Widespread Pressure Pain Hypersensitivity, Health History, and Trigger Points in Patients with Chronic Neck Pain: A Preliminary Study.

BACKGROUND Pain sensitivity in chronic neck pain patients may be influenced by health conditions related to higher levels of widespread pressure pain hypersensitivity (sensitization). Trigger points have also been reported to play a role in the sensitization process. OBJECTIVES To investigate the association between pressure pain thresholds, trigger points, and health conditions in patients with chronic neck pain. DESIGN Original research, preliminary study. SETTING A private clinic. SUBJECTS Thirty-four chronic mechanical neck pain patients and 34 chronic whiplash-associated neck pain patients, giving a final sample of 68 chronic neck pain patients. METHODS Patients underwent an assessment of pressure pain thresholds over the upper trapezius, extensor carpi radialis longus, and tibialis anterior muscles and were screened for the presence of trigger points in the upper trapezius muscle. Further, information about health history conditions was obtained and collected in a form. RESULTS Significantly negative correlations between all pressure pain thresholds and duration of health history conditions were found (all P < 0.02). Significantly lower pressure pain thresholds (all P < 0.01) were found in patients with active trigger points as compared with those with latent trigger points. CONCLUSION Widespread pressure pain hypersensitivity was associated with duration of health history conditions, suggesting that long-lasting health complaints may act as a triggering/perpetuating factor, driving sensitization in individuals with chronic neck pain. Active trigger points may be associated with higher widespread pressure hypersensitivity.

[1]  L. Arendt-Nielsen,et al.  Identification of subgroups of patients with tension type headache with higher widespread pressure pain hyperalgesia , 2017, The Journal of Headache and Pain.

[2]  R. La Touche,et al.  Widespread Pressure Pain Hyperalgesia in Chronic Nonspecific Neck Pain with Neuropathic Features: A Descriptive Cross-Sectional Study. , 2016, Pain physician.

[3]  C. Fernández‐de‐las‐Peñas,et al.  Prevalence of Myofascial Trigger Points in Spinal Disorders: A Systematic Review and Meta-Analysis. , 2016, Archives of physical medicine and rehabilitation.

[4]  L. Arendt-Nielsen,et al.  A mechanism‐based pain sensitivity index to characterize knee osteoarthritis patients with different disease stages and pain levels , 2015, European journal of pain.

[5]  B. Cagnie,et al.  Lack of evidence for central sensitization in idiopathic, non-traumatic neck pain: a systematic review. , 2015, Pain physician.

[6]  A. Ferrari,et al.  Medication overuse and chronic migraine: a critical review according to clinical pharmacology , 2015, Expert opinion on drug metabolism & toxicology.

[7]  L. Arendt-Nielsen,et al.  MTPs are a peripheral source of nociception. , 2015, Pain medicine.

[8]  G. Wallen,et al.  233) Temporal summation testing provides evidence for increased pain sensitivity and central sensitization in sickle cell anemia , 2015 .

[9]  L. Arendt-Nielsen,et al.  Presurgical assessment of temporal summation of pain predicts the development of chronic postoperative pain 12 months after total knee replacement , 2015, Pain.

[10]  J. Van Oosterwijck,et al.  Evidence for central sensitization in patients with osteoarthritis pain: A systematic literature review , 2014, European journal of pain.

[11]  D. Beckwée,et al.  Applying modern pain neuroscience in clinical practice: criteria for the classification of central sensitization pain. , 2014, Pain physician.

[12]  L Arendt-Nielsen,et al.  Facilitation of pain sensitization in knee osteoarthritis and persistent post‐operative pain: A cross‐sectional study , 2014, European journal of pain.

[13]  L. Arendt-Nielsen,et al.  Pain evoked by distension of the uterine cervix in women with dysmenorrhea: evidence for central sensitization , 2014, Acta obstetricia et gynecologica Scandinavica.

[14]  Rachelle Buchbinder,et al.  The global burden of low back pain: estimates from the Global Burden of Disease 2010 study , 2014, Annals of the rheumatic diseases.

[15]  T. Vos,et al.  The global burden of neck pain: estimates from the Global Burden of Disease 2010 study , 2014, Annals of the rheumatic diseases.

[16]  R. Baron,et al.  Peripheral input and its importance for central sensitization , 2013, Annals of neurology.

[17]  T. Willems,et al.  Central sensitization in urogynecological chronic pelvic pain: a systematic literature review. , 2013, Pain physician.

