Lysozyme fibrillation induced by convective flow under quasi contact-free conditions

The evaporation of a lysozyme solution drop containing Ca2+ ions on a superhydrophobic poly(methyl methacrylate) surface was probed by X-ray microbeam raster-diffraction. We observe the rapid deposition of fibrillar lysozyme with amyloidic cross-β structure at the interface of the drop with the substrate under conditions of weak acidity, close to physiological.

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