Pericyte physiology

Endothelial cells are the primary physical barrier between blood and tissue in microvessels. The other capillary and post‐capillary venule wall cell is the pericyte. The literature on the biology of endothelium is appreciable but less is known about pericytes. Pericytes are morphologically, biochemically, and physiologically heterogeneous. Some of pericyte functional characteristics observed in vivo and in vitro are that they: regulate endothelial proliferation and differentiation; contract in manners that either exacerbate or stem endothelial cell functional inflammatory leakage; function as a progenitor cell; synthesize and secrete a wide variety of vasoactive autoregulating agonists; synthesize and release structural constituents of the basement membrane and extracellular matrix. Pericytes are also involved in specific microvascular diseases. This review focuses principally on nonmesangial pericytes and specific activities such as the posttranslational, short‐term responses that affect microvascular perfusion and permeability, and on pericyte‐endothelial cell interaction.—Shepro, D., Morel, N. M. L. Pericyte physiology. FASEB J. 7: 1031‐1038; 1993.

[1]  H. Hechtman,et al.  Pericyte Modulation of Tubular Formation and Cytoskeletal Actin Distribution in Pulmonary Microvessel Endothelial Cells , 1993 .

[2]  S. Wakui.  Epidermal growth factor receptor at endothelial cell and pericyte interdigitation in human granulation tissue. , 1992, Microvascular research.

[3]  D. Schuschke,et al.  Differentiation of light-dye effects in the microcirculation. , 1992, Microvascular research.

[4]  M. Wiederholt,et al.  Membrane potentials in retinal capillary pericytes: excitability and effect of vasoactive substances. , 1992, Investigative ophthalmology & visual science.

[5]  F. Pugliese,et al.  Signal transduction in mesangial cells. , 1992, Journal of the American Society of Nephrology : JASN.

[6]  Y. Wang,et al.  Cellular signaling by endothelin peptides: pathways to the nucleus. , 1992, Journal of the American Society of Nephrology : JASN.

[7]  D. Lorich,et al.  The pericyte as a possible osteoblast progenitor cell. , 1992, Clinical orthopaedics and related research.

[8]  D. R. Anderson,et al.  Effects of cholinergic and adrenergic agonists on adenylate cyclase activity of retinal microvascular pericytes in culture. , 1992, Investigative ophthalmology & visual science.

[9]  T. Oite,et al.  Modulation of mesangial cell proliferation by endothelial cells in coculture. , 1991, The American journal of pathology.

[10]  T. Miyakawa,et al.  Observations of Microvessels in the Brain with Alzheimer's Disease by the Scanning Electron Microscopy , 1991, The Japanese journal of psychiatry and neurology.

[11]  A. Miura,et al.  Biochemical characterization of contractile proteins of rat cultured mesangial cells. , 1991, Kidney international.

[12]  B. Coomber.  Cytoskeleton in TFG-β- and bFGF-modulated endothelial monolayer repair , 1991 .

[13]  L. Raij,et al.  The glomerular mesangium: role in initiation and progression of renal injury. , 1991, American journal of kidney diseases : the official journal of the National Kidney Foundation.

[14]  V Nehls,et al.  Heterogeneity of microvascular pericytes for smooth muscle type alpha- actin , 1991, The Journal of cell biology.

[15]  M. Miyazato,et al.  Growth Characteristics of Retinal Capillary Endothelial Cells Compared with Pulmonary Vein Endothelial Cells in Culture , 1991, Acta pathologica japonica.

[16]  D. Sims.  Recent advances in pericyte biology--implications for health and disease. , 1991, The Canadian journal of cardiology.

[17]  D. R. Anderson,et al.  Cholinergic binding sites in pericytes isolated from retinal capillaries. , 1991, Blood vessels.

[18]  H. Hechtman,et al.  Microvascular endothelial-derived autacoids regulate pericyte contractility. , 1991, Cell motility and the cytoskeleton.

[19]  M. Kan,et al.  Bifunctional effects of transforming growth factor-β (TGF-β) on endothelial cell growth correlate with phenotypes of TGF-β binding sites , 1990 .

[20]  H. Holthöfer,et al.  Identification of specific glomerular cell types in culture by use of lectin and antibody binding. , 1990, Cell differentiation and development : the official journal of the International Society of Developmental Biologists.

