From selenium to selenoproteins: synthesis, identity, and their role in human health.
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Kum Kum Khanna | K. Khanna | A. Holmgren | Jun Lu | Arne Holmgren | L. Papp | Jun Lu | Laura Vanda Papp
[1] A. Böck,et al. Nucleotide sequence and expression of the selenocysteine-containing polypeptide of formate dehydrogenase (formate-hydrogen-lyase-linked) from Escherichia coli. , 1986, Proceedings of the National Academy of Sciences of the United States of America.
[2] J. Gnarra,et al. Loss of heterozygosity of the human cytosolic glutathione peroxidase I gene in lung cancer. , 1994, Carcinogenesis.
[3] F. Muntoni,et al. Mutations in SEPN1 cause congenital muscular dystrophy with spinal rigidity and restrictive respiratory syndrome , 2001, Nature Genetics.
[4] J. Seong,et al. Proteomic analysis of diet‐induced hypercholesterolemic mice , 2004, Proteomics.
[5] V. Gladyshev,et al. Association between the 15-kDa Selenoprotein and UDP-glucose:Glycoprotein Glucosyltransferase in the Endoplasmic Reticulum of Mammalian Cells* , 2001, The Journal of Biological Chemistry.
[6] J. Harney,et al. Distinct subcellular localization of transiently expressed types 1 and 2 iodothyronine deiodinases as determined by immunofluorescence confocal microscopy. , 2000, Endocrinology.
[7] P. Carbon,et al. The SBP2 and 15.5 kD/Snu13p proteins share the same RNA binding domain: identification of SBP2 amino acids important to SECIS RNA binding. , 2002, RNA.
[8] C. Thomson,et al. Long-term supplementation with selenate and selenomethionine: Selenium and glutathione peroxidase (EC 1.11.1.9) in blood components of New Zealand women , 1993, British Journal of Nutrition.
[9] B. Carlson,et al. A novel RNA binding protein, SBP2, is required for the translation of mammalian selenoprotein mRNAs , 2000, The EMBO journal.
[10] D. Mustacich,et al. The role of the redox protein thioredoxin in cell growth and cancer. , 2000, Free radical biology & medicine.
[11] E. Guallar,et al. Selenium intake and cardiovascular risk: what is new? , 2008, Current opinion in lipidology.
[12] A. Holmgren,et al. Analysis of the inhibition of mammalian thioredoxin, thioredoxin reductase, and glutaredoxin by cis-diamminedichloroplatinum (II) and its major metabolite, the glutathione-platinum complex. , 2001, Free radical biology & medicine.
[13] S. Rhee,et al. Peroxiredoxins: a historical overview and speculative preview of novel mechanisms and emerging concepts in cell signaling. , 2005, Free radical biology & medicine.
[14] D. Albanes,et al. Glutathione peroxidase codon 198 polymorphism variant increases lung cancer risk. , 2000, Cancer research.
[15] F. Ursini,et al. Male Fertility Is Linked to the Selenoprotein Phospholipid Hydroperoxide Glutathione Peroxidase1 , 2002, Biology of reproduction.
[16] B. Turnbull,et al. Baseline characteristics and the effect of selenium supplementation on cancer incidence in a randomized clinical trial: a summary report of the Nutritional Prevention of Cancer Trial. , 2002, Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology.
[17] M. Saito,et al. Early embryonic lethality caused by targeted disruption of the mouse PHGPx gene. , 2003, Biochemical and biophysical research communications.
[18] K. Tsunekawa,et al. Association of antipituitary antibody and type 2 iodothyronine deiodinase antibody in patients with autoimmune thyroid disease. , 2005, Endocrine journal.
[19] R. Brigelius-Flohé,et al. Gastrointestinal glutathione peroxidase , 1999, BioFactors.
[20] P. Grabowski,et al. Evidence for Direct Roles of Two Additional Factors, SECp43 and Soluble Liver Antigen, in the Selenoprotein Synthesis Machinery* , 2005, Journal of Biological Chemistry.
[21] J. Hunter,et al. Inhibition of ultraviolet B radiation‐induced interleukin 10 expression in murine keratinocytes by selenium compounds , 2002, The British journal of dermatology.
[22] D. Alberts,et al. Increased expression of thioredoxin-1 in human colorectal cancer is associated with decreased patient survival. , 2003, The Journal of laboratory and clinical medicine.
[23] H. Kuhn,et al. Synthesis of a new seleninic acid anhydride and mechanistic studies into its glutathione peroxidase activity. , 2008, Chemistry.
[24] B. Carlson,et al. Erratum: A novel RNA binding protein, SBP2, is required for the translation of mammalian selenoprotein mRNAs (The EMBO Journal (2000) 19 (306-314)) , 2000 .
[25] A. Holmgren,et al. Ebselen is a dehydroascorbate reductase mimic, facilitating the recycling of ascorbate via mammalian thioredoxin systems. , 2004, Antioxidants & redox signaling.
[26] J. S. Morris,et al. Printed in U.S.A. Copyright © 2000 by The Endocrine Society Effects of Selenium Deficiency on Tissue Selenium Content, Deiodinase Activity, and Thyroid Hormone Economy in the Rat during Development* , 2022 .
[27] A. Sytkowski,et al. Differential expression and androgen regulation of the human selenium-binding protein gene hSP56 in prostate cancer cells. , 1998, Cancer research.
[28] L. Schomburg,et al. Selenium and selenoproteins in mammals: extraordinary, essential, enigmatic , 2004, Cellular and Molecular Life Sciences CMLS.
[29] T. Lundh,et al. Short-term effects of selenium supplementation of cows' feed on the content and distribution of selenium, copper and zinc in bovine milk, whey and blood plasma. , 2008, The Journal of dairy research.
[30] T. Anthony,et al. Coping with stress: eIF2 kinases and translational control. , 2006, Biochemical Society transactions.
[31] P. Kovacic,et al. Mechanisms of carcinogenesis: focus on oxidative stress and electron transfer. , 2001, Current medicinal chemistry.
[32] Whanger Pd. Selenoprotein W: a review. , 2000 .
[33] A. Holmgren,et al. Two resident ER‐proteins, CaBP1 and CaBP2, with thioredoxin domains, are substrates for thioredoxin reductase: comparison with protein disulfide isomerase , 1995, FEBS letters.
[34] J. Harney,et al. The Iodothyronine Selenodeiodinases Are Thioredoxin-fold Family Proteins Containing a Glycoside Hydrolase Clan GH-A-like Structure* , 2003, Journal of Biological Chemistry.
[35] M. Rayman. Food-chain selenium and human health: emphasis on intake , 2008, British Journal of Nutrition.
[36] Charles E. Chapple,et al. Diversity and functional plasticity of eukaryotic selenoproteins: identification and characterization of the SelJ family. , 2005, Proceedings of the National Academy of Sciences of the United States of America.
[37] Y. Yamaoka,et al. Inverse correlation of thioredoxin expression with estrogen receptor- and p53-dependent tumor growth in breast cancer tissues. , 2001, Clinical cancer research : an official journal of the American Association for Cancer Research.
[38] L. Schomburg,et al. On the importance of selenium and iodine metabolism for thyroid hormone biosynthesis and human health. , 2008, Molecular nutrition & food research.
[39] V. Gladyshev,et al. Methionine sulfoxide reduction in mammals: characterization of methionine-R-sulfoxide reductases. , 2003, Molecular biology of the cell.
[40] S. Rhee,et al. Molecular Cloning and Characterization of a Mitochondrial Selenocysteine-containing Thioredoxin Reductase from Rat Liver* , 1999, The Journal of Biological Chemistry.
[41] J. Harney,et al. Supramolecular Complexes Mediate Selenocysteine Incorporation In Vivo , 2006, Molecular and Cellular Biology.
[42] D. Hatfield,et al. Identification of a selenocysteyl-tRNA(Ser) in mammalian cells that recognizes the nonsense codon, UGA. , 1989, The Journal of biological chemistry.
[43] A. Tappel,et al. Identification of the catalytic site of rat liver glutathione peroxidase as selenocysteine. , 1978, Biochemistry.
