Pharmacological targeting of mitochondrial complex I deficiency: the cellular level and beyond.
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[1] R. Garesse,et al. Animal models of mitochondrial DNA transactions in disease and ageing , 2010, Experimental Gerontology.
[2] C. Hunte,et al. Functional Modules and Structural Basis of Conformational Coupling in Mitochondrial Complex I , 2010, Science.
[3] S. Hersh. Mitochondria: An Emerging Target for Therapeutics , 2010, Clinical pharmacology and therapeutics.
[4] Sion L. Williams,et al. Emerging therapeutic approaches to mitochondrial diseases. , 2010, Developmental disabilities research reviews.
[5] J. Smeitink,et al. Detection and manipulation of mitochondrial reactive oxygen species in mammalian cells. , 2010, Biochimica et biophysica acta.
[6] Y. Al-sheikh,et al. The effect of aging and increasing ascorbate concentrations on respiratory chain activity in cultured human fibroblasts , 2010, Cell biochemistry and function.
[7] R. Rodenburg,et al. Complex I disorders: causes, mechanisms, and development of treatment strategies at the cellular level. , 2010, Developmental disabilities research reviews.
[8] R. Palmiter,et al. Complex I deficiency due to loss of Ndufs4 in the brain results in progressive encephalopathy resembling Leigh syndrome , 2010, Proceedings of the National Academy of Sciences.
[9] Cindy E J Dieteren,et al. Mammalian mitochondrial complex I: biogenesis, regulation, and reactive oxygen species generation. , 2010, Antioxidants & redox signaling.
[10] S. Moncada. Mitochondria as pharmacological targets , 2010, British journal of pharmacology.
[11] P. Bénit,et al. Genetic background influences mitochondrial function: modeling mitochondrial disease for therapeutic development. , 2010, Trends in molecular medicine.
[12] Rouslan G. Efremov,et al. The architecture of respiratory complex I , 2010, Nature.
[13] J. Finsterer,et al. Drugs interfering with mitochondrial disorders , 2010, Drug and chemical toxicology.
[14] P. Kador,et al. Multifunctional antioxidants for the treatment of age-related diseases. , 2010, Journal of medicinal chemistry.
[15] Ana Navarro,et al. Frontiers in Aging Neuroscience Aging Neuroscience Mammalian Aging and Brain Mitochondrial Impairment in Aging and Neurodegenerative Diseases Brain Mitochondrial Dysfunction in Aging, Neurodegeneration, and Parkinson's Disease , 2022 .
[16] D. Wallace,et al. Mitochondrial energetics and therapeutics. , 2010, Annual review of pathology.
[17] D. Rubinsztein,et al. Consequences of long-term oral administration of the mitochondria-targeted antioxidant MitoQ to wild-type mice. , 2010, Free radical biology & medicine.
[18] J. Smeitink,et al. Mouse models for nuclear DNA-encoded mitochondrial complex I deficiency , 2011, Journal of Inherited Metabolic Disease.
[19] J. Esseling,et al. Calcium and ATP handling in human NADH:ubiquinone oxidoreductase deficiency. , 2009, Biochimica et biophysica acta.
[20] T. Wenz. PGC‐1α activation as a therapeutic approach in mitochondrial disease , 2009, IUBMB life.
[21] Z. Ungvari,et al. Resveratrol attenuates mitochondrial oxidative stress in coronary arterial endothelial cells , 2009, American journal of physiology. Heart and circulatory physiology.
[22] J. Smeitink,et al. Mitochondrial dynamics in human NADH:ubiquinone oxidoreductase deficiency. , 2009, The international journal of biochemistry & cell biology.
[23] I. Cho,et al. Resveratrol Protects Mitochondria against Oxidative Stress through AMP-Activated Protein Kinase-Mediated Glycogen Synthase Kinase-3β Inhibition Downstream of Poly(ADP-ribose)polymerase-LKB1 Pathway , 2009, Molecular Pharmacology.
[24] D. Wallace,et al. The pathophysiology of mitochondrial disease as modeled in the mouse. , 2009, Genes & development.
[25] Z. Ungvari,et al. Resveratrol induces mitochondrial biogenesis in endothelial cells , 2009, American journal of physiology. Heart and circulatory physiology.
[26] C. Pinkert,et al. NDUFS4: creation of a mouse model mimicking a Complex I disorder. , 2009, Mitochondrion.
