Frail older adults are more likely to have autonomic dysfunction: A systematic review and meta-analysis

[1]  O. Hanon,et al.  Blood pressure variability: A potential marker of aging , 2022, Ageing Research Reviews.

[2]  M. Cankurtaran,et al.  Orthostatic intolerance: a frailty marker for older adults , 2022, European Geriatric Medicine.

[3]  N. Toosizadeh,et al.  Frailty assessment using a novel approach based on combined motor and cardiac functions: a pilot study , 2021, BMC Geriatrics.

[4]  R. Kenny,et al.  Eight Orthostatic Haemodynamic Patterns in The Irish Longitudinal Study on Ageing (TILDA): Stability and Clinical Associations after 4 Years , 2021, Geriatrics.

[5]  O. Hanon,et al.  Visit-to-visit blood pressure variability and incident frailty in older adults. , 2021, The journals of gerontology. Series A, Biological sciences and medical sciences.

[6]  R. Varadhan,et al.  The physical frailty syndrome as a transition from homeostatic symphony to cacophony , 2021, Nature Aging.

[7]  S. Parthasarathy,et al.  Frailty and heart response to physical activity. , 2020, Archives of gerontology and geriatrics.

[8]  C. Meskers,et al.  Orthostatic blood pressure recovery associates with physical performance, frailty and number of falls in geriatric outpatients , 2020, Journal of hypertension.

[9]  S. Ancoli-Israel,et al.  Association of Circadian Abnormalities in Older Adults With an Increased Risk of Developing Parkinson Disease. , 2020, JAMA neurology.

[10]  C. Meskers,et al.  Blood Pressure Drop Rate After Standing Up Is Associated With Frailty and Number of Falls in Geriatric Outpatients , 2020, Journal of the American Heart Association.

[11]  Zhichun Chen,et al.  Autonomic dysfunction in Parkinson’s disease: Implications for pathophysiology, diagnosis, and treatment , 2019, Neurobiology of Disease.

[12]  J. Ishikawa,et al.  Orthostatic blood pressure rise is associated with frailty in older patients , 2019, Geriatrics & gerontology international.

[13]  A. Kasiukiewicz,et al.  Health and Functional Determinants of Orthostatic Hypotension in Geriatric Ward Patients: A Retrospective Cross Sectional Cohort Study , 2019, The journal of nutrition, health & aging.

[14]  A. Porta,et al.  Baroreflex sensitivity in frailty syndrome , 2019, Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas.

[15]  S. Robinovitch,et al.  Relationships between orthostatic hypotension, frailty, falling and mortality in elderly care home residents , 2019, BMC Geriatrics.

[16]  P. Soysal,et al.  What is the relationship between frailty and orthostatic hypotension in older adults? , 2019, Journal of geriatric cardiology : JGC.

[17]  R. Romero-Ortuño,et al.  Delaying and reversing frailty: a systematic review of primary care interventions. , 2018, The British journal of general practice : the journal of the Royal College of General Practitioners.

[18]  C. Meskers,et al.  Orthostatic hypotension and physical functioning in older adults: A systematic review and meta-analysis , 2018, Ageing Research Reviews.

[19]  Yaxin Zhang,et al.  Elevated serum IL-6 and adiponectin levels are associated with frailty and physical function in Chinese older adults , 2018, Clinical interventions in aging.

[20]  P. Abete,et al.  Orthostatic Hypotension in the Elderly: A Marker of Clinical Frailty? , 2018, Journal of the American Medical Directors Association.

[21]  R. Yu,et al.  Variability in Repeated Blood Pressure Measurements as a Marker of Frailty , 2018, The journal of nutrition, health & aging.

[22]  L. Ferrucci,et al.  Inflammageing: chronic inflammation in ageing, cardiovascular disease, and frailty , 2018, Nature Reviews Cardiology.

[23]  Oliver Kuss,et al.  A comparison of methods for meta‐analysis of a small number of studies with binary outcomes , 2018, Research synthesis methods.

[24]  Jose-Alberto Palma,et al.  Treatment of autonomic dysfunction in Parkinson disease and other synucleinopathies , 2018, Movement disorders : official journal of the Movement Disorder Society.

[25]  Robert Suurmond,et al.  Introduction, comparison, and validation of Meta‐Essentials: A free and simple tool for meta‐analysis , 2017, Research synthesis methods.

[26]  S. Chong,et al.  Prevalence and associative factors of orthostatic hypotension in older adults: Results from the Well-being of the Singapore Elderly (WiSE) study. , 2017, Archives of gerontology and geriatrics.