[44] G. Powis,et al. The Absence of Mitochondrial Thioredoxin 2 Causes Massive Apoptosis, Exencephaly, and Early Embryonic Lethality in Homozygous Mice , 2003, Molecular and Cellular Biology.
[45] David E. Misek,et al. Reduced selenium‐binding protein 1 expression is associated with poor outcome in lung adenocarcinomas , 2004, The Journal of pathology.
[46] V. Gladyshev,et al. The microbial selenoproteome of the Sargasso Sea , 2005, Genome Biology.
[47] A. Krol,et al. Evolutionarily different RNA motifs and RNA-protein complexes to achieve selenoprotein synthesis. , 2002, Biochimie.
[48] D. Hilvert,et al. Selenoglutaredoxin as a Glutathione Peroxidase Mimic , 2008, Chembiochem : a European journal of chemical biology.
[49] M. Matsui,et al. Early embryonic lethality caused by targeted disruption of the mouse thioredoxin gene. , 1996, Developmental biology.
[50] X. Lei,et al. Impacts of glutathione peroxidase-1 knockout on the protection by injected selenium against the pro-oxidant-induced liver aponecrosis and signaling in selenium-deficient mice. , 2003, Free radical biology & medicine.
[51] R. Brigelius-Flohé,et al. Part of the Series: From dietary antioxidants to regulators in cellular signaling and gene regulation , 2006, Free radical research.
[52] D. Birle,et al. Up-regulation of the redox mediators thioredoxin and apurinic/apyrimidinic excision (APE)/Ref-1 in hypoxic microregions of invasive cervical carcinomas, mapped using multispectral, wide-field fluorescence image analysis. , 2004, The American journal of pathology.
[53] P Griffiths,et al. Mice with a Homozygous Null Mutation for the Most Abundant Glutathione Peroxidase, Gpx1, Show Increased Susceptibility to the Oxidative Stress-inducing Agents Paraquat and Hydrogen Peroxide* , 1998, The Journal of Biological Chemistry.
[54] A. Monks,et al. Elucidation of thioredoxin as a molecular target for antitumor quinols. , 2005, Cancer research.
[55] A. Holmgren,et al. Rat liver thioredoxin and thioredoxin reductase: purification and characterization. , 1982, Biochemistry.
[56] D. Hwang,et al. Differentially Expressed Genes in Transgenic Mice Carrying Human Mutant Presenilin-2 (N141I): Correlation of Selenoprotein M with Alzheimer’s Disease , 2005, Neurochemical Research.
[57] L. Schomburg,et al. New insights into the physiological actions of selenoproteins from genetically modified mice , 2005, IUBMB life.
[58] A. Holmgren,et al. Enzymatic reduction of alloxan by thioredoxin and NADPH-thioredoxin reductase. , 1980, Proceedings of the National Academy of Sciences of the United States of America.
[59] A. Holmgren,et al. Up‐regulation of thioredoxin and thioredoxin reductase in human malignant pleural mesothelioma , 2001, International journal of cancer.
[60] S. Bae,et al. Differential expression of the liver proteome in senescence accelerated mice , 2003, Proteomics.
[61] M. O. Fenley,et al. Molecular basis of box C/D RNA-protein interactions; cocrystal structure of archaeal L7Ae and a box C/D RNA. , 2004, Structure.
[62] J. Yodoi,et al. Thioredoxin reductase regulates AP-1 activity as well as thioredoxin nuclear localization via active cysteines in response to ionizing radiation , 2002, Oncogene.
[63] F. Ursini,et al. Distinct Promoters Determine Alternative Transcription of gpx-4 into Phospholipid-Hydroperoxide Glutathione Peroxidase Variants* , 2003, Journal of Biological Chemistry.
[64] V. Gladyshev,et al. Functional characterization of alternatively spliced human SECISBP2 transcript variants , 2008, Nucleic acids research.
[65] R. Versteeg,et al. Regulation of type III iodothyronine deiodinase expression in human cell lines. , 2006, Endocrinology.
[66] B. Carlson,et al. Transfer RNAs that insert selenocysteine. , 2002, Methods in enzymology.
[67] J. Harney,et al. Decoding apparatus for eukaryotic selenocysteine insertion , 2000, EMBO reports.
[68] S. Florian,et al. Cellular and subcellular localization of gastrointestinal glutathione peroxidase in normal and malignant human intestinal tissue , 2001, Free radical research.
[69] M. Berry,et al. Functional characterization of the eukaryotic SECIS elements which direct selenocysteine insertion at UGA codons. , 1993, The EMBO journal.
[70] Vincent Stepanik,et al. Insight into Mammalian Selenocysteine Insertion: Domain Structure and Ribosome Binding Properties of Sec Insertion Sequence Binding Protein 2 , 2001, Molecular and Cellular Biology.
[71] V. Georgoulias,et al. Thioredoxin expression is associated with lymph node status and prognosis in early operable non-small cell lung cancer. , 2001, Clinical cancer research : an official journal of the American Association for Cancer Research.
[72] V. Winfrey,et al. Sequential development of flagellar defects in spermatids and epididymal spermatozoa of selenium-deficient rats. , 2004, Reproduction.
[73] N. Copeland,et al. Identification of a novel selD homolog from eukaryotes, bacteria, and archaea: is there an autoregulatory mechanism in selenocysteine metabolism? , 1996, Proceedings of the National Academy of Sciences of the United States of America.
[74] M. Scheurlen,et al. Glutathione peroxidase isoforms as part of the local antioxidative defense system in normal and Barrett's esophagus , 2003, International journal of cancer.
[75] T. Stadtman,et al. A new selenoprotein from human lung adenocarcinoma cells: purification, properties, and thioredoxin reductase activity. , 1996, Proceedings of the National Academy of Sciences of the United States of America.
[76] L. Schomburg,et al. Selenium-dependent pre- and posttranscriptional mechanisms are responsible for sexual dimorphic expression of selenoproteins in murine tissues. , 2006, Endocrinology.
[77] J. Köhrle,et al. Differential selenium-dependent expression of type I 5'-deiodinase and glutathione peroxidase in the porcine epithelial kidney cell line LLC-PK1. , 1995, The Biochemical journal.
[78] T M Grogan,et al. Thioredoxin, a putative oncogene product, is overexpressed in gastric carcinoma and associated with increased proliferation and increased cell survival. , 2000, Human pathology.
[79] Hoshing Chang,et al. Involvements of mitochondrial thioredoxin reductase (TrxR2) in cell proliferation. , 2003, Biochemical and biophysical research communications.
[80] A. Holmgren,et al. Thioredoxin is associated with proliferation, p53 expression and negative estrogen and progesterone receptor status in breast carcinoma , 2004, APMIS : acta pathologica, microbiologica, et immunologica Scandinavica.
[81] D. Graham,et al. The neuroprotective efficacy of ebselen (a glutathione peroxidase mimic) on brain damage induced by transient focal cerebral ischaemia in the rat , 1995, Neuroscience Letters.
[82] A. Damdimopoulos,et al. Human mitochondrial thioredoxin reductase reduces cytochrome c and confers resistance to complex III inhibition. , 2004, Free radical biology & medicine.
[83] Ursula Jakob,et al. Not every disulfide lasts forever: disulfide bond formation as a redox switch. , 2003, Antioxidants & redox signaling.
[84] Vadim N. Gladyshev,et al. Mammalian Selenoprotein in Which Selenocysteine (Sec) Incorporation Is Supported by a New Form of Sec Insertion Sequence Element , 2002, Molecular and Cellular Biology.
[85] J. Köhrle,et al. Selenium, the thyroid, and the endocrine system. , 2005, Endocrine reviews.
[86] A. Holmgren,et al. Thioredoxin Reductase Is Irreversibly Modified by Curcumin , 2005, Journal of Biological Chemistry.
[87] F. Muntoni,et al. Mutations of the selenoprotein N gene, which is implicated in rigid spine muscular dystrophy, cause the classical phenotype of multiminicore disease: reassessing the nosology of early-onset myopathies. , 2002, American journal of human genetics.
[88] M. Pastor,et al. SEPS1 Gene is Activated during Astrocyte Ischemia and Shows Prominent Antiapoptotic Effects , 2008, Journal of Molecular Neuroscience.
[89] G. Powis,et al. Mechanism-based inhibition of thioredoxin reductase by antitumor quinoid compounds. , 1992, Biochemical pharmacology.
[90] A. Nauman,et al. Disturbed expression of type 1 and type 2 iodothyronine deiodinase as well as titf1/nkx2-1 and pax-8 transcription factor genes in papillary thyroid cancer. , 2005, Thyroid : official journal of the American Thyroid Association.
[91] R. Brigelius-Flohé,et al. Estimation of individual types of glutathione peroxidases. , 2002, Methods in enzymology.
[92] Michael M Lieber,et al. Designing the Selenium and Vitamin E Cancer Prevention Trial (SELECT). , 2005, Journal of the National Cancer Institute.
[93] G. Powis,et al. Inhibition of cellular thioredoxin reductase by diaziquone and doxorubicin. Relationship to the inhibition of cell proliferation and decreased ribonucleotide reductase activity. , 1992, Biochemical pharmacology.
[94] H. Imai,et al. Biological significance of phospholipid hydroperoxide glutathione peroxidase (PHGPx, GPx4) in mammalian cells. , 2003, Free radical biology & medicine.
[95] J. Dumont,et al. Effects of selenium deficiency on thyroid necrosis, fibrosis and proliferation: a possible role in myxoedematous cretinism. , 1995, European journal of endocrinology.
[96] N. Petit,et al. A single homozygous point mutation in a 3′untranslated region motif of selenoprotein N mRNA causes SEPN1‐related myopathy , 2006, EMBO reports.
[97] N. Sonenberg,et al. Translational control in stress and apoptosis , 2005, Nature Reviews Molecular Cell Biology.
[98] R. Eeles,et al. Association between the GCG polymorphism of the selenium dependent GPX1 gene and the risk of young onset prostate cancer , 2002, Prostate Cancer and Prostatic Diseases.
[99] A. Holmgren,et al. Thioredoxin and glutaredoxin systems. , 2019, The Journal of biological chemistry.
[100] Â.,et al. Tissue distribution and influence of selenium status on levels of selenoprotein , 2004 .
[101] A. Böck,et al. Selenoprotein synthesis in archaea: identification of an mRNA element of Methanococcus jannaschii probably directing selenocysteine insertion. , 1997, Journal of molecular biology.
[102] Amanda K. Pearce,et al. Stress-Activated Protein Kinase Pathway Functions To Support Protein Synthesis and Translational Adaptation in Response to Environmental Stress in Fission Yeast , 2005, Eukaryotic Cell.
[103] D. Hilvert,et al. Preparation of the β3‐Homoselenocysteine Derivatives Fmoc‐β3hSec(PMB)‐OH and Boc‐β3hSec(PMB)‐OH for Solution and Solid‐Phase‐Peptide Synthesis and Selenoligation , 2007 .
[104] H. Imai,et al. Induction of phospholipid hydroperoxide glutathione peroxidase in human polymorphonuclear neutrophils and HL60 cells stimulated with TNF-alpha. , 2005, Biochemical and biophysical research communications.
[105] K. Takakura,et al. Ebselen in acute ischemic stroke: a placebo-controlled, double-blind clinical trial. Ebselen Study Group. , 1998, Stroke.
[106] T C Stadtman,et al. Selenocysteine, identified as the penultimate C-terminal residue in human T-cell thioredoxin reductase, corresponds to TGA in the human placental gene. , 1996, Proceedings of the National Academy of Sciences of the United States of America.
[107] F. Ursini,et al. Dual function of the selenoprotein PHGPx during sperm maturation. , 1999, Science.
[108] X. Lei,et al. Selenium‐dependent cellular glutathione peroxidase protects mice against a pro‐oxidant‐induced oxidation of NADPH, NADH, lipids, and protein , 1999, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
[109] N. Imura,et al. Effects of selenium deficiency on expression of selenoproteins in bovine arterial endothelial cells. , 2001, Biological & pharmaceutical bulletin.
[110] R. Koenig. Regulation of type 1 iodothyronine deiodinase in health and disease. , 2005, Thyroid : official journal of the American Thyroid Association.
[111] P. Harrison,et al. The structure of the mouse glutathione peroxidase gene: the selenocysteine in the active site is encoded by the ‘termination’ codon, TGA. , 1986, The EMBO journal.
[112] J. Harney,et al. Type 2 iodothyronine deiodinase is the major source of plasma T3 in euthyroid humans. , 2005, The Journal of clinical investigation.
[113] Elias S. J. Arnér,et al. Efficient reduction of lipoamide and lipoic acid by mammalian thioredoxin reductase. , 1996, Biochemical and biophysical research communications.
[114] W. Vorachek,et al. Deletion analysis of the rodent selenoprotein W promoter. , 2005, Journal of inorganic biochemistry.
[115] H. Steinbrenner,et al. Selenium, oxidative stress, and health aspects. , 2005, Molecular aspects of medicine.
[116] S. Jhanwar,et al. Growth inhibition and induction of apoptosis in mesothelioma cells by selenium and dependence on selenoprotein SEP15 genotype , 2004, Oncogene.
[117] A. Kyriakopoulos,et al. Two new selenoproteins found in the prostatic glandular epithelium and in the spermatid nuclei. , 1997, Biomedical and environmental sciences : BES.
[118] C. E. Cobb,et al. Reduction of the Ascorbyl Free Radical to Ascorbate by Thioredoxin Reductase* , 1998, The Journal of Biological Chemistry.
[119] Elias S. J. Arnér,et al. Regulation of the mammalian selenoprotein thioredoxin reductase 1 in relation to cellular phenotype, growth, and signaling events. , 2004, Antioxidants & redox signaling.
[120] A. Porat,et al. A 56-kDa Selenium-binding Protein Participates in Intra-Golgi Protein Transport* , 2000, The Journal of Biological Chemistry.
[121] A. Bianco,et al. Deiodinases: implications of the local control of thyroid hormone action. , 2006, The Journal of clinical investigation.
[122] S. Baek,et al. Induction of apoptosis by the overexpression of an alternative splicing variant of mitochondrial thioredoxin reductase , 2005, Free radical biology & medicine.
[123] Joachim Diebold,et al. Functional epigenomics identifies genes frequently silenced in prostate cancer. , 2005, Cancer research.
[124] Elias S. J. Arnér,et al. Preparation and assay of mammalian thioredoxin and thioredoxin reductase. , 1999, Methods in enzymology.
[125] R. Burk,et al. Selenoprotein P. A selenium-rich extracellular glycoprotein. , 1994, The Journal of nutrition.
[126] A. Holmgren,et al. S-Nitrosoglutathione Is Cleaved by the Thioredoxin System with Liberation of Glutathione and Redox Regulating Nitric Oxide* , 1996, The Journal of Biological Chemistry.
[127] A. Kyriakopoulos,et al. Mammalian selenium-containing proteins. , 2003, Annual review of nutrition.
[128] M. Berry,et al. Recognition of UGA as a selenocysteine codon in Type I deiodinase requires sequences in the 3′ untranslated region , 1991, Nature.
[129] Yusuke Nakamura,et al. Molecular diagnosis of colorectal tumors by expression profiles of 50 genes expressed differentially in adenomas and carcinomas , 2002, Oncogene.
[130] H. Nishiyama,et al. Increased risk of bladder cancer associated with a glutathione peroxidase 1 codon 198 variant. , 2004, The Journal of urology.
[131] R. Guigó,et al. Characterization of Mammalian Selenoproteomes , 2003, Science.
[132] P. Whanger. Selenium and the Brain: A Review , 2001, Nutritional neuroscience.
[133] M. Tanito,et al. Sulforaphane induces thioredoxin through the antioxidant-responsive element and attenuates retinal light damage in mice. , 2005, Investigative ophthalmology & visual science.
[134] H. Gill,et al. Selenium, immune function and resistance to viral infections , 2008 .
