Deciding whether to go with the flow: evaluating the merits of flow reactors for synthesis.
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[1] G. Taylor. Dispersion of soluble matter in solvent flowing slowly through a tube , 1953, Proceedings of the Royal Society of London. Series A. Mathematical and Physical Sciences.
[2] Richard C. Bailie,et al. Axial diffusion in isothermal tubular flow reactors , 1960 .
[3] Julio M. Ottino,et al. A framework for description of mechanical mixing of fluids , 1981 .
[4] H. Aref. Stirring by chaotic advection , 1984, Journal of Fluid Mechanics.
[5] Julio M. Ottino,et al. Mixing and chemical reactions a tutorial , 1994 .
[6] Laurent Falk,et al. A new parallel competing reaction system for assessing micromixing efficiency—Experimental approach , 1996 .
[7] Paul N. Sharratt. Handbook of Batch Process Design , 1997 .
[8] L. Gladden,et al. Correlations between dispersion and structure in porous media probed by nuclear magnetic resonance , 1999 .
[9] D. Ende,et al. Preparation of Grignard Reagents: FTIR and Calorimetric Investigation for Safe Scale-Up , 1999 .
[10] D. Blackmond,et al. Comprehensive Kinetic Screening of Catalysts Using Reaction Calorimetry , 1999 .
[11] Fernando J. Muzzio,et al. Experimental and computational investigation of the laminar flow structure in a stirred tank , 1999 .
[12] Wolfgang Ehrfeld,et al. Characterization of Mixing in Micromixers by a Test Reaction: Single Mixing Units and Mixer Arrays , 1999 .
[13] G. Whitesides,et al. Microfabrication inside capillaries using multiphase laminar flow patterning , 1999, Science.
[14] G. Whitesides,et al. Experimental and theoretical scaling laws for transverse diffusive broadening in two-phase laminar flows in microchannels , 2000 .
[15] S. Quake,et al. Monolithic microfabricated valves and pumps by multilayer soft lithography. , 2000, Science.
[16] L. Falk,et al. Characterisation of micromixing efficiency by the iodide–iodate reaction system. Part I: experimental procedure , 2000 .
[17] J. Villermaux,et al. Characterisation of micromixing efficiency by the iodide–iodate reaction system. Part II: kinetic study , 2000 .
[18] Klavs F. Jensen,et al. Microfabricated multiphase packed-bed reactors : Characterization of mass transfer and reactions , 2001 .
[19] K. Jensen. Microreaction engineering * is small better? , 2001 .
[20] David J. Lamberto,et al. Computational analysis of regular and chaotic mixing in a stirred tank reactor , 2001 .
[21] Shahriyar Taghavi-Moghadam,et al. Microreaction Technology as a Novel Approach to Drug Design, Process Development and Reliability , 2001 .
[22] R. Chambers,et al. Elemental fluorine. Part 13. Gas-liquid thin film microreactors for selective direct fluorination. , 2001, Lab on a chip.
[23] Troy Shinbrot,et al. Mechanisms of Mixing and Creation of Structure in Laminar Stirred Tanks , 2002 .
[24] Fernando J. Muzzio,et al. Using CFD to understand chaotic mixing in laminar stirred tanks , 2002 .
[25] Robin Fortt,et al. On-chip generation and reaction of unstable intermediates-monolithic nanoreactors for diazonium chemistry: azo dyes. , 2002, Lab on a chip.
[26] Paul Watts,et al. Micro reactors: principles and applications in organic synthesis , 2002 .
[27] K. Jensen,et al. Design and fabrication of microfluidic devices for multiphase mixing and reaction , 2002 .
[28] Robin H. Liu,et al. Bubble-induced acoustic micromixing. , 2002, Lab on a chip.
[29] Troy Shinbrot,et al. Practical chaotic mixing , 2002 .
[30] John R. Bourne,et al. Mixing and the Selectivity of Chemical Reactions , 2003 .
[31] Nadine Aubry,et al. Enhancement of microfluidic mixing using time pulsing. , 2003, Lab on a chip.
[32] Helen Song,et al. Millisecond kinetics on a microfluidic chip using nanoliters of reagents. , 2003, Journal of the American Chemical Society.
