Joint Effect of Hostility and Severity of Depressive Symptoms on Plasma Interleukin‐6 Concentration

Objective: Although interleukin (IL)‐6 plays a significant role in cardiovascular disease, little is known about its relation to psychological risk factors, such as hostility and severity of depressive symptoms. The current study examined the joint effects of severity of depressive symptoms and hostility on plasma IL‐6 in a sample of 90 healthy, nonsmoking men. Methods: After an overnight fast, blood samples for plasma IL‐6 and fasting lipids were collected on the same day that the Beck Depression Inventory (BDI) and the Cook‐Medley hostility (Ho) scale were administered. Plasma IL‐6 was determined using enzymatic‐linked immunosorbent assay (ELISA). Results: Analyses of logarithmically normalized plasma IL‐6 adjusting for age, body mass index (BMI), fasting total cholesterol, high density lipoprotein (HDL), and resting diastolic blood pressure (DBP) revealed a significant BDI by Ho interaction (p = .026). Post hoc decomposition revealed that Ho was correlated with log‐normalized plasma IL‐6 (r = 0.59, p = .025) but only among men with BDI scores of 10 and above. Alternatively, BDI was correlated with log‐normalized plasma IL‐6 (r = 0.61, p = .003) but only among men with Ho scores of 23 and higher. Comparisons among BDI/Ho groups indicated that men with high scores on both the BDI and the Ho exhibited the highest median levels of plasma IL‐6. Conclusion: Hostile men who exhibited above normal levels of depressive symptoms had higher plasma levels of IL‐6 suggestive of a subpopulation at increased risk for future cardiac events.

[1]  C. Kuhn,et al.  The relation of aggression, hostility, and anger to lipopolysaccharide-stimulated tumor necrosis factor (TNF)-α by blood monocytes from normal men , 2002, Brain, Behavior, and Immunity.

[2]  M. Bourassa,et al.  Five-Year Risk of Cardiac Mortality in Relation to Initial Severity and One-Year Changes in Depression Symptoms After Myocardial Infarction , 2002, Circulation.

[3]  T. Kamarck,et al.  Covariation of Psychosocial Characteristics Associated With Cardiovascular Disease: Genetic and Environmental Influences , 2002, Psychosomatic medicine.

[4]  W. Rief,et al.  Immunological differences between patients with major depression and somatization syndrome , 2001, Psychiatry Research.

[5]  R. Balaban,et al.  Arterial wall MRI characteristics are associated with elevated serum markers of inflammation in humans , 2001, Journal of magnetic resonance imaging : JMRI.

[6]  U. Ikeda,et al.  Interleukin‐6 and acute coronary syndrome , 2001, Clinical cardiology.

[7]  P. Ridker,et al.  Blood Pressure and Inflammation in Apparently Healthy Men , 2001, Hypertension.

[8]  E. Zorrilla,et al.  The Relationship of Depression and Stressors to Immunological Assays: A Meta-Analytic Review , 2001, Brain, Behavior, and Immunity.

[9]  A Steptoe,et al.  Acute mental stress elicits delayed increases in circulating inflammatory cytokine levels. , 2001, Clinical science.

[10]  B. Penninx,et al.  Depression and cardiac mortality: results from a community-based longitudinal study. , 2001, Archives of general psychiatry.

[11]  C. Stoney,et al.  Plasma homocysteine concentrations are positively associated with hostility and anger. , 2000, Life sciences.

[12]  P. Ridker,et al.  Plasma concentration of interleukin-6 and the risk of future myocardial infarction among apparently healthy men. , 2000, Circulation.

[13]  R. Carney,et al.  Severe depression is associated with markedly reduced heart rate variability in patients with stable coronary heart disease. , 2000, Journal of psychosomatic research.

[14]  P. Ridker,et al.  C-reactive protein and other markers of inflammation in the prediction of cardiovascular disease in women. , 2000, The New England journal of medicine.

[15]  P. Reitsma,et al.  Elevated levels of homocysteine increase IL-6 production in monocytic Mono Mac 6 cells. , 2000, Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis.

[16]  S. Humphries,et al.  Inflammation, obesity, stress and coronary heart disease: is interleukin-6 the link? , 2000, Atherosclerosis.

