXYLUM ZANTHOXYLOIDES LEAVES ON BLOOD GLUCOSE, LIPID PROFILE AND SOME LIVER ENZYMES IN ALLOXAN INDUCED DIABETIC RATS , 2012 .

[27]  M. Teerarak,et al.  An allelopathic substance isolated from Zanthoxylum limonella Alston fruit , 2010 .

[28]  G. Zirihi,et al.  Evaluation in vitro of antiplasmodial activity of ethanolic extracts of Funtumia elastica, Rauvolfia vomitoria and Zanthoxylum gilletii on Plasmodium falciparum isolates from Côte-d'Ivoire. , 2009 .

[29]  W. Lewis The Useful Plants of West Tropical Africa , 1986, Economic Botany.

[30]  Zirihi Guédé Noêl,et al.  Phytochemical and pharmacological studies of alcoholic extract of Faga唱 ra macrophylla ( Oliv) Engl ( Rutaceae):chemical structure of active compound inducing antipaludic activity , 2007 .

[31]  K. Hostettmann,et al.  New and bioactive aromatic compounds from Zanthoxylum zanthoxyloides. , 2006, Planta medica.

[32]  S. Adesina THE NIGERIAN ZANTHOXYLUM ; CHEMICAL AND BIOLOGICAL VALUES , 2005 .

[33]  B. Bodo,et al.  In vitro antiplasmodial activity and cytotoxicity of 33 West African plants used for treatment of malaria. , 2005, Journal of ethnopharmacology.

[34]  Hideyuki Ito,et al.  Aliphatic acid amides of the fruits of Zanthoxylum piperitum. , 2004, Phytochemistry.

[35]  M. Curini,et al.  Antifungal activity of some Cuban Zanthoxylum species. , 2003, Fitoterapia.

[36]  K. Hostettmann,et al.  Antifungal and antioxidant compounds from the root bark of Fagara zanthoxyloides. , 2003, Planta medica.

[37]  G. Buchbauer,et al.  Analysis of leaf volatiles of Zanthoxylum gillettii used in folk medicine of Cameroon. , 1999, Planta medica.

[38]  D. Bergenthal,et al.  Extractives from Zanthoxylum lemairie root and stem , 1997 .

[39]  C. Teng,et al.  Coumarins and anti-platelet aggregation constituents from Zanthoxylum schinifolium. , 1995, Phytochemistry.

[40]  M. Hattori,et al.  Effects of extracts of Zanthoxylum fruit and their constituents on spontaneous beating rate of myocardial cell sheets in culture , 1993 .

[41]  J. Wijnberg,et al.  Antimalarial compounds containing an alpha,beta-unsaturated carbonyl moiety from Tanzanian medicinal plants. , 1990, Planta medica.

[42]  M. Wani,et al.  Plant antitumor agents, 27. Isolation, structure, and structure activity relationships of alkaloids from Fagara macrophylla. , 1987, Journal of natural products.

[43]  G. Muriuki,et al.  Structure and anti-hypertensive properties of nitidine chloride from fagara species. , 1986, Planta medica.

[44]  S. Nishibe,et al.  The Ca2+ antagonist activity of lignans. , 1986, Chemical & pharmaceutical bulletin.

[45]  P. Waterman A phytochemist in the african rain forest , 1985 .

[46]  M. Leboeuf,et al.  Chemistry and Chemical Taxonomy of the Rutales , 1985 .

[47]  J. Reisch,et al.  Constituents of zanthoxylum leprieurii fruit pericarps. CIII: Natural product chemistry , 1985 .

[48]  H. Greger Alkamides: structural relationships, distribution and biological activity. , 1984, Planta medica.

[49]  I. Kubo,et al.  Insecticidal and Molluscicidal Activities of Isobutylamides Isolated fromFagara macrophyllaand Their Synthetic Analogs , 1984 .

[50]  M. Shamma,et al.  The benzophenanthridine alkaloids , 1984 .

[51]  J. Ojewole,et al.  Mechanism of the Hypotensive Effect of Scopoletin Isolated from the Fruit of Tetrapleura tetraptera , 1983, Planta medica.

[52]  A. T. Bryant Zulu Medicine and Medicine-Men , 1983 .

[53]  M. Oriowo Anti-Inflammatory Activity of Piperonyl-4-Acrylic Isobutyl Amide, an Extractive from Zanthoxylum zanthoxyloides , 1982, Planta medica.

[54]  B. Oliver-bever Medicinal plants in tropical West Africa. I. Plants acting on the cardiovascular system. , 1982, Journal of ethnopharmacology.

[55]  H. Itokawa,et al.  Two New Pungent Principles isolated from the Pericarps of Zanthoxylum ailanthoides , 1981 .

[56]  T. Mabry,et al.  Chemistry and utilization of phenylpropanoids including flavonoids, coumarins, and lignans. , 1980, Journal of agricultural and food chemistry.