论文信息 - Determination of the Enantiomeric Purity by 1h NMR with Eu(tfc)3 of β‐Hetarylalanine Derivatives. Correlation Of the Enantiomeric Shift Difference with Absolute Configuration

Determination of the Enantiomeric Purity by 1h NMR with Eu(tfc)3 of β‐Hetarylalanine Derivatives. Correlation Of the Enantiomeric Shift Difference with Absolute Configuration

The best conditions (solvent, lanthanide/substrate molar ratios…) to determine the enantiomeric purity of a nonracemic mixture of R and S N-acetyl (or benzoyl)-β-hetarylalanine methyl esters by 1H NMR with tris (3-trifluoromethyl-hydroxymethylene-d-camphorato)europium(III) «Eu(tfc)3» were studied. A direct correlation between configuration and chemical shift differences, ΔΔδR-S, between the methyl singlets was observed.

J. Mayoral | C. Cativiela | J. García | E. Meléndez | M. D. D. D. Villegas

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