Esters and amides of 2,3-dimethoxy-8,9-methylenedioxy-benzo[i]phenanthridine-12-carboxylic acid: potent cytotoxic and topoisomerase I-targeting agents.
暂无分享,去创建一个
[1] Nai Zhou,et al. 5-(2-aminoethyl)dibenzo[c,h][1,6]naphthyridin-6-ones: variation of n-alkyl substituents modulates sensitivity to efflux transporters associated with multidrug resistance. , 2005, Journal of medicinal chemistry.
[2] E. LaVoie,et al. Dimethoxybenzo[i]phenanthridine-12-carboxylic acid derivatives and 6H-dibenzo[c,h][2,6]naphthyridin-5-ones with potent topoisomerase I-targeting activity and cytotoxicity. , 2004, Bioorganic & medicinal chemistry letters.
[3] E. LaVoie,et al. Nitro and amino substitution within the A-ring of 5H-8,9-dimethoxy-5-(2-N,N-dimethylaminoethyl)dibenzo[c,h][1,6]naphthyridin-6-ones: influence on topoisomerase I-targeting activity and cytotoxicity. , 2004, Bioorganic & medicinal chemistry.
[4] Alexander L. Ruchelman,et al. Cytotoxicity of 5H-Dibenzo[c,h][1,6]naphthyridin-6-ones and 6H-Indeno[1,2-c]isoquinolin-5,11-diones in Tumor Cells Sensitive and Resistant to Camptothecin Analogs , 2004 .
[5] A. Ray,et al. 11H-Isoquino[4,3-c]cinnolin-12-ones; novel anticancer agents with potent topoisomerase I-targeting activity and cytotoxicity. , 2004, Bioorganic & medicinal chemistry.
[6] Peter J Houghton,et al. Characterization of ARC-111 as a novel topoisomerase I-targeting anticancer drug. , 2003, Cancer research.
[7] E. LaVoie,et al. Aza-analogs of dibenzo[c,h]cinnoline: Triazachrysenes as potent topoisomerase I-targeting anticancer agents , 2003 .
[8] E. LaVoie,et al. 5H-8,9-dimethoxy-5-(2-N,N-dimethylaminoethyl)dibenzo[c,h][1,6]naphthyridin-6-ones and related compounds as TOP1-targeting agents: influence of structure on the ternary cleavable complex formation. , 2003, Bioorganic & medicinal chemistry letters.
[9] E. LaVoie,et al. 8,9-methylenedioxybenzo[i]phenanthridines: topoisomerase I-targeting activity and cytotoxicity. , 2003, Bioorganic & medicinal chemistry.
[10] E. LaVoie,et al. Nitro and amino substitution in the D-ring of 5-(2-dimethylaminoethyl)- 2,3-methylenedioxy-5H-dibenzo[c,h][1,6]naphthyridin-6-ones: effect on topoisomerase-I targeting activity and cytotoxicity. , 2003, Journal of medicinal chemistry.
[11] A. Ray,et al. 5H-Dibenzo[c,h]1,6-naphthyridin-6-ones: novel topoisomerase I-targeting anticancer agents with potent cytotoxic activity. , 2003, Bioorganic & medicinal chemistry.
[12] E. LaVoie,et al. Substituted benzo[i]phenanthridines as mammalian topoisomerase-targeting agents. , 2003, Bioorganic & medicinal chemistry.
[13] E. LaVoie,et al. 2,3-Dimethoxybenzo[i]phenanthridines: topoisomerase I-targeting anticancer agents. , 2003, Bioorganic & medicinal chemistry.
[14] A. Ray,et al. Diaza- and triazachrysenes: potent topoisomerase-targeting agents with exceptional antitumor activity against the human tumor xenograft, MDA-MB-435. , 2002, Bioorganic & medicinal chemistry letters.
