Map‐ISODATA demarcates regional response to combination rt‐PA and 7E3 F(ab′)2 treatment of embolic stroke in the rat

To investigate the ability of map‐ISODATA (Iterative Self‐Organizing Data Analysis Technique) to classify the different categories of ischemic damage in the lesion and to evaluate a combined (thrombolysis plus antiplatelet) treatment efficacy in an embolic stroke of rat.

[1]  G. D. del Zoppo The role of platelets in ischemic stroke , 1998, Neurology.

[2]  S. Williams,et al.  Diffusion‐Weighted Imaging Studies of Cerebral Ischemia in Gerbils: Potential Relevance to Energy Failure , 1992, Stroke.

[3]  M. Chopp,et al.  Temporal evolution and spatial distribution of the diffusion constant of water in rat brain after transient middle cerebral artery occlusion , 1993, Journal of the Neurological Sciences.

[4]  P. Grenier,et al.  MR imaging of intravoxel incoherent motions: application to diffusion and perfusion in neurologic disorders. , 1986, Radiology.

[5]  D. Collen Designing thrombolytic agents: focus on safety and efficacy. , 1992, The American journal of cardiology.

[6]  R A Knight,et al.  Unsupervised segmentation of multiparameter MRI in experimental cerebral ischemia with comparison to T2, diffusion, and ADC MRI parameters and histopathological validation , 2000, Journal of magnetic resonance imaging : JMRI.

[7]  R A Knight,et al.  Magnetic Resonance Imaging Indexes of Therapeutic Efficacy of Recombinant Tissue Plasminogen Activator Treatment of Rat at 1 and 4 Hours after Embolic Stroke , 2000, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[8]  M. Chopp,et al.  Adjuvant Treatment With a Glycoprotein IIb/IIIa Receptor Inhibitor Increases the Therapeutic Window for Low-Dose Tissue Plasminogen Activator Administration in a Rat Model of Embolic Stroke , 2003, Circulation.

[9]  Trial of abciximab with and without low-dose reteplase for acute myocardial infarction. Strategies for Patency Enhancement in the Emergency Department (SPEED) Group. , 2000, Circulation.

[10]  Y. S. Zhou,et al.  Monocytes and tissue factor promote thrombosis in a murine model of oxygen deprivation. , 1997, The Journal of clinical investigation.

[11]  E. Antman,et al.  Combination reperfusion therapy with abciximab and reduced dose reteplase: results from TIMI 14. The Thrombolysis in Myocardial Infarction (TIMI) 14 Investigators. , 2000, European heart journal.

[12]  C. Korninger,et al.  Studies on the Specific Fibrinolytic Effect of Human Extrinsic (Tissue-Type) Plasminogen Activator in Human Blood and in Various Animal Species in Vitro , 1981, Thrombosis and Haemostasis.

[13]  B. Dardzinski,et al.  Apparent diffusion coefficient mapping of experimental focal cerebral ischemia using diffusion‐weighted echo‐planar imaging , 1993, Magnetic resonance in medicine.

[14]  J Seega,et al.  Diffusion- and T2-weighted imaging: evaluation of oedema reduction in focal cerebral ischaemia by the calcium and serotonin antagonist levemopamil. , 1993, Magnetic resonance imaging.

[15]  K. Schrör Antiplatelet drugs. A comparative review. , 1995, Drugs.

[16]  E. Bates,et al.  Prevention of Rethrombosis After Coronary Thrombolysis in a Chronic Canine Model. I. Adjunctive Therapy with Monoclonal Antibody 7E3 F(ab')2 Fragment , 1994, Journal of cardiovascular pharmacology.

[17]  H Soltanian-Zadeh,et al.  A Model for Multiparametric MRI Tissue Characterization in Experimental Cerebral Ischemia With Histological Validation in Rat: Part 1 , 2001, Stroke.

[18]  R. Ordidge,et al.  Magnetic Resonance Imaging Assessment of Evolving Focal Cerebral Ischemia Comparison With Histopathology in Rats , 1994, Stroke.