[27]  F. Rodríguez‐Artalejo,et al.  Metabolic syndrome and insulin resistance are associated with frailty in older adults: a prospective cohort study , 2017, Age and ageing.

[28]  P. Abete,et al.  The Italian version of the “frailty index” based on deficits in health: a validation study , 2017, Aging Clinical and Experimental Research.

[29]  E. Vidal-Petiot,et al.  Orthostatic hypotension: A review. , 2017, Nephrologie & therapeutique.

[30]  F. Rodríguez‐Artalejo,et al.  Serum Leptin Concentration is Associated with Incident Frailty in Older Adults , 2017, Aging and disease.

[31]  L. Vanderlei,et al.  Can geometric indices of heart rate variability predict improvement in autonomic modulation after resistance training in chronic obstructive pulmonary disease? , 2017, Clinical physiology and functional imaging.

[32]  Hossam M. Hammady,et al.  Rayyan—a web and mobile app for systematic reviews , 2016, Systematic Reviews.

[33]  D. Beckwée,et al.  Frailty and the Prediction of Negative Health Outcomes: A Meta-Analysis. , 2016, Journal of the American Medical Directors Association.

[34]  G. Sergi,et al.  Inflammation and frailty in the elderly: A systematic review and meta-analysis , 2016, Ageing Research Reviews.

[35]  C. Cooper,et al.  Sarcopenia in daily practice: assessment and management , 2016, BMC Geriatrics.

[36]  E. Hoogendijk,et al.  Frailty measurement in research and clinical practice: A review. , 2016, European journal of internal medicine.

[37]  G. Sergi,et al.  Orthostatic Changes in Blood Pressure and Mortality in the Elderly: The Pro.V.A Study. , 2015, American journal of hypertension.

[38]  Bijan Najafi,et al.  Regulation of Cardiac Autonomic Nervous System Control across Frailty Statuses: A Systematic Review , 2015, Gerontology.

[39]  R. Kenny,et al.  Orthostatic hypotension, orthostatic intolerance and frailty: The Irish Longitudinal Study on Aging-TILDA. , 2015, Archives of gerontology and geriatrics.

[40]  R. Arena,et al.  Potential effect of 6 versus 12-weeks of physical training on cardiac autonomic function and exercise capacity in chronic obstructive pulmonary disease. , 2015, European journal of physical and rehabilitation medicine.

[41]  P. L. Katayama,et al.  Cardiac autonomic modulation in non-frail, pre-frail and frail elderly women: a pilot study , 2015, Aging Clinical and Experimental Research.

[42]  D. Mozaffarian,et al.  Physical Activity and Heart Rate Variability in Older Adults: The Cardiovascular Health Study , 2014, Circulation.

[43]  V. P. Chacko,et al.  Skeletal muscle ATP kinetics are impaired in frail mice , 2014, AGE.

[44]  Roy Bhaskar,et al.  Nonlinear Methods to Assess Changes in Heart Rate Variability in Type 2 Diabetic Patients , 2013, Arquivos brasileiros de cardiologia.

[45]  S. Iliffe,et al.  Frailty in elderly people , 2013, The Lancet.

[46]  R. Varadhan,et al.  Frailty status and altered glucose-insulin dynamics. , 2012, The journals of gerontology. Series A, Biological sciences and medical sciences.

[47]  R. Varadhan,et al.  Frailty status and altered dynamics of circulating energy metabolism hormones after oral glucose in older women , 2012, The journal of nutrition, health & aging.

[48]  Y. Schoon,et al.  Diastolic blood pressure drop after standing as a clinical sign for increased mortality in older falls clinic patients , 2012, Journal of hypertension.

[49]  K. Rockwood,et al.  Orthostatic hypotension (OH) and mortality in relation to age, blood pressure and frailty. , 2012, Archives of gerontology and geriatrics.

[50]  Robert L. Hester,et al.  Cardiovascular Responses to Exercise , 2011 .

[51]  B. Lawlor,et al.  Orthostatic haemodynamics may be impaired in frailty. , 2011, Age and ageing.

[52]  Qian-Li Xue,et al.  Prediction of risk of falling, physical disability, and frailty by rate of decline in grip strength: the women's health and aging study. , 2011, Archives of internal medicine.

[53]  Rose Anne Kenny,et al.  Continuous Noninvasive Orthostatic Blood Pressure Measurements and Their Relationship with Orthostatic Intolerance, Falls, and Frailty in Older People , 2011, Journal of the American Geriatrics Society.

