The development of AIDS or AIDS‐related conditions in a cohort of HIV antibody‐positive homosexual men during a 3‐year follow‐up period

Abstract. One hundred and thirty‐three homosexual men seropositive for the antibody against human immunodeficiency virus (HIV) were enrolled in a prospective study in 1984–85. The 3‐year cumulative incidences of the acquired immunodeficiency syndrome (AIDS) and AIDS‐related conditions, by life‐table analyses, were 18% and 34%. The cumulative incidence of immune deficiency defined as CD4 lymphocytes < 0.5 times 109 l−1 was 70% at 3 years. Absence of antibodies to p24 antigen, HIV antigenaemia, CD4 lymphocytes < 0.3 times 10 l−1 and elevated serum level of IgA were significantly associated with the development of AIDS. There was no association between disease progression and persistent generalized lymphadenopathy.

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