Pharmacology: The Influence of the Neuropeptide Galanin on the Contractility and the Effective Refractory Period of Guinea‐pig Heart Papillary Muscle Under Normoxic and Hypoxic Conditions

The aim of this study was to discover the effects of galanin, a neuropeptide comprising 29 amino acids capable of activating inward‐rectifier K+ channels (IK1) in cardiomyocytes, on the force of contraction (Fc), velocity of contraction (+dF/dt), velocity of relaxation (—dF/dt) and effective refractory period (ERP) of guinea‐pig heart. The influence of galanin on the time‐course of hypoxia‐induced disturbances in contractility and ERP was also examined. Experiments were performed on the isolated right ventricle papillary muscle of guinea‐pig heart.

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