[135] H. Steinbrenner,et al. Involvement of selenoprotein P in protection of human astrocytes from oxidative damage. , 2006, Free radical biology & medicine.
[136] Ken Walder,et al. Tanis: a link between type 2 diabetes and inflammation? , 2002, Diabetes.
[137] E. Sontheimer,et al. Autoantibodies against a serine tRNA-protein complex implicated in cotranslational selenocysteine insertion. , 1992, Proceedings of the National Academy of Sciences of the United States of America.
[138] J. Mann,et al. Low glutathione peroxidase activity in Gpx1 knockout mice protects jejunum crypts from gamma-irradiation damage. , 2000, American journal of physiology. Gastrointestinal and liver physiology.
[139] Bruce W. Turnbull,et al. Effects of Selenium Supplementation for Cancer Prevention in Patients With Carcinoma of the Skin: A Randomized Controlled Trial , 1996 .
[140] V. Gladyshev,et al. Redox Regulation of Cell Signaling by Selenocysteine in Mammalian Thioredoxin Reductases* , 1999, The Journal of Biological Chemistry.
[141] K. Ge,et al. Keshan disease-an endemic cardiomyopathy in China , 2004, Virchows Archiv A.
[142] G. Kryukov,et al. Selective Inhibition of Selenocysteine tRNA Maturation and Selenoprotein Synthesis in Transgenic Mice Expressing Isopentenyladenosine-Deficient Selenocysteine tRNA , 2001, Molecular and Cellular Biology.
[143] K. Caban,et al. Size matters: a view of selenocysteine incorporation from the ribosome , 2005, Cellular and Molecular Life Sciences.
[144] M. Scheurlen,et al. Expression Profiling and Genetic Alterations of the Selenoproteins GI-GPx and SePP in Colorectal Carcinogenesis , 2004, Nutrition and cancer.
[145] V. Gladyshev,et al. High-Throughput Identification of Catalytic Redox-Active Cysteine Residues , 2007, Science.
[146] A. Holmgren,et al. Protein disulfide-isomerase is a substrate for thioredoxin reductase and has thioredoxin-like activity. , 1990, The Journal of biological chemistry.
[147] J. Mann,et al. Low glutathione peroxidase activity in Gpx1knockout mice protects jejunum crypts from γ-irradiation damage , 2000 .
[148] J. L. Leonard,et al. Thyroxine 5'-deiodinase activity of rat kidney: observations on activation by thiols and inhibition by propylthiouracil. , 1978, Endocrinology.
[149] So Yeon Kwon,et al. Structure-Expression Relationships of the 15-kDa Selenoprotein Gene , 2000, The Journal of Biological Chemistry.
[150] S. Osawa,et al. Recent evidence for evolution of the genetic code , 1992, Microbiological reviews.
[151] Qiong Liu,et al. Inhibitory effects of thioredoxin reductase antisense RNA on the growth of human hepatocellular carcinoma cells , 2005, Journal of cellular biochemistry.
[152] M. Beck,et al. Interacting nutritional and infectious etiologies of Keshan disease , 2007, Biological Trace Element Research.
[153] J. Harney,et al. Coupled tRNA(Sec)-dependent assembly of the selenocysteine decoding apparatus. , 2003, Molecular cell.
[154] R. Cook,et al. DNA sequencing of a mouse liver protein that binds selenium: implications for selenium's mechanism of action in cancer prevention. , 1990, Carcinogenesis.
[155] L. Maquat. Evidence that selenium deficiency results in the cytoplasmic decay of GPx1 mRNA dependent on pre-mRNA splicing proteins bound to the mRNA exon-exon junction. , 2001, BioFactors.
[156] Peter F Surai,et al. Producing specialist poultry products to meet human nutrition requirements: Selenium enriched eggs , 2008 .
[157] N Jones,et al. Regulation of yAP‐1 nuclear localization in response to oxidative stress , 1997, The EMBO journal.
[158] M. Kurzyna,et al. The conversion of thyroxine to triiodothyronine in the lung: comparison of activity of type I iodothyronine 5' deiodinase in lung cancer with peripheral lung tissues. , 2003, Monaldi archives for chest disease = Archivio Monaldi per le malattie del torace.
[159] Y. Bignon,et al. Nutrigenomics and antioxidants. , 2008, Personalized medicine.
[160] K. Caban,et al. Characterization of the SECIS binding protein 2 complex required for the co-translational insertion of selenocysteine in mammals , 2005, Nucleic acids research.
[161] Josef Köhrle,et al. The impact of iron and selenium deficiencies on iodine and thyroid metabolism: biochemistry and relevance to public health. , 2002, Thyroid : official journal of the American Thyroid Association.
[162] Ben van Ommen,et al. A network biology model of micronutrient related health. , 2008, The British journal of nutrition.
[163] D. Hatfield,et al. Dietary selenium affects methylation of the wobble nucleoside in the anticodon of selenocysteine tRNA([Ser]Sec). , 1993, The Journal of biological chemistry.
[164] B. Carlson,et al. Hepatically derived selenoprotein P is a key factor for kidney but not for brain selenium supply. , 2005, The Biochemical journal.
[165] V. Gladyshev,et al. Identity and functions of CxxC-derived motifs. , 2003, Biochemistry.
[166] Sheila M. Williams,et al. An estimation of selenium requirements for New Zealanders. , 1999, The American journal of clinical nutrition.
[167] P. Carbon,et al. An essential non-Watson-Crick base pair motif in 3'UTR to mediate selenoprotein translation. , 1998, RNA.
[168] R. Burk,et al. Selenoprotein P: an extracellular protein with unique physical characteristics and a role in selenium homeostasis. , 2005, Annual review of nutrition.
[169] P. Grabowski,et al. Identification of a protein component of a mammalian tRNA(Sec) complex implicated in the decoding of UGA as selenocysteine. , 1999, RNA.
[170] J. Harney,et al. Nuclear Assembly of UGA Decoding Complexes on Selenoprotein mRNAs: a Mechanism for Eluding Nonsense-Mediated Decay? , 2006, Molecular and Cellular Biology.
[171] A. Holmgren,et al. Selenite is a substrate for calf thymus thioredoxin reductase and thioredoxin and elicits a large non-stoichiometric oxidation of NADPH in the presence of oxygen. , 1992, European journal of biochemistry.
[172] L. Flohé,et al. Glutathione peroxidase: A selenoenzyme , 1973, FEBS letters.
[173] H. Masumoto,et al. Ebselen as a glutathione peroxidase mimic and as a scavenger of peroxynitrite. , 1997, Advances in pharmacology.
[174] H. Ganther,et al. In vitro and in vivo studies of methylseleninic acid: evidence that a monomethylated selenium metabolite is critical for cancer chemoprevention. , 2000, Cancer research.
[175] K. Desai,et al. Identification of a Novel Putative Non-selenocysteine Containing Phospholipid Hydroperoxide Glutathione Peroxidase (NPGPx) Essential for Alleviating Oxidative Stress Generated from Polyunsaturated Fatty Acids in Breast Cancer Cells* , 2004, Journal of Biological Chemistry.
[176] K. Esser,et al. GPx-1 modulates Akt and P70S6K phosphorylation and Gadd45 levels in MCF-7 cells. , 2004, Free radical biology & medicine.
[177] M. Saito,et al. Identification of the positive regulatory and distinct core regions of promoters, and transcriptional regulation in three types of mouse phospholipid hydroperoxide glutathione peroxidase. , 2006, Journal of biochemistry.
[178] S. Novoselov,et al. Non‐animal origin of animal thioredoxin reductases: Implications for selenocysteine evolution and evolution of protein function through carboxy‐terminal extensions , 2003, Protein science : a publication of the Protein Society.
[179] F. Chu,et al. Expression of selenium-dependent glutathione peroxidase in human breast tumor cell lines. , 1995, Cancer research.
[180] Yoshiharu Inoue,et al. Regulation of the Yeast Yap1p Nuclear Export Signal Is Mediated by Redox Signal-Induced Reversible Disulfide Bond Formation , 2001, Molecular and Cellular Biology.