[17]  Soo-Jung Lee,et al.  Psychological Stress May Induce Increased Humoral and Decreased Cellular Immunity , 2000, Behavioral medicine.

[18]  K. Buckwalter,et al.  Life stress, mood disturbance, and elevated interleukin-6 in healthy older women. , 1999, The journals of gerontology. Series A, Biological sciences and medical sciences.

[19]  M. McCarty.  Interleukin-6 as a central mediator of cardiovascular risk associated with chronic inflammation, smoking, diabetes, and visceral obesity: down-regulation with essential fatty acids, ethanol and pentoxifylline. , 1999, Medical hypotheses.

[20]  J. Blumenthal,et al.  Impact of psychological factors on the pathogenesis of cardiovascular disease and implications for therapy. , 1999, Circulation.

[21]  H. Cohen,et al.  Association of Interleukin‐6 and Other Biologic Variables with Depression in Older People Living in the Community , 1999, Journal of the American Geriatrics Society.

[22]  R. Ross,et al.  Atherosclerosis is an inflammatory disease. , 1998, American heart journal.

[23]  A. Sherwood,et al.  Hostility and adrenergic receptor responsiveness: evidence of reduced beta-receptor responsiveness in high hostile men. , 1998, Journal of psychosomatic research.

[24]  S. Schanberg,et al.  Neuroendocrine, Cardiovascular, and Emotional Responses of Hostile Men: The Role of Interpersonal Challenge , 1998, Psychosomatic medicine.

[25]  S. Schanberg,et al.  The Relationship Between Hostility and beta-Adrenergic Receptor Physiology in Healthy Young Males , 1997, Psychosomatic medicine.

[26]  H. Rus,et al.  Interleukin-6 and interleukin-8 protein and gene expression in human arterial atherosclerotic wall. , 1996, Atherosclerosis.

[27]  G. Felsten.  Hostility, stress and symptoms of depression , 1996 .

[28]  L. Kuller,et al.  Relation of C-reactive protein and coronary heart disease in the MRFIT nested case-control study. Multiple Risk Factor Intervention Trial. , 1996, American journal of epidemiology.

[29]  B. Barton.  The biological effects of interleukin 6 , 1996, Medicinal research reviews.

[30]  J. Weatherbee,et al.  Circadian characteristics of interleukin-6 in blood and urine of clinically healthy men. , 1995, In vivo.

[31]  H J Cohen,et al.  Variability of plasma IL-6 and crosslinked fibrin dimers over time in community dwelling elderly subjects. , 1994, American journal of clinical pathology.

[32]  P. Richter,et al.  PSYCHOMETRIC PROPERTIES OF THE BECK DEPRESSION INVENTORY , 1994 .

[33]  J. Manson,et al.  The primary prevention of myocardial infarction. , 1992, The New England journal of medicine.

[34]  J V Castell,et al.  Interleukin-6 and the acute phase response. , 1990, The Biochemical journal.

[35]  R B Williams,et al.  Situational determinants of cardiovascular and emotional reactivity in high and low hostile men. , 1989, Psychosomatic medicine.

[36]  Philip C. Kendall,et al.  Issues and recommendations regarding use of the Beck Depression Inventory , 1987, Cognitive Therapy and Research.

[37]  R. Plomin,et al.  "Covariation of psychosocial characteristics associated with cardiovascular disease: Genetic and environmental influences": Comment , 2002 .

[38]  P. Shapiro,et al.  Depression and the course of coronary artery disease. , 1998, The American journal of psychiatry.

[39]  U. Ikeda,et al.  Interleukin 6 gene transcripts are expressed in human atherosclerotic lesions. , 1994, Cytokine.

[40]  A. Buss,et al.  The aggression questionnaire. , 1992, Journal of personality and social psychology.

[41]  N. Sartorius,et al.  Assessment of Depression , 1986, Springer Berlin Heidelberg.

[42]  T. W. Smith,et al.  What's so unhealthy about hostility? Construct validity and psychosocial correlates of the Cook and Medley Ho scale. , 1985, Health psychology : official journal of the Division of Health Psychology, American Psychological Association.

[43]  A. Beck,et al.  Psychometric properties of the Beck Depression Inventory: Twenty-five years of evaluation , 1988 .

[44]  Walter W. Cook,et al.  Proposed hostility and Pharisaic-virtue scales for the MMPI. , 1954 .