Ssu72 phosphatase is essential for thermogenic adaptation by regulating cytosolic translation

[1]  C. Lindskog,et al.  A human adipose tissue cell-type transcriptome atlas. , 2022, Cell reports.

[2]  P. Seale,et al.  Adipose-tissue plasticity in health and disease , 2022, Cell.

[3]  Hyun-Soo Kim,et al.  Mammalian Ssu72 phosphatase preferentially considers tissue-specific actively transcribed gene expression by regulating RNA Pol II transcription , 2022, Theranostics.

[4]  Hyun-Soo Kim,et al.  Ssu72-HNF4α signaling axis classify the transition from steatohepatitis to hepatocellular carcinoma , 2021, Cell Death & Differentiation.

[5]  M. Surette,et al.  Lower brown adipose tissue activity is associated with non-alcoholic fatty liver disease but not changes in the gut microbiota , 2021, Cell reports. Medicine.

[6]  E. Yi,et al.  Ssu72 phosphatase directly binds to ZAP-70, thereby providing fine-tuning of TCR signaling and preventing spontaneous inflammation , 2021, Proceedings of the National Academy of Sciences.

[7]  P. Gao,et al.  The Role of Brown Adipose Tissue Dysfunction in the Development of Cardiovascular Disease , 2021, Frontiers in Endocrinology.

[8]  Ho Lee,et al.  Ssu72 is a T-cell receptor-responsive modifier that is indispensable for regulatory T cells , 2021, Cellular & Molecular Immunology.

[9]  P. Puigserver,et al.  A cold-stress-inducible PERK/OGT axis controls TOM70-assisted mitochondrial protein import and cristae formation. , 2021, Cell metabolism.

[10]  A. Mark,et al.  Brown adipose tissue is associated with cardiometabolic health , 2021, Nature Medicine.

[11]  J. Teodoro,et al.  Mitohormesis , 2021, Mitochondrial Physiology and Vegetal Molecules.

[12]  Y. Jeon,et al.  Ssu72 regulates alveolar macrophage development and allergic airway inflammation by fine tuning of GM-CSF receptor signaling. , 2020, The Journal of allergy and clinical immunology.

[13]  K. Ikeda,et al.  UCP1 Dependent and Independent Thermogenesis in Brown and Beige Adipocytes , 2020, Frontiers in Endocrinology.

[14]  Robert W. Taylor,et al.  Mitochondrial OXPHOS Biogenesis: Co-Regulation of Protein Synthesis, Import, and Assembly Pathways , 2020, International journal of molecular sciences.

[15]  Katsuaki Sato,et al.  ER-resident sensor PERK is essential for mitochondrial thermogenesis in brown adipose tissue , 2020, Life Science Alliance.

[16]  A. Bartelt,et al.  Proteostasis in thermogenesis and obesity , 2019, Biological chemistry.

[17]  J. Kingdom,et al.  Noncanonical mitochondrial unfolded protein response impairs placental oxidative phosphorylation in early-onset preeclampsia , 2019, Proceedings of the National Academy of Sciences.

[18]  B. Habermann,et al.  Mitochondrial fusion is required for regulation of mitochondrial DNA replication , 2019, PLoS genetics.

[19]  P. Puigserver,et al.  ER and Nutrient Stress Promote Assembly of Respiratory Chain Supercomplexes through the PERK-eIF2α Axis. , 2019, Molecular cell.

[20]  F. Gribble,et al.  Inactivation of Ppp1r15a minimises weight gain and insulin resistance during caloric excess in female mice , 2019, Scientific Reports.

[21]  B. Spiegelman,et al.  New Advances in Adaptive Thermogenesis: UCP1 and Beyond. , 2019, Cell metabolism.

[22]  S. Steensels,et al.  Fatty acid activation in thermogenic adipose tissue. , 2019, Biochimica et biophysica acta. Molecular and cell biology of lipids.

[23]  D. Ron,et al.  Early Events in the Endoplasmic Reticulum Unfolded Protein Response. , 2018, Cold Spring Harbor perspectives in biology.

[24]  Aditi Jain,et al.  Systematic evaluation of the adaptability of the non-radioactive SUnSET assay to measure cardiac protein synthesis , 2018, Scientific Reports.

[25]  R. L. Wiseman,et al.  The PERK Arm of the Unfolded Protein Response Regulates Mitochondrial Morphology during Acute Endoplasmic Reticulum Stress , 2018, Cell reports.

[26]  S. Kajimura,et al.  The Common and Distinct Features of Brown and Beige Adipocytes , 2018, Trends in Endocrinology & Metabolism.

