A tale of coronary artery disease and myocardial infarction.

In this review of heart disease, Nabel and Braunwald focus on two themes — coronary artery disease and myocardial infarction — and explain how our understanding has evolved over the past two centuries. The authors consider therapies that have led to improved survival.

[1]  J. LeLorier,et al.  Intensive versus moderate lipid lowering with statins after acute coronary syndromes. , 2004, The New England journal of medicine.

[2]  Kenneth R Chien,et al.  Regeneration next: toward heart stem cell therapeutics. , 2009, Cell stem cell.

[3]  S. Russell,et al.  Advanced heart failure treated with continuous-flow left ventricular assist device. , 2009, The New England journal of medicine.

[4]  A. Endo,et al.  The discovery and development of HMG-CoA reductase inhibitors. , 1992, Journal of lipid research.

[5]  Børge G Nordestgaard,et al.  Reduction in C-reactive protein and LDL cholesterol and cardiovascular event rates after initiation of rosuvastatin: a prospective study of the JUPITER trial , 2009, The Lancet.

[6]  Wojciech Zareba,et al.  Prophylactic implantation of a defibrillator in patients with myocardial infarction and reduced ejection fraction. , 2002, The New England journal of medicine.

[7]  J O'Keefe,et al.  A Comparison of Immediate Angioplasty with Thrombolytic Therapy for Acute Myocardial Infarction , 1993 .

[8]  W. Siegenthaler,et al.  Nonoperative dilatation of coronary-artery stenosis: percutaneous transluminal coronary angioplasty. , 1979, The New England journal of medicine.

[9]  C. Mahaim.  [Catheterization of the right heart]. , 1961, Praxis.

[10]  J. Slattery,et al.  Randomised trial of cholesterol lowering in 4444 patients with coronary heart disease: the Scandinavian Simvastatin Survival Study (4S). 1994. , 1994, Atherosclerosis. Supplements.

[11]  Richard M Weinshilboum,et al.  Genomics and drug response. , 2011, The New England journal of medicine.

[12]  T. Sanborn,et al.  The history of interventional cardiology: cardiac catheterization, angioplasty, and related interventions. , 1995, American heart journal.

[13]  J. Hare,et al.  Mesenchymal stem cells: biology, pathophysiology, translational findings, and therapeutic implications for cardiac disease. , 2011, Circulation research.

[14]  R. Furchgott,et al.  The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine , 1980, Nature.

[15]  W. Porter.  On the Results of Ligation of the Coronary Arteries , 1893, The Journal of physiology.

[16]  E. J. Brown,et al.  Effect of captopril on mortality and morbidity in patients with left ventricular dysfunction after myocardial infarction. Results of the survival and ventricular enlargement trial. The SAVE Investigators. , 1992, The New England journal of medicine.

[17]  M. Pfeffer,et al.  C-reactive protein levels and outcomes after statin therapy. , 2005, The New England journal of medicine.

[18]  Stephen Colagiuri,et al.  Grand challenges in chronic non-communicable diseases , 2007, Nature.

[19]  J. Covell,et al.  Factors Influencing Infarct Size Following Experimental Coronary Artery Occlusions , 1971, Circulation.

[20]  J. Burkhardt,et al.  Interventional Electrophysiology and Cardiac Resynchronization Therapy: Delivering Electrical Therapies for Heart Failure , 2007, Circulation.

[21]  J. Herrick.  CLINICAL FEATURES OF SUDDEN OBSTRUCTION OF THE CORONARY ARTERIES , 1912 .

[22]  Bridget B. Kelly,et al.  Promoting Cardiovascular Health in the Developing World: A Critical Challenge to Achieve Global Health , 2010 .

[23]  J. Warren.  Remarks on angina pectoris. , 1962, The New England journal of medicine.

[24]  J A McWilliam,et al.  Cardiac Failure and Sudden Death , 1889, British medical journal.

[25]  E. Antman,et al.  Cytochrome p-450 polymorphisms and response to clopidogrel. , 2009, The New England journal of medicine.

[26]  S. Sarić.  [Catheterization of the right heart]. , 1955, Lijecnicki vjesnik.

[27]  E. Nabel.  Cardiovascular disease , 2000, Nature Biotechnology.

[28]  T. Farag.  Familial hypercholesterolemia. , 1988, Journal of the Royal Society of Medicine.

[29]  C. Peterson.  A comparison of immediate angioplasty with thrombolytic therapy for acute myocardial infarction: Grines CL, Browne KF, Marco J, et al. N Engl J Med 328:673–679 Mar 1993 , 1993 .

[30]  Scandinavian Simvastatin Survival Study Group.  Randomised trial of cholesterol lowering in 4444 patients with coronary heart disease: the Scandinavian Simvastatin Survival Study (4S) , 1994, The Lancet.

[31]  J. Goldstein,et al.  History of Discovery The LDL Receptor , 2009 .

[32]  E. Veys,et al.  HL-A AND INFECTIVE SACROILEITIS , 1974 .

