Mismatch negativity in detection of interval duration deviation in schizophrenia

Temporal processing deficits have been noted in behavioral studies assessing patients with schizophrenia. The current study sought to explore the physiology of temporal perception while controlling the effects of motivation, attention and other cognitive processes that may contribute to behavioral measures of temporal processing. Mismatch negativity (MMN) waveforms were measured in response to variations in the temporal parameters of an ongoing train of pure tones. A standard inter-stimulus interval of 400 ms was interrupted, on average, every 20th tone by an inter-stimulus interval of 340 ms. Amplitude of MMN waveform elicited by the temporal deviance was significantly reduced in the schizophrenia group compared with controls (p = 0.016). Results suggest that behavioral difficulties on time processing tasks in schizophrenia may reflect a physiological deficit in temporal perception in this population rather than simply more general difficulties in attention or motivation.

[1]  I. P. Christensen,et al.  Psychophysics , 2019, Encyclopedia of Evolutionary Psychological Science.

[2]  M. Kisley,et al.  Deficits in auditory and visual temporal perception in schizophrenia , 2002, Cognitive neuropsychiatry.

[3]  Ulrich Schall,et al.  Modulation of mismatch negativity by stimulus deviance and modality of attention , 2002, Neuroreport.

[4]  T. Baldeweg,et al.  Impairment in frontal but not temporal components of mismatch negativity in schizophrenia. , 2002, International journal of psychophysiology : official journal of the International Organization of Psychophysiology.

[5]  R Näätänen,et al.  The mismatch negativity as an index of temporal processing in audition , 2001, Clinical Neurophysiology.

[6]  H. Sauer,et al.  Time estimation in schizophrenia: an fMRI study at adjusted levels of difficulty , 2001, Neuroreport.

[7]  D. Javitt,et al.  Diminished responsiveness of ERPs in schizophrenic subjects to changes in auditory stimulation parameters: implications for theories of cortical dysfunction , 1999, Schizophrenia Research.

[8]  D. Javitt,et al.  Effects of clozapine on auditory event-related potentials in schizophrenia , 1998, Biological Psychiatry.

[9]  R B Ivry,et al.  Dissociable contributions of the prefrontal and neocerebellar cortex to time perception. , 1998, Brain research. Cognitive brain research.

[10]  J. Tracy,et al.  Information-Processing Characteristics of Explicit Time Estimation by Patients with Schizophrenia and Normal Controls , 1998, Perceptual and motor skills.

[11]  R. Oades,et al.  Impaired attention-dependent augmentation of MMN in nonparanoid vs paranoid schizophrenic patients: A comparison with obsessive-compulsive disorder and healthy subjects , 1997, Biological Psychiatry.

[12]  Alexander L. Miller,et al.  The functional significance of symptomatology and cognitive function in schizophrenia , 1997, Schizophrenia Research.

[13]  C. Gallistel,et al.  Toward a neurobiology of temporal cognition: advances and challenges , 1997, Current Opinion in Neurobiology.

[14]  R Freedman,et al.  Inhibitory gating of an evoked response to repeated auditory stimuli in schizophrenic and normal subjects. Human recordings, computer simulation, and an animal model. , 1996, Archives of general psychiatry.

[15]  Streichenwein Sm,et al.  Am J Psychiatry , 1996 .

[16]  S. Andrews,et al.  Brain potential evidence for an auditory sensory memory deficit in schizophrenia. , 1995, The American journal of psychiatry.

[17]  B. Schmand,et al.  Cognitive disorders and negative symptoms as correlates of motivational deficits in psychotic patients , 1994, Psychological Medicine.

[18]  R. McCarley,et al.  Auditory ERPs to non-target stimuli in schizophrenia: relationship to probability, task-demands, and target ERPs. , 1994, International journal of psychophysiology : official journal of the International Organization of Psychophysiology.

[19]  R Näätänen,et al.  Event-related potentials reveal a memory trace for temporal features. , 1993, Neuroreport.

[20]  G. Csibra,et al.  Age and inter-stimulus interval effects on event-related potentials to frequent and infrequent auditory stimuli , 1992, Biological Psychology.

[21]  L. Tysk.  Estimation of Time by Patients with Positive and Negative Schizophrenia , 1990, Perceptual and motor skills.

[22]  T. Picton,et al.  The N1 wave of the human electric and magnetic response to sound: a review and an analysis of the component structure. , 1987, Psychophysiology.

[23]  J. Gentile,et al.  Time Estimation by Hyperactive and Normal Children , 1977, Perceptual and motor skills.

[24]  D. Braff,et al.  Neurocognitive deficits and functional outcome in schizophrenia: are we measuring the "right stuff"? , 2000, Schizophrenia bulletin.