Design and Synthesis of Quipazine Based Re-Complexes for the Development of Potential SPECT Imaging Agents with 99m Tc for 5-HT Transporter

6-Nitroquipazine has higher binding affinity for SERT than other selective serotonin reuptake inhibitors. We have prepared 6-nitroquipazine based rhenium complexes which would lead to the development of potential SPECT imaging agents with 9 9 m Tc for 5-HT transporter.

[1]  L. Bryan-Lluka.  Neurotransmitter Transporters: Structure, Function and Regulation , 2003 .

[2]  Y. Choe,et al.  Syntheses and binding affinities of 6-nitroquipazine analogues for serotonin transporter. Part 1. , 2000, Bioorganic & medicinal chemistry letters.

[3]  P. Acton,et al.  A new single-photon emission computed tomography imaging agent for serotonin transporters: [123I]IDAM, 5-iodo-2-((2-((dimethylamino)methyl)phenyl)thio)benzyl alcohol. , 1999, Journal of medicinal chemistry.

[4]  D. Chi,et al.  A new efficient synthesis of 6-nitroquipazine , 1998 .

[5]  D. Kupfer,et al.  Serotonin in Aging, Late-Life Depression, and Alzheimer's Disease: The Emerging Role of Functional Imaging , 1998, Neuropsychopharmacology.

[6]  T. Omori,et al.  Technetium and Rhenium Their Chemistry and Its Applications , 1996 .

[7]  C. Mathis,et al.  Synthesis of 123I‐and labelled 5‐iodo‐6‐nitroquipazine , 1994 .

[8]  J. Katzenellenbogen,et al.  Preparation and structural characterization of monoamine-monoamide bis(thiol) oxo complexes of technetium(V) and rhenium(V) , 1994 .

[9]  C. Mathis,et al.  [125I]5-iodo-6-nitroquipazine: a potent and selective ligand for the 5-hyfroxytryptamine uptake complex. I. In vitro studies , 1993, Brain Research.

[10]  H N Wagner,et al.  [11C](+)McN5652 as a radiotracer for imaging serotonin uptake sites with PET. , 1993, Life sciences.

[11]  K. Hashimoto,et al.  High affinity binding of [3H]6-nitroquipazine to cortical membranes in the rat: Inhibition by 5-hydroxytryptamine and 5-hydroxytryptamine uptake inhibitors , 1991, Neuropharmacology.