[181] P. Larsen,et al. Biochemistry, cellular and molecular biology, and physiological roles of the iodothyronine selenodeiodinases. , 2002, Endocrine reviews.
[182] N. Ghyselinck,et al. In vitro expression of a mouse tissue specific glutathione-peroxidase-like protein lacking the selenocysteine can protect stably transfected mammalian cells against oxidative damage. , 1996, Biochemistry and cell biology = Biochimie et biologie cellulaire.
[183] R. Cook,et al. A 14-kilodalton selenium-binding protein in mouse liver is fatty acid-binding protein. , 1989, The Journal of biological chemistry.
[184] J. Yodoi,et al. A Comparative Study on the Hydroperoxide and Thiol Specificity of the Glutathione Peroxidase Family and Selenoprotein P* , 2002, The Journal of Biological Chemistry.
[185] E. Stadtman. Protein oxidation and aging. , 1992, Free radical research.
[186] A. Holmgren,et al. Widespread expression of thioredoxin and thioredoxin reductase in non-small cell lung carcinoma. , 2001, Clinical cancer research : an official journal of the American Association for Cancer Research.
[187] P. Carbon,et al. cDNA cloning, expression pattern and RNA binding analysis of human selenocysteine insertion sequence (SECIS) binding protein 2. , 2002, Gene.
[188] M. Rayman,et al. The importance of selenium to human health , 2000, The Lancet.
[189] A. Holmgren,et al. Motexafin Gadolinium, a Tumor-selective Drug Targeting Thioredoxin Reductase and Ribonucleotide Reductase* , 2006, Journal of Biological Chemistry.
[190] Mark M Huycke,et al. Bacteria-Induced Intestinal Cancer in Mice with Disrupted Gpx1 and Gpx2 Genes , 2004, Cancer Research.
[191] E. Stadtman,et al. Protein Oxidation in Aging, Disease, and Oxidative Stress* , 1997, The Journal of Biological Chemistry.
[192] A. Tarun,et al. SELENIUM IN HIGHER PLANTS. , 2003, Annual review of plant physiology and plant molecular biology.
[193] Cheryl Jorcyk,et al. Alterations in gene expression profiles during prostate cancer progression: functional correlations to tumorigenicity and down-regulation of selenoprotein-P in mouse and human tumors. , 2002, Cancer research.
[194] D. Lubman,et al. Mouse liver selenium‐binding protein decreased in abundance by peroxisome proliferators , 2000, Electrophoresis.
[195] X. Lei,et al. New roles for an old selenoenzyme: evidence from glutathione peroxidase-1 null and overexpressing mice. , 2005, The Journal of nutrition.
[196] S. Novoselov,et al. Specific Excision of the Selenocysteine tRNA[Ser]Sec (Trsp) Gene in Mouse Liver Demonstrates an Essential Role of Selenoproteins in Liver Function* , 2004, Journal of Biological Chemistry.
[197] M. S. Wagner,et al. Decreased type 1 iodothyronine deiodinase expression might be an early and discrete event in thyroid cell dedifferentation towards papillary carcinoma , 2005, Clinical endocrinology.
[198] Peter F Surai. Selenium in Nutrition and Health , 2006 .
[199] G. Kryukov,et al. Spatial and temporal expression patterns of selenoprotein genes during embryogenesis in zebrafish. , 2003, Gene expression patterns : GEP.
[200] P. Alewood,et al. Selenopeptide chemistry , 2008, Journal of peptide science : an official publication of the European Peptide Society.
[201] Mats Andersson,et al. NK-lysin, a Disulfide-containing Effector Peptide of T-lymphocytes, Is Reduced and Inactivated by Human Thioredoxin Reductase , 1996, The Journal of Biological Chemistry.
[202] D R Schwartz,et al. Coordinately up-regulated genes in ovarian cancer. , 2001, Cancer research.
[203] G. Hampton,et al. Allelic loss on chromosome 1 is associated with tumor progression of cervical carcinoma , 1999, Cancer.
[204] A. Diamond,et al. Role of glutathione peroxidase 1 in breast cancer: loss of heterozygosity and allelic differences in the response to selenium. , 2003, Cancer research.
[205] M. Waye,et al. Isolation, characterization, and chromosomal mapping of a novel cDNA clone encoding human selenium binding protein , 1997 .
[206] B. Turnbull,et al. Selenium supplementation and lung cancer incidence: an update of the nutritional prevention of cancer trial. , 2002, Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology.
[207] K. Takahashi,et al. Primary structure of human plasma glutathione peroxidase deduced from cDNA sequences. , 1992, Journal of biochemistry.
[208] Elias S. J. Arnér,et al. Physiological functions of thioredoxin and thioredoxin reductase. , 2000, European journal of biochemistry.
[209] G Vivoli,et al. Adverse Health Effects of Selenium in Humans , 2001, Reviews on environmental health.
[210] E. Taylor,et al. Functional studies of an HIV‐1 encoded glutathione peroxidase , 2006, BioFactors.
[211] K. Sugimachi,et al. Enhanced coexpression of thioredoxin and high mobility group protein 1 genes in human hepatocellular carcinoma and the possible association with decreased sensitivity to cisplatin. , 1996, Cancer research.
[212] G. Storz,et al. Structural basis for redox regulation of Yap1 transcription factor localization , 2004, Nature.
[213] A. Holmgren,et al. A Novel Antioxidant Mechanism of Ebselen Involving Ebselen Diselenide, a Substrate of Mammalian Thioredoxin and Thioredoxin Reductase* , 2002, The Journal of Biological Chemistry.
[214] Kazuhiko Takahashi,et al. Primary Structure of Human Plasma Glutathione Peroxidase Deduced from eDNA Sequences , 1990 .
[215] A. Fernandes,et al. Effects of the antioxidant Pycnogenol® on cellular redox systems in U1285 human lung carcinoma cells , 2009, The FEBS journal.
[216] D. Driscoll,et al. Mechanism and regulation of selenoprotein synthesis. , 2003, Annual review of nutrition.
[217] A. Krol,et al. Cellular and Molecular Life Sciences Review Understanding the importance of selenium and selenoproteins in muscle function , 2005 .
[218] H. Ganther,et al. Comparison of selenium and sulfur analogs in cancer prevention. , 1992, Carcinogenesis.
[219] R. Berkowitz,et al. Selenium binding protein 1 in ovarian cancer , 2006, International journal of cancer.
[220] N. Hannan,et al. Activation of the selenoprotein SEPS1 gene expression by pro-inflammatory cytokines in HepG2 cells. , 2006, Cytokine.
[221] P. Whanger. Selenoprotein W: a review , 2000, Cellular and Molecular Life Sciences CMLS.
[222] A. Luke,et al. Distribution and functional consequences of nucleotide polymorphisms in the 3'-untranslated region of the human Sep15 gene. , 2001, Cancer research.
[223] M. Alakavuklar,et al. Toxicity Induced by he Chemical Carcinogen 7,12-Dimethylbenz[a]anthracene and the Protective Effects of Selenium in Wistar Rats , 2005, Journal of toxicology and environmental health. Part A.
[224] R. Schirmer,et al. The mechanism of thioredoxin reductase from human placenta is similar to the mechanisms of lipoamide dehydrogenase and glutathione reductase and is distinct from the mechanism of thioredoxin reductase from Escherichia coli. , 1997, Proceedings of the National Academy of Sciences of the United States of America.
[225] Gerhard K. H. Przemeck,et al. Cytoplasmic Thioredoxin Reductase Is Essential for Embryogenesis but Dispensable for Cardiac Development , 2005, Molecular and Cellular Biology.
[226] Donald Voet,et al. Fundamentals of Biochemistry , 1999 .
[227] H. Steinbrenner,et al. Selenoprotein P protects endothelial cells from oxidative damage by stimulation of glutathione peroxidase expression and activity , 2006, Free radical research.
[228] G. Combs,et al. Selenium in global food systems , 2001, British Journal of Nutrition.
[229] R. Burk,et al. Purification of selenoprotein P from human plasma. , 1994, Biochimica et biophysica acta.
[230] H. Vinters,et al. The Role of Oxidative Stress in the Pathophysiology of Cerebrovascular Lesions in Alzheimer's Disease , 2002, Brain pathology.