[27]  S. Enerbäck,et al.  Targeting thermogenesis in brown fat and muscle to treat obesity and metabolic disease , 2018, Nature Reviews Endocrinology.

[28]  Oliver T. Bruns,et al.  Brown adipose tissue thermogenic adaptation requires Nrf1-mediated proteasomal activity , 2018, Nature Medicine.

[29]  Cole M. Haynes,et al.  The mitochondrial UPR: mechanisms, physiological functions and implications in ageing , 2017, Nature Reviews Molecular Cell Biology.

[30]  Kim Schneider,et al.  Coping with Protein Quality Control Failure. , 2017, Annual review of cell and developmental biology.

[31]  Kinyui A. Lo,et al.  Dynamic transcriptome changes during adipose tissue energy expenditure reveal critical roles for long noncoding RNA regulators , 2017, PLoS biology.

[32]  J. Keaney,et al.  Mitochondrial retrograde signaling connects respiratory capacity to thermogenic gene expression , 2017, Scientific Reports.

[33]  R. Wiesner,et al.  CLPP coordinates mitoribosomal assembly through the regulation of ERAL1 levels , 2016, The EMBO journal.

[34]  S. Oeljeklaus,et al.  Mitochondrial Protein Synthesis Adapts to Influx of Nuclear-Encoded Protein , 2016, Cell.

[35]  L. Sidossis,et al.  Brown Adipose Tissue Activation Is Linked to Distinct Systemic Effects on Lipid Metabolism in Humans. , 2016, Cell metabolism.

[36]  S. Kajimura,et al.  Transcriptional and epigenetic control of brown and beige adipose cell fate and function , 2016, Nature Reviews Molecular Cell Biology.

[37]  L. S. Churchman,et al.  Synchronized mitochondrial and cytosolic translation programs , 2016, Nature.

[38]  D. Guertin,et al.  Emerging Complexities in Adipocyte Origins and Identity. , 2016, Trends in cell biology.

[39]  P. Pitule,et al.  Mitochondria in White, Brown, and Beige Adipocytes , 2016, Stem cells international.

[40]  B. Nair,et al.  Down-regulation of the mitochondrial matrix peptidase ClpP in muscle cells causes mitochondrial dysfunction and decreases cell proliferation. , 2016, Free radical biology & medicine.

[41]  Randal J. Kaufman,et al.  Protein misfolding in the endoplasmic reticulum as a conduit to human disease , 2016, Nature.

[42]  Hyun-Soo Kim,et al.  Hepatocyte homeostasis for chromosome ploidization and liver function is regulated by Ssu72 protein phosphatase , 2016, Hepatology.

[43]  M. Kaneko,et al.  IRE1α-XBP1 is a novel branch in the transcriptional regulation of Ucp1 in brown adipocytes , 2015, Scientific Reports.

[44]  Bruce M. Spiegelman,et al.  Brown and Beige Fat: Physiological Roles beyond Heat Generation. , 2015, Cell metabolism.

[45]  K. Isobe,et al.  GADD34-deficient mice develop obesity, nonalcoholic fatty liver disease, hepatic carcinoma and insulin resistance , 2015, Scientific Reports.

[46]  M. Cooper,et al.  Role of Energy Metabolism in the Brown Fat Gene Program , 2015, Front. Endocrinol..

[47]  J. Speakman,et al.  Brown Adipose Tissue Transplantation Reverses Obesity in Ob/Ob Mice. , 2015, Endocrinology.

[48]  L. Sidossis,et al.  Brown and beige fat in humans: thermogenic adipocytes that control energy and glucose homeostasis. , 2015, The Journal of clinical investigation.

[49]  J. Ellis,et al.  Adipose fatty acid oxidation is required for thermogenesis and potentiates oxidative stress-induced inflammation. , 2015, Cell reports.

[50]  A. Doria,et al.  Activation of human brown adipose tissue by a β3-adrenergic receptor agonist. , 2015, Cell metabolism.

[51]  William Dieckmann,et al.  Temperature-Acclimated Brown Adipose Tissue Modulates Insulin Sensitivity in Humans , 2014, Diabetes.

[52]  Clark R. Andersen,et al.  Brown Adipose Tissue Improves Whole-Body Glucose Homeostasis and Insulin Sensitivity in Humans , 2014, Diabetes.

[53]  D. Ron,et al.  Hypothalamic eIF2α signaling regulates food intake. , 2014, Cell reports.

[54]  Dalwoong Choi,et al.  Recent advance in brown adipose physiology and its therapeutic potential , 2014, Experimental & Molecular Medicine.

[55]  D. Ron,et al.  Hypothalamic eIF2 alpha signaling regulates food intake , 2014 .