[33]  R. Ross.  The pathogenesis of atherosclerosis: a perspective for the 1990s , 1993, Nature.

[34]  T. Lancet.  The Global Alliance for Chronic Diseases , 2009, The Lancet.

[35]  D. Julian.  Treatment of cardiac arrest in acute myocardial ischaemia and infarction. , 1961, Lancet.

[36]  B. Davis,et al.  The effect of pravastatin on coronary events after myocardial infarction in patients with average cholesterol levels. Cholesterol and Recurrent Events Trial investigators. , 1996, The New England journal of medicine.

[37]  André Cournand,et al.  Catheterization of the Right Auricle in Man , 1941 .

[38]  C. Scriver,et al.  The Metabolic and Molecular Bases of Inherited Disease, 8th Edition 2001 , 2001, Journal of Inherited Metabolic Disease.

[39]  L. Bolognese,et al.  RANDOMISED TRIAL OF INTRAVENOUS STREPTOKINASE, ORAL ASPIRIN, BOTH, OR NEITHER AMONG 17 187 CASES OF SUSPECTED ACUTE MYOCARDIAL INFARCTION: ISIS-2 , 1988, The Lancet.

[40]  R. Ross.  The pathogenesis of atherosclerosis--an update. , 1986, The New England journal of medicine.

[41]  Shih-Chieh Chang,et al.  Images in clinical medicine. Acute mesenteric infarction associated with atrial fibrillation. , 2011, The New England journal of medicine.

[42]  Holger Gerhardt,et al.  Basic and Therapeutic Aspects of Angiogenesis , 2011, Cell.

[43]  Robert M. Rapoport,et al.  Endothelium-dependent relaxation in rat aorta may be mediated through cyclic GMP-dependent protein phosphorylation , 1983, Nature.

[44]  D. Scholtens,et al.  The Hemostatic System as a Modulator of Atherosclerosis , 2011 .

[45]  B. Gersh.  Safety of Anacetrapib in Patients with or at High Risk for Coronary Heart Disease , 2011 .

[46]  P. Libby,et al.  Progress and challenges in translating the biology of atherosclerosis , 2011, Nature.

[47]  Paul Burton,et al.  Rivaroxaban in patients with a recent acute coronary syndrome. , 2012, The New England journal of medicine.

[48]  J. Goldstein,et al.  The LDL receptor. , 2009, Arteriosclerosis, thrombosis, and vascular biology.

[49]  M. Silverman.  William heberden and some account of a disorder of the breast , 1987, Clinical cardiology.

[50]  HOMAS,et al.  The Effect of Pravastatin on Coronary Events after Myocardial Infarction in Patients with Average Cholesterol Levels , 2000 .

[51]  J. T. Wearn.  THROMBOSIS OF THE CORONARY ARTERIES, WITH INFARCTION OF THE HEART , 1923 .

[52]  M. Davies,et al.  Pathology of acute myocardial infarction with particular reference to occlusive coronary thrombi. , 1976, British heart journal.

[53]  G. Blaise.  Endothelium derived relaxing factor/nitric oxide , 1992, Canadian journal of anaesthesia = Journal canadien d'anesthesie.

[54]  E. Nabel,et al.  Genomics of cardiovascular disease. , 2011, The New England journal of medicine.

[55]  J. H. Gibbon,et al.  Application of a mechanical heart and lung apparatus to cardiac surgery. , 1954, Minnesota medicine.

[56]  P. Ganz,et al.  Paradoxical vasoconstriction induced by acetylcholine in atherosclerotic coronary arteries. , 1986, The New England journal of medicine.

[57]  W. Kannel,et al.  Factors of risk in the development of coronary heart disease--six year follow-up experience. The Framingham Study. , 1961, Annals of internal medicine.

[58]  P. Serruys,et al.  Intravascular Ultrasound Findings in the Multicenter, Randomized, Double-Blind RAVEL (RAndomized study with the sirolimus-eluting VElocity balloon-expandable stent in the treatment of patients with de novo native coronary artery Lesions) Trial , 2002, Circulation.

[59]  K. Musunuru,et al.  Stem cell models of cardiac development and disease. , 2010, Annual review of cell and developmental biology.

[60]  J. Goldstein,et al.  A Receptor‐Mediated Pathway for Cholesterol Homeostasis (Nobel Lecture) , 1986 .

[61]  Chazov Ei,et al.  Intracoronary administration of fibrinolysin in acute myocardial infarct , 1976 .

[62]  Werner Forssmann,et al.  Die Sondierung des Rechten Herzens , 1929, Klinische Wochenschrift.

[63]  F. Sones,et al.  Cine-coronary arteriography. , 1962, The Ohio State medical journal.

[64]  Barry Greenberg,et al.  Calcium Upregulation by Percutaneous Administration of Gene Therapy in Cardiac Disease (CUPID): A Phase 2 Trial of Intracoronary Gene Therapy of Sarcoplasmic Reticulum Ca2+-ATPase in Patients With Advanced Heart Failure , 2011, Circulation.