Shape Memory Polymer Stent With Expandable Foam: A New Concept for Endovascular Embolization of Fusiform Aneurysms

We demonstrate a new concept for endovascular embolization of nonnecked fusiform aneurysms. A device prototype consisting of a stent augmented with expandable foam, both made from shape memory polymer, was fabricated and deployed in an in vitro model. Visual observation indicated that the foam achieved embolization of the aneurysm while the stent maintained an open lumen in the parent artery. The shape memory polymer stent-foam device is a potential tool for treatment of nonnecked fusiform aneurysms, as well as an alternative to stent- and balloon-assisted coil embolization of wide-necked aneurysms

[1]  Melodie F Metzger,et al.  Photothermal properties of shape memory polymer micro‐actuators for treating stroke * , 2002, Lasers in surgery and medicine.

[2]  Duncan Maitland,et al.  Laser-activated shape memory polymer intravascular thrombectomy device. , 2005, Optics express.

[3]  加藤 武志 Contrast-enhanced 2D cine phase MR angiography for measurement of basilar artery blood flow in posterior circulation ischemia , 2003 .

[4]  Stephan Felber,et al.  Endovascular Coil Occlusion of 1811 Intracranial Aneurysms: Early Angiographic and Clinical Results , 2004, Neurosurgery.

[5]  Silvia Farè,et al.  In vitro interaction of human fibroblasts and platelets with a shape-memory polyurethane. , 2005, Journal of biomedical materials research. Part A.

[6]  D. Maitland,et al.  Laser-activated shape memory polymer microactuator for thrombus removal following ischemic stroke: preliminary in vitro analysis , 2005, IEEE Journal of Selected Topics in Quantum Electronics.

[7]  S. Simon,et al.  Polyurethane shape-memory polymers demonstrate functional biocompatibility in vitro. , 2007, Macromolecular bioscience.

[8]  Ching-ping Wong,et al.  Mechanical and radiographic properties of a shape memory polymer composite for intracranial aneurysm coils , 2006 .

[9]  Wei Min Huang,et al.  On the effects of moisture in a polyurethane shape memory polymer , 2004 .

[10]  Duncan J. Maitland,et al.  Shape memory polymer therapeutic devices for stroke , 2005, SPIE Optics East.

[11]  Alastair J. Martin,et al.  Computational approach to quantifying hemodynamic forces in giant cerebral aneurysms. , 2003, AJNR. American journal of neuroradiology.

[12]  M Negoro,et al.  Interventional neuroradiology. , 2004, Stroke.

[13]  Howard A Riina,et al.  Endovascular procedures for treating wide-necked aneurysms. , 2005, Neurosurgical focus.

[14]  M. Lawton,et al.  Correlation between lumenal geometry changes and hemodynamics in fusiform intracranial aneurysms. , 2005, AJNR. American journal of neuroradiology.

[15]  D. Nichols,et al.  Unruptured intracranial aneurysms: natural history, clinical outcome, and risks of surgical and endovascular treatment , 2003, The Lancet.