Polycyclic aromatic hydrocarbon-DNA adducts in humans: relevance as biomarkers for exposure and cancer risk.

[1]  D. Phillips,et al.  Smoking-associated bulky DNA adducts in bronchial tissue related to CYP1A1 MspI and GSTM1 genotypes in lung patients. , 1998, Carcinogenesis.

[2]  H. Bartsch,et al.  High benzo[a]pyrene diol-epoxide DNA adduct levels in lung and blood cells from individuals with combined CYP1A1 MspI/Msp-GSTM1*0/*0 genotypes. , 1998, Pharmacogenetics.

[3]  R. Baan,et al.  The use of benzo[a]pyrene diolepoxide-modified DNA standards for adduct quantification in 32P-postlabelling to assess exposure to polycyclic aromatic hydrocarbons: application in a biomonitoring study. , 1997, Mutation research.

[4]  L. V. van't Veer,et al.  32P-postlabelling of aromatic DNA adducts in white blood cells and alveolar macrophages of smokers: saturation at high exposures. , 1997, Mutation research.

[5]  D. Phillips Detection of DNA modifications by the 32P-postlabelling assay. , 1997, Mutation research.

[6]  J. Lewtas,et al.  Air pollution exposure-DNA adduct dosimetry in humans and rodents: evidence for non-linearity at high doses. , 1997, Mutation research.

[7]  F P Perera,et al.  Contribution of genetic and nutritional factors to DNA damage in heavy smokers. , 1997, Carcinogenesis.

[8]  Yu-jing Zhang,et al.  Immunoperoxidase quantitation of 4-aminobiphenyl- and polycyclic aromatic hydrocarbon-DNA adducts in exfoliated oral and urothelial cells of smokers and nonsmokers. , 1997, Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology.

[9]  F. Perera,et al.  Aromatic DNA adducts in foundry workers in relation to exposure, life style and CYP1A1 and glutathione transferase M1 genotype. , 1997, Carcinogenesis.

[10]  S. Parodi,et al.  Detection of DNA adducts in human nasal mucosa tissue by 32P-postlabeling analysis. , 1997, Carcinogenesis.

[11]  M. Tang,et al.  Preferential Formation of Benzo[a]pyrene Adducts at Lung Cancer Mutational Hotspots in P53 , 1996, Science.

[12]  D. Phillips,et al.  p53 mutations in lung tumours: relationship to gender and lung DNA adduct levels. , 1996, Carcinogenesis.

[13]  H. Bartsch,et al.  Evidence of anti-benzo[a]pyrene diolepoxide-DNA adduct formation in human colon mucosa. , 1996, Carcinogenesis.

[14]  J. Kleinjans,et al.  Enhanced DNA damage in heart tissue of cigarette smokers , 1996 .

[15]  P. S. Nielsen,et al.  Comparative synchronous fluorescence spectrophotometry and 32P-postlabeling analysis of PAH-DNA adducts in human lung and the relationship to TP53 mutations. , 1996, Mutation research.

[16]  P. S. Nielsen,et al.  Biomonitoring of diesel exhaust-exposed workers. DNA and hemoglobin adducts and urinary 1-hydroxypyrene as markers of exposure. , 1996, Toxicology letters.

[17]  H. Bartsch DNA adducts in human carcinogenesis: etiological relevance and structure-activity relationship. , 1996, Mutation research.

[18]  P. S. Nielsen,et al.  Environmental air pollution and DNA adducts in Copenhagen bus drivers--effect of GSTM1 and NAT2 genotypes on adduct levels. , 1996, Carcinogenesis.

[19]  H. Bartsch,et al.  The role of individual susceptibility in cancer burden related to environmental exposure. , 1996, Environmental health perspectives.

[20]  J. Lewtas,et al.  Biomarker studies in northern Bohemia. , 1996, Environmental health perspectives.