[15] R. SanMartin,et al. Revisiting the Ullmann-ether reaction: a concise and amenable synthesis of novel dibenzoxepino[4,5-d]pyrazoles by intramolecular etheration of 4,5-(o,o'-halohydroxy)arylpyrazoles. , 2002, The Journal of organic chemistry.
[16] L. Liu,et al. Stimulation of topoisomerase II-mediated DNA damage via a mechanism involving protein thiolation. , 2001, Biochemistry.
[17] L. Doyle,et al. Breast cancer resistance protein directly confers SN-38 resistance of lung cancer cells. , 2001, Biochemical and biophysical research communications.
[18] J. Sambrook,et al. Molecular Cloning: A Laboratory Manual , 2001 .
[19] M. Kuo,et al. BCRP/MXR/ABCP expression in topotecan-resistant human breast carcinoma cells. , 2000, Biochemical pharmacology.
[20] W. Scherer,et al. Volatile Donor-Functionalized Alkoxy Derivatives of Lutetium and Their Structural Characterization(1). , 1997, Inorganic chemistry.
[21] Y. Sugiyama,et al. Multiplicity of biliary excretion mechanisms for irinotecan, CPT-11, and its metabolites in rats. , 1997, Cancer research.
[22] B. Gatto,et al. Identification of topoisomerase I as the cytotoxic target of the protoberberine alkaloid coralyne. , 1996, Cancer research.
[23] D. Kufe,et al. Identification of a mutant human topoisomerase I with intact catalytic activity and resistance to 9-nitro-camptothecin. , 1994, The Journal of biological chemistry.
[24] T. Burke,et al. Ethyl substitution at the 7 position extends the half-life of 10-hydroxycamptothecin in the presence of human serum albumin. , 1993, Journal of medicinal chemistry.
[25] T. Burke,et al. Preferential binding of the carboxylate form of camptothecin by human serum albumin. , 1993, Analytical biochemistry.
[26] G. Weiss,et al. A phase I clinical and pharmacokinetic study of the topoisomerase I inhibitor topotecan (SK&F 104864) given as an intravenous bolus every 21 days , 1992, Anti-cancer drugs.
[27] C. Yu,et al. Camptothecin overcomes MDR1-mediated resistance in human KB carcinoma cells. , 1991, Cancer research.
[28] J. Gervasoni,et al. Subcellular distribution of daunorubicin in P-glycoprotein-positive and -negative drug-resistant cell lines using laser-assisted confocal microscopy. , 1991, Cancer research.
[29] L. Liu,et al. Arrest of replication forks by drug-stabilized topoisomerase I-DNA cleavable complexes as a mechanism of cell killing by camptothecin. , 1989, Cancer research.
[30] Y. Suzuki,et al. Characterization of a mammalian mutant with a camptothecin-resistant DNA topoisomerase I. , 1987, Proceedings of the National Academy of Sciences of the United States of America.
[31] James B. Mitchell,et al. Evaluation of a tetrazolium-based semiautomated colorimetric assay: assessment of chemosensitivity testing. , 1987, Cancer research.
[32] F. Denizot,et al. Rapid colorimetric assay for cell growth and survival. Modifications to the tetrazolium dye procedure giving improved sensitivity and reliability. , 1986, Journal of immunological methods.
[33] L. Liu,et al. Adriamycin-induced DNA damage mediated by mammalian DNA topoisomerase II. , 1984, Science.
[34] T. Mosmann. Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. , 1983, Journal of immunological methods.
[35] L. Liu,et al. DNA topoisomerases: essential enzymes and lethal targets. , 1994, Annual review of pharmacology and toxicology.
[36] R. Hertzberg,et al. Camptothecin hyper-resistant P388 cells: drug-dependent reduction in topoisomerase I content. , 1992, Oncology research.
[37] L. Liu,et al. DNA topoisomerase poisons as antitumor drugs. , 1989, Annual review of biochemistry.
[38] D. B. Luten. THE PREPARATION OF AMINONITRILES AND THEIR QUATERNARY AMMONIUM DERIVATIVES , 1939 .