Integrated product formation and recovery in fermentation

Abstract Fermentation processes are hampered by a variety of problems originating from the accumulation of products in the fermenter. Integration of fermentation and a primary product separation step can accelerate the product formation, improve the product yield, and facilitate downstream processing. The advantages of integrated bioprocesses, however, are counteracted by the incompatibility of the subprocesses. Over the past few years, research in this field has been directed towards the development of engineering tools to reduce integration problems, to select a suitable approach, and to predict the feasibility of the integrated process. More fundamental knowledge about metabolic pathways, control mechanisms, and process dynamics is needed in order to optimally design integrated systems.

[1]  J T Hsu,et al.  Fundamental studies of biomolecule partitioning in aqueous two‐phase systems , 1989, Biotechnology and bioengineering.

[2]  H. Renon,et al.  Ethanol extraction by supported liquid membrane during fermentation , 1990, Biotechnology and bioengineering.

[3]  J. Tramper,et al.  Growth and thiophene production by hairy root cultures of Tagetes patula in various two-liquid-phase bioreactors. , 1991 .

[4]  D. I. Wang,et al.  Extractive fermentation for lactic acid production , 1991, Biotechnology and bioengineering.

[5]  K. Ch. A. M. Luyben,et al.  Integration of pervaporation and continuous butanol fermentation with immobilized cells: II: Mathematical modelling and simulations , 1991 .

[6]  R. Busche.  Extractive fermentation of acetic acid , 1991 .

[7]  Masayoshi Iwahara,et al.  Novel Method of Lactic Acid Production by Electrodialysis Fermentation , 1986, Applied and environmental microbiology.

[8]  D. I. Wang,et al.  Strategies for reducing solvent toxicity in extractive fermentations , 1991, Biotechnology and bioengineering.

[9]  P. Wankat,et al.  Acetone‐Butanol‐Ethanol (ABE) Fermentation and Simultaneous Separation in a Trickle Bed Reactor , 1991 .

[10]  John L. Gainer,et al.  Acid Fermentation in Water‐Organic Solvent Two‐Liquid Phase Systems , 1987 .

[11]  J. Lehmann,et al.  Vortex chamber for in situ recovery of the antibiotic myxovirescin A in continuous cultivation , 1987, Biotechnology and bioengineering.

[12]  Christian Wandrey,et al.  Integrierte Produktaufarbeitung mittels Elektrodialyse bei der mikrobiellen Produktion organischer Säuren , 1990 .

[13]  K. Ch. A. M. Luyben,et al.  Ethanol production in an integrated process of fermentation and ethanol recovery by pervaporation , 1992 .

[14]  Hiroshi Kataoka,et al.  Continuous ethanol fermentation of concentrated sugar solutions coupled with membrane distillation using a PTFE module , 1989 .

[15]  A. Daugulis.  Integrated Reaction and Product Recovery in Bioreactor Systems , 1988 .

[16]  A. Daugulis,et al.  Solvent Selection Strategies for Extractive Biocatalysis , 1991, Biotechnology progress.

[17]  R. Reid,et al.  Estimation of the solubilities of organic compounds in polymers by group-contribution methods , 1989 .

[18]  R. Bajpai,et al.  Nondispersive extraction for recovering lactic acid , 1991 .

[19]  C. Laane,et al.  On optimizing organic solvents in multi-liquid-phase biocatalysis , 1985 .

[20]  H. Chang,et al.  Enhanced shikonin production from Lithospermum erythrorhizon by in situ extraction and calcium alginate immobilization , 1990, Biotechnology and bioengineering.

[21]  Antonio A. Garcia.  Strategies for the Recovery of Chemicals from Fermentation: A Review of the Use of Polymeric Adsorbents , 1991, Biotechnology progress.

[22]  K. Ch. A. M. Luyben,et al.  Integration of pervaporation and continuous butanol fermentation with immobilized cells. I: Experimental results , 1991 .

[23]  Computer modeling of antibiotic fermentation with on‐line product removal , 1988, Biotechnology and bioengineering.

[24]  Harvey W. Blanch,et al.  Economic evaluation of alternative ethanol fermentation processes , 1984 .

[25]  Mark A. Eiteman,et al.  Predicting partition coefficients in polyethylene glycol-potassium phosphate aqueous two-phase systems , 1991 .

[26]  Harvey W. Blanch,et al.  Extractive Fermentation of Acetone and Butanol: Process Design and Economic Evaluation , 1987 .

[27]  K. Ch. A. M. Luyben,et al.  Butanol recovery from fermentations by liquid-liquid extraction and membrane solvent extraction , 1990 .