Lymphocyte‐predominant lesional inflammatory infiltrates of the skin are associated with mucosal‐dominant phenotype in pemphigus

Pemphigus is a potentially life‐threatening autoimmune blistering disease. To date, studies assessing the association of histopathology with clinical phenotype are lacking. We sought to evaluate the main histopathologic findings and, also, the potential links between cutaneous inflammatory infiltrates and clinical characteristics in pemphigus.

[1]  Papara Cristian,et al.  Lymphocyte‐predominant lesional inflammatory infiltrates of the skin are associated with mucosal‐dominant phenotype in pemphigus , 2023, Journal of cutaneous pathology.

[2]  A. S.  Pemphigus and its variants with direct immunofluorescence: Case series of 32 cases , 2021, Journal of Medical and Scientific Research.

[3]  D. Zillikens,et al.  The impact of lesional inflammatory cellular infiltrate on the phenotype of bullous pemphigoid , 2021, Journal of the European Academy of Dermatology and Venereology : JEADV.

[4]  R. Pollmann,et al.  Autoreactive T cells in pemphigus. Perpetrator and target. , 2020, Giornale italiano di dermatologia e venereologia : organo ufficiale, Societa italiana di dermatologia e sifilografia.

[5]  Gang Wang,et al.  The role of T cells in pemphigus vulgaris and bullous pemphigoid. , 2020, Autoimmunity reviews.

[6]  Yuan Liu,et al.  Prevalence and Predictors of Pruritus in Pemphigus as Compared to Bullous Pemphigoid: A Cross-sectional Study. , 2020, Journal of the American Academy of Dermatology.

[7]  J. Fairley,et al.  The Intersection of IgE Autoantibodies and Eosinophilia in the Pathogenesis of Bullous Pemphigoid , 2019, Front. Immunol..

[8]  Bhagyalakshmi Atla,et al.  Clinical, histopathological and immunofluorescent study of vesicobullous lesions of skin , 2019, International Journal of Research in Medical Sciences.

[9]  D. Zillikens,et al.  Diagnosis of Autoimmune Blistering Diseases , 2018, Front. Med..

[10]  K. Kridin,et al.  The Role of Eosinophils in Bullous Pemphigoid: A Developing Model of Eosinophil Pathogenicity in Mucocutaneous Disease , 2018, Front. Med..

[11]  D. Ateş.  Histomorphologic and Direct Immunofluorescence Findings of Autoimmune Bullous Disease , 2018 .

[12]  R. Pollmann,et al.  TH1/TH17 cell recognition of desmoglein 3 and bullous pemphigoid antigen 180 in patients with lichen planus. , 2018, The Journal of allergy and clinical immunology.

[13]  K. Kridin.  Pemphigus group: overview, epidemiology, mortality, and comorbidities , 2018, Immunologic research.

[14]  R. Pollmann,et al.  Pemphigus: a Comprehensive Review on Pathogenesis, Clinical Presentation and Novel Therapeutic Approaches , 2018, Clinical Reviews in Allergy & Immunology.

[15]  Jie Zheng,et al.  Pivotal Role of Lesional and Perilesional T/B Lymphocytes in Pemphigus Pathogenesis. , 2017, The Journal of investigative dermatology.

[16]  Plain language summaries , 2016, The British journal of dermatology.

[17]  M. Furumura,et al.  Locations of acantholysis in pemphigus vulgaris and pemphigus foliaceus , 2014, Journal of cutaneous pathology.

[18]  R. Holmdahl,et al.  Pathogenic IgG Antibodies against Desmoglein 3 in Pemphigus Vulgaris Are Regulated by HLA-DRB1*04:02–Restricted T Cells , 2014, The Journal of Immunology.

[19]  T. Hashimoto,et al.  Molecular Diagnosis in Autoimmune Skin Blistering Conditions , 2014, Current molecular medicine.

[20]  V. Sharma,et al.  Involvement of TH1/TH2 Cytokines in the Pathogenesis of Autoimmune Skin Disease—Pemphigus Vulgaris , 2009, Immunological investigations.

[21]  H. Shimizu,et al.  Consensus statement on definitions of disease, end points, and therapeutic response for pemphigus. , 2008, Journal of the American Academy of Dermatology.

[22]  W. Uter,et al.  Autoreactive T and B Cells from Bullous Pemphigoid (BP) Patients Recognize Epitopes Clustered in Distinct Regions of BP180 and BP2301 , 2006, The Journal of Immunology.

[23]  J. Guitart,et al.  Induction of keratinocyte IL‐8 expression and secretion by IgG autoantibodies as a novel mechanism of epidermal neutrophil recruitment in a pemphigus variant , 2000, Clinical and experimental immunology.

[24]  E. Schöpf,et al.  Granulocyte activation in bullous diseases: release of granular proteins in bullous pemphigoid and pemphigus vulgaris. , 1993, Journal of the American Academy of Dermatology.

[25]  M. Sadeep,et al.  Pemphigus – A clinical study with clinico-immuno-histopathologic correlation , 2019, Journal of Mahatma Gandhi Institute of Medical Sciences.

[26]  L. Marshall,et al.  Pemphigus , 2017, Nature Reviews Disease Primers.

[27]  R Core Team,et al.  R: A language and environment for statistical computing. , 2014 .

[28]  H. Simon,et al.  Eosinophils in Autoimmune Bullous Diseases , 2011 .

[29]  Joseph P. Near,et al.  How to cite this article , 2011 .

[30]  Alpana Sharma,et al.  Involvement of T H 1/T H 2 Cytokines in the Pathogenesis of Autoimmune Skin Disease— , 2009 .

[31]  R. Eming,et al.  Introducing a novel Autoimmune Bullous Skin Disorder Intensity Score (ABSIS) in pemphigus. , 2007, European journal of dermatology : EJD.