[231] L. Maquat,et al. Selenium Deficiency Reduces the Abundance of mRNA for Se-Dependent Glutathione Peroxidase 1 by a UGA-Dependent Mechanism Likely To Be Nonsense Codon-Mediated Decay of Cytoplasmic mRNA , 1998, Molecular and Cellular Biology.
[232] D. Graham,et al. Antioxidant ebselen reduces oxidative damage in focal cerebral ischemia. , 2003, Free radical biology & medicine.
[233] L. Schomburg,et al. Synthesis and metabolism of thyroid hormones is preferentially maintained in selenium-deficient transgenic mice. , 2006, Endocrinology.
[234] K. Suzuki,et al. Biological interaction between transition metals (Ag, Cd and Hg), selenide/sulfide and selenoprotein P. , 1998, Journal of inorganic biochemistry.
[235] R. Bronson,et al. Mice Deficient in Cellular Glutathione Peroxidase Develop Normally and Show No Increased Sensitivity to Hyperoxia* , 1997, The Journal of Biological Chemistry.
[236] A. Diamond,et al. A regulatory role for Sec tRNA[Ser]Sec in selenoprotein synthesis. , 2004, RNA.
[237] P. Larsen,et al. Cellular and structural biology of the deiodinases. , 2005, Thyroid : official journal of the American Thyroid Association.
[238] W. Ream,et al. Purification, characterization, and glutathione binding to selenoprotein W from monkey muscle. , 1999, Archives of biochemistry and biophysics.
[239] M. Berry,et al. Unique features of selenocysteine incorporation function within the context of general eukaryotic translational processes. , 2005, Biochemical Society transactions.
[240] J. Vilardell,et al. Multiple functions of an evolutionarily conserved RNA binding domain. , 2000, Molecular cell.
[241] M. Rayman. Selenium in cancer prevention: a review of the evidence and mechanism of action , 2005, Proceedings of the Nutrition Society.
[242] Elias S. J. Arnér,et al. Selenocysteine in proteins-properties and biotechnological use. , 2005, Biochimica et biophysica acta.
[243] J. Arthur. The glutathione peroxidases , 2001, Cellular and Molecular Life Sciences CMLS.
[244] Elias S. J. Arnér,et al. Structure and mechanism of mammalian thioredoxin reductase: the active site is a redox-active selenolthiol/selenenylsulfide formed from the conserved cysteine-selenocysteine sequence. , 2000, Proceedings of the National Academy of Sciences of the United States of America.
[245] A. Krol,et al. The selenocysteine incorporation machinery: interactions between the SECIS RNA and the SECIS-binding protein SBP2. , 2001, RNA.
[246] K. Esser,et al. Selenium influences the turnover of selenocysteine tRNA([Ser]Sec) in Chinese hamster ovary cells. , 2002, The Journal of nutrition.
[247] H. Hiai,et al. Expression of stress-response and cell proliferation genes in renal cell carcinoma induced by oxidative stress. , 2000, The American journal of pathology.
[248] Nathan I. Lopez,et al. Selenoprotein W during development and oxidative stress. , 2006, Journal of inorganic biochemistry.
[249] P. Mushak. Potential impact of acid precipitation on arsenic and selenium. , 1985, Environmental health perspectives.
[250] E. Cadenas,et al. A novel biologically active seleno-organic compound--I. Glutathione peroxidase-like activity in vitro and antioxidant capacity of PZ 51 (Ebselen). , 1984, Biochemical pharmacology.
[251] R. Benya,et al. Allelic loss of the gene for the GPX1 selenium-containing protein is a common event in cancer. , 2005, The Journal of nutrition.
[252] Vadim N. Gladyshev,et al. How Selenium Has Altered Our Understanding of the Genetic Code , 2002, Molecular and Cellular Biology.
[253] D. Alberts,et al. Selenium and inhibition of disease progression in men diagnosed with prostate carcinoma: study design and baseline characteristics of the 'Watchful Waiting' Study. , 2003, Anti-cancer drugs.
[254] R. Korneluk,et al. Distinct Regulation of Internal Ribosome Entry Site-mediated Translation following Cellular Stress Is Mediated by Apoptotic Fragments of eIF4G Translation Initiation Factor Family Members eIF4GI and p97/DAP5/NAT1* , 2003, The Journal of Biological Chemistry.
[255] T. Tanaka,et al. Thioredoxin expression in primary T-cell acute lymphoblastic leukemia and its therapeutic implication. , 2001, Cancer research.
[256] D. Byrne,et al. Effectiveness of selenium supplements in a low-selenium area of China. , 2005, The American journal of clinical nutrition.
[257] S. Gromer,et al. Methylseleninate Is a Substrate Rather Than an Inhibitor of Mammalian Thioredoxin Reductase , 2002, The Journal of Biological Chemistry.
[258] W H Lamers,et al. Internal Ribosome Entry Site-mediated Translation of a Mammalian mRNA Is Regulated by Amino Acid Availability* , 2001, The Journal of Biological Chemistry.
[259] U. Tinggi. Selenium: its role as antioxidant in human health , 2008, Environmental health and preventive medicine.
[260] G. Kryukov,et al. The prokaryotic selenoproteome , 2004, EMBO reports.
[261] K. Khanna,et al. The Redox State of SECIS Binding Protein 2 Controls Its Localization and Selenocysteine Incorporation Function , 2006, Molecular and Cellular Biology.
[262] J. Doroshow,et al. Mice with combined disruption of Gpx1 and Gpx2 genes have colitis. , 2001, American journal of physiology. Gastrointestinal and liver physiology.
[263] D. Goldowitz,et al. Brainstem Axonal Degeneration in Mice with Deletion of Selenoprotein P , 2005, Toxicologic pathology.
[264] H. Kuhn,et al. Regulation of Expression of the Phospholipid Hydroperoxide/Sperm Nucleus Glutathione Peroxidase Gene , 2003, The Journal of Biological Chemistry.
[265] M. Berry,et al. Selenium and selenoproteins in the brain and brain diseases , 2003, Journal of neurochemistry.
[266] Ying Wang,et al. Two major branches of anti-cadmium defense in the mouse: MTF-1/metallothioneins and glutathione , 2005, Nucleic acids research.
[267] B. Zhivotovsky,et al. Inhibition of Mammalian thioredoxin reductase by some flavonoids: implications for myricetin and quercetin anticancer activity. , 2006, Cancer research.
[268] B. Martin,et al. A metabolite of acetaminophen covalently binds to the 56 kDa selenium binding protein. , 1992, Biochemical and biophysical research communications.
[269] J. Yeh,et al. Tissue distribution and influence of selenium status on levels of selenoprotein W , 1995, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
[270] L. Stavenow,et al. Selenoprotein P in Plasma in Relation to Cancer Morbidity in Middle-Aged Swedish Men , 2000, Nutrition and cancer.
[271] W. Wurst,et al. Essential Role for Mitochondrial Thioredoxin Reductase in Hematopoiesis, Heart Development, and Heart Function , 2004, Molecular and Cellular Biology.
[272] Shu-Yu Yu,et al. A preliminary report on the intervention trials of primary liver cancer in high-risk populations with nutritional supplementation of selenium in China , 1991, Biological Trace Element Research.
[273] A. Delaunay,et al. H2O2 sensing through oxidation of the Yap1 transcription factor , 2000, The EMBO journal.
[274] E. Larsen,et al. Selenium prevents tumor development in a rat model for chemical carcinogenesis. , 2004, Carcinogenesis.
[275] R. Brigelius-Flohé,et al. Glutathione peroxidases and redox-regulated transcription factors , 2006, Biological chemistry.
[276] V. Gladyshev,et al. Selective Rescue of Selenoprotein Expression in Mice Lacking a Highly Specialized Methyl Group in Selenocysteine tRNA* , 2005, Journal of Biological Chemistry.
[277] C. Moskaluk,et al. Hypermethylation and loss of expression of glutathione peroxidase-3 in Barrett's tumorigenesis. , 2005, Neoplasia.
