High-yield production of FK228 and new derivatives in a Burkholderia chassis.

[1]  R. Müller,et al.  Rational construction of genome-reduced Burkholderiales chassis facilitates efficient heterologous production of natural products from proteobacteria , 2021, Nature Communications.

[2]  Kai Gong,et al.  Development and application of an efficient recombineering system for Burkholderia glumae and Burkholderia plantarii , 2021, Microbial biotechnology.

[3]  A. Stewart,et al.  RedEx: a method for seamless DNA insertion and deletion in large multimodular polyketide synthase gene clusters , 2020, Nucleic acids research.

[4]  Rodrigo Ledesma-Amaro,et al.  Microbial Chassis Development for Natural Product Biosynthesis. , 2020, Trends in biotechnology.

[5]  H. Schweizer,et al.  Efflux Pumps of Burkholderia thailandensis Control the Permeability Barrier of the Outer Membrane , 2019, Antimicrobial Agents and Chemotherapy.

[6]  H. Bode,et al.  Modification and de novo design of non-ribosomal peptide synthetases using specific assembly points within condensation domains , 2019, Nature Chemistry.

[7]  A. Stewart,et al.  Enhanced Heterologous Spinosad Production from a 79-kb Synthetic Multioperon Assembly. , 2019, ACS synthetic biology.

[8]  Xueting Liu,et al.  Genomics-guided discovery of a new and significantly better source of anticancer natural drug FK228 , 2018, Synthetic and systems biotechnology.

[9]  J. Hashimoto,et al.  Reprogramming of the antimycin NRPS-PKS assembly lines inspired by gene evolution , 2018, Nature Communications.

[10]  R. Müller,et al.  Discovery of recombinases enables genome mining of cryptic biosynthetic gene clusters in Burkholderiales species , 2018, Proceedings of the National Academy of Sciences.

[11]  A. Stewart,et al.  ExoCET: exonuclease in vitro assembly combined with RecET recombination for highly efficient direct DNA cloning from complex genomes , 2017, Nucleic acids research.

[12]  Xiaoyang Li,et al.  Advances and Challenges of HDAC Inhibitors in Cancer Therapeutics , 2018, Advances in cancer research.

[13]  Jingao Dong,et al.  AFEAP cloning: a precise and efficient method for large DNA sequence assembly , 2017, BMC Biotechnology.

[14]  K. Walker,et al.  Paclitaxel Biosynthesis: Adenylation and Thiolation Domains of an NRPS TycA PheAT Module Produce Various Arylisoserine CoA Thioesters. , 2017, Biochemistry.

[15]  Minoru Yoshida,et al.  Synthesis and biological evaluation of novel FK228 analogues as potential isoform selective HDAC inhibitors. , 2016, European journal of medicinal chemistry.

[16]  J. Kalinowski,et al.  An influence of the copy number of biosynthetic gene clusters on the production level of antibiotics in a heterologous host. , 2016, Journal of biotechnology.

[17]  A. Stewart,et al.  RecET direct cloning and Redαβ recombineering of biosynthetic gene clusters, large operons or single genes for heterologous expression , 2016, Nature Protocols.

[18]  Christopher A. Voigt,et al.  Synthetic biology to access and expand nature's chemical diversity , 2016, Nature Reviews Microbiology.

[19]  Alex Toftgaard Nielsen,et al.  CRMAGE: CRISPR Optimized MAGE Recombineering , 2016, Scientific Reports.

[20]  F. Zunino,et al.  New macrocyclic analogs of the natural histone deacetylase inhibitor FK228; design, synthesis and preliminary biological evaluation. , 2015, Bioorganic & medicinal chemistry.

[21]  R. Lockey,et al.  CRISPR/Cas9 nuclease cleavage combined with Gibson assembly for seamless cloning. , 2015, BioTechniques.

[22]  Huimin Zhao,et al.  Recent advances in combinatorial biosynthesis for drug discovery , 2015, Drug design, development and therapy.

[23]  M. Geng,et al.  Chromopeptide A, a highly cytotoxic depsipeptide from the marine sediment-derived bacterium Chromobacterium sp. HS-13-94 , 2015, Acta pharmaceutica Sinica. B.

[24]  S. Hiebert,et al.  Class I HDACs Affect DNA Replication, Repair, and Chromatin Structure: Implications for Cancer Therapy. , 2014, Antioxidants & redox signaling.

