Norepinephrine in the brain is associated with aversion to financial loss

Understanding the molecular mechanism of extreme or impaired decision-making observed in neuropsychiatric disorders, such as pathological gambling and attention-deficit hyperactivity disorder (ADHD), could contribute to better assessment and the development of novel pharmacological therapies for those disorders. Typically, most people show a disproportionate distaste for possible losses compared with equal-sized gains. This human in vivo molecular imaging study has demonstrated that individuals with lower thalamic norepinephrine transporters (NET) showed more exaggerated aversion to financial loss.