Age-Related Changes in Mobility Evaluated by the Timed Up and Go Test Instrumented through a Single Sensor

Mobility across people with a large range of age was evaluated, for the first time, by using an instrumented timed up and go test (iTUG) based on signals acquired by a single wearable inertial sensor. Eighty healthy participants, from childhood to old age, performed the test, covering walking distances of 3 m and 7 m. Total time, temporal, and velocity parameters of linear and turning subcomponents of the test were quantified. While children, adults, and senior adults exhibited similar values for all the parameters, older adults showed increases in duration and reductions in velocity during the turning phases when compared with the other groups. an increase in velocity was observed during mid turning when the test was performed along the longer distance. Similarity across children, adults, and senior adults indicates that healthy individuals develop the abilities performed in the iTUG early, while the slowing down shown during the turning phases by the older adults may reflect the need to implement adaptive adjustments to face changes of direction. These results emphasize the idea that reducing equipment to a single sensor provides an appropriate quantification when the iTUG is used to investigate a broader age range or different levels of complexity.

[1]  Ian Sheret,et al.  A smart device inertial-sensing method for gait analysis. , 2014, Journal of biomechanics.

[2]  Cristina Colón-Semenza,et al.  Test-Retest Reliability and Minimal Detectable Change for the 10-Meter Walk Test in Older Adults With Parkinson's disease , 2016, Journal of geriatric physical therapy.

[3]  Kazuya Okamoto,et al.  Reliability and validity of gait analysis by android-based smartphone. , 2012, Telemedicine journal and e-health : the official journal of the American Telemedicine Association.

[4]  Renata D'Agostini Nicolini-Panisson,et al.  Timed "Up & Go" test in children and adolescents , 2013, Revista paulista de pediatria : orgao oficial da Sociedade de Pediatria de Sao Paulo.

[5]  B. Fisher,et al.  Anticipatory postural adjustments and spatial organization of motor cortex: evidence of adaptive compensations in healthy older adults. , 2018, Journal of neurophysiology.

[6]  Irma Sterpi,et al.  Criterion validity of the instrumented Timed Up and Go test: A partial least square regression study. , 2018, Gait & posture.

[7]  Giovanni Morone,et al.  Development and Decline of Upright Gait Stability , 2014, Front. Aging Neurosci..

[8]  Mauro Serpelloni,et al.  Use of Wearable Inertial Sensor in the Assessment of Timed-Up-and-Go Test: Influence of Device Placement on Temporal Variable Estimation , 2016, MobiHealth.

[9]  Kamiar Aminian,et al.  The instrumented timed up and go test: potential outcome measure for disease modifying therapies in Parkinson's disease , 2009, Journal of Neurology, Neurosurgery & Psychiatry.

[10]  A. Berthoz,et al.  Eye-head coordination for the steering of locomotion in humans: an anticipatory synergy , 1998, Neuroscience Letters.

[11]  M. Cioni,et al.  Responsiveness to sensory cues using the Timed Up and Go test in patients with Parkinson's disease: a prospective cohort study. , 2015, Journal of rehabilitation medicine.

[12]  John A Rogers,et al.  Augmenting Clinical Outcome Measures of Gait and Balance with a Single Inertial Sensor in Age-Ranged Healthy Adults , 2019, Sensors.

[13]  H. Topaloglu,et al.  Effect of muscle weakness distribution on balance in neuromuscular disease , 2015, Pediatrics international : official journal of the Japan Pediatric Society.

[14]  M. Tinetti Performance‐Oriented Assessment of Mobility Problems in Elderly Patients , 1986, Journal of the American Geriatrics Society.

[15]  M. Morris,et al.  The biomechanics and motor control of gait in Parkinson disease. , 2001, Clinical biomechanics.

[16]  V. Weerdesteyn,et al.  Gait adaptability. , 2018, Handbook of clinical neurology.

[17]  Lori Ann Vallis,et al.  Age-related modifications in steering behaviour: effects of base-of-support constraints at the turn point , 2008, Experimental Brain Research.

[18]  N. Vuillerme,et al.  Spatiotemporal and Kinematic Parameters Relating to Oriented Gait and Turn Performance in Patients with Chronic Stroke , 2015, PloS one.

[19]  J. Guralnik,et al.  Short Physical Performance Battery , 2017 .

[20]  J. Mathers,et al.  Towards measurement of the Healthy Ageing Phenotype in lifestyle-based intervention studies. , 2013, Maturitas.

[21]  Marco Schieppati,et al.  Walking Along Curved Trajectories. Changes With Age and Parkinson's Disease. Hints to Rehabilitation , 2019, Front. Neurol..

