Light-emitting diodes--Their potential in biomedical applications

The rapid development of high brightness light-emitting diodes (LEDs) makes feasible the use of LEDs, among other light sources (such as laser, intense pulse light and other incoherent light systems), for medical treatment and light therapy. This paper provides a general review on red, green, blue, ultraviolet LED applications in photo rejuvenation and medical treatments of a variety of physical abnormalities, as well as the relief of stress, circadian rhythm disorders, and seasonal affective disorder. The review, concentrated in the papers published after 1990, intends to show that LEDs are well qualified to succeed its more energy demanding counterparts in the named areas and beyond.

[1]  M. Trelles.  Phototherapy in anti‐aging and its photobiologic basics: a new approach to skin rejuvenation , 2006, Journal of cosmetic dermatology.

[2]  M. Trelles,et al.  Red light‐emitting diode (LED) therapy accelerates wound healing post‐blepharoplasty and periocular laser ablative resurfacing , 2006, Journal of cosmetic and laser therapy : official publication of the European Society for Laser Dermatology.

[3]  A M Kligman,et al.  Ultraviolet phototherapy and photochemotherapy of acne vulgaris. , 1978, Archives of dermatology.

[4]  K. Moraes,et al.  Cellular and molecular studies of the initial process of the photodynamic therapy in HEp‐2 cells using LED light source and two different photosensitizers , 2009, Cell biology international.

[5]  Rina Das,et al.  Effect of NASA light-emitting diode irradiation on molecular changes for wound healing in diabetic mice. , 2003, Journal of clinical laser medicine & surgery.

[6]  Walter W. Hauck,et al.  Light Therapy for Seasonal Affective Disorder with Blue Narrow-Band Light-Emitting Diodes (LEDs) , 2006, Biological Psychiatry.

[7]  A. Kligman,et al.  Sunburn protection by longwave ultraviolet radiation-induced pigmentation. , 1978, Archives of dermatology.

[8]  Harry T. Whelan,et al.  NASA light emitting diode medical applications from deep space to deep sea , 2001 .

[9]  Rina Das,et al.  Clinical and experimental applications of NIR-LED photobiomodulation. , 2006, Photomedicine and laser surgery.

[10]  Y. Finkelstein,et al.  Narrow-band red light phototherapy in perennial allergic rhinitis and nasal polyposis. , 1997, Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology.

[11]  A. Pentland,et al.  Effects of Continuous‐Wave (670‐nm) Red Light on Wound Healing , 2008, Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.].

[12]  Noel T. Whelan,et al.  Effect of NASA light-emitting diode irradiation on wound healing. , 2001, Journal of clinical laser medicine & surgery.

[13]  Vanderlei Salvador Bagnato,et al.  Photobiomodulation on the angiogenesis of skin wounds in rats using different light sources. , 2007, Photomedicine and laser surgery.

[14]  P. Papageorgiou,et al.  Phototherapy with blue (415 nm) and red (660 nm) light in the treatment of acne vulgaris , 2000, The British journal of dermatology.

[15]  R. Cremer,et al.  Influence of light on the hyperbilirubinaemia of infants. , 1958, Lancet.

[16]  E. Munin,et al.  Comparative analysis of coherent light action (laser) versus non-coherent light (light-emitting diode) for tissue repair in diabetic rats , 2009, Lasers in Medical Science.

[17]  J. Lucey,et al.  Prevention of hyperbilirubinemia of prematurity by phototherapy. , 1968, Pediatrics.

[18]  Seung Yoon Lee,et al.  Blue and red light combination LED phototherapy for acne vulgaris in patients with skin phototype IV , 2007, Lasers in surgery and medicine.

[19]  A. Kligman,et al.  The acute effects of long-wave ultraviolet radiation on human skin. , 1979, The Journal of investigative dermatology.

[20]  Misook Kim,et al.  The anti‐inflammatory mechanism of 635 nm light‐emitting‐diode irradiation compared with existing COX inhibitors , 2007, Lasers in surgery and medicine.

[21]  H. Friedmann,et al.  A reasonable mechanism for visible light-induced skin rejuvenation , 2007, Lasers in Medical Science.

[22]  F. Eduardo,et al.  LED phototherapy to prevent mucositis: a case report. , 2008, Photomedicine and laser surgery.

[23]  A. Knulst,et al.  Phototherapy of acne vulgaris with visible light. , 1997, Dermatology.

[24]  K. Jandt,et al.  Light-emitting diode (LED) polymerisation of dental composites: flexural properties and polymerisation potential. , 2000, Biomaterials.

[25]  Naichia Yeh,et al.  High-brightness LEDs—Energy efficient lighting sources and their potential in indoor plant cultivation , 2009 .

[26]  R. Cremer,et al.  INFLUENCE OF LIGHT ON THE HYPERBILIRUBINÆMIA OF INFANTS , 1958 .

[27]  C. Enwemeka,et al.  Phototherapy improves healing of chronic venous ulcers. , 2009, Photomedicine and laser surgery.

[28]  S. Mordon,et al.  Facial rejuvenation and light: our personal experience , 2007, Lasers in Medical Science.

[29]  J. Emens,et al.  The circadian basis of winter depression. , 2006, Proceedings of the National Academy of Sciences of the United States of America.

[30]  M. Wong-Riley,et al.  DARPA Soldier Self Care: Rapid Healing of Laser Eye Injuries with Light Emitting Diode Technology , 2004 .

[31]  M. Landthaler,et al.  Split‐face‐study using two different light sources for topical PDT of actinic keratoses:non‐inferiority of the LED system , 2007, Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG.