Mitochondrial fission in apoptosis

Mitochondria fuse and divide continuously within cells to form a dynamic network. One of the steps in apoptosis is the fragmentation of mitochondria, and recent evidence indicates that the mitochondrial fission machinery actively participates in the process of programmed cell death.

[1]  Y. Lazebnik,et al.  The two cytochrome c species, DC3 and DC4, are not required for caspase activation and apoptosis in Drosophila cells , 2004, The Journal of cell biology.

[2]  J. Mestan,et al.  SH3GLB, a new endophilin-related protein family featuring an SH3 domain. , 2001, Genomics.

[3]  J. Pevsner,et al.  Mitochondrial fission proteins regulate programmed cell death in yeast. , 2004, Genes & development.

[4]  J. Shaw,et al.  The dynamin-related GTPase Dnm1 regulates mitochondrial fission in yeast , 1999, Nature Cell Biology.

[5]  K. G. Hales,et al.  Developmentally Regulated Mitochondrial Fusion Mediated by a Conserved, Novel, Predicted GTPase , 1997, Cell.

[6]  P. De Camilli,et al.  Generation of high curvature membranes mediated by direct endophilin bilayer interactions , 2001, The Journal of cell biology.

[7]  K. Mihara,et al.  Mitofusin 1 and 2 play distinct roles in mitochondrial fusion reactions via GTPase activity , 2004, Journal of Cell Science.

[8]  R. Youle,et al.  Endophilin B1 is required for the maintenance of mitochondrial morphology , 2004, The Journal of cell biology.

[9]  B. Lorenz,et al.  Mutation spectrum and splicing variants in the OPA1 gene , 2001, Human Genetics.

[10]  L. Scorrano,et al.  OPA1 requires mitofusin 1 to promote mitochondrial fusion. , 2004, Proceedings of the National Academy of Sciences of the United States of America.

[11]  A. Ruusala,et al.  Atypical Rho GTPases Have Roles in Mitochondrial Homeostasis and Apoptosis* , 2003, The Journal of Biological Chemistry.

[12]  Sujay K. Singh,et al.  Molecular Cloning and Characterization of Bif-1 , 2001, The Journal of Biological Chemistry.

[13]  P. De Camilli,et al.  Recruitment of an alternatively spliced form of synaptojanin 2 to mitochondria by the interaction with the PDZ domain of a mitochondrial outer membrane protein , 1999, The EMBO journal.

[14]  J. McCaffery,et al.  Structural Basis of Mitochondrial Tethering by Mitofusin Complexes , 2004, Science.

[15]  H. McBride,et al.  Endoplasmic reticulum BIK initiates DRP1‐regulated remodelling of mitochondrial cristae during apoptosis , 2005, The EMBO journal.

[16]  A. M. van der Bliek,et al.  C. elegans dynamin-related protein DRP-1 controls severing of the mitochondrial outer membrane. , 1999, Molecular cell.

[17]  T. Kirchhausen,et al.  Constriction and Dnm1p recruitment are distinct processes in mitochondrial fission. , 2003, Molecular biology of the cell.

[18]  A. Gittis,et al.  Cytosolic domain of the human mitochondrial fission protein fis1 adopts a TPR fold , 2003, Proteins.

[19]  M. McNiven,et al.  Mammalian dynamin-like protein DLP1 tubulates membranes. , 2001, Molecular biology of the cell.

[20]  J. Martinou,et al.  Mitochondria as the central control point of apoptosis. , 2000, Trends in cell biology.

[21]  M. Yaffe,et al.  The Yeast Dynamin-like Protein, Mgm1p, Functions on the Mitochondrial Outer Membrane to Mediate Mitochondrial Inheritance , 1999, The Journal of cell biology.

[22]  R. Youle,et al.  Bax and Bak Coalesce into Novel Mitochondria-Associated Clusters during Apoptosis , 2001, The Journal of cell biology.

[23]  G. Lenaers,et al.  Loss of OPA1 Perturbates the Mitochondrial Inner Membrane Structure and Integrity, Leading to Cytochrome c Release and Apoptosis* , 2003, The Journal of Biological Chemistry.

[24]  C. Streuli,et al.  Spatial and temporal changes in Bax subcellular localization during anoikis , 2003, The Journal of cell biology.

[25]  S. Jakobs,et al.  The inner membrane protein Mdm33 controls mitochondrial morphology in yeast , 2003, The Journal of cell biology.

