Development of novel benzofuran-based SLC-0111 analogs as selective cancer-associated carbonic anhydrase isoform IX inhibitors.

[1]  T. Al-Warhi,et al.  Novel oxindole/benzofuran hybrids as potential dual CDK2/GSK-3β inhibitors targeting breast cancer: design, synthesis, biological evaluation, and in silico studies , 2020, Journal of enzyme inhibition and medicinal chemistry.

[2]  C. Supuran,et al.  Benzofuran-Based Carboxylic Acids as Carbonic Anhydrase Inhibitors and Antiproliferative Agents against Breast Cancer. , 2020, ACS medicinal chemistry letters.

[3]  C. Supuran,et al.  Discovery of potent dual-tailed benzenesulfonamide inhibitors of human carbonic anhydrases im-plicated in glaucoma and in vivo profiling of their intraocular pressure lowering action. , 2020, Journal of medicinal chemistry.

[4]  C. Supuran,et al.  Inclusion of a 5-fluorouracil moiety in nitrogenous bases derivatives as human carbonic anhydrase IX and XII inhibitors produced a targeted action against MDA-MB-231 and T47D breast cancer cells. , 2020, European journal of medicinal chemistry.

[5]  I. Eissa,et al.  Design, eco-friendly synthesis, molecular modeling and anticancer evaluation of thiazol-5(4H)-ones as potential tubulin polymerization inhibitors targeting the colchicine binding site , 2020, RSC advances.

[6]  Abdullah A. Elgazar,et al.  Sulfonamide-based ring-fused analogues for CAN508 as novel carbonic anhydrase inhibitors endowed with antitumor activity: Design, synthesis, and in vitro biological evaluation. , 2020, European journal of medicinal chemistry.

[7]  A. Hamed,et al.  Antitumor properties of certain spirooxindoles towards hepatocellular carcinoma endowed with antioxidant activity , 2020, Journal of enzyme inhibition and medicinal chemistry.

[8]  Mohamed A. Abdelrahman,et al.  Novel benzofuran-based sulphonamides as selective carbonic anhydrases IX and XII inhibitors: synthesis and in vitro biological evaluation , 2019, Journal of enzyme inhibition and medicinal chemistry.

[9]  S. Gayen,et al.  Structure-activity relationship of human carbonic anhydrase-II inhibitors: Detailed insight for future development as anti-glaucoma agents. , 2019, Bioorganic chemistry.

[10]  R. Kumar,et al.  Continued exploration and tail approach synthesis of benzenesulfonamides containing triazole and dual triazole moieties as carbonic anhydrase I, II, IV and IX inhibitors. , 2019, European journal of medicinal chemistry.

[11]  Mohamed A. Abdelrahman,et al.  Synthesis, biological evaluation and in silico studies with 4-benzylidene-2-phenyl-5(4H)-imidazolone-based benzenesulfonamides as novel selective carbonic anhydrase IX inhibitors endowed with anticancer activity. , 2019, Bioorganic chemistry.

[12]  K. Saied,et al.  Design, synthesis and anticancer evaluation of thieno[2,3-d]pyrimidine derivatives as dual EGFR/HER2 inhibitors and apoptosis inducers. , 2019, Bioorganic chemistry.

[13]  C. Supuran,et al.  SLC-0111 enaminone analogs, 3/4-(3-aryl-3-oxopropenyl) aminobenzenesulfonamides, as novel selective subnanomolar inhibitors of the tumor-associated carbonic anhydrase isoform IX. , 2019, Bioorganic chemistry.

[14]  C. Supuran,et al.  Enhancement of the tail hydrophobic interactions within the carbonic anhydrase IX active site via structural extension: Design and synthesis of novel N-substituted isatins-SLC-0111 hybrids as carbonic anhydrase inhibitors and antitumor agents. , 2019, European journal of medicinal chemistry.

[15]  C. Supuran.  Carbonic anhydrase inhibitors as emerging agents for the treatment and imaging of hypoxic tumors , 2018, Expert opinion on investigational drugs.

[16]  C. Supuran,et al.  Inhibition of carbonic anhydrase IX targets primary tumors, metastases, and cancer stem cells: Three for the price of one , 2018, Medicinal research reviews.

[17]  C. Supuran,et al.  Carbonic anhydrase inhibitors as antitumor/antimetastatic agents: a patent review (2008–2018) , 2018, Expert opinion on therapeutic patents.