[19]  E. Connolly,et al.  Reduced microvascular thrombosis and improved outcome in acute murine stroke by inhibiting GP IIb/IIIa receptor-mediated platelet aggregation. , 1998, The Journal of clinical investigation.

[20]  J. Soria,et al.  Disaggregation of In Vitro Preformed Platelet-Rich Clots by Abciximab Increases Fibrin Exposure and Promotes Fibrinolysis , 2001, Arteriosclerosis, thrombosis, and vascular biology.

[21]  D. Look,et al.  Time Saving in Measurement of NMR and EPR Relaxation Times , 1970 .

[22]  L R Schad,et al.  Fast and precise T1 imaging using a TOMROP sequence. , 1990, Magnetic resonance imaging.

[23]  Michael Chopp,et al.  MAGNETIC-RESONANCE-IMAGING ASSESSMENT OF EVOLVING FOCAL CEREBRAL-ISCHEMIA - COMPARISON WITH HISTOPATHOLOGY IN RATS (VOL 25, PG 1252, 1994) , 1994 .

[24]  Joseph P. Broderick,et al.  Tissue plasminogen activator for acute ischemic stroke. The National Institute of Neurological Disorders and Stroke rt-PA Stroke Study Group. , 1995 .

[25]  Michael Chopp,et al.  A rat model of focal embolic cerebral ischemia , 1997, Brain Research.

[26]  Coller Bs Augmentation of thrombolysis with antiplatelet drugs. , 1995 .

[27]  E. Topol,et al.  Platelet glycoprotein IIb/IIIa receptors in cardiovascular medicine. , 1995, The New England journal of medicine.

[28]  Hamid Soltanian-Zadeh,et al.  Multiparametric ISODATA analysis of embolic stroke and rt-PA intervention in rat , 2004, Journal of the Neurological Sciences.

[29]  J. Soria,et al.  Effects of Abciximab on the Architecture of Platelet-Rich Clots in Patients With Acute Myocardial Infarction Undergoing Primary Coronary Intervention , 2001, Circulation.

[30]  J P Windham,et al.  Eigenimage Filtering in MR Imaging , 1988, Journal of computer assisted tomography.

[31]  R. Jordan,et al.  7E3 F(ab’)2, an Effective Antagonist of Rat αIIbβ3 and αvβ3, Blocks In Vivo Thrombus Formation and In Vitro Angiogenesis , 2001, Thrombosis and Haemostasis.

[32]  Michael Chopp,et al.  The temporal evolution of MRI tissue signatures after transient middle cerebral artery occlusion in rat , 1997, Journal of the Neurological Sciences.

[33]  Hamid Soltanian-Zadeh,et al.  MRI tissue characterization of experimental cerebral ischemia in rat , 2003, Journal of magnetic resonance imaging : JMRI.

[34]  B. Coller Augmentation of thrombolysis with antiplatelet drugs. , 1995, Coronary artery disease.

[35]  A. Kastrati,et al.  Effect of glycoprotein IIb/IIIa receptor blockade on recovery of coronary flow and left ventricular function after the placement of coronary-artery stents in acute myocardial infarction. , 1998, Circulation.

[36]  Katsuhiro Yamashita,et al.  Changes of relaxation times (T1, T2) and apparent diffusion coefficient after permanent middle cerebral artery occlusion in the rat: temporal evolution, regional extent, and comparison with histology , 1995, Magnetic resonance in medicine.

[37]  G H Ball,et al.  A clustering technique for summarizing multivariate data. , 1967, Behavioral science.

[38]  R. Sacco,et al.  Antithrombotic and thrombolytic therapy for ischemic stroke. , 1998, Chest.

[39]  E. Ohman,et al.  Relation between inhibition of platelet aggregation and clinical outcomes. , 1998, American heart journal.

[40]  M Chopp,et al.  Diffusion-, T2-, and Perfusion-Weighted Nuclear Magnetic Resonance Imaging of Middle Cerebral Artery Embolic Stroke and Recombinant Tissue Plasminogen Activator Intervention in the Rat , 1998, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[41]  M. Bednar,et al.  Antiplatelet therapy in acute cerebral ischemia. , 1999, Stroke.