[21]  R. Santella,et al.  A sensitive color ELISA for detecting polycyclic aromatic hydrocarbon-DNA adducts in human tissues. , 1996, Mutation research.

[22]  Donghui Li,et al.  Aromatic DNA adducts in adjacent tissues of breast cancer patients: clues to breast cancer etiology. , 1996, Cancer research.

[23]  K. Hemminki,et al.  Seasonal variation of DNA adduct pattern in human lymphocytes analyzed by 32P-HPLC. , 1996, Carcinogenesis.

[24]  E. Mark,et al.  Correlation of DNA adducts in blood mononuclear cells with tobacco carcinogen-induced damage in human lung. , 1995, Cancer research.

[25]  N. Rothman,et al.  The impact of glutathione s‐transferase M1 and cytochrome P450 1A1 genotypes on white‐blood‐cell polycyclic aromatic hydrocarbon‐dna adduct levels in humans , 1995, Molecular carcinogenesis.

[26]  T B Cooper,et al.  Decline of DNA damage and other biomarkers in peripheral blood following smoking cessation. , 1995, Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology.

[27]  E. Bowman,et al.  Human Lung Carcinogen—DNA Adduct Levels Mediated by Genetic Polymorphisms In Vivo , 1995 .

[28]  F P Perera,et al.  A molecular epidemiological case-control study of lung cancer. , 1995, Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology.

[29]  H. Bartsch,et al.  Anti-benzo[a]pyrene diolepoxide--DNA adduct levels in peripheral mononuclear cells from coke oven workers and the enhancing effect of smoking. , 1995, Carcinogenesis.

[30]  B S Schwartz,et al.  Interindividual differences in the concentration of 1-hydroxypyrene-glucuronide in urine and polycyclic aromatic hydrocarbon-DNA adducts in peripheral white blood cells after charbroiled beef consumption. , 1995, Carcinogenesis.

[31]  J. Lewtas,et al.  DNA adducts and personal air monitoring of carcinogenic polycyclic aromatic hydrocarbons in an environmentally exposed population. , 1995, Carcinogenesis.

[32]  F. Perera,et al.  Polycyclic aromatic hydrocarbon-DNA and protein adducts in coal tar treated patients and controls and their relationship to glutathione S-transferase genotype. , 1995, Mutation research.

[33]  F. Perera,et al.  Immunohistochemical quantitation of polycyclic aromatic hydrocarbon-DNA adducts in human lymphocytes. , 1995, Cancer research.

[34]  N. J. Jones,et al.  Development of a human biomonitoring assay using buccal mucosa: comparison of smoking-related DNA adducts in mucosa versus biopsies. , 1995, Cancer research.

[35]  J. Lewtas,et al.  Cancer biomarkers in human atherosclerotic lesions: detection of DNA adducts. , 1995, Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology.

[36]  F J van Schooten,et al.  Polycyclic aromatic hydrocarbon-DNA adducts in white blood cell DNA and 1-hydroxypyrene in the urine from aluminum workers: relation with job category and synergistic effect of smoking. , 1995, Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology.

[37]  C. Vahrenholz,et al.  Risk estimation in coke-oven workers by determining some biomarkers of carcinogen exposure. , 1995, Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie.

[38]  H. Bartsch,et al.  Metabolic polymorphism affecting DNA binding and excretion of carcinogens in humans. , 1995, Pharmacogenetics.

[39]  F. Perera,et al.  Carcinogen-DNA adducts and gene mutation in foundry workers with low-level exposure to polycyclic aromatic hydrocarbons. , 1994, Carcinogenesis.

[40]  D. Phillips,et al.  Different susceptibility to smoking-induced DNA damage among male and female lung cancer patients. , 1994, Cancer research.

[41]  F. Perera,et al.  Polycyclic aromatic hydrocarbon-DNA adducts in smokers and their relationship to micronutrient levels and the glutathione-S-transferase M1 genotype. , 1994, Carcinogenesis.