[27] E. Bertini,et al. Pathogenetic mechanisms in hereditary dysfunctions of complex I of the respiratory chain in neurological diseases. , 2009, Biochimica et biophysica acta.
[28] A. Falcão,et al. Pharmacokinetic and safety profile of trans-resveratrol in a rising multiple-dose study in healthy volunteers. , 2009, Molecular nutrition & food research.
[29] L. A. Obukhova,et al. An attempt to prevent senescence: a mitochondrial approach. , 2009, Biochimica et biophysica acta.
[30] J. Smeitink,et al. The antioxidant Trolox restores mitochondrial membrane potential and Ca2+-stimulated ATP production in human complex I deficiency , 2009, Journal of Molecular Medicine.
[31] A. Suomalainen,et al. Mouse models of mitochondrial DNA defects and their relevance for human disease , 2009, EMBO reports.
[32] R. Rodenburg,et al. Mitochondrial complex I deficiency: from organelle dysfunction to clinical disease. , 2008, Brain : a journal of neurology.
[33] G. Paradies,et al. Mitochondrial complex I dysfunction in rat heart with aging: critical role of reactive oxygen species and cardiolipin. , 2009, Free radical biology & medicine.
[34] M. Hink,et al. Chapter 16 The use of fluorescence correlation spectroscopy to probe mitochondrial mobility and intramatrix protein diffusion. , 2009, Methods in enzymology.
[35] Rutger O. Vogel,et al. Subunits of Mitochondrial Complex I Exist as Part of Matrix- and Membrane-associated Subcomplexes in Living Cells* , 2008, Journal of Biological Chemistry.
[36] A. Torraco,et al. Mouse models of oxidative phosphorylation dysfunction and disease. , 2008, Methods.
[37] V. Skulachev,et al. Mitochondria-targeted plastoquinone derivatives as tools to interrupt execution of the aging program. 2. Treatment of some ROS- and Age-related diseases (heart arrhythmia, heart infarctions, kidney ischemia, and stroke) , 2008, Biochemistry (Moscow).
[38] N. Wood,et al. Mitochondrial function and morphology are impaired in parkin‐mutant fibroblasts , 2008, Annals of neurology.
[39] B. Spiegelman,et al. Activation of the PPAR/PGC-1alpha pathway prevents a bioenergetic deficit and effectively improves a mitochondrial myopathy phenotype. , 2008, Cell metabolism.
[40] A. Bonen,et al. PGC-1alpha-mediated regulation of gene expression and metabolism: implications for nutrition and exercise prescriptions. , 2008, Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme.
[41] J. Brotchie,et al. Dietary resveratrol administration increases MnSOD expression and activity in mouse brain. , 2008, Biochemical and biophysical research communications.
[42] J. Smeitink,et al. Mitigation of NADH: ubiquinone oxidoreductase deficiency by chronic Trolox treatment. , 2008, Biochimica et biophysica acta.
[43] J. Smeitink,et al. Mitochondrial Ca2+ homeostasis in human NADH:ubiquinone oxidoreductase deficiency. , 2008, Cell calcium.
[44] J. Fransen,et al. Inherited complex I deficiency is associated with faster protein diffusion in the matrix of moving mitochondria. , 2008, American journal of physiology. Cell physiology.
[45] F. Daussin,et al. Training at high exercise intensity promotes qualitative adaptations of mitochondrial function in human skeletal muscle. , 2008, Journal of applied physiology.
[46] Robin A. J. Smith,et al. Rapid and extensive uptake and activation of hydrophobic triphenylphosphonium cations within cells. , 2008, The Biochemical journal.
[47] R. Houtkooper,et al. Cardiolipin, the heart of mitochondrial metabolism , 2008, Cellular and Molecular Life Sciences.
[48] W. Watt,et al. Mice with mitochondrial complex I deficiency develop a fatal encephalomyopathy. , 2008, Cell metabolism.
[49] A. Munnich,et al. Activation of peroxisome proliferator-activated receptor pathway stimulates the mitochondrial respiratory chain and can correct deficiencies in patients' cells lacking its components. , 2008, The Journal of clinical endocrinology and metabolism.
[50] R. Scarpulla. Transcriptional paradigms in mammalian mitochondrial biogenesis and function. , 2008, Physiological reviews.
[51] J. Smeitink,et al. Life cell quantification of mitochondrial membrane potential at the single organelle level , 2008, Cytometry. Part A : the journal of the International Society for Analytical Cytology.
[52] H. Szeto. Mitochondria-targeted peptide antioxidants: Novel neuroprotective agents , 2006, The AAPS Journal.