[54]  Jens Jordan,et al.  Consensus statement on the definition of orthostatic hypotension, neurally mediated syncope and the postural tachycardia syndrome , 2011, Clinical Autonomic Research.

[55]  A. Moore,et al.  Polymorphisms in the Mitochondrial DNA Control Region and Frailty in Older Adults , 2010, PloS one.

[56]  J. Thayer,et al.  The relationship of autonomic imbalance, heart rate variability and cardiovascular disease risk factors. , 2010, International journal of cardiology.

[57]  A. Zygmunt,et al.  Methods of evaluation of autonomic nervous system function , 2010, Archives of medical science : AMS.

[58]  R. Varadhan,et al.  Relationships of cardiac, pulmonary, and muscle reserves and frailty to exercise capacity in older women. , 2010, The journals of gerontology. Series A, Biological sciences and medical sciences.

[59]  L. Ferrucci,et al.  Measuring systemic inflammatory regulation in older adults: evidence and utility. , 2009, Rejuvenation research.

[60]  Byron C. Wallace,et al.  Meta-Analyst: software for meta-analysis of binary, continuous and diagnostic data , 2009, BMC medical research methodology.

[61]  A. Kenny,et al.  The association between dehydroepiandosterone and frailty in older men and women. , 2009, Age and ageing.

[62]  R. Varadhan,et al.  Frailty and impaired cardiac autonomic control: new insights from principal components aggregation of traditional heart rate variability indices. , 2009, The journals of gerontology. Series A, Biological sciences and medical sciences.

[63]  M. Puig-Domingo,et al.  Effect of age and frailty on ghrelin and cholecystokinin responses to a meal test. , 2009, The American journal of clinical nutrition.

[64]  D. Lyons,et al.  Sitting and standing blood pressure measurements are not accurate for the diagnosis of orthostatic hypotension. , 2009, QJM : monthly journal of the Association of Physicians.

[65]  L. Fried,et al.  Is Hyperglycemia Associated with Frailty Status in Older Women? , 2009, Journal of the American Geriatrics Society.

[66]  Ravi Varadhan,et al.  Physiological Complexity Underlying Heart Rate Dynamics and Frailty Status in Community‐Dwelling Older Women , 2008, Journal of the American Geriatrics Society.

[67]  B. Levine,et al.  Dose-response relationship of endurance training for autonomic circulatory control in healthy seniors. , 2005, Journal of applied physiology.

[68]  R. Sheldon,et al.  Dissection of long-range heart rate variability: controlled induction of prognostic measures by activity in the laboratory. , 2004, Journal of the American College of Cardiology.

[69]  Daniel E Roach,et al.  Activity‐Responsive Pacing Produces Long‐Term Heart Rate Variability , 2004, Journal of cardiovascular electrophysiology.

[70]  J. Gerritsen,et al.  Measures of cardiovascular autonomic nervous function: agreement, reproducibility, and reference values in middle age and elderly subjects , 2003, Diabetologia.

[71]  L. Fried,et al.  Frailty in older adults: evidence for a phenotype. , 2001, The journals of gerontology. Series A, Biological sciences and medical sciences.

[72]  D Kromhout,et al.  Heart rate variability from short electrocardiographic recordings predicts mortality from all causes in middle-aged and elderly men. The Zutphen Study. , 1997, American journal of epidemiology.

[73]  J. Taylor,et al.  Exercise and aging: autonomic control of the circulation. , 1994, Medicine and science in sports and exercise.

[74]  A. Goldberger,et al.  Loss of 'complexity' and aging. Potential applications of fractals and chaos theory to senescence. , 1992, JAMA.

[75]  R. Cohen,et al.  Power spectrum analysis of heart rate fluctuation: a quantitative probe of beat-to-beat cardiovascular control. , 1981, Science.

[76]  Wei‐Ju Lee,et al.  Association Between Orthostatic Hypotension and Frailty in Hospitalized Older Patients: A Geriatric Syndrome More Than a Cardiovascular Condition , 2019, The journal of nutrition, health & aging.

[77]  K. Walsh,et al.  Autonomic dysfunction: Diagnosis and management. , 2019, Handbook of clinical neurology.

[78]  A. Moore,et al.  Association of mitochondrial DNA levels with frailty and all-cause mortality , 2014, Journal of Molecular Medicine.

[79]  M. Malik Heart rate variability. Standards of measurement, physiological interpretation, and clinical use. Task Force of the European Society of Cardiology and the North American Society of Pacing and Electrophysiology. , 1996, European heart journal.

[80]  B. Kingwell,et al.  Aging effects on human sympathetic neuronal function. , 1995, The American journal of physiology.