[33] Klavs F. Jensen,et al. Microfabricated Multiphase Reactors for the Selective Direct Fluorination of Aromatics , 2003 .
[34] Phil Paik,et al. Electrowetting-based droplet mixers for microfluidic systems. , 2003, Lab on a chip.
[35] Helen Song,et al. A microfluidic system for controlling reaction networks in time. , 2003, Angewandte Chemie.
[36] G. Whitesides,et al. Solvent compatibility of poly(dimethylsiloxane)-based microfluidic devices. , 2003, Analytical chemistry.
[37] Robert K. Prud'homme,et al. Chemical Processing and Micromixing in Confined Impinging Jets , 2003 .
[38] Wenka Schweikert,et al. Analysis and Improvement of Strong Exothermic Nitrations in Microreactors , 2003 .
[39] Robert C. R. Wootton,et al. Continuous-Flow Generation of Anhydrous Diazonium Species: Monolithic Microfluidic Reactors for the Chemistry of Unstable Intermediates , 2003 .
[40] Helen Song,et al. Experimental test of scaling of mixing by chaotic advection in droplets moving through microfluidic channels. , 2003, Applied physics letters.
[41] Phil Paik,et al. Rapid droplet mixers for digital microfluidic systems. , 2003, Lab on a chip.
[42] V. Hessel,et al. Laminar mixing in different interdigital micromixers: I. Experimental characterization , 2003 .
[43] Slobodan Panić,et al. Experimental approaches to a better understanding of mixing performance of microfluidic devices , 2004 .
[44] V. Hessel,et al. Numbering-up of micro devices: a first liquid-flow splitting unit , 2004 .
[45] H. Löwe,et al. Chemistry in microstructured reactors. , 2004, Angewandte Chemie.
[46] Paul Watts,et al. Benchmarking of Microreactor Applications , 2004 .
[47] Frank J. Villani,et al. Application of Microreactor Technology in Process Development , 2004 .
[48] A. deMello,et al. Continuous laminar evaporation: micron-scale distillation. , 2004, Chemical communications.
[49] Saif A. Khan,et al. Transport and reaction in microscale segmented gas-liquid flow. , 2004, Lab on a chip.
[50] Holger Löwe,et al. Chemie in Mikrostrukturreaktoren , 2004 .
[51] Suresh Valiyaveettil,et al. Design of a capillary-microreactor for efficient Suzuki coupling reactions , 2004 .
[52] Saif A. Khan,et al. Microfluidic synthesis of colloidal silica. , 2004, Langmuir : the ACS journal of surfaces and colloids.
[53] Stephen Wiggins,et al. Introduction: mixing in microfluidics , 2004, Philosophical Transactions of the Royal Society of London. Series A: Mathematical, Physical and Engineering Sciences.
[54] Takehiko Kitamori,et al. A Microfluidic Device for Conducting Gas-Liquid-Solid Hydrogenation Reactions , 2004, Science.
[55] Thomas Laurell,et al. Ultrasonic agitation in microchannels , 2004, Analytical and bioanalytical chemistry.
[56] Howard A. Stone,et al. ENGINEERING FLOWS IN SMALL DEVICES , 2004 .
[57] K. Mae,et al. Control of extremely fast competitive consecutive reactions using micromixing. Selective Friedel-Crafts aminoalkylation. , 2005, Journal of the American Chemical Society.
[58] K. Mae,et al. Room-temperature Swern oxidations by using a microscale flow system. , 2005, Angewandte Chemie.
[59] A. Moment,et al. Process Development and Pilot Plant Synthesis of Methyl 2-Bromo-6-chlorobenzoate , 2005 .
[60] Jianfeng Chen,et al. Micromixing Efficiency in a Rotating Packed Bed: Experiments and Simulation , 2005 .
[61] Nam-Trung Nguyen,et al. Micromixers?a review , 2005 .
[62] Hydrogenation reactions using scCO2 as a solvent in microchannel reactors. , 2005, Chemical communications.
[63] S. Quake,et al. Multistep Synthesis of a Radiolabeled Imaging Probe Using Integrated Microfluidics , 2005, Science.