[53] J. Smeitink,et al. Mitochondrial and cytosolic thiol redox state are not detectably altered in isolated human NADH:ubiquinone oxidoreductase deficiency. , 2007, Biochimica et biophysica acta.
[54] I. Tucker,et al. Quantitation and metabolism of mitoquinone, a mitochondria-targeted antioxidant, in rat by liquid chromatography/tandem mass spectrometry. , 2007, Rapid communications in mass spectrometry : RCM.
[55] J. Smeitink,et al. Partial complex I inhibition decreases mitochondrial motility and increases matrix protein diffusion as revealed by fluorescence correlation spectroscopy. , 2007, Biochimica et biophysica acta.
[56] J. Smeitink,et al. Human NADH:ubiquinone oxidoreductase deficiency: radical changes in mitochondrial morphology? , 2007, American journal of physiology. Cell physiology.
[57] Massimo Zeviani,et al. Impaired complex III assembly associated with BCS1L gene mutations in isolated mitochondrial encephalopathy. , 2007, Human molecular genetics.
[58] M. Lazarou,et al. Analysis of the Assembly Profiles for Mitochondrial- and Nuclear-DNA-Encoded Subunits into Complex I , 2007, Molecular and Cellular Biology.
[59] Rutger O. Vogel,et al. Identification of Mitochondrial Complex I Assembly Intermediates by Tracing Tagged NDUFS3 Demonstrates the Entry Point of Mitochondrial Subunits* , 2007, Journal of Biological Chemistry.
[60] Christian Gluud,et al. Mortality in randomized trials of antioxidant supplements for primary and secondary prevention: systematic review and meta-analysis. , 2007, JAMA.
[61] Robin A. J. Smith,et al. Targeting antioxidants to mitochondria by conjugation to lipophilic cations. , 2007, Annual review of pharmacology and toxicology.
[62] C. Pinkert,et al. Generation of transmitochondrial mice: development of xenomitochondrial mice to model neurodegenerative diseases. , 2007, Methods in cell biology.
[63] P. Puigserver,et al. Resveratrol Improves Mitochondrial Function and Protects against Metabolic Disease by Activating SIRT1 and PGC-1α , 2006, Cell.
[64] J. Smeitink,et al. Simultaneous quantification of oxidative stress and cell spreading using 5‐(and‐6)‐chloromethyl‐2′,7′‐dichlorofluorescein , 2006, Cytometry. Part A : the journal of the International Society for Analytical Cytology.
[65] P. Puigserver,et al. Resveratrol improves health and survival of mice on a high-calorie diet , 2006, Nature.
[66] Ulrich Brandt,et al. Energy converting NADH:quinone oxidoreductase (complex I). , 2006, Annual review of biochemistry.
[67] M. Sharpley,et al. Interactions between phospholipids and NADH:ubiquinone oxidoreductase (complex I) from bovine mitochondria. , 2006, Biochemistry.
[68] A. Leusink,et al. Decreased agonist-stimulated mitochondrial ATP production caused by a pathological reduction in endoplasmic reticulum calcium content in human complex I deficiency. , 2006, Biochimica et biophysica acta.
[69] Werner J H Koopman,et al. Simultaneous quantitative measurement and automated analysis of mitochondrial morphology, mass, potential, and motility in living human skin fibroblasts , 2006, Cytometry. Part A : the journal of the International Society for Analytical Cytology.
[70] H. Szeto,et al. Mitochondria-targeted peptide prevents mitochondrial depolarization and apoptosis induced by tert-butyl hydroperoxide in neuronal cell lines. , 2005, Biochemical pharmacology.
[71] R. Haller,et al. Exercise and training in mitochondrial myopathies. , 2005, Medicine and science in sports and exercise.
[72] A. Navarro,et al. Vitamin E at high doses improves survival, neurological performance, and brain mitochondrial function in aging male mice. , 2005, American journal of physiology. Regulatory, integrative and comparative physiology.
[73] E. Shoubridge,et al. A molecular chaperone for mitochondrial complex I assembly is mutated in a progressive encephalopathy. , 2005, The Journal of clinical investigation.
[74] J. Smeitink,et al. Mitochondrial network complexity and pathological decrease in complex I activity are tightly correlated in isolated human complex I deficiency. , 2005, American journal of physiology. Cell physiology.
[75] D. Chan,et al. Disruption of Fusion Results in Mitochondrial Heterogeneity and Dysfunction* , 2005, Journal of Biological Chemistry.
