PTSD is associated with increased DNA methylation across regions of HLA-DPB1 and SPATC1L

[1]  R. Kessler,et al.  Epigenome-wide meta-analysis of PTSD across 10 military and civilian cohorts identifies methylation changes in AHRR , 2020, Nature Communications.

[2]  R. Kessler,et al.  An epigenome-wide association study of posttraumatic stress disorder in US veterans implicates several new DNA methylation loci , 2020, Clinical Epigenetics.

[3]  R. Kessler,et al.  Longitudinal epigenome-wide association studies of three male military cohorts reveal multiple CpG sites associated with post-traumatic stress disorder , 2020, Clinical Epigenetics.

[4]  Andrew R. Jones,et al.  Allele frequency net database (AFND) 2020 update: gold-standard data classification, open access genotype data and new query tools , 2019, Nucleic Acids Res..

[5]  C. Nievergelt,et al.  Successful treatment of post-traumatic stress disorder reverses DNA methylation marks , 2019, Molecular Psychiatry.

[6]  Christopher R. Erbes,et al.  International meta-analysis of PTSD genome-wide association studies identifies sex- and ancestry-specific genetic risk loci , 2019, Nature Communications.

[7]  P. Sullivan,et al.  Genome-wide association study of post-traumatic stress disorder reexperiencing symptoms in >165,000 US veterans , 2019, Nature Neuroscience.

[8]  A. Wingo,et al.  Association of HLA locus alleles with posttraumatic stress disorder , 2019, Brain, Behavior, and Immunity.

[9]  R. Kessler,et al.  Epigenome-wide meta-analysis of PTSD across 10 military and civilian cohorts identifies novel methylation loci , 2019, bioRxiv.

[10]  M. Miller,et al.  DNA methylation correlates of PTSD: Recent findings and technical challenges , 2019, Progress in Neuro-Psychopharmacology and Biological Psychiatry.

[11]  C. Nievergelt,et al.  Epigenetic meta-analysis across three civilian cohorts identifies NRG1 and HGS as blood-based biomarkers for post-traumatic stress disorder. , 2018, Epigenomics.

[12]  R. Scott,et al.  Increased DNA methylation of SLFN12 in CD4+ and CD8+ T cells from multiple sclerosis patients , 2018, PloS one.

[13]  Robert C. Altshuler,et al.  Allele-specific epigenome maps reveal sequence-dependent stochastic switching at regulatory loci , 2018, Science.

[14]  Eleazar Eskin,et al.  An integrated -omics analysis of the epigenetic landscape of gene expression in human blood cells , 2018, BMC Genomics.

[15]  Pedro Carmona-Saez,et al.  mCSEA: Detecting subtle differentially methylated regions , 2018, bioRxiv.

[16]  K. Ressler,et al.  Recent Genetics and Epigenetics Approaches to PTSD , 2018, Current Psychiatry Reports.

[17]  D. Veltman,et al.  Genetic variant in CACNA1C is associated with PTSD in traumatized police officers , 2018, European Journal of Human Genetics.

[18]  J. Potash,et al.  Genome-wide DNA methylation comparison between live human brain and peripheral tissues within individuals , 2019, Translational Psychiatry.

[19]  R. Kotov,et al.  Gene expression associated with PTSD in World Trade Center responders: An RNA sequencing study , 2017, Translational Psychiatry.

[20]  C. Nievergelt,et al.  Epigenome‐wide association of PTSD from heterogeneous cohorts with a common multi‐site analysis pipeline , 2017, American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics.

[21]  E. Ogłodek Evaluation of ADMA, carbonyl groups, CAT and NKA in depressed patients with and without posttraumatic stress disorder , 2017, Pharmacological reports : PR.

[22]  C. Nievergelt,et al.  Longitudinal analyses of the DNA methylome in deployed military servicemen identify susceptibility loci for post-traumatic stress disorder , 2017, Molecular Psychiatry.

[23]  Lisa Bastarache,et al.  Phenome-wide scanning identifies multiple diseases and disease severity phenotypes associated with HLA variants , 2017, Science Translational Medicine.

[24]  Dan J Stein,et al.  Posttraumatic stress disorder in the World Mental Health Surveys , 2017, Psychological Medicine.