[64] Richard F Winkle,et al. A method for rapid reaction optimisation in continuous-flow microfluidic reactors using online Raman spectroscopic detection. , 2005, In Analysis.
[65] Metin Muradoglu,et al. Mixing in a drop moving through a serpentine channel: A computational study , 2005 .
[66] Klavs F. Jensen,et al. Silicon Micromixers with Infrared Detection for Studies of Liquid-Phase Reactions , 2005 .
[67] Wolfgang Ehrfeld,et al. Modular Microreaction Systems for Homogeneously and Heterogeneously Catalyzed Chemical Synthesis , 2005 .
[68] Holger Löwe,et al. Bromination of Thiophene in Micro Reactors , 2005 .
[69] Klavs F Jensen,et al. Microreactor-based reaction optimization in organic chemistry--glycosylation as a challenge. , 2005, Chemical communications.
[70] J. Yoshida,et al. Free Radical Polymerization in Microreactors. Significant Improvement in Molecular Weight Distribution Control , 2005 .
[71] Holger Löwe,et al. Aqueous Kolbe−Schmitt Synthesis Using Resorcinol in a Microreactor Laboratory Rig under High-p,T Conditions , 2005 .
[72] Volker Hessel,et al. Organic Synthesis with Microstructured Reactors , 2005 .
[73] V. Hessel,et al. Micromixers—a review on passive and active mixing principles , 2005 .
[74] Masayoshi Esashi,et al. Micro instrumentation for characterizing thermoelectric properties of nanomaterials , 2005 .
[75] J. Yoshida,et al. Grignard Exchange Reaction Using a Microflow System: From Bench to Pilot Plant , 2005 .
[76] Fernando Benito-Lopez,et al. Optical fiber-based on-line UV/Vis spectroscopic monitoring of chemical reaction kinetics under high pressure in a capillary microreactor. , 2005, Chemical communications.
[77] Laurent Ducry,et al. Controlled autocatalytic nitration of phenol in a microreactor. , 2005, Angewandte Chemie.
[78] Dominique M. Roberge,et al. Microreactor Technology: A Revolution for the Fine Chemical and Pharmaceutical Industries? , 2005 .
[79] D. Ripin,et al. Survey of GMP Bulk Reactions Run in a Research Facility between 1985 and 2002 , 2005 .
[80] Axel Günther,et al. A microfabricated gas-liquid segmented flow reactor for high-temperature synthesis: the case of CdSe quantum dots. , 2005, Angewandte Chemie.
[81] Axel Günther,et al. Micromixing of miscible liquids in segmented gas-liquid flow. , 2005, Langmuir : the ACS journal of surfaces and colloids.
[82] Holger Löwe,et al. Addition of Secondary Amines to α,β-Unsaturated Carbonyl Compounds and Nitriles by Using Microstructured Reactors , 2006 .
[83] M. Haaf,et al. Solving the clogging problem: precipitate-forming reactions in flow. , 2006, Angewandte Chemie.
[84] Masaaki Sato,et al. Low pressure Pd-catalyzed carbonylation in an ionic liquid using a multiphase microflow system. , 2006, Chemical communications.
[85] A. Manz,et al. Micro total analysis systems. Latest advancements and trends. , 2006, Analytical chemistry.
[86] Peter H Seeberger,et al. Microreactors as tools for synthetic chemists-the chemists' round-bottomed flask of the 21st century? , 2006, Chemistry.
[87] J. S. Carey,et al. Analysis of the reactions used for the preparation of drug candidate molecules. , 2006, Organic & biomolecular chemistry.
[88] Asterios Gavriilidis,et al. Scalable Reactor Design for Pharmaceuticals and Fine Chemicals Production. 1: Potential Scale-up Obstacles , 2006 .
[89] Stephen Quake,et al. Enhanced signals and fast nucleic acid hybridization by microfluidic chaotic mixing. , 2006, Angewandte Chemie.
[90] Nicolas Szita,et al. A well‐mixed, polymer‐based microbioreactor with integrated optical measurements , 2006, Biotechnology and bioengineering.
[91] Andreas Kirschning,et al. Combining enabling techniques in organic synthesis: continuous flow processes with heterogenized catalysts. , 2006, Chemistry.
[92] Paul Watts,et al. Microreactors as tools for chemical research , 2006 .