[76] F. H. van der Westhuizen,et al. Inhibition of complex I of the electron transport chain causes O2-. -mediated mitochondrial outgrowth. , 2005, American journal of physiology. Cell physiology.
[77] K. Kraemer,et al. Vitamins E and C are safe across a broad range of intakes. , 2005, The American journal of clinical nutrition.
[78] D. Kelly,et al. Mouse models of mitochondrial dysfunction and heart failure. , 2005, Journal of molecular and cellular cardiology.
[79] R. Haller,et al. Implications of exercise training in mtDNA defects--use it or lose it? , 2004, Biochimica et biophysica acta.
[80] G. Rutter,et al. Inhibition of Mitochondrial Na (cid:1) -Ca 2 (cid:1) Exchange Restores Agonist-induced ATP Production and Ca 2 (cid:1) Handling in Human Complex I Deficiency* , 2004 .
[81] H. Szeto,et al. Cell-permeable Peptide Antioxidants Targeted to Inner Mitochondrial Membrane inhibit Mitochondrial Swelling, Oxidative Cell Death, and Reperfusion Injury* , 2004, Journal of Biological Chemistry.
[82] A. Boneh,et al. Effect of high-dose vitamins, coenzyme Q and high-fat diet in paediatric patients with mitochondrial diseases , 2004, Journal of Inherited Metabolic Disease.
[83] E. Ojuka. Role of calcium and AMP kinase in the regulation of mitochondrial biogenesis and GLUT4 levels in muscle , 2004, The Proceedings of the Nutrition Society.
[84] C. Bruno,et al. Respiratory complex III is required to maintain complex I in mammalian mitochondria. , 2004, Molecular cell.
[85] J. Smeitink,et al. Differences in assembly or stability of complex I and other mitochondrial OXPHOS complexes in inherited complex I deficiency. , 2004, Human molecular genetics.
[86] Deborah Gustafson,et al. Reduced risk of Alzheimer disease in users of antioxidant vitamin supplements: the Cache County Study. , 2004, Archives of neurology.
[87] D. Glerum,et al. Nutritional cofactor treatment in mitochondrial disorders. , 2003, Journal of the American Dietetic Association.
[88] R. Bassel-Duby,et al. Regulation of Mitochondrial Biogenesis in Skeletal Muscle by CaMK , 2002, Science.
[89] O. Elpeleg,et al. Effect of various agents on adenosine triphosphate synthesis in mitochondrial complex I deficiency. , 2001, The Journal of pediatrics.
[90] I. Nissim,et al. Brain amino acid metabolism and ketosis , 2001, Journal of neuroscience research.
[91] B. Cohen,et al. Treatment of Mitochondrial Cytopathies , 2001, Seminars in neurology.
[92] P. Mongan,et al. Ascorbate reduces superoxide production and improves mitochondrial respiratory chain function in human fibroblasts with electron transport chain deficiencies. , 2001, Mitochondrion.
[93] Britton Chance,et al. Ketone Bodies, Potential Therapeutic Uses , 2001, IUBMB life.
[94] M. L. Greenberg,et al. The biosynthesis and functional role of cardiolipin. , 2000, Progress in lipid research.
[95] C. Angelini,et al. Riboflavin therapy. Biochemical heterogeneity in two adult lipid storage myopathies. , 1999, Brain : a journal of neurology.
[96] E. Schon,et al. A calcium signaling defect in the pathogenesis of a mitochondrial DNA inherited oxidative phosphorylation deficiency , 1999, Nature Medicine.
[97] V. Mootha,et al. Mechanisms Controlling Mitochondrial Biogenesis and Respiration through the Thermogenic Coactivator PGC-1 , 1999, Cell.
[98] S. Combs,et al. Effects of ascorbic acid on proliferation and collagen synthesis in relation to the donor age of human dermal fibroblasts. , 1994, The Journal of investigative dermatology.
[99] P. Bergsten,et al. Ascorbic acid accumulation and transport in human fibroblasts. , 1993, The Biochemical journal.
[100] M. A. Matlib,et al. A role for the mitochondrial Na(+)-Ca2+ exchanger in the regulation of oxidative phosphorylation in isolated heart mitochondria. , 1993, The Journal of biological chemistry.
[101] E. Niki,et al. Action of ascorbic acid as a scavenger of active and stable oxygen radicals. , 1991, The American journal of clinical nutrition.