Proliferative verrucous leukoplakia: A diagnostic dilemma

Oral leukoplakia is one of the most common potentially malignant disorders of the oral cavity. Many variants of oral leukoplakia exist, with oral proliferative verrucous leukoplakia (OPVL) being one. OPVL, a slow growing, long-term progressive lesion was first described in 1985 by Hansen et al. It is an aggressive form of oral leukoplakia with multifocal presentation, high rates of malignant transformation and recurrence. It is a rare clinico-pathological entity, which remains an enigma even today. The term proliferative verrucous leukoplakia (PVL) has been the subject of an ongoing discussion with regard to its definition. Its etiology too remains unclear until date. Tobacco use does not seem to have a significant influence on the appearance or progression of PVL. These lesions are known to occur in both smokers and nonsmokers. In the light of current information available, this article describes the etiology, clinical aspects, histological features, and various diagnostic criteria of OPVL.

[1]  Namdeo Prabhu,et al.  Oral proliferative verrucous leukoplakia: A case report with an update , 2013, Contemporary clinical dentistry.

[2]  J. Bagan,et al.  Proliferative verrucous leukoplakia: a proposal for diagnostic criteria. , 2010, Medicina oral, patologia oral y cirugia bucal.

[3]  S. Warnakulasuriya.  Global epidemiology of oral and oropharyngeal cancer. , 2009, Oral oncology.

[4]  Isaäc van der Waal,et al.  Potentially malignant disorders of the oral and oropharyngeal mucosa; terminology, classification and present concepts of management , 2009 .

[5]  B. Casto,et al.  Frequent Alterations of p16INK4a and p14ARF in Oral Proliferative Verrucous Leukoplakia , 2008, Cancer Epidemiology Biomarkers & Prevention.

[6]  A. Giovanini,et al.  Oral proliferative verrucous leukoplakia (PVL) in a post-bone marrow transplant patient. , 2008, Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation.

[7]  I. van der Waal,et al.  Oral proliferative verrucous leukoplakia revisited. , 2008, Oral oncology.

[8]  E. Turatti,et al.  Potentially malignant epithelial oral lesions: discrepancies between clinical and histological diagnosis. , 2008, Oral diseases.

[9]  C. Scully,et al.  Epstein-Barr virus in oral proliferative verrucous leukoplakia and squamous cell carcinoma: A preliminary study. , 2008, Medicina oral, patologia oral y cirugia bucal.

[10]  S. Warnakulasuriya,et al.  Nomenclature and classification of potentially malignant disorders of the oral mucosa. , 2007, Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology.

[11]  R. Brannon,et al.  Proliferative verrucous leukoplakia: an aggressive form of oral leukoplakia. , 2004, Journal of dental hygiene : JDH.

[12]  C. Scully,et al.  Proliferative verrucous leukoplakia: unusual locations of oral squamous cell carcinomas, and field cancerization as shown by the appearance of multiple OSCCs. , 2004, Oral oncology.

[13]  R. Zain,et al.  Aggressive, multifocal oral verrucous leukoplakia: proliferative verrucous leukoplakia or not? , 2003, Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology.

[14]  C. Scully,et al.  Proliferative verrucous leukoplakia: high incidence of gingival squamous cell carcinoma. , 2003, Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology.

[15]  C. Ostwald,et al.  Human papillomavirus 6/11, 16 and 18 in oral carcinomas and benign oral lesions , 2003, Medical Microbiology and Immunology.

[16]  M. Pogrel,et al.  Proliferative verrucous leukoplakia of the gingiva. , 2000, Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics.

[17]  K. Schepman,et al.  Malignant transformation of oral leukoplakia: a follow-up study of a hospital-based population of 166 patients with oral leukoplakia from The Netherlands. , 1998, Oral oncology.

[18]  M. Gorsky,et al.  Proliferative verrucous leukoplakia: a follow-up study of 54 cases. , 1997, Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics.

[19]  F. Praetorius,et al.  HPV-associated diseases of oral mucosa. , 1997, Clinics in dermatology.

[20]  P. Speight,et al.  Proliferative verrucous leukoplakia: a report of ten cases. , 1996, Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics.

[21]  S. Silverman,et al.  Proliferative verrucous leukoplakia: A long-term study of thirty patients , 1985 .

[22]  Hongmei Zhou,et al.  Case report of rapidly progressive proliferative verrucous leukoplakia and a proposal for aetiology in mainland China. , 2011, World journal of surgical oncology.

[23]  N. Gale,et al.  Epithelial precursor lesions , 2005 .