[278] R. Schirmer,et al. Thioredoxin reductase two modes of catalysis have evolved. , 2000, European journal of biochemistry.
[279] W. Reeves,et al. Reversible cardiomyopathy due to selenium deficiency. , 1989, JPEN. Journal of parenteral and enteral nutrition.
[280] G. Arteel,et al. Function of thioredoxin reductase as a peroxynitrite reductase using selenocystine or ebselen. , 1999, Chemical research in toxicology.
[281] P. Ghezzi. ReviewRegulation of protein function by glutathionylation , 2005, Free radical research.
[282] P. Harrison,et al. Different patterns of regulation of the genes encoding the closely related 56 kDa selenium- and acetaminophen-binding proteins in normal tissues and during carcinogenesis. , 1993, Carcinogenesis.
[283] M. T. Howard,et al. Recoding elements located adjacent to a subset of eukaryal selenocysteine‐specifying UGA codons , 2005, The EMBO journal.
[284] G. Arteel,et al. Protection by selenoprotein P in human plasma against peroxynitrite-mediated oxidation and nitration. , 1998, Biological chemistry.
[285] L. Flohé,et al. Gene disruption discloses role of selenoprotein P in selenium delivery to target tissues. , 2003, The Biochemical journal.
[286] D. Driscoll,et al. Purification, Redox Sensitivity, and RNA Binding Properties of SECIS-binding Protein 2, a Protein Involved in Selenoprotein Biosynthesis* , 1999, The Journal of Biological Chemistry.
[287] P. Whanger. Selenium and its relationship to cancer: an update† , 2004, British Journal of Nutrition.
[288] S. Leung,et al. Diverse proteomic alterations in gastric adenocarcinoma , 2004, Proteomics.
[289] David Botstein,et al. Diverse and specific gene expression responses to stresses in cultured human cells. , 2004, Molecular biology of the cell.
[290] R. Sunde,et al. Selenium regulation of transcript abundance and translational efficiency of glutathione peroxidase-1 and -4 in rat liver. , 2001, The Biochemical journal.
[291] R. Brigelius-Flohé,et al. The GI-GPx Gene Is a Target for Nrf2 , 2005, Molecular and Cellular Biology.
[292] A. Holmgren,et al. Essential Role of Selenium in the Catalytic Activities of Mammalian Thioredoxin Reductase Revealed by Characterization of Recombinant Enzymes with Selenocysteine Mutations* , 2000, The Journal of Biological Chemistry.
[293] W. Markesbery,et al. Trace element imbalances in isolated subcellular fractions of Alzheimer's disease brains , 1990, Brain Research.
[294] G. Combs,et al. Cellular glutathione peroxidase is the mediator of body selenium to protect against paraquat lethality in transgenic mice. , 1998, The Journal of nutrition.
[295] R. Burk,et al. Selenium and amino acid composition of selenoprotein P, the major selenoprotein in rat serum. , 1990, The Journal of biological chemistry.
[296] H. Ballance. THE THYROID AND THE ENDOCRINE SYSTEM , 1922 .
[297] J. Harney,et al. Overexpression of type 2 iodothyronine deiodinase in follicular carcinoma as a cause of low circulating free thyroxine levels. , 2003, The Journal of clinical endocrinology and metabolism.
[298] N. Petit,et al. Selenoprotein N: an endoplasmic reticulum glycoprotein with an early developmental expression pattern. , 2003, Human molecular genetics.
[299] Jason G. Belter,et al. The selenoprotein GPX4 is essential for mouse development and protects from radiation and oxidative damage insults. , 2003, Free radical biology & medicine.
[300] K. Mori,et al. AP-1 transcriptional activity is regulated by a direct association between thioredoxin and Ref-1. , 1997, Proceedings of the National Academy of Sciences of the United States of America.
[301] B W Turnbull,et al. Effects of selenium supplementation for cancer prevention in patients with carcinoma of the skin. A randomized controlled trial. Nutritional Prevention of Cancer Study Group. , 1996, JAMA.
[302] O. Jensen,et al. Purification and properties of selenoprotein W from rat muscle. , 1993, The Journal of biological chemistry.
[303] J. F. Atkins,et al. Deletion of Selenoprotein P Alters Distribution of Selenium in the Mouse* , 2003, The Journal of Biological Chemistry.
[304] S. Jonnalagadda,et al. Toxicity, bioavailability and metal speciation. , 1993, Comparative biochemistry and physiology. C, Comparative pharmacology and toxicology.
[305] J. Harney,et al. Efficient Incorporation of Multiple Selenocysteines Involves an Inefficient Decoding Step Serving as a Potential Translational Checkpoint and RibosomeBottleneck , 2006, Molecular and Cellular Biology.
[306] P. Carbon,et al. Characterization of mSelB, a novel mammalian elongation factor for selenoprotein translation , 2000, The EMBO journal.
[307] V. Gladyshev,et al. Selective Removal of the Selenocysteine tRNA[Ser]Sec Gene (Trsp) in Mouse Mammary Epithelium , 2003, Molecular and Cellular Biology.
[308] G. Hardy,et al. Serum selenium and glutathione peroxidase-3 activity: biomarkers of systemic inflammation in the critically ill? , 2009, Intensive Care Medicine.
[309] J. Gustafsson,et al. Human mitochondrial thioredoxin reductase cDNA cloning, expression and genomic organization. , 1999, European journal of biochemistry.
[310] M. Hamberg,et al. Human Thioredoxin Reductase Directly Reduces Lipid Hydroperoxides by NADPH and Selenocystine Strongly Stimulates the Reaction via Catalytically Generated Selenols(*) , 1995, The Journal of Biological Chemistry.
[311] V. Gladyshev,et al. Crystal structures of oxidized and reduced mitochondrial thioredoxin reductase provide molecular details of the reaction mechanism. , 2005, Proceedings of the National Academy of Sciences of the United States of America.
[312] A. Holmgren,et al. Glutaredoxin from calf thymus. Purification to homogeneity. , 1982, The Journal of biological chemistry.
[313] V. Ray,et al. Selenoprotein deficiency accelerates prostate carcinogenesis in a transgenic model. , 2006, Proceedings of the National Academy of Sciences of the United States of America.
[314] K. Inagaki,et al. Selenophosphate synthetase genes from lung adenocarcinoma cells: Sps1 for recycling L-selenocysteine and Sps2 for selenite assimilation. , 2004, Proceedings of the National Academy of Sciences of the United States of America.
[315] A. Diplock,et al. Iodine and selenium deficiency associated with cretinism in northern Zaire. , 1990, The American journal of clinical nutrition.
[316] Arturo Hernandez,et al. Insights into the role of deiodinases from studies of genetically modified animals. , 2005, Thyroid : official journal of the American Thyroid Association.
[317] W. Leinfelder,et al. Gene for a novel tRNA species that accepts L-serine and cotranslationally inserts selenocysteine , 1988, Nature.
[318] G. Schneider,et al. Three-dimensional structure of a mammalian thioredoxin reductase: Implications for mechanism and evolution of a selenocysteine-dependent enzyme , 2001, Proceedings of the National Academy of Sciences of the United States of America.
[319] James B Atkinson,et al. Centrilobular Endothelial Cell Injury by Diquat in the Selenium-Deficient Rat Liver , 2001, Laboratory Investigation.
[320] J. Harney,et al. A novel retinoid X receptor-independent thyroid hormone response element is present in the human type 1 deiodinase gene , 1995, Molecular and cellular biology.
[321] V. Gladyshev,et al. A Novel Cysteine-rich Domain of Sep15 Mediates the Interaction with UDP-glucose:Glycoprotein Glucosyltransferase* , 2005, Journal of Biological Chemistry.
[322] J. Deisenhofer,et al. NMR Structures of the Selenoproteins Sep15 and SelM Reveal Redox Activity of a New Thioredoxin-like Family* , 2006, Journal of Biological Chemistry.
[323] J. Harney,et al. Human Type 3 Iodothyronine Selenodeiodinase Is Located in the Plasma Membrane and Undergoes Rapid Internalization to Endosomes* , 2003, The Journal of Biological Chemistry.