[56]  Xiaolei Jin,et al.  Redox regulation of mitochondrial function with emphasis on cysteine oxidation reactions , 2013, Redox biology.

[57]  J. Heeren,et al.  Adipose tissue browning and metabolic health , 2014, Nature Reviews Endocrinology.

[58]  A. Vidal-Puig,et al.  Regulation of glucose homoeostasis by brown adipose tissue. , 2013, The lancet. Diabetes & endocrinology.

[59]  P. Seale,et al.  Brown and beige fat: development, function and therapeutic potential , 2013, Nature Medicine.

[60]  K. Horie-Inoue,et al.  A stabilizing factor for mitochondrial respiratory supercomplex assembly regulates energy metabolism in muscle , 2013, Nature Communications.

[61]  J. Speakman,et al.  Brown adipose tissue transplantation improves whole-body energy metabolism , 2013, Cell Research.

[62]  David G Hendrickson,et al.  Differential analysis of gene regulation at transcript resolution with RNA-seq , 2012, Nature Biotechnology.

[63]  Cole M. Haynes,et al.  Mitochondrial Import Efficiency of ATFS-1 Regulates Mitochondrial UPR Activation , 2012, Science.

[64]  F. Haj,et al.  Protein Tyrosine Phosphatase 1B Deficiency Potentiates PERK/eIF2α Signaling in Brown Adipocytes , 2012, PloS one.

[65]  D. Piston,et al.  Reversal of Type 1 Diabetes in Mice by Brown Adipose Tissue Transplant , 2012, Diabetes.

[66]  A. Carpentier,et al.  Brown adipose tissue oxidative metabolism contributes to energy expenditure during acute cold exposure in humans. , 2012, The Journal of clinical investigation.

[67]  Pierre-Étienne Jacques,et al.  A universal RNA polymerase II CTD cycle is orchestrated by complex interplays between kinase, phosphatase, and isomerase enzymes along genes. , 2012, Molecular cell.

[68]  P. Walter,et al.  The Unfolded Protein Response: From Stress Pathway to Homeostatic Regulation , 2011, Science.

[69]  W. D. van Marken Lichtenbelt,et al.  Brown Adipose Tissue in Morbidly Obese Subjects , 2011, PloS one.

[70]  Oliver T. Bruns,et al.  Brown adipose tissue activity controls triglyceride clearance , 2011, Nature Medicine.

[71]  Jan Nedergaard,et al.  Nonshivering thermogenesis and its adequate measurement in metabolic studies , 2011, Journal of Experimental Biology.

[72]  W. D. van Marken Lichtenbelt,et al.  Cold-activated brown adipose tissue in healthy men. , 2009, The New England journal of medicine.

[73]  E. Ravussin,et al.  The role of mitochondria in health and disease. , 2009, Current opinion in pharmacology.

[74]  Philippe Pierre,et al.  SUnSET, a nonradioactive method to monitor protein synthesis , 2009, Nature Methods.

[75]  B. Spiegelman,et al.  Modulation of PGC-1 Coactivator Pathways in Brown Fat Differentiation through LRP130* , 2008, Journal of Biological Chemistry.

[76]  D. Ron,et al.  Dephosphorylation of translation initiation factor 2alpha enhances glucose tolerance and attenuates hepatosteatosis in mice. , 2008, Cell metabolism.

[77]  M. Czech,et al.  Adipocyte dysfunctions linking obesity to insulin resistance and type 2 diabetes , 2008, Nature Reviews Molecular Cell Biology.

[78]  L. Samavati,et al.  Regulation of mitochondrial oxidative phosphorylation through cell signaling. , 2007, Biochimica et biophysica acta.

[79]  T. Anthony,et al.  Coping with stress: eIF2 kinases and translational control. , 2006, Biochemical Society transactions.

[80]  E. Chevet,et al.  Protein-tyrosine Phosphatase 1B Potentiates IRE1 Signaling during Endoplasmic Reticulum Stress* , 2004, Journal of Biological Chemistry.

[81]  L. Glimcher,et al.  Endoplasmic Reticulum Stress Links Obesity, Insulin Action, and Type 2 Diabetes , 2004, Science.

[82]  Michael Hampsey,et al.  Ssu72 Is an RNA polymerase II CTD phosphatase. , 2004, Molecular cell.

[83]  D. Lewin,et al.  Cold elicits the simultaneous induction of fatty acid synthesis and β‐oxidation in murine brown adipose tissue: prediction from differential gene expression and confirmation in vivo , 2002, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[84]  Thomas D. Schmittgen,et al.  Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. , 2001, Methods.