30‐Second bound and pore water concentration mapping of cortical bone using 2D UTE with optimized half‐pulses

MRI of cortical bone has the potential to offer new information about fracture risk. Current methods are typically performed with 3D acquisitions, which suffer from long scan times and are generally limited to extremities. This work proposes using 2D UTE with half pulses for quantitatively mapping bound and pore water in cortical bone.

[1]  D. Altman,et al.  STATISTICAL METHODS FOR ASSESSING AGREEMENT BETWEEN TWO METHODS OF CLINICAL MEASUREMENT , 1986, The Lancet.

[2]  A. Macovski,et al.  Variable-rate selective excitation , 1988 .

[3]  H. Gudbjartsson,et al.  The rician distribution of noisy mri data , 1995, Magnetic resonance in medicine.

[4]  J A Frank,et al.  Simple correction method for k-space trajectory deviations in MRI. , 1998, Journal of magnetic resonance.

[5]  Mark Bydder,et al.  Ultrashort echo time spectroscopic imaging (UTESI) of cortical bone , 2007, Magnetic resonance in medicine.

[6]  Mary B Leonard,et al.  Cortical bone water: in vivo quantification with ultrashort echo-time MR imaging. , 2008, Radiology.

[7]  Felix W Wehrli,et al.  In vivo MRI of submillisecond T2 species with two‐dimensional and three‐dimensional radial sequences and applications to the measurement of cortical bone water , 2008, NMR in biomedicine.

[8]  J. Pauly,et al.  Improved half RF slice selectivity in the presence of eddy currents with out‐of‐slice saturation , 2009, Magnetic resonance in medicine.

[9]  J. Pauly,et al.  Double half RF pulses for reduced sensitivity to eddy currents in UTE imaging , 2009, Magnetic resonance in medicine.

[10]  Jeffry S Nyman,et al.  Characterization of 1H NMR signal in human cortical bone for magnetic resonance imaging , 2010, Magnetic resonance in medicine.

[11]  Consequences of T2 relaxation during half‐pulse slice selection for ultrashort TE imaging , 2010, Magnetic resonance in medicine.

[12]  D. Gochberg,et al.  Non-invasive Predictors of Human Cortical Bone Mechanical Properties: T2-Discriminated 1H NMR Compared with High Resolution X-ray , 2011, PloS one.

[13]  Koichi Masuda,et al.  Quantitative ultrashort echo time (UTE) MRI of human cortical bone: Correlation with porosity and biomechanical properties , 2012, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[14]  G. Bydder,et al.  Ultrashort echo time spectroscopic imaging (UTESI): an efficient method for quantifying bound and free water , 2012, NMR in biomedicine.

[15]  Jeffry S Nyman,et al.  Clinically compatible MRI strategies for discriminating bound and pore water in cortical bone , 2012, Magnetic resonance in medicine.

[16]  Markus Weiger,et al.  ZTE imaging in humans , 2013, Magnetic resonance in medicine.

[17]  T. Abe Half radiofrequency pulse excitation with a dedicated prescan to correct eddy current effect and gradient delay. , 2013, Medical physics.

[18]  Martin Benning,et al.  Ultrashort echo time (UTE) imaging using gradient pre-equalization and compressed sensing. , 2014, Journal of magnetic resonance.

[19]  Mary Kate Manhard,et al.  Validation of quantitative bound‐ and pore‐water imaging in cortical bone , 2014, Magnetic resonance in medicine.

[20]  William A. Grissom,et al.  Iterative Method for Predistortion of MRI Gradient Waveforms , 2014, IEEE Transactions on Medical Imaging.

[21]  Simple and robust saturation‐based slice selection for ultrashort echo time MRI , 2015, Magnetic resonance in medicine.

[22]  Mary Kate Manhard,et al.  In Vivo Quantitative MR Imaging of Bound and Pore Water in Cortical Bone. , 2015, Radiology.

[23]  Volumetric Cortical Bone Porosity Assessment with MR Imaging: Validation and Clinical Feasibility. , 2015, Radiology.

[24]  Mary Kate Manhard,et al.  MRI-derived bound and pore water concentrations as predictors of fracture resistance. , 2016, Bone.

[25]  David Atkinson,et al.  Using the robust principal component analysis algorithm to remove RF spike artifacts from MR images , 2016, Magnetic resonance in medicine.

[26]  Yajun Ma,et al.  Fast volumetric imaging of bound and pore water in cortical bone using three‐dimensional ultrashort‐TE (UTE) and inversion recovery UTE sequences , 2016, NMR in biomedicine.