[324] C. Abnet,et al. Prospective study of serum selenium concentrations and esophageal and gastric cardia cancer, heart disease, stroke, and total death. , 2004, The American journal of clinical nutrition.
[325] V. Gladyshev,et al. Selenoprotein oxidoreductase with specificity for thioredoxin and glutathione systems , 2001, Proceedings of the National Academy of Sciences of the United States of America.
[326] D. Jeong,et al. Selenoprotein W is a glutathione‐dependent antioxidant in vivo , 2002, FEBS letters.
[327] A. Böck,et al. Occurrence in vivo of selenocysteyl-tRNA(SERUCA) in Escherichia coli. Effect of sel mutations. , 1989, The Journal of biological chemistry.
[328] K. Elliott,et al. Genetic variation in selenoprotein S influences inflammatory response , 2005, Nature Genetics.
[329] M. Berry,et al. Selenocysteine codons decrease polysome association on endogenous selenoprotein mRNAs , 2001, Genes to cells : devoted to molecular & cellular mechanisms.
[330] Lixin Yang,et al. Epithelium-specific glutathione peroxidase, Gpx2, is involved in the prevention of intestinal inflammation in selenium-deficient mice. , 2005, The Journal of nutrition.
[331] T. Schewe. Molecular actions of ebselen--an antiinflammatory antioxidant. , 1995, General pharmacology.
[332] Xiaozhong Peng,et al. Identification and characterization of selenoprotein K: An antioxidant in cardiomyocytes , 2006, FEBS letters.
[333] O. Jensen,et al. Selenoprotein W of rat muscle binds glutathione and an unknown small molecular weight moiety. , 1996, Journal of inorganic biochemistry.
[334] H. Ganther,et al. Selenium metabolism, selenoproteins and mechanisms of cancer prevention: complexities with thioredoxin reductase. , 1999, Carcinogenesis.
[335] J. Gustafsson,et al. An Alternative Splicing Variant of the Selenoprotein Thioredoxin Reductase Is a Modulator of Estrogen Signaling* , 2004, Journal of Biological Chemistry.
[336] P. Whanger. Selenocompounds in Plants and Animals and their Biological Significance , 2002, Journal of the American College of Nutrition.
[337] R. Caprioli,et al. Mass Spectrometric Characterization of Full-length Rat Selenoprotein P and Three Isoforms Shortened at the C Terminus , 2002, The Journal of Biological Chemistry.
[338] M. Scheurlen,et al. Inverse mRNA Expression of the Selenocysteine-Containing Proteins GI-GPx and SeP in Colorectal Adenomas Compared With Adjacent Normal Mucosa , 2000, Nutrition and cancer.
[339] A. Girotti,et al. Photooxidation of cell membranes in the presence of hematoporphyrin derivative: reactivity of phospholipid and cholesterol hydroperoxides with glutathione peroxidase. , 1988, Biochimica et biophysica acta.
[340] A. Holmgren,et al. Ebselen: A substrate for human thioredoxin reductase strongly stimulating its hydroperoxide reductase activity and a superfast thioredoxin oxidant , 2002, Proceedings of the National Academy of Sciences of the United States of America.
[341] W. Ream,et al. Identification of putative transcription factor binding sites in rodent selenoprotein W promoter. , 2004, Journal of inorganic biochemistry.
[342] D. Hatfield,et al. Selenium induces changes in the selenocysteine tRNA[Ser]Sec population in mammalian cells. , 1991, Nucleic acids research.
[343] Hoguen Kim,et al. Suppression of human selenium‐binding protein 1 is a late event in colorectal carcinogenesis and is associated with poor survival , 2006, Proteomics.
[344] A. Böck. Biosynthesis of selenoproteins--an overview. , 2000, BioFactors.
[345] D. Hatfield,et al. "Selenium: Its Molecular Biology and Role in Human Health" , 2002 .
[346] G. Kryukov,et al. Identification and characterization of phosphoseryl-tRNA[Ser]Sec kinase. , 2004, Proceedings of the National Academy of Sciences of the United States of America.
[347] Vadim N. Gladyshev,et al. Selenoprotein R is a zinc-containing stereo-specific methionine sulfoxide reductase , 2002, Proceedings of the National Academy of Sciences of the United States of America.
[348] D. Alberts,et al. Design and Progress of a Trial of Selenium to Prevent Prostate Cancer among Men with High-Grade Prostatic Intraepithelial Neoplasia , 2006, Cancer Epidemiology Biomarkers & Prevention.
[349] M. Dolan,et al. Allelic loss at the GPx-1 locus in cancer of the head and neck , 2004, Biological Trace Element Research.
[350] H. Steinbrenner,et al. Selenoprotein P Protects Low-density Lipoprotein Against Oxidation , 2004, Free radical research.
[351] K. Shroyer,et al. Quantitative and qualitative differences in protein expression between papillary thyroid carcinoma and normal thyroid tissue , 2006, Molecular carcinogenesis.
[352] C. Grant,et al. The thioredoxin system protects ribosomes against stress-induced aggregation. , 2005, Molecular biology of the cell.
[353] W. Wurst,et al. The Nuclear Form of Phospholipid Hydroperoxide Glutathione Peroxidase Is a Protein Thiol Peroxidase Contributing to Sperm Chromatin Stability , 2005, Molecular and Cellular Biology.
[354] V. Gladyshev,et al. Thioredoxin Reductase 1 Deficiency Reverses Tumor Phenotype and Tumorigenicity of Lung Carcinoma Cells* , 2006, Journal of Biological Chemistry.
[355] D. Alberts,et al. Selenium and prevention of prostate cancer in high-risk men: the Negative Biopsy Study. , 2003, Anti-cancer drugs.
[356] H. Kikuchi,et al. Ebselen in Acute Middle Cerebral Artery Occlusion: A Placebo-Controlled, Double-Blind Clinical Trial , 1999, Cerebrovascular Diseases.
[357] H. Sies,et al. Biochemistry of oxidative stress , 1986 .
[358] V. Gladyshev,et al. Biosynthesis of Selenocysteine on Its tRNA in Eukaryotes , 2006, PLoS biology.
[359] M. Beck,et al. Glutathione peroxidase protects mice from viral‐induced myocarditis , 1998, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
[360] L. Chavatte,et al. Ribosomal protein L30 is a component of the UGA-selenocysteine recoding machinery in eukaryotes , 2005, Nature Structural &Molecular Biology.
[361] H. Robinson. Selenodiglutathione is a highly efficient oxidant of reduced thioredoxin and a substrate for mammalian thioredoxin reductase , 2001 .
[362] R. Brigelius-Flohé. Tissue-specific functions of individual glutathione peroxidases. , 1999, Free radical biology & medicine.
[363] V. Gladyshev,et al. Heterogeneity within Animal Thioredoxin Reductases , 2001, The Journal of Biological Chemistry.
[364] E. Weeber,et al. Altered hippocampus synaptic function in selenoprotein P deficient mice , 2006, Molecular Neurodegeneration.
[365] M. Taketo,et al. Early embryonic lethality caused by targeted disruption of the mouse selenocysteine tRNA gene (Trsp). , 1997, Proceedings of the National Academy of Sciences of the United States of America.
[366] L. Schomburg,et al. Mutations in SECISBP2 result in abnormal thyroid hormone metabolism , 2005, Nature Genetics.
[367] D. Sagher,et al. Methionine sulfoxide reductases B1, B2, and B3 are present in the human lens and confer oxidative stress resistance to lens cells. , 2005, Investigative ophthalmology & visual science.
[368] D. Driscoll,et al. Polysome distribution of phospholipid hydroperoxide glutathione peroxidase mRNA: evidence for a block in elongation at the UGA/selenocysteine codon. , 2000, RNA.
[369] P. R. Lyons,et al. Differential regulation of rat liver selenoprotein mRNAs in selenium deficiency. , 1992, Biochemical and biophysical research communications.
[370] M. Fenech,et al. The effect of selenium, as selenomethionine, on genome stability and cytotoxicity in human lymphocytes measured using the cytokinesis-block micronucleus cytome assay. , 2009, Mutagenesis.