[21]  T. Allen,et al.  Modulation of extracellular matrix biosynthesis by bovine retinal pericytes in vitro: effects of the substratum and cell density. , 1990, Journal of cell science.

[22]  B. Engelhardt,et al.  Immune function of the blood-brain barrier: incomplete presentation of protein (auto-)antigens by rat brain microvascular endothelium in vitro , 1990, The Journal of cell biology.

[23]  S Ferrone,et al.  Expression of the high molecular weight melanoma-associated antigen by pericytes during angiogenesis in tumors and in healing wounds. , 1989, The American journal of pathology.

[24]  P. D’Amore.  Culture and Study of Pericytes , 1990 .

[25]  R. Wagner,et al.  Morphometric changes in pericyte-capillary endothelial cell associations correlated with vasoactive stimulus. , 1990, Microcirculation, endothelium, and lymphatics.

[26]  M. Dunn,et al.  Physiology of the mesangial cell. , 1989, Physiological reviews.

[27]  D. Rifkin,et al.  Inhibition of endothelial cell movement by pericytes and smooth muscle cells: activation of a latent transforming growth factor-beta 1-like molecule by plasmin during co-culture , 1989, The Journal of cell biology.

[28]  Sandra R. Smith,et al.  An activated form of transforming growth factor beta is produced by cocultures of endothelial cells and pericytes. , 1989, Proceedings of the National Academy of Sciences of the United States of America.

[29]  J. Rhodin,et al.  Capillary growth in the mesentery of normal young rats. Intravital video and electron microscope analyses. , 1989, Journal of submicroscopic cytology and pathology.

[30]  S. Tasca,et al.  Culture of pericytes isolated from rat adipose microvasculature and characterization of their prostanoid production. , 1988, Cell biology international reports.

[31]  G. Hudes,et al.  Prostacyclin is the major prostaglandin synthesized by bovine retinal capillary pericytes in culture. , 1988, Investigative ophthalmology & visual science.

[32]  R. Cannon,et al.  "Microvascular angina" as a cause of chest pain with angiographically normal coronary arteries. , 1988, The American journal of cardiology.

[33]  G. King,et al.  A monoclonal antibody (3G5)-defined ganglioside antigen is expressed on the cell surface of microvascular pericytes , 1988, The Journal of experimental medicine.

[34]  I. Herman,et al.  In situ analysis of microvascular pericytes in hypertensive rat brains. , 1988, Tissue & cell.

[35]  M. P. Carson,et al.  Junctional transfer of small molecules in cultured bovine brain microvascular endothelial cells and pericytes. , 1987, Microvascular research.

[36]  P A D'Amore,et al.  Inhibition of capillary endothelial cell growth by pericytes and smooth muscle cells , 1987, The Journal of cell biology.

[37]  I. Herman,et al.  Characterization of microvascular cell cultures from normotensive and hypertensive rat brains: pericyte-endothelial cell interactions in vitro. , 1987, Tissue & cell.

[38]  R. M. Hays,et al.  Contraction and relaxation of cultured mesangial cells on a silicone rubber surface. , 1986, Kidney international.

[39]  A. Schor,et al.  The isolation and culture of endothelial cells and pericytes from the bovine retinal microvasculature: a comparative study with large vessel vascular cells. , 1986, Microvascular research.

[40]  I. Herman,et al.  Microvascular pericytes contain muscle and nonmuscle actins , 1985, The Journal of cell biology.

[41]  N. Joyce,et al.  Contractile proteins in pericytes. II. Immunocytochemical evidence for the presence of two isomyosins in graded concentrations , 1985, The Journal of cell biology.

[42]  N. Joyce,et al.  Contractile proteins in pericytes. I. Immunoperoxidase localization of tropomyosin , 1985, The Journal of cell biology.

[43]  N. Joyce,et al.  Pericytes, like vascular smooth muscle cells, are immunocytochemically positive for cyclic GMP-dependent protein kinase. , 1984, Microvascular research.

[44]  J. Gitlin,et al.  Culture of retinal capillary cells using selective growth media. , 1983, Microvascular research.

[45]  C. Kilo,et al.  Pericyte-endothelial relationships in cardiac and skeletal muscle capillaries. , 1979, Microvascular research.

[46]  T. Murad,et al.  Role of the pericyte in wound healing. An ultrastructural study. , 1970, Experimental and molecular pathology.