Intravenous aminophylline and cerebral blood flow in preterm infants.

The effect of aminophylline on cerebral blood flow (CBF) was studied in 10 preterm infants who were receiving 6.2 mg/kg intravenously over 20 minutes followed by a maintenance infusion. CBF was measured intermittently using near infrared spectroscopy. Heart rate, blood pressure, oxygen saturation, and transcutaneously measured carbon dioxide tension (TcPCO2) were recorded continuously. Aminophylline administration was associated with a fall in CBF from a median of 15.9 ml/100 g/min to 11.2 ml/100 g/min. Median fall in CBF was 4.1 ml/100 g/min (95% confidence interval 1.7 to 6.5). Heart rate rose and TcPCO2 fell in all infants, median fall being 0.66 kPa. The reduction in CBF was greater than would be expected on the basis of the modest fall in TcPCO2.

[1]  S. Kety,et al.  The effects of intravenously administered aminophylline on cerebral circulation and metabolism in man. , 1950, The Journal of clinical investigation.

[2]  Susan Wray,et al.  QUANTIFICATION OF CEREBRAL OXYGENATION AND HAEMODYNAMICS IN SICK NEWBORN INFANTS BY NEAR INFRARED SPECTROPHOTOMETRY , 1986, The Lancet.

[3]  D. Delpy,et al.  Effects of indomethacin on cerebral haemodynamics in very preterm infants , 1990, The Lancet.

[4]  K. Mcculloch,et al.  Regional cerebral blood flow velocity after aminophylline therapy in premature newborn infants. , 1989, The Journal of pediatrics.

[5]  D. Delpy,et al.  COTSIDE MEASUREMENT OF CEREBRAL BLOOD FLOW IN ILL NEWBORN INFANTS BY NEAR INFRARED SPECTROSCOPY , 1988, The Lancet.

[6]  M E Raichle,et al.  Positron emission tomography in the newborn: extensive impairment of regional cerebral blood flow with intraventricular hemorrhage and hemorrhagic intracerebral involvement. , 1983, Pediatrics.

[7]  F. Walther,et al.  Cardiac output changes secondary to theophylline therapy in preterm infants , 1986 .

[8]  O. Pryds,et al.  Cerebral Blood Flow Reactivity in Spontaneously Breathing, Preterm Infants Shortly after Birth , 1990, Acta paediatrica Scandinavica.

[9]  W. Oh,et al.  Aminophylline reduces cerebral blood flow velocity in low-birth-weight infants. , 1984, American journal of diseases of children.

[10]  F. Simons,et al.  Physiologic changes induced by theophylline in the treatment of apnea in preterm infants. , 1978, The Journal of pediatrics.

[11]  L. Skov,et al.  Estimating Cerebral Blood Flow in Newborn Infants: Comparison of Near Infrared Spectroscopy and 133Xe Clearance , 1991, Pediatric Research.

[12]  13 COMPARISON BETWEEN 133XENON CLEARANCE AND NEAR INFRARED SPECTROSCOPY FOR ESTIMATION OF CEREBRAL BLOOD FLOW , 1991, Pediatric Research.

[13]  T. Rall.  Central nervous system stimulants, the methylxanthines. , 1985 .

[14]  R. A. Jones,et al.  Dosage schedule for intravenous aminophylline in apnoea of prematurity, based on pharmacokinetic studies. , 1979, Archives of disease in childhood.