论文信息 - A population pharmacokinetic‐pharmacodynamic analysis and model validation of azimilide

A population pharmacokinetic‐pharmacodynamic analysis and model validation of azimilide

Pharmacokinetic (PK) and pharmacodynamic (PD) models for azimilide were developed and validated with sparse blood sampling and QTc interval data obtained during three clinical trials of azimilide for prevention of supraventricular arrhythmia recurrence.

[1] A. Corey,et al. Pharmacokinetics and Pharmacodynamics following Intravenous Doses of Azimilide Dihydrochloride , 1999, Journal of clinical pharmacology.

[2] G. Reeder. Heart Disease: A Textbook of Cardiovascular Medicine , 1984 .

[3] J. Knoben,et al. "Handbook of clinical drug data". , 1983, Canadian Medical Association journal.

[4] M. H. Gault,et al. Prediction of creatinine clearance from serum creatinine. , 1975, Nephron.

[5] S. Connolly,et al. Antiarrhythmic effects of azimilide in atrial fibrillation: efficacy and dose-response. Azimilide Supraventricular Arrhythmia Program 3 (SVA-3) Investigators. , 2000, Journal of the American College of Cardiology.

[6] R. Brooks,et al. Azimilide dihydrochloride, a novel antiarrhythmic agent. , 1998, The American journal of cardiology.

[7] G. Thompson,et al. Azimilide Pharmacokinetics following Intravenous and Oral Administration of a Solution and Capsule Formulation , 1999, Journal of clinical pharmacology.

[8] A. Corey,et al. Azimilide pharmacokinetics and pharmacodynamics upon multiple oral dosing , 1999, Biopharmaceutics & drug disposition.