[18]  L. Rashed,et al.  Novel coumarin-6-sulfonamides as apoptotic anti-proliferative agents: synthesis, in vitro biological evaluation, and QSAR studies , 2018, Journal of enzyme inhibition and medicinal chemistry.

[19]  C. Supuran,et al.  Discovery of New Selenoureido Analogues of 4-(4-Fluorophenylureido)benzenesulfonamide as Carbonic Anhydrase Inhibitors. , 2017, ACS medicinal chemistry letters.

[20]  C. Supuran,et al.  Synthesis of bulky-tailed sulfonamides incorporating pyrido[2,3-d][1,2,4]triazolo[4,3-a]pyrimidin-1(5H)-yl) moieties and evaluation of their carbonic anhydrases I, II, IV and IX inhibitory effects. , 2017, Bioorganic & medicinal chemistry.

[21]  C. Supuran,et al.  7-Aryl-triazolyl-substituted sulfocoumarins are potent, selective inhibitors of the tumor-associated carbonic anhydrase IX and XII , 2016, Journal of enzyme inhibition and medicinal chemistry.

[22]  C. Supuran.  How many carbonic anhydrase inhibition mechanisms exist? , 2016, Journal of enzyme inhibition and medicinal chemistry.

[23]  Abdul-Malek S. Al-Tamimi,et al.  Development of certain new 2-substituted-quinazolin-4-yl-aminobenzenesulfonamide as potential antitumor agents. , 2016, European journal of medicinal chemistry.

[24]  C. Supuran,et al.  Efficient Expression and Crystallization System of Cancer-Associated Carbonic Anhydrase Isoform IX. , 2015, Journal of medicinal chemistry.

[25]  C. Supuran,et al.  Click-tailed coumarins with potent and selective inhibitory action against the tumor-associated carbonic anhydrases IX and XII. , 2015, Bioorganic & medicinal chemistry.

[26]  S. Gražulis,et al.  Intrinsic thermodynamics of 4-substituted-2,3,5,6-tetrafluorobenzenesulfonamide binding to carbonic anhydrases by isothermal titration calorimetry. , 2015, Biophysical chemistry.

[27]  J. Pastorek,et al.  Hypoxia-induced carbonic anhydrase IX as a target for cancer therapy: from biology to clinical use. , 2015, Seminars in cancer biology.

[28]  C. Supuran,et al.  Sulfa and trimethoprim-like drugs – antimetabolites acting as carbonic anhydrase, dihydropteroate synthase and dihydrofolate reductase inhibitors , 2014, Journal of enzyme inhibition and medicinal chemistry.

[29]  C. Supuran,et al.  Combining the tail and the ring approaches for obtaining potent and isoform-selective carbonic anhydrase inhibitors: solution and X-ray crystallographic studies. , 2014, Bioorganic & medicinal chemistry.

[30]  R. McKenna,et al.  Anticonvulsant/antiepileptic carbonic anhydrase inhibitors: a patent review , 2013, Expert opinion on therapeutic patents.

[31]  C. Supuran.  Carbonic anhydrases: from biomedical applications of the inhibitors and activators to biotechnological use for CO2 capture , 2013, Journal of enzyme inhibition and medicinal chemistry.

[32]  Claudiu T Supuran,et al.  Carbonic anhydrase inhibitors and activators for novel therapeutic applications. , 2011, Future medicinal chemistry.

[33]  Claudiu T. Supuran,et al.  Carbonic anhydrases: novel therapeutic applications for inhibitors and activators , 2008, Nature Reviews Drug Discovery.

[34]  R. Whomsley,et al.  Inhibition of Aromatase (P450Arom) by some 1‐(Benzofuran‐2‐ylmethyl)imidazoles , 1999, The Journal of pharmacy and pharmacology.

[35]  S. Kim,et al.  The conformation and activity relationship of benzofuran derivatives as angiotensin II receptor antagonists. , 1997, Bioorganic & medicinal chemistry.

[36]  T. Mosmann.  Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. , 1983, Journal of immunological methods.

[37]  R. Khalifah,et al.  The carbon dioxide hydration activity of carbonic anhydrase. I. Stop-flow kinetic studies on the native human isoenzymes B and C. , 1971, The Journal of biological chemistry.