Human germline nuclear transfer to overcome mitochondrial disease and failed fertilization after ICSI

[1]  Qing Sang,et al.  Genetic factors as potential molecular markers of human oocyte and embryo quality , 2021, Journal of Assisted Reproduction and Genetics.

[2]  B. Heindryckx,et al.  Digital Polymerase Chain Reaction for Assessment of Mutant Mitochondrial Carry-over after Nuclear Transfer for In Vitro Fertilization. , 2021, Clinical chemistry.

[3]  S. Mitalipov,et al.  Germline transmission of donor, maternal and paternal mtDNA in primates. , 2020, Human reproduction.

[4]  B. Heindryckx,et al.  Diagnosis and Treatment of Male Infertility-Related Fertilization Failure , 2020, Journal of clinical medicine.

[5]  B. Menten,et al.  Germline nuclear transfer in mice may rescue poor embryo development associated with advanced maternal age and early embryo arrest. , 2020, Human reproduction.

[6]  I. Miguel-Escalada,et al.  Maternal spindle transfer overcomes embryo developmental arrest caused by ooplasmic defects in mice , 2020, eLife.

[7]  Ling Wu,et al.  Novel mutations in PLCZ1 cause male infertility due to fertilization failure or poor fertilization. , 2020, Human reproduction.

[8]  B. Heindryckx,et al.  Comparative analysis of different nuclear transfer techniques to prevent the transmission of mitochondrial DNA variants. , 2019, Molecular human reproduction.

[9]  B. Heindryckx,et al.  Vitrification negatively affects the Ca2+-releasing and activation potential of mouse oocytes, but vitrified oocytes are potentially useful for diagnostic purposes. , 2019, Reproductive biomedicine online.

[10]  B. Heindryckx,et al.  Assisted oocyte activation significantly increases fertilization and pregnancy outcome in patients with low and total failed fertilization after intracytoplasmic sperm injection: a 17-year retrospective study. , 2019, Fertility and sterility.

[11]  Robert W. Taylor,et al.  Mitochondrial Donation - Which Women Could Benefit? , 2019, The New England journal of medicine.

[12]  Ling-bo Cai,et al.  Homozygous missense mutation Arg207Cys in the WEE2 gene causes female infertility and fertilization failure , 2019, Journal of Assisted Reproduction and Genetics.

[13]  G. Lin,et al.  New biallelic mutations in WEE2: expanding the spectrum of mutations that cause fertilization failure or poor fertilization. , 2019, Fertility and sterility.

[14]  M. Herbert,et al.  Progress in mitochondrial replacement therapies , 2018, Nature Reviews Molecular Cell Biology.

[15]  B. Heindryckx,et al.  Novel reproductive technologies to prevent mitochondrial disease , 2017, Human reproduction update.

[16]  P. Trerotoli,et al.  Leber's hereditary optic neuropathy (LHON) in an Apulian cohort of subjects. , 2017, Acta myologica : myopathies and cardiomyopathies : official journal of the Mediterranean Society of Myology.

[17]  K. Thangaraj,et al.  Leber's Hereditary Optic Neuropathy-Specific Mutation m.11778G>A Exists on Diverse Mitochondrial Haplogroups in India. , 2017, Investigative ophthalmology & visual science.

[18]  Zi-jiang Chen,et al.  Polar bodies are efficient donors for reconstruction of human embryos for potential mitochondrial replacement therapy , 2017, Cell Research.

[19]  A. Chavez-Badiola,et al.  Live birth derived from oocyte spindle transfer to prevent mitochondrial disease. , 2017, Reproductive biomedicine online.

[20]  H. Smeets,et al.  PGD for the m.14487 T>C mitochondrial DNA mutation resulted in the birth of a healthy boy , 2017, Human reproduction.

[21]  G. Lin,et al.  Polar body transfer restores the developmental potential of oocytes to blastocyst stage in a case of repeated embryo fragmentation , 2017, Journal of Assisted Reproduction and Genetics.

[22]  J. Ecker,et al.  Functional Human Oocytes Generated by Transfer of Polar Body Genomes. , 2017, Cell stem cell.

[23]  J. C. Belmonte,et al.  Mitochondrial replacement in human oocytes carrying pathogenic mitochondrial DNA mutations , 2016, Nature.

[24]  J. Grifo,et al.  Pregnancy derived from human zygote pronuclear transfer in a patient who had arrested embryos after IVF. , 2016, Reproductive biomedicine online.

[25]  D. Egli,et al.  Genetic Drift Can Compromise Mitochondrial Replacement by Nuclear Transfer in Human Oocytes. , 2016, Cell stem cell.

[26]  Douglass M. Turnbull,et al.  Towards clinical application of pronuclear transfer to prevent mitochondrial DNA disease , 2016, Nature.

[27]  S. Dimauro,et al.  Mitochondrial diseases , 2016, Nature Reviews Disease Primers.

[28]  S. Vansteelandt,et al.  Cellular Heterogeneity in the Level of mtDNA Heteroplasmy in Mouse Embryonic Stem Cells. , 2015, Cell reports.

[29]  John Zhang,et al.  Cytoplasm replacement following germinal vesicle transfer restores meiotic maturation and spindle assembly in meiotically arrested oocytes. , 2015, Reproductive biomedicine online.

[30]  J. Vandesompele,et al.  Flexible, Scalable, and Efficient Targeted Resequencing on a Benchtop Sequencer for Variant Detection in Clinical Practice , 2015, Human mutation.

[31]  D. Turnbull,et al.  Mitochondrial donation--how many women could benefit? , 2015, The New England journal of medicine.

[32]  S. Mitalipov,et al.  Mitochondrial replacement therapy in reproductive medicine. , 2015, Trends in molecular medicine.

[33]  B. Heindryckx,et al.  Mutation-free baby born from a mitochondrial encephalopathy, lactic acidosis and stroke-like syndrome carrier after blastocyst trophectoderm preimplantation genetic diagnosis. , 2014, Mitochondrion.

[34]  Jianhong Zhu,et al.  Polar Body Genome Transfer for Preventing the Transmission of Inherited Mitochondrial Diseases , 2014, Cell.

[35]  Marni J. Falk,et al.  Limitations of preimplantation genetic diagnosis for mitochondrial DNA diseases. , 2014, Cell reports.

[36]  B. Heindryckx,et al.  A systematic analysis of the suitability of preimplantation genetic diagnosis for mitochondrial diseases in a heteroplasmic mitochondrial mouse model. , 2014, Human reproduction.

[37]  J. Mollison,et al.  Factors Associated with Failed Treatment: an Analysis of 121,744 Women Embarking on Their First IVF Cycles , 2013, PloS one.

[38]  Yunlong Liu,et al.  NGSUtils: a software suite for analyzing and manipulating next-generation sequencing datasets , 2013, Bioinform..

[39]  B. Heindryckx,et al.  Assisted oocyte activation is not beneficial for all patients with a suspected oocyte-related activation deficiency. , 2012, Human reproduction.

[40]  R. Rodenburg,et al.  Clinical features and heteroplasmy in blood, urine and saliva in 34 Dutch families carrying the m.3243A > G mutation , 2012, Journal of Inherited Metabolic Disease.

[41]  P. Devroey,et al.  Closed blastocyst vitrification of biopsied embryos: evaluation of 100 consecutive warming cycles. , 2011, Human reproduction.

[42]  C. Racowsky,et al.  Diagnosing cellular defects in an unexplained case of total fertilization failure. , 2010, Human reproduction.

[43]  Patrick F Chinnery,et al.  Pronuclear transfer in human embryos to prevent transmission of mitochondrial DNA disease , 2010, Nature.

[44]  Y. Li,et al.  Mitochondrial Gene Replacement in Primate Offspring and Embryonic Stem Cells , 2009, Nature.

[45]  Gonçalo R. Abecasis,et al.  The Sequence Alignment/Map format and SAMtools , 2009, Bioinform..

[46]  B. Heindryckx,et al.  Efficiency of assisted oocyte activation as a solution for failed intracytoplasmic sperm injection. , 2008, Reproductive biomedicine online.

[47]  I. D. de Coo,et al.  The transmission of OXPHOS disease and methods to prevent this. , 2006, Human reproduction update.

[48]  B. Heindryckx,et al.  Treatment option for sperm- or oocyte-related fertilization failure: assisted oocyte activation following diagnostic heterologous ICSI. , 2005, Human reproduction.

[49]  K. Huoponen,et al.  Segregation of the ND4/11778 and the ND1/3460 mutations in four heteroplasmic LHON families , 2002, Journal of the Neurological Sciences.

[50]  P Barrière,et al.  Mitochondrial DNA content affects the fertilizability of human oocytes. , 2001, Molecular human reproduction.

[51]  S. Dimauro,et al.  Genetic counseling and prenatal diagnosis for the mitochondrial DNA mutations at nucleotide 8993. , 1999, American journal of human genetics.

[52]  J. Grifo,et al.  In vitro maturation of human preovulatory oocytes reconstructed by germinal vesicle transfer. , 1999, Fertility and sterility.

[53]  Dk Gardner,et al.  In-vitro culture of human blastocysts , 1999 .

[54]  R. Jansen,et al.  The bottleneck: mitochondrial imperatives in oogenesis and ovarian follicular fate , 1998, Molecular and Cellular Endocrinology.

[55]  N. Newman,et al.  The clinical characteristics of pedigrees of Leber's hereditary optic neuropathy with the 11778 mutation. , 1991, American journal of ophthalmology.

[56]  D. Wallace,et al.  Mitochondrial DNA mutation associated with Leber's hereditary optic neuropathy. , 1988, Science.

[57]  W. Hauswirth,et al.  Mitochondrial DNA polymorphism in a maternal lineage of Holstein cows. , 1982, Proceedings of the National Academy of Sciences of the United States of America.