[26]  G. Lenaers,et al.  The human dynamin‐related protein OPA1 is anchored to the mitochondrial inner membrane facing the inter‐membrane space , 2002, FEBS letters.

[27]  C. Borner,et al.  Conformational control of Bax localization and apoptotic activity by Pro168 , 2004, The Journal of cell biology.

[28]  Harvey T. McMahon,et al.  The dynamin superfamily: universal membrane tubulation and fission molecules? , 2004, Nature Reviews Molecular Cell Biology.

[29]  J. Shaw,et al.  The Dynamin-Related Gtpase, Mgm1p, Is an Intermembrane Space Protein Required for Maintenance of Fusion Competent Mitochondria , 2000, The Journal of cell biology.

[30]  Kara L. Cerveny,et al.  Division of mitochondria requires a novel DNM1-interacting protein, Net2p. , 2001, Molecular biology of the cell.

[31]  S. Bhattacharya,et al.  OPA1, encoding a dynamin-related GTPase, is mutated in autosomal dominant optic atrophy linked to chromosome 3q28 , 2000, Nature Genetics.

[32]  A. M. van der Bliek,et al.  Dynamin-related protein Drp1 is required for mitochondrial division in mammalian cells. , 2001, Molecular biology of the cell.

[33]  Tullio Pozzan,et al.  The Ca2+ concentration of the endoplasmic reticulum is a key determinant of ceramide‐induced apoptosis: significance for the molecular mechanism of Bcl‐2 action , 2001, The EMBO journal.

[34]  Mason R. Mackey,et al.  Bid, Bax, and Lipids Cooperate to Form Supramolecular Openings in the Outer Mitochondrial Membrane , 2002, Cell.

[35]  L. Brodin,et al.  Endophilin/SH3p4 Is Required for the Transition from Early to Late Stages in Clathrin-Mediated Synaptic Vesicle Endocytosis , 1999, Neuron.

[36]  M. Schrader,et al.  Peroxisome elongation and constriction but not fission can occur independently of dynamin-like protein 1 , 2004, Journal of Cell Science.

[37]  A. Lombès,et al.  Membrane topology and mitochondrial targeting of mitofusins, ubiquitous mammalian homologs of the transmembrane GTPase Fzo. , 2002, Journal of cell science.

[38]  杉岡 梨恵.  Fzo1, a protein involved in mitochondrial fusion, inhibits apoptosis , 2005 .

[39]  D. Danino,et al.  Rapid constriction of lipid bilayers by the mechanochemical enzyme dynamin. , 2004, Journal of structural biology.

[40]  A. Klippel,et al.  Knockdown of MTP18, a Novel Phosphatidylinositol 3-Kinase-dependent Protein, Affects Mitochondrial Morphology and Induces Apoptosis* , 2004, Journal of Biological Chemistry.

[41]  J. Grosgeorge,et al.  Nuclear gene OPA1, encoding a mitochondrial dynamin-related protein, is mutated in dominant optic atrophy , 2000, Nature Genetics.

[42]  J. Shaw,et al.  Dnm1p Gtpase-Mediated Mitochondrial Fission Is a Multi-Step Process Requiring the Novel Integral Membrane Component Fis1p , 2000, The Journal of cell biology.

[43]  S. Frank,et al.  Spatial and temporal association of Bax with mitochondrial fission sites, Drp1, and Mfn2 during apoptosis , 2002, The Journal of cell biology.

[44]  R. Jagasia,et al.  DRP-1-mediated mitochondrial fragmentation during EGL-1-induced cell death in C. elegans , 2005, Nature.

[45]  H. McBride,et al.  Sumo1 Conjugates Mitochondrial Substrates and Participates in Mitochondrial Fission , 2004, Current Biology.

[46]  J. McCaffery,et al.  Mitochondrial Fusion Intermediates Revealed in Vitro , 2004, Science.

[47]  A. Kimchi,et al.  Death-associated Protein 3 Localizes to the Mitochondria and Is Involved in the Process of Mitochondrial Fragmentation during Cell Death* , 2004, Journal of Biological Chemistry.

[48]  Rebecca L. Frederick,et al.  Yeast Miro GTPase, Gem1p, regulates mitochondrial morphology via a novel pathway , 2004, The Journal of cell biology.