[93] Helen Song,et al. Reaktionen in Mikrofluidiktröpfchen , 2006 .
[94] Helen Song,et al. Reactions in droplets in microfluidic channels. , 2006, Angewandte Chemie.
[95] Michael E Phelps,et al. Integrated microfluidics for parallel screening of an in situ click chemistry library. , 2006, Angewandte Chemie.
[96] K. Jensen,et al. Multiphase microfluidics: from flow characteristics to chemical and materials synthesis. , 2006, Lab on a chip.
[97] Wenka Schweikert,et al. Inline Analysis in Microreaction Technology: A Suitable Tool for Process Screening and Optimization , 2007 .
[98] Igor Mezić,et al. An ultrashort mixing length micromixer: the shear superposition micromixer. , 2007, Lab on a chip.
[99] Neil Gershenfeld,et al. Ultra-small-sample molecular structure detection using microslot waveguide nuclear spin resonance , 2007, Proceedings of the National Academy of Sciences.
[100] K. Jensen,et al. Multistep continuous-flow microchemical synthesis involving multiple reactions and separations. , 2007, Angewandte Chemie.
[101] Jun-ichi Yoshida,et al. Generation and reactions of o-bromophenyllithium without benzyne formation using a microreactor. , 2007, Journal of the American Chemical Society.
[102] Jeremy L. Steinbacher,et al. Greener approaches to organic synthesis using microreactor technology. , 2007, Chemical reviews.
[103] A. deMello,et al. Intelligent routes to the controlled synthesis of nanoparticles. , 2007, Lab on a chip.
[104] Klavs F Jensen,et al. Accelerating reactions with microreactors at elevated temperatures and pressures: profiling aminocarbonylation reactions. , 2007, Angewandte Chemie.
[105] Klavs F. Jensen,et al. Microfluidic Synthesis of Titania Shells on Colloidal Silica , 2007 .
[106] P. H. Seeberger,et al. New Avenues to Efficient Chemical Synthesis , 2007 .
[107] K. Jensen,et al. Integrated continuous microfluidic liquid-liquid extraction. , 2007, Lab on a chip.
[108] D. Reinhoudt,et al. Substantial rate enhancements of the esterification reaction of phthalic anhydride with methanol at high pressure and using supercritical CO2 as a co-solvent in a glass microreactor. , 2007, Lab on a chip.
[109] Paul Watts,et al. Recent advances in synthetic micro reaction technology. , 2007, Chemical communications.
[110] Dirk Janasek,et al. A novel method for determining residence time distribution in intricately structured microreactors. , 2008, Lab on a chip.
[111] N. Kockmann,et al. Microreactor Technology and Continuous Processes in the Fine Chemical and Pharmaceutical Industry: Is the Revolution Underway? , 2008 .
[112] Klavs F. Jensen,et al. Supercritical Continuous‐Microflow Synthesis of Narrow Size Distribution Quantum Dots , 2008 .
[113] Erik V. Van der Eycken,et al. Transition Metal-Catalyzed Carbon-Carbon Bond Formation Suzuki, Heck, and Sonogashira Reactions Using Microwave and Microtechnology , 2008 .
[114] Philipp Rudolf von Rohr,et al. Transparent silicon/glass microreactor for high-pressure and high-temperature reactions , 2008 .
[115] Dominique M. Roberge,et al. Development of an Industrial Multi‐Injection Microreactor for Fast and Exothermic Reactions – Part II , 2008 .
[116] Donald J. Knoechel,et al. Continuous Reaction/Crystallization Process for Production of a Hazardous Intermediate , 2008 .
[117] Chris R. Kleijn,et al. Velocity fluctuations of segmented flow in microchannels , 2008 .
[118] Propylphosphonic Acid Anhydride: A Highly Expedient and Versatile Coupling Agent , 2009 .
[119] T. Wirth,et al. Microreactors in organic synthesis and catalysis , 2008 .
[120] Stephen L. Buchwald,et al. Biarylphosphanliganden in der palladiumkatalysierten Aminierung , 2008 .
[121] S. Buchwald,et al. Biaryl phosphane ligands in palladium-catalyzed amination. , 2008, Angewandte Chemie.
