Copper-62 ATSM as a hypoxic tissue tracer in myocardial ischemia

Copper-62 labeled diacetyl-bis (N4-methylthiosemicarbazone) (62Cu-ATSM) has been proposed as a generator produced positron-emitting tracer for hypoxic tissue imaging. To clarify the usefulness of62Cu-ATSM for myocardial ischemia,62Cu-ATSM PET was performed in 7 patients with coronary artery disease. Increased myocardial uptake of62Cu-ATSM was observed (myocardium/blood ratio: 3.09) in one patient with unstable angina, who had increased18F-fluorodeoxyglucose (18F-FDG) uptake under the fasting condition. The other 6 patients, who were clinically stable, did not have increased62Cu-ATSM uptake, although abnormal18F-FDG uptake was seen in 4 patients. This preliminary study suggests that62Cu-ATSM is a promising PET tracer for hypoxic imaging in acute ischemia.

[1]  C. Dence,et al.  Myocardial kinetics of fluorine-18 misonidazole: a marker of hypoxic myocardium. , 1989, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

[2]  M. Graham,et al.  Noninvasive detection of hypoxic myocardium using fluorine-18-fluoromisonidazole and positron emission tomography. , 1992, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

[3]  A. Nunn,et al.  TcO(PnA.O-1-(2-nitroimidazole)) [BMS-181321], a new technetium-containing nitroimidazole complex for imaging hypoxia: synthesis, characterization, and xanthine oxidase-catalyzed reduction. , 1994, Journal of medicinal chemistry.

[4]  J. D. Chapman,et al.  Characteristics of the metabolism-induced binding of misonidazole to hypoxic mammalian cells. , 1983, Cancer research.

[5]  N. Sadato,et al.  Evaluation of62Cu labeled diacetyl-bis(N4-methylthiosemicarbazone) as a hypoxic tissue tracer in patients with lung cancer , 2000 .

[6]  John M. Hoffman,et al.  Binding of the hypoxia tracer [3H]misonidazole in cerebral ischemia. , 1987, Stroke.

[7]  A. Sinusas,et al.  Technetium-99m-nitroimidazole (BMS181321): a positive imaging agent for detecting myocardial ischemia. , 1995, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

[8]  E. Braunwald,et al.  Reversible ischemic left ventricular dysfunction: evidence for the "hibernating myocardium". , 1986, Journal of the American College of Cardiology.

[9]  J. D. Chapman,et al.  Radioiodinated 1-(5-iodo-5-deoxy-beta-D-arabinofuranosyl)-2-nitroimidazole (iodoazomycin arabinoside: IAZA): a novel marker of tissue hypoxia. , 1991, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

[10]  C. H. Bayley,et al.  THE PREPARATION OF SOME THIOSEMICARBAZONES AND THEIR COPPER COMPLEXES: PART III , 1960 .

[11]  T G Turkington,et al.  Performance characteristics of a whole-body PET scanner. , 1994, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

[12]  Y. Yonekura,et al.  Differential mechanism of retention of Cu-pyruvaldehyde-bis(N4-methylthiosemicarbazone) (Cu-PTSM) by brain and tumor: A novel radiopharmaceutical for positron emission tomography imaging , 1995 .

[13]  Y Yonekura,et al.  Copper-62-ATSM: a new hypoxia imaging agent with high membrane permeability and low redox potential. , 1997, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

[14]  Y. Yonekura,et al.  Application of the new zinc-62/copper-62 generator: an effective labeling method for 62Cu-PTSM. , 1992, International journal of radiation applications and instrumentation. Part B, Nuclear medicine and biology.

[15]  T W Griffin,et al.  Imaging of hypoxia in human tumors with [F-18]fluoromisonidazole. , 1992, International journal of radiation oncology, biology, physics.

[16]  Y. Yonekura,et al.  Comparative studies of Cu-64-ATSM and C-11-acetate in an acute myocardial infarction model: ex vivo imaging of hypoxia in rats. , 1999, Nuclear medicine and biology.

[17]  Y. Yonekura,et al.  Reciprocal ST-segment depression associated with exercise-induced ST-segment elevation indicates residual viability after myocardial infarction. , 1999, Journal of the American College of Cardiology.

[18]  K. Krohn,et al.  Characterization of iodovinylmisonidazole as a marker for myocardial hypoxia. , 1993, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.