[49]  J. Zimmerberg,et al.  Bax-type Apoptotic Proteins Porate Pure Lipid Bilayers through a Mechanism Sensitive to Intrinsic Monolayer Curvature* , 2002, The Journal of Biological Chemistry.

[50]  A. Mayer,et al.  Mutual Control of Membrane Fission and Fusion Proteins , 2004, Cell.

[51]  J. Nunnari,et al.  The Division of Endosymbiotic Organelles , 2003, Science.

[52]  N. Tjandra,et al.  The solution structure of human mitochondria fission protein Fis1 reveals a novel TPR-like helix bundle. , 2003, Journal of molecular biology.

[53]  J. Martinou,et al.  hFis1, a Novel Component of the Mammalian Mitochondrial Fission Machinery* , 2003, Journal of Biological Chemistry.

[54]  R. Youle,et al.  Roles of the mammalian mitochondrial fission and fusion mediators Fis1, Drp1, and Opa1 in apoptosis. , 2004, Molecular biology of the cell.

[55]  S. Schmid,et al.  Tubular membrane invaginations coated by dynamin rings are induced by GTP-γS in nerve terminals , 1995, Nature.

[56]  J. Nunnari,et al.  The WD repeat protein, Mdv1p, functions as a molecular adaptor by interacting with Dnm1p and Fis1p during mitochondrial fission , 2002, The Journal of cell biology.

[57]  R. Jensen,et al.  UGO1 Encodes an Outer Membrane Protein Required for Mitochondrial Fusion , 2001, The Journal of cell biology.

[58]  R. Jensen,et al.  Mgm1p, a dynamin-related GTPase, is essential for fusion of the mitochondrial outer membrane. , 2003, Molecular biology of the cell.

[59]  P. Paty,et al.  Mitochondrial Proliferation and Paradoxical Membrane Depolarization during Terminal Differentiation and Apoptosis in a Human Colon Carcinoma Cell Line , 1997, The Journal of cell biology.

[60]  Stefan Fritz,et al.  Genetic basis of mitochondrial function and morphology in Saccharomyces cerevisiae. , 2002, Molecular biology of the cell.

[61]  J. Thatcher,et al.  Mitochondrial Fusion in Yeast Requires the Transmembrane GTPase Fzo1p , 1998, The Journal of cell biology.

[62]  John D. Scott,et al.  Rab32 is an A-kinase anchoring protein and participates in mitochondrial dynamics , 2002, The Journal of cell biology.

[63]  T. Kuroiwa,et al.  Dynamic recruitment of dynamin for final mitochondrial severance in a primitive red alga , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[64]  M. Crompton,et al.  Biphasic translocation of Bax to mitochondria. , 2002, The Biochemical journal.

[65]  G. Shore,et al.  Caspase cleavage product of BAP31 induces mitochondrial fission through endoplasmic reticulum calcium signals, enhancing cytochrome c release to the cytosol , 2003, The Journal of cell biology.

[66]  A. M. van der Bliek,et al.  Loss of the Intermembrane Space Protein Mgm1/OPA1 Induces Swelling and Localized Constrictions along the Lengths of Mitochondria* , 2004, Journal of Biological Chemistry.

[67]  A Mitochondrial Division Apparatus Takes Shape , 2000, The Journal of cell biology.

[68]  R. Youle,et al.  Quantitation of mitochondrial dynamics by photolabeling of individual organelles shows that mitochondrial fusion is blocked during the Bax activation phase of apoptosis , 2004, The Journal of cell biology.

[69]  Erik E. Griffin,et al.  Mitofusins Mfn1 and Mfn2 coordinately regulate mitochondrial fusion and are essential for embryonic development , 2003, The Journal of cell biology.

[70]  S. Frank,et al.  The role of dynamin-related protein 1, a mediator of mitochondrial fission, in apoptosis. , 2001, Developmental cell.

[71]  M. McNiven,et al.  The Mitochondrial Protein hFis1 Regulates Mitochondrial Fission in Mammalian Cells through an Interaction with the Dynamin-Like Protein DLP1 , 2003, Molecular and Cellular Biology.

[72]  Luca Scorrano,et al.  A distinct pathway remodels mitochondrial cristae and mobilizes cytochrome c during apoptosis. , 2002, Developmental cell.

[73]  A. Santel,et al.  Control of mitochondrial morphology by a human mitofusin. , 2001, Journal of cell science.