Comparison of clinicopathological characteristics, gene expression profiles, mutational analysis, and clinical outcomes of pure and mixed small‐cell carcinoma of the bladder

Small cell bladder carcinoma (SCBC) is a rare, divergent form of urothelial carcinoma (UC). We aimed to determine whether pure (n = 16) and mixed (SCBC and UC; n = 30) tumours differed in pathology, gene expression characteristics, genetic alterations, and clinical outcomes.

[1]  D. McConkey,et al.  Update on bladder cancer molecular subtypes , 2020, Translational andrology and urology.

[2]  P. Pierorazio,et al.  Clinical Restaging and Tumor Sequencing are Inaccurate Indicators of Response to Neoadjuvant Chemotherapy for Muscle-invasive Bladder Cancer. , 2020, European urology.

[3]  G. Cancel-Tassin,et al.  Urothelial Cancers with Small Cell Variant Histology Have Confirmed High Tumor Mutational Burden, Frequent TP53 and RB Mutations, and a Unique Gene Expression Profile. , 2020, European urology oncology.

[4]  C. Jackson,et al.  Analysis of Intestinal Metaplasia Without Dysplasia in the Urinary Bladder Reveal Only Rare Mutations Associated With Colorectal Adenocarcinoma , 2019, Applied immunohistochemistry & molecular morphology : AIMM.

[5]  A. Lopez‐Beltran,et al.  Variants and new entities of bladder cancer , 2018, Histopathology.

[6]  H. Williams,et al.  The oncological outcomes of small cell carcinoma of the bladder. , 2018, Canadian Urological Association journal = Journal de l'Association des urologues du Canada.

[7]  G. Iyer,et al.  Updates on the Genetics and Molecular Subtypes of Urothelial Carcinoma and Select Variants. , 2018, Surgical pathology clinics.

[8]  B. Czerniak,et al.  Small cell carcinoma of the urinary bladder: a clinicopathological and immunohistochemical analysis of 81 cases. , 2018, Human pathology.

[9]  N. Socci,et al.  Small-Cell Carcinomas of the Bladder and Lung Are Characterized by a Convergent but Distinct Pathogenesis , 2017, Clinical Cancer Research.

[10]  Steven J. M. Jones,et al.  Comprehensive Molecular Characterization of Muscle-Invasive Bladder Cancer , 2017, Cell.

[11]  J. Warrick Clinical Significance of Histologic Variants of Bladder Cancer. , 2017, Journal of the National Comprehensive Cancer Network : JNCCN.

[12]  J. Epstein,et al.  Sarcomatoid carcinoma associated with small cell carcinoma of the urinary bladder: a series of 28 cases. , 2017, Human pathology.

[13]  S. Lipsitz,et al.  Effect of Nonurothelial Histologic Variants on the Outcomes of Radical Cystectomy for Nonmetastatic Muscle‐invasive Urinary Bladder Cancer , 2017, Clinical genitourinary cancer.

[14]  F. Montorsi,et al.  Pure but Not Mixed Histologic Variants Are Associated With Poor Survival at Radical Cystectomy in Bladder Cancer Patients , 2017, Clinical genitourinary cancer.

[15]  E. Plimack,et al.  Small‐Cell Carcinoma of the Bladder: 20‐Year Single‐Institution Retrospective Review , 2017, Clinical genitourinary cancer.

[16]  J. Cheville,et al.  High grade neuroendocrine carcinoma of the urinary bladder treated by radical cystectomy: a series of small cell, mixed neuroendocrine and large cell neuroendocrine carcinoma , 2015, Pathology.

[17]  M. Amichetti,et al.  Small Cell Carcinoma of the Urinary Bladder: A Retrospective, Multicenter Rare Cancer Network Study of 107 Patients. , 2015, International journal of radiation oncology, biology, physics.

[18]  J. Cheville,et al.  Long‐term results of radical cystectomy and role of adjuvant chemotherapy for small cell carcinoma of the bladder , 2015, International journal of urology : official journal of the Japanese Urological Association.

[19]  W. Huber,et al.  Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2 , 2014, Genome Biology.

[20]  S. Barni,et al.  Correlation of pathologic complete response with survival after neoadjuvant chemotherapy in bladder cancer treated with cystectomy: a meta-analysis. , 2014, European urology.

[21]  R. Millikan,et al.  Neoadjuvant chemotherapy in small cell urothelial cancer improves pathologic downstaging and long-term outcomes: results from a retrospective study at the MD Anderson Cancer Center. , 2013, European urology.

[22]  Xiangrong Zhao,et al.  Small cell carcinoma of the urinary bladder: a rare, aggressive neuroendocrine malignancy. , 2012, Archives of pathology & laboratory medicine.

[23]  T. Terada Small cell carcinoma of the urinary bladder. , 2012, International journal of clinical and experimental pathology.

[24]  A. Flesken-Nikitin,et al.  Cell lineage-specific interactions between Men1 and Rb in neuroendocrine neoplasia. , 2008, Carcinogenesis.

[25]  S. Groshen,et al.  Radical cystectomy for primary neuroendocrine tumors of the bladder: the university of southern california experience. , 2005, The Journal of urology.

[26]  J. Montie Small cell carcinoma of the urinary bladder. A clinicopathologic analysis of 64 patients. , 2005, The Journal of urology.

[27]  Ryan P. McCarthy,et al.  Molecular genetic evidence for a common clonal origin of urinary bladder small cell carcinoma and coexisting urothelial carcinoma. , 2005, The American journal of pathology.

[28]  C. Moran,et al.  Small cell carcinoma of the bladder: a contemporary clinicopathological study of 51 cases , 2005, Histopathology.

[29]  R. Millikan,et al.  Evidence supporting preoperative chemotherapy for small cell carcinoma of the bladder: a retrospective review of the M. D. Anderson cancer experience. , 2004, The Journal of urology.

[30]  D. Botstein,et al.  Cluster analysis and display of genome-wide expression patterns. , 1998, Proceedings of the National Academy of Sciences of the United States of America.

[31]  J. Crawford,et al.  Randomized study of cyclophosphamide, doxorubicin, and vincristine versus etoposide and cisplatin versus alternation of these two regimens in extensive small-cell lung cancer: a phase III trial of the Southeastern Cancer Study Group. , 1992, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.