[18]  L. Arendt-Nielsen,et al.  Normalization of widespread pressure pain hypersensitivity after total hip replacement in patients with hip osteoarthritis is associated with clinical and functional improvements. , 2013, Arthritis and rheumatism.

[19]  C. Graversen,et al.  Quantitative Sensory Testing Predicts Pregabalin Efficacy in Painful Chronic Pancreatitis , 2013, PloS one.

[20]  Bernadette A. Thomas,et al.  Years lived with disability (YLDs) for 1160 sequelae of 289 diseases and injuries 1990–2010: a systematic analysis for the Global Burden of Disease Study 2010 , 2012, The Lancet.

[21]  C. Cescon,et al.  Intra-rater reliability of an experienced physiotherapist in locating myofascial trigger points in upper trapezius muscle , 2012, The Journal of manual & manipulative therapy.

[22]  A. Johnson,et al.  Aldosterone Acting through the Central Nervous System Sensitizes Angiotensin Ii-induced Hypertension , 2022 .

[23]  F. Wolfe,et al.  Diagnosis and diagnostic tests for fibromyalgia (syndrome). , 2012, Reumatismo.

[24]  L. Arendt-Nielsen,et al.  Normalization of widespread hyperesthesia and facilitated spatial summation of deep-tissue pain in knee osteoarthritis patients after knee replacement. , 2012, Arthritis and rheumatism.

[25]  M. Monticone,et al.  Development of the Italian Version of the Neck Disability Index: Cross-cultural Adaptation, Factor Analysis, Reliability, Validity, and Sensitivity to Change , 2012, Spine.

[26]  R. Jensen,et al.  Pain perception is altered in patients with medication-overuse headache but can improve after detoxification , 2012, The Journal of Headache and Pain.

[27]  Nikolai Bogduk,et al.  The Role of Tissue Damage in Whiplash-Associated Disorders: Discussion Paper 1 , 2011, Spine.

[28]  M. Arroyo-Morales,et al.  Changes in pain and pressure pain sensitivity after manual treatment of active trigger points in patients with unilateral shoulder impingement: a case series. , 2011, Journal of bodywork and movement therapies.

[29]  R. Teasell,et al.  Reliability, standard error, and minimum detectable change of clinical pressure pain threshold testing in people with and without acute neck pain. , 2011, The Journal of orthopaedic and sports physical therapy.

[30]  J. Bruce,et al.  Chronic Post Surgical Pain , 2011, Reviews in pain.

[31]  C. Terwee,et al.  Measurement properties of disease-specific questionnaires in patients with neck pain: a systematic review , 2011, Quality of Life Research.

[32]  C. Fernández‐de‐las‐Peñas,et al.  Myofascial trigger points: spontaneous electrical activity and its consequences for pain induction and propagation , 2011, Chinese medicine.

[33]  C. Woolf.  Central sensitization: Implications for the diagnosis and treatment of pain , 2011, PAIN.

[34]  T. Hedberg,et al.  Central sensitization and Ca(V)α₂δ ligands in chronic pain syndromes: pathologic processes and pharmacologic effect. , 2010, The journal of pain : official journal of the American Pain Society.

[35]  Lars Arendt-Nielsen,et al.  Assessment of mechanisms in localized and widespread musculoskeletal pain , 2010, Nature Reviews Rheumatology.

[36]  J. Miangolarra-Page,et al.  Exploration of somatosensory impairments in subjects with mechanical idiopathic neck pain: a preliminary study. , 2010, Journal of manipulative and physiological therapeutics.

[37]  S. Evers,et al.  Clinical features, pathophysiology, and treatment of medication-overuse headache , 2010, The Lancet Neurology.

[38]  M. Sterling,et al.  Sensory hypoaesthesia is a feature of chronic whiplash but not chronic idiopathic neck pain. , 2010, Manual therapy.

[39]  D. Price,et al.  The mechanisms of manual therapy in the treatment of musculoskeletal pain: a comprehensive model. , 2009, Manual therapy.

[40]  L. Arendt-Nielsen,et al.  Widespread Mechanical Pain Hypersensitivity as Sign of Central Sensitization in Unilateral Epicondylalgia: A Blinded, Controlled Study , 2009, The Clinical journal of pain.

[41]  H. Kehlet,et al.  Chronic post-thoracotomy pain: a critical review of pathogenic mechanisms and strategies for prevention. , 2009, European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery.