[42]  K. Hemminki,et al.  Aromatic DNA adducts in larynx biopsies and leukocytes. , 1994, Carcinogenesis.

[43]  F. Guengerich,et al.  Metabolic activation and carcinogen-DNA adduct detection in human larynx. , 1994, Cancer research.

[44]  K. Hemminki,et al.  Aromatic DNA adducts, micronuclei and genetic polymorphism for CYP1A1 and GST1 in chimney sweeps. , 1994, Carcinogenesis.

[45]  D. Ryberg,et al.  p53 mutations in lung tumors: relationship to putative susceptibility markers for cancer. , 1994, Cancer research.

[46]  H. Bartsch,et al.  Validation of a new fluorometric assay for benzo[a]pyrene diolepoxide-DNA adducts in human white blood cells: comparisons with 32P-postlabeling and ELISA. , 1994, Carcinogenesis.

[47]  M. Poirier,et al.  Human exposure monitoring, dosimetry, and cancer risk assessment: the use of antisera specific for carcinogen-DNA adducts and carcinogen-modified DNA. , 1994, Drug metabolism reviews.

[48]  K. Randerath,et al.  32P-postlabeling methods for DNA adduct detection: overview and critical evaluation. , 1994, Drug metabolism reviews.

[49]  K. Hemminki,et al.  Seasonal variation of aromatic DNA adducts in human lymphocytes and granulocytes. , 1993, Carcinogenesis.

[50]  A. Miller,et al.  Are female smokers at higher risk for lung cancer than male smokers? A case-control analysis by histologic type. , 1993, American journal of epidemiology.

[51]  E. Bowman,et al.  Polycyclic aromatic hydrocarbon-DNA adducts in human lung and cancer susceptibility genes. , 1993, Cancer research.

[52]  P. Vodicka,et al.  Optimization of an HPLC method for analyses of 32P-postlabeled DNA adducts. , 1993, Carcinogenesis.

[53]  M. Poirier Antisera specific for carcinogen-DNA adducts and carcinogen-modified DNA: applications for detection of xenobiotics in biological samples. , 1993, Mutation research.

[54]  D P Ford,et al.  Contribution of occupation and diet to white blood cell polycyclic aromatic hydrocarbon-DNA adducts in wildland firefighters. , 1993, Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology.

[55]  P. Strickland,et al.  Increased sensitivity for determination of polycyclic aromatic hydrocarbon-DNA adducts in human DNA samples by dissociation-enhanced lanthanide fluoroimmunoassay (DELFIA). , 1993, Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology.

[56]  F. Perera,et al.  HPRT and glycophorin A mutations in foundry workers: relationship to PAH exposure and to PAH-DNA adducts. , 1993, Carcinogenesis.

[57]  D. Phillips,et al.  DNA adducts in peripheral blood lymphocytes from aluminum production plant workers determined by 32P-postlabeling and enzyme-linked immunosorbent assay. , 1993, Environmental health perspectives.

[58]  D. Phillips,et al.  Results of an interlaboratory trial of 32P-postlabelling. , 1993, IARC scientific publications.

[59]  P. Strickland,et al.  Correlation between PAH airborne concentration and PAH-DNA adducts levels in coke-oven workers , 1993, International archives of occupational and environmental health.

[60]  F. Perera,et al.  Molecular and genetic damage in humans from environmental pollution in Poland , 1992, Nature.

[61]  H. Bartsch,et al.  An improved fluorometric assay for dosimetry of benzo(a)pyrene diol-epoxide-DNA adducts in smokers' lung: comparisons with total bulky adducts and aryl hydrocarbon hydroxylase activity. , 1992, Cancer research.

[62]  F. Perera,et al.  Cigarette smoking related polycyclic aromatic hydrocarbon-DNA adducts in peripheral mononuclear cells. , 1992, Carcinogenesis.

[63]  G. Talaska,et al.  32P-postlabelling and mass spectrometric methods for analysis of bulky, polyaromatic carcinogen-DNA adducts in humans. , 1992, Journal of chromatography.