[25]  Hui Jun-yua.  Production of Thailandepsin A from Burkholderia thailandensis E264/p BMTL3-tdp R Fermentation , 2015 .

[26]  Roger G. Linington,et al.  Insights into Secondary Metabolism from a Global Analysis of Prokaryotic Biosynthetic Gene Clusters , 2014, Cell.

[27]  Yi-Qiang Cheng,et al.  Identification and characterization of the spiruchostatin biosynthetic gene cluster enable yield improvement by overexpressing a transcriptional activator , 2014, Journal of Industrial Microbiology & Biotechnology.

[28]  R. Johnstone,et al.  New and emerging HDAC inhibitors for cancer treatment. , 2014, The Journal of clinical investigation.

[29]  A. Stewart,et al.  Improved seamless mutagenesis by recombineering using ccdB for counterselection , 2013, Nucleic acids research.

[30]  K. Ishida,et al.  Genomics-driven discovery of burkholderic acid, a noncanonical, cryptic polyketide from human pathogenic Burkholderia species. , 2012, Angewandte Chemie.

[31]  S. Brady,et al.  Malleilactone, a polyketide synthase-derived virulence factor encoded by the cryptic secondary metabolome of Burkholderia pseudomallei group pathogens. , 2012, Journal of the American Chemical Society.

[32]  Yi-Qiang Cheng,et al.  Discovery and activity profiling of thailandepsins A through F, potent histone deacetylase inhibitors, from Burkholderia thailandensis E264. , 2012, MedChemComm.

[33]  K. Ishida,et al.  Assembly and absolute configuration of short-lived polyketides from Burkholderia thailandensis. , 2012, Angewandte Chemie.

[34]  Rolf Müller,et al.  Full-length RecE enhances linear-linear homologous recombination and facilitates direct cloning for bioprospecting , 2012, Nature Biotechnology.

[35]  W. Edelmann,et al.  SLiCE: a novel bacterial cell extract-based DNA cloning method , 2012, Nucleic acids research.

[36]  Huimin Zhao,et al.  DNA assembler: a synthetic biology tool for characterizing and engineering natural product gene clusters. , 2012, Methods in enzymology.

[37]  S. Bates,et al.  Histone deacetylase inhibitors: emerging mechanisms of resistance. , 2011, Molecular pharmaceutics.

[38]  R. Ebright,et al.  The antibacterial threaded-lasso peptide capistruin inhibits bacterial RNA polymerase. , 2011, Journal of molecular biology.

[39]  Franz-Josef Meyer-Almes,et al.  Thailandepsins: Bacterial Products with Potent Histone Deacetylase Inhibitory Activities and Broad-spectrum Antiproliferative Activities , 2022 .

[40]  P. Keim,et al.  Knockout and pullout recombineering for naturally transformable Burkholderia thailandensis and Burkholderia pseudomallei , 2011, Nature Protocols.

[41]  S. Brady,et al.  Acyldepsipeptide HDAC inhibitor production induced in Burkholderia thailandensis. , 2011, Organic letters.

[42]  Yi-Qiang Cheng,et al.  New Insights into the Genetic Organization of the FK228 Biosynthetic Gene Cluster in Chromobacterium violaceum No. 968 , 2010, Applied and Environmental Microbiology.

[43]  S. Behnken,et al.  Induced biosynthesis of cryptic polyketide metabolites in a Burkholderia thailandensis quorum sensing mutant. , 2010, Journal of the American Chemical Society.

[44]  Mohammad R. Seyedsayamdost,et al.  Quorum-Sensing-Regulated Bactobolin Production by Burkholderia thailandensis E264 , 2010, Organic letters.

[45]  Richard H. Baltz,et al.  Genetically Engineered Lipopeptide Antibiotics Related to A54145 and Daptomycin with Improved Properties , 2010, Antimicrobial Agents and Chemotherapy.

[46]  StatBite: FDA oncology drug product approvals in 2009. , 2010, Journal of the National Cancer Institute.

[47]  Minoru Yoshida,et al.  Total synthesis of the bicyclic depsipeptide HDAC inhibitors spiruchostatins A and B, 5''-epi-spiruchostatin B, FK228 (FR901228) and preliminary evaluation of their biological activity. , 2009, Chemistry.

[48]  H. Schweizer,et al.  Versatile Dual-Technology System for Markerless Allele Replacement in Burkholderia pseudomallei , 2009, Applied and Environmental Microbiology.