[25]  A. Amstadter,et al.  The genetics and epigenetics of PTSD: overview, recent advances, and future directions. , 2017, Current opinion in psychology.

[26]  Shijie C. Zheng,et al.  A comparison of reference-based algorithms for correcting cell-type heterogeneity in Epigenome-Wide Association Studies , 2017, bioRxiv.

[27]  Jean-Philippe Fortin,et al.  Preprocessing, normalization and integration of the Illumina HumanMethylationEPIC array with minfi , 2016, bioRxiv.

[28]  P. Özdemir,et al.  Altered lipid peroxidation markers are related to post-traumatic stress disorder (PTSD) and not trauma itself in earthquake survivors , 2016, European Archives of Psychiatry and Clinical Neuroscience.

[29]  A. McIntosh,et al.  Identification of polymorphic and off-target probe binding sites on the Illumina Infinium MethylationEPIC BeadChip , 2016, bioRxiv.

[30]  J. Holbrook,et al.  How to make DNA methylome wide association studies more powerful , 2016, Epigenomics.

[31]  Dan J Stein,et al.  The epidemiology of traumatic event exposure worldwide: results from the World Mental Health Survey Consortium , 2015, Psychological Medicine.

[32]  E. Binder,et al.  Epigenetics of Posttraumatic Stress Disorder: Current Evidence, Challenges, and Future Directions , 2015, Biological Psychiatry.

[33]  M. Kas,et al.  Traumatic stress and human DNA methylation: a critical review. , 2015, Epigenomics.

[34]  K. Kelsey,et al.  DNA Methylation in Whole Blood: Uses and Challenges , 2015, Current Environmental Health Reports.

[35]  R. Pepperkok,et al.  A Fluorescent Live Imaging Screening Assay Based on Translocation Criteria Identifies Novel Cytoplasmic Proteins Implicated in G Protein-coupled Receptor Signaling Pathways* , 2015, Molecular & Cellular Proteomics.

[36]  C. Nievergelt,et al.  Blood-based gene-expression biomarkers of post-traumatic stress disorder among deployed marines: A pilot study , 2015, Psychoneuroendocrinology.

[37]  N. Mimica,et al.  Oxidative status and the severity of clinical symptoms in patients with post-traumatic stress disorder , 2015, Annals of clinical biochemistry.

[38]  T. Onaga Tachykinin: recent developments and novel roles in health and disease , 2014, Biomolecular concepts.

[39]  Rafael A. Irizarry,et al.  Minfi: a flexible and comprehensive Bioconductor package for the analysis of Infinium DNA methylation microarrays , 2014, Bioinform..

[40]  C. Nievergelt,et al.  Assessment of plasma C-reactive protein as a biomarker of posttraumatic stress disorder risk. , 2014, JAMA psychiatry.

[41]  Lynn M Almli,et al.  Methylation quantitative trait loci (meQTLs) are consistently detected across ancestry, developmental stage, and tissue type , 2014, BMC Genomics.

[42]  David I. Wilson,et al.  Genome-wide DNA methylation analysis of patients with imprinting disorders identifies differentially methylated regions associated with novel candidate imprinted genes , 2014, Journal of Medical Genetics.

[43]  Alexandra M. Binder,et al.  Recommendations for the design and analysis of epigenome-wide association studies , 2013, Nature Methods.

[44]  Janet B W Williams,et al.  Diagnostic and Statistical Manual of Mental Disorders , 2013 .

[45]  B. Bradley,et al.  Childhood maltreatment is associated with distinct genomic and epigenetic profiles in posttraumatic stress disorder , 2013, Proceedings of the National Academy of Sciences.

[46]  Richard T. Barfield,et al.  CpGassoc: an R function for analysis of DNA methylation microarray data , 2012, Bioinform..

[47]  Andrew E. Jaffe,et al.  Bioinformatics Applications Note Gene Expression the Sva Package for Removing Batch Effects and Other Unwanted Variation in High-throughput Experiments , 2022 .

[48]  Jeffrey T Leek,et al.  Bump hunting to identify differentially methylated regions in epigenetic epidemiology studies. , 2012, International journal of epidemiology.