[22]  T. del Ser,et al.  Normative Data and Determinants for the Timed “Up and Go” Test in a Population‐Based Sample of Elderly Individuals Without Gait Disturbances , 2008, Journal of geriatric physical therapy.

[23]  Arnaud Delval,et al.  The interaction between cognition and motor control: A theoretical framework for dual-task interference effects on posture, gait initiation, gait and turning , 2018, Neurophysiologie Clinique.

[24]  Caroline Paquette,et al.  Medio-lateral stability during walking turns in older adults , 2018, PloS one.

[25]  S. Westcott,et al.  Assessment of Anthropometric Factors on Balance Tests in Children , 1998 .

[26]  Thurmon E Lockhart,et al.  Corner height influences center of mass kinematics and path trajectory during turning. , 2015, Journal of biomechanics.

[27]  M. Orendurff,et al.  The kinematics and kinetics of turning: limb asymmetries associated with walking a circular path. , 2006, Gait & posture.

[28]  C. Assaiante,et al.  Action and representation of action during childhood and adolescence: A functional approach , 2012, Neurophysiologie Clinique/Clinical Neurophysiology.

[29]  Barry R. Greene,et al.  Quantitative Falls Risk Assessment Using the Timed Up and Go Test , 2010, IEEE Transactions on Biomedical Engineering.

[30]  Rezaul Begg,et al.  A Multiple Regression Approach to Normalization of Spatiotemporal Gait Features. , 2016, Journal of applied biomechanics.

[31]  Thóra B. Hafsteinsdóttir,et al.  Clinimetric Properties of the Timed Up and Go Test for Patients With Stroke: A Systematic Review , 2014, Topics in stroke rehabilitation.

[32]  K. Berg Measuring balance in the elderly: preliminary development of an instrument , 1989 .

[33]  Chun-Hou Wang,et al.  Psychometric Properties of Functional Balance Assessment in Children With Cerebral Palsy , 2008, Neurorehabilitation and neural repair.

[34]  D. Mccarty,et al.  Simple method for measurement of lower extremity muscle strength. , 1985, The American journal of medicine.

[35]  T. Hortobágyi,et al.  Multivariate Analyses and Classification of Inertial Sensor Data to Identify Aging Effects on the Timed-Up-and-Go Test , 2016, PloS one.

[36]  Richard Baker,et al.  Comprehensive non-dimensional normalization of gait data. , 2014, Gait & posture.

[37]  Karl S Rosengren,et al.  Anticipatory Postural Adjustments for Altering Direction During Walking , 2004, Journal of motor behavior.

[38]  S. Flynn,et al.  Turning difficulty characteristics of adults aged 65 years or older. , 2000, Physical therapy.

[39]  A. Patla,et al.  “Look where you’re going!”: gaze behaviour associated with maintaining and changing the direction of locomotion , 2002, Experimental Brain Research.

[40]  O. Edholm,et al.  Studies of gait and mobility in the elderly. , 1981, Age and ageing.

[41]  Anne K. Silverman,et al.  Whole-body and segment angular momentum during 90-degree turns. , 2019, Gait & posture.

[42]  J. Heathcock,et al.  Reliability and Responsiveness of the Timed Up and Go Test in Children With Cerebral Palsy , 2016, Pediatric physical therapy : the official publication of the Section on Pediatrics of the American Physical Therapy Association.

[43]  A. Aruin,et al.  Improvement of anticipatory postural adjustments for balance control: effect of a single training session. , 2015, Journal of electromyography and kinesiology : official journal of the International Society of Electrophysiological Kinesiology.

[44]  DR McCluskey,et al.  Aids to the examination of the peripheral nervous system , 1989, Practical Neurology.

[45]  Sakineh B Akram,et al.  Effect of walking velocity on segment coordination during pre-planned turns in healthy older adults. , 2010, Gait & posture.

[46]  Brian Caulfield,et al.  Longitudinal assessment of falls in patients with Parkinson’s disease using inertial sensors and the Timed Up and Go test , 2018, Journal of rehabilitation and assistive technologies engineering.

[47]  L. Gunnarsson,et al.  Clinical relevance using timed walk tests and 'timed up and go' testing in persons with multiple sclerosis. , 2007, Physiotherapy research international : the journal for researchers and clinicians in physical therapy.

[48]  Nir Giladi,et al.  Transition Between the Timed up and Go Turn to Sit Subtasks: Is Timing Everything? , 2016, Journal of the American Medical Directors Association.