[49]  B. Wilcox,et al.  Glyphosate Resistance as a Novel Select-Agent-Compliant, Non-Antibiotic-Selectable Marker in Chromosomal Mutagenesis of the Essential Genes asd and dapB of Burkholderia pseudomallei , 2009, Applied and Environmental Microbiology.

[50]  Yi-Qiang Cheng,et al.  An FAD-dependent pyridine nucleotide-disulfide oxidoreductase is involved in disulfide bond formation in FK228 anticancer depsipeptide. , 2009, Chemistry & biology.

[51]  D. G. Gibson,et al.  Enzymatic assembly of DNA molecules up to several hundred kilobases , 2009, Nature Methods.

[52]  D. Court,et al.  Recombineering: a homologous recombination-based method of genetic engineering , 2009, Nature Protocols.

[53]  Linquan Bai,et al.  Incomplete beta-ketone processing as a mechanism for polyene structural variation in the FR-008/candicidin complex. , 2008, Chemistry & biology.

[54]  M. Son,et al.  Genetic Tools for Allelic Replacement in Burkholderia Species , 2008, Applied and Environmental Microbiology.

[55]  V. Paul,et al.  Structure and activity of largazole, a potent antiproliferative agent from the Floridian marine cyanobacterium Symploca sp. , 2008, Journal of the American Chemical Society.

[56]  K. Glaser.  HDAC inhibitors: clinical update and mechanism-based potential. , 2007, Biochemical pharmacology.

[57]  Manel Esteller,et al.  The role of histone deacetylases (HDACs) in human cancer , 2007, Molecular oncology.

[58]  Yi-Qiang Cheng,et al.  Characterization of a Gene Cluster Responsible for the Biosynthesis of Anticancer Agent FK228 in Chromobacterium violaceum No. 968 , 2007, Applied and Environmental Microbiology.

[59]  S. Elledge,et al.  Harnessing homologous recombination in vitro to generate recombinant DNA via SLIC , 2007, Nature Methods.

[60]  Dylan Alexander,et al.  Combinatorial biosynthesis of novel antibiotics related to daptomycin , 2006, Proceedings of the National Academy of Sciences.

[61]  M. Marahiel,et al.  Construction of hybrid peptide synthetases for the production of alpha-l-aspartyl-l-phenylalanine, a precursor for the high-intensity sweetener aspartame. , 2003, European journal of biochemistry.

[62]  C Richard Hutchinson,et al.  A model of structure and catalysis for ketoreductase domains in modular polyketide synthases. , 2003, Biochemistry.

[63]  V. Richon,et al.  Histone deacetylase inhibitors as new cancer drugs , 2001, Current opinion in oncology.

[64]  K. Shin‐ya,et al.  Spiruchostatins A and B, novel gene expression-enhancing substances produced by Pseudomonas sp. , 2001 .

[65]  Giuseppe Testa,et al.  DNA cloning by homologous recombination in Escherichia coli , 2000, Nature Biotechnology.

[66]  T. Hamamoto,et al.  A water-soluble tetrazolium salt useful for colorimetric cell viability assay , 1999 .

[67]  M. Yoshida,et al.  FR901228, a potent antitumor antibiotic, is a novel histone deacetylase inhibitor. , 1998, Experimental cell research.

[68]  K. Harada,et al.  A Nonempirical Method Using LC/MS for Determination of the Absolute Configuration of Constituent Amino Acids in a Peptide: Combination of Marfey's Method with Mass Spectrometry and Its Practical Application , 1997 .

[69]  Khan W. Li,et al.  Total Synthesis of the Antitumor Depsipeptide FR-901,228 , 1996 .

[70]  T. Stachelhaus,et al.  Rational design of peptide antibiotics by targeted replacement of bacterial and fungal domains. , 1995, Science.

[71]  M. Okuhara,et al.  FR901228, a novel antitumor bicyclic depsipeptide produced by Chromobacterium violaceum No. 968. I. Taxonomy, fermentation, isolation, physico-chemical and biological properties, and antitumor activity. , 1994, The Journal of antibiotics.

[72]  H. Tanaka,et al.  FR901228, a novel antitumor bicyclic depsipeptide produced by Chromobacterium violaceum No. 968. II. Structure determination. , 1994, The Journal of antibiotics.