[64]  A. C. Beach,et al.  Human biomonitoring and the 32P-postlabeling assay. , 1992, Carcinogenesis.

[65]  N. van Zandwijk,et al.  Polycyclic aromatic hydrocarbon--DNA adducts in white blood cells from lung cancer patients: no correlation with adduct levels in lung. , 1992, Carcinogenesis.

[66]  H. Bartsch,et al.  Carcinogen mmetabolism and DNA adducts in human lung tissues as affected by tobacco smoking or metabolic phenotype: a case-control study on lung cancer patients , 1991 .

[67]  J. van Benthem,et al.  Immunocytochemical analysis of in vivo DNA modification. , 1990, Mutation research.

[68]  F. V. van Schooten,et al.  Determination of benzo[a]pyrene diol epoxide-DNA adducts in white blood cell DNA from coke-oven workers: the impact of smoking. , 1990, Journal of the National Cancer Institute.

[69]  R. Albertini Annual meeting of the environmental mutagen society , 1990 .

[70]  C. Harris,et al.  An applied synchronous fluorescence spectrophotometric assay to study benzo[a]pyrene-diolepoxide-DNA adducts. , 1985, Carcinogenesis.

[71]  D. Phillips Fifty years of benzo(a)pyrene , 1983, Nature.

[72]  R. Gupta,et al.  32P-postlabeling analysis of non-radioactive aromatic carcinogen--DNA adducts. , 1982, Carcinogenesis.

[73]  E C Miller,et al.  Searches for ultimate chemical carcinogens and their reactions with cellular macromolecules , 1981, Cancer.

[74]  I. Weinstein,et al.  Quantitation of benzo(a)pyrene-deoxyguanosine adducts by radioimmunoassay. , 1980, Cancer research.

[75]  I. Weinstein,et al.  Detection of carcinogen–DNA adducts by radioimmunoassay , 1977, Nature.

[76]  R. Harvey,et al.  The reaction of (±)‐7α, 8β‐dihydroxy‐9β, 10β‐epoxy‐7,8,9,10‐tetrahydrobenzo(a)pyrene with dna , 1976 .

[77]  K. Nakanishi,et al.  Letter: Benzo[a]pyrene-nucleic acid derivative found in vivo: structure of a benzo[a]pyrenetetrahydrodiol epoxide-guanosine adduct. , 1976, Journal of the American Chemical Society.

[78]  A. Hewer,et al.  Metabolic activation of benzo(a)pyrene proceeds by a diol-epoxide , 1974, Nature.

[79]  P. Grover,et al.  Epoxides in polycyclic aromatic hydrocarbon metabolism and carcinogenesis. , 1974, Advances in cancer research.

[80]  A. Borgen,et al.  Metabolic conversion of benzo(a)pyrene by Syrian hamster liver microsomes and binding of metabolites to deoxyribonucleic acid. , 1973, Journal of medicinal chemistry.

[81]  H. Gelboin A microsome-dependent binding of benzo[a]pyrene to DNA. , 1969, Cancer research.

[82]  P. Grover,et al.  Enzyme-catalysed reactions of polycyclic hydrocarbons with deoxyribonucleic acid and protein in vitro. , 1968, The Biochemical journal.

[83]  P. D. Lawley,et al.  Evidence for the Binding of Polynuclear Aromatic Hydrocarbons to the Nucleic Acids of Mouse Skin : Relation between Carcinogenic Power of Hydrocarbons and their Binding to Deoxyribonucleic Acid , 1964, Nature.

[84]  N. M. Kennaway,et al.  The production of cancer by pure hydrocarbons. V , 1932, Proceedings of the Royal Society of London. Series B - Biological Sciences.

[85]  J. W. Cook,et al.  106. The isolation of a cancer-producing hydrocarbon from coal tar. Parts I, II, and III , 1933 .