[42]  L. Arendt-Nielsen,et al.  Bilateral widespread mechanical pain sensitivity in carpal tunnel syndrome: evidence of central processing in unilateral neuropathy. , 2009, Brain : a journal of neurology.

[43]  C. Goldsmith,et al.  Measurement properties of the neck disability index: a systematic review. , 2009, The Journal of orthopaedic and sports physical therapy.

[44]  M. Freeman,et al.  Journal of Brachial Plexus and Peripheral Nerve Injury Chronic Whiplash and Central Sensitization; an Evaluation of the Role of a Myofascial Trigger Points in Pain Modulation , 2022 .

[45]  Linda J. Carroll,et al.  Course and Prognostic Factors for Neck Pain in Workers: Results of the Bone and Joint Decade 2000–2010 Task Force on Neck Pain and Its Associated Disorders , 2008, Spine.

[46]  Scott Haldeman,et al.  The Burden and Determinants of Neck Pain in Workers: Results of the Bone and Joint Decade 2000–2010 Task Force on Neck Pain and Its Associated Disorders , 2008, Spine.

[47]  J. Fritz,et al.  Preliminary Examination of a Proposed Treatment-Based Classification System for Patients Receiving Physical Therapy Interventions for Neck Pain , 2007, Physical Therapy.

[48]  J. C. Miangolarra,et al.  Myofascial trigger points in subjects presenting with mechanical neck pain: a blinded, controlled study. , 2007, Manual therapy.

[49]  P. M. Lang,et al.  Sensory neuropathy and signs of central sensitization in patients with peripheral arterial disease , 2006, Pain.

[50]  R. Jensen,et al.  Generalized Hyperalgesia in Patients With Chronic Tension-Type Headache , 2006, Cephalalgia : an international journal of headache.

[51]  D. Price,et al.  Peripheral and central contributions to hyperalgesia in irritable bowel syndrome. , 2006, The journal of pain : official journal of the American Pain Society.

[52]  J. Kenardy,et al.  Physical and psychological factors maintain long-term predictive capacity post-whiplash injury , 2006, PAIN.

[53]  Martin S. Angst,et al.  Opioid-induced Hyperalgesia: A Qualitative Systematic Review , 2006, Anesthesiology.

[54]  L. Gerber,et al.  An in vivo microanalytical technique for measuring the local biochemical milieu of human skeletal muscle. , 2005, Journal of applied physiology.

[55]  J. Dommerholt.  Persistent myalgia following whiplash , 2005, Current pain and headache reports.

[56]  Michele Sterling,et al.  Widespread Sensory Hypersensitivity Is a Feature of Chronic Whiplash-Associated Disorder but not Chronic Idiopathic Neck Pain , 2005, The Clinical journal of pain.

[57]  S. Svebak,et al.  Analgesic overuse among subjects with headache, neck, and low-back pain , 2004, Neurology.

[58]  J. Kenardy,et al.  Sensory hypersensitivity occurs soon after whiplash injury and is associated with poor recovery , 2003, Pain.

[59]  P. Dayer,et al.  Neurophysiologic evidence for a central sensitization in patients with fibromyalgia. , 2003, Arthritis and rheumatism.

[60]  J C Arezzo,et al.  Quantitative sensory testing , 2003, Neurology.

[61]  L. Arendt-Nielsen,et al.  Peripheral and central sensitization in musculoskeletal pain disorders: An experimental approach , 2002, Current rheumatology reports.

[62]  Lex M Bouter,et al.  Cost-of-illness of neck pain in The Netherlands in 1996 , 1999, Pain.

[63]  W. Spitzer,et al.  Scientific monograph of the Quebec Task Force on Whiplash-Associated Disorders: redefining "whiplash" and its management. , 1995, Spine.

[64]  T. Sand,et al.  Neck Pain in the General Population , 1994, Spine.

[65]  Gunilla Brattberg,et al.  The prevalence of pain in a general population. The results of a postal survey in a county of Sweden , 1989, Pain.

[66]  L. Gerber,et al.  Biochemicals associated with pain and inflammation are elevated in sites near to and remote from active myofascial trigger points. , 2008, Archives of physical medicine and rehabilitation.

[67]  John D. Childs,et al.  Psychometric properties of the Neck Disability Index and Numeric Pain Rating Scale in patients with mechanical neck pain. , 2008, Archives of physical medicine and rehabilitation.

[68]  J. Ylinen.  Pressure algometry. , 2007, The Australian journal of physiotherapy.