[49]  B. Bradley,et al.  Differential immune system DNA methylation and cytokine regulation in post‐traumatic stress disorder , 2011, American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics.

[50]  E. Walker,et al.  Diagnostic and Statistical Manual of Mental Disorders , 2013 .

[51]  Andrey A. Shabalin,et al.  Matrix eQTL: ultra fast eQTL analysis via large matrix operations , 2011, Bioinform..

[52]  Xiao Zhang,et al.  Comparison of Beta-value and M-value methods for quantifying methylation levels by microarray analysis , 2010, BMC Bioinformatics.

[53]  A. Chess,et al.  Extensive sequence-influenced DNA methylation polymorphism in the human genome , 2010, Epigenetics & Chromatin.

[54]  S. Galea,et al.  Epigenetic and immune function profiles associated with posttraumatic stress disorder , 2010, Proceedings of the National Academy of Sciences.

[55]  B. Bradley,et al.  Impaired fear inhibition is a biomarker of PTSD but not depression , 2010, Depression and anxiety.

[56]  Albert Jeltsch,et al.  Non-imprinted allele-specific DNA methylation on human autosomes , 2009, Genome Biology.

[57]  B. Bradley,et al.  Trauma exposure and stress-related disorders in inner city primary care patients. , 2009, General hospital psychiatry.

[58]  L. Samson,et al.  Genomic predictors of interindividual differences in response to DNA damaging agents. , 2008, Genes & development.

[59]  K. Ressler,et al.  Influence of child abuse on adult depression: moderation by the corticotropin-releasing hormone receptor gene. , 2008, Archives of general psychiatry.

[60]  R Spanagel,et al.  Differential gene expression in peripheral blood of patients suffering from post-traumatic stress disorder , 2007, Molecular Psychiatry.

[61]  K. Ressler,et al.  Posttraumatic stress disorder among African Americans in an inner city mental health clinic. , 2005, Psychiatric services.

[62]  M. Candolfi,et al.  Effects of lipopolysaccharide on neurokinin A content and release in the hypothalamic–pituitary axis , 2003, Regulatory Peptides.

[63]  G. Griebel,et al.  Selective blockade of neurokinin-2 receptors produces antidepressant-like effects associated with reduced corticotropin-releasing factor function. , 2001, Journal of Pharmacology and Experimental Therapeutics.

[64]  E. Foa,et al.  Comparison of the PTSD Symptom Scale–Interview Version and the Clinician-Administered PTSD Scale , 2000, Journal of traumatic stress.

[65]  R. Kessler,et al.  Trauma and posttraumatic stress disorder in the community: the 1996 Detroit Area Survey of Trauma. , 1998, Archives of general psychiatry.

[66]  R. Kessler,et al.  Posttraumatic stress disorder in the National Comorbidity Survey. , 1995, Archives of general psychiatry.

[67]  M. G. Dube,et al.  The effects of interleukin 1β on the hypothalamic tachykinin, neurokinin A , 1994, Brain Research.

[68]  R. Dantzer,et al.  A behaviorally active dose of lipopolysaccharide increases sensory neuropeptides levels in mouse spinal cord , 1994, Neuroscience Letters.

[69]  H. Resnick,et al.  The Modified PTSD Symptom Scale: A brief self-report measure of posttraumatic stress disorder. , 1993 .

[70]  W. Cleveland Robust Locally Weighted Regression and Smoothing Scatterplots , 1979 .

[71]  C. Nievergelt,et al.  Neuroepigenetics of Post-Traumatic Stress Disorder. , 2018, Progress in molecular biology and translational science.

[72]  K. Ressler,et al.  Inflammation in Fear- and Anxiety-Based Disorders: PTSD, GAD, and Beyond , 2017, Neuropsychopharmacology.

[73]  J. Davidson,et al.  Clinician‐administered PTSD scale: A review of the first ten years of research , 2001, Depression and anxiety.

[74]  Y. Benjamini,et al.  Controlling the false discovery rate: a practical and powerful approach to multiple testing , 1995 .

[75]  D. Charney,et al.  The development of a Clinician-Administered PTSD Scale , 1995, Journal of traumatic stress.