[122] Axel Günther,et al. Sample dispersion for segmented flow in microchannels with rectangular cross section. , 2008, Analytical chemistry.
[123] Jun-ichi Yoshida,et al. Flash chemistry: fast chemical synthesis by using microreactors. , 2008, Chemistry.
[124] Dominique M. Roberge,et al. Dibal-H Reduction of Methyl Butyrate into Butyraldehyde using Microreactors , 2008 .
[125] N. Kockmann,et al. Enabling continuous-flow chemistry in microstructured devices for pharmaceutical and fine-chemical production. , 2008, Chemistry.
[126] Klavs F. Jensen,et al. Increasing Productivity of Microreactors for Fast Gas−Liquid Reactions: The Case of Direct Fluorination of Toluene , 2009 .
[127] Hydrogenation of a Pharmaceutical Intermediate by a Continuous Stirred Tank Reactor System , 2009 .
[128] Shelly Gulati,et al. Chemical imaging of microfluidic flows using ATR-FTIR spectroscopy. , 2009, Lab on a chip.
[129] Daniele Vigo,et al. Efficient continuous flow synthesis of hydroxamic acids and suberoylanilide hydroxamic acid preparation. , 2009, The Journal of organic chemistry.
[130] P. Seeberger,et al. 5‐(Pyrrolidin‐2‐yl)tetrazol‐katalysierte Aldol‐ und Mannich‐Reaktionen: schnellere Reaktionen und niedrigere Katalysatorbeladung in einem Durchflussreaktor , 2009 .
[131] Malcolm R. Mackley,et al. The measurement and characterisation of residence time distributions for laminar liquid flow in plastic microcapillary arrays , 2009 .
[132] Steven J. Broadwater,et al. The continuous-flow synthesis of Ibuprofen. , 2009, Angewandte Chemie.
[133] P. Seeberger,et al. 5-(Pyrrolidin-2-yl)tetrazole-catalyzed aldol and mannich reactions: acceleration and lower catalyst loading in a continuous-flow reactor. , 2009, Angewandte Chemie.
[134] Steven V. Ley,et al. Development of fluorination methods using continuous-flow microreactors , 2009 .
[135] Ryan L Hartman,et al. Microchemical systems for continuous-flow synthesis. , 2009, Lab on a chip.
[136] Andrew R. Bogdan,et al. The Use of Copper Flow Reactor Technology for the Continuous Synthesis of 1,4‐Disubstituted 1,2,3‐Triazoles , 2009 .
[137] Steven V Ley,et al. Multistep synthesis using modular flow reactors: Bestmann-Ohira reagent for the formation of alkynes and triazoles. , 2009, Angewandte Chemie.
[138] Volker Hessel,et al. Novel Process Windows – Gate to Maximizing Process Intensification via Flow Chemistry , 2009 .
[139] Jun-ichi Yoshida,et al. Nitro-substituted aryl lithium compounds in microreactor synthesis: switch between kinetic and thermodynamic control. , 2009, Angewandte Chemie.
[140] John R. Goodell,et al. Development of an automated microfluidic reaction platform for multidimensional screening: reaction discovery employing bicyclo[3.2.1]octanoid scaffolds. , 2009, The Journal of organic chemistry.
[141] Atsushi Sugimoto,et al. Microflow photo-radical reaction using a compact light source: application to the Barton reaction leading to a key intermediate for myriceric acid A , 2009 .
[142] Christopher J. Welch,et al. Online Analysis of Flowing Streams Using Microflow HPLC , 2009 .
[143] Koichi Fukase,et al. Renaissance of Traditional Organic Reactions under Microfluidic Conditions: A New Paradigm for Natural Products Synthesis , 2009 .
[144] Holger Löwe,et al. Ionic Liquids on Demand in Continuous Flow , 2009 .
[145] Ryan L Hartman,et al. Distillation in microchemical systems using capillary forces and segmented flow. , 2009, Lab on a chip.
[146] Lukas Küpper,et al. An Ozonolysis−Reduction Sequence for the Synthesis of Pharmaceutical Intermediates in Microstructured Devices , 2009 .
[147] C. Oliver Kappe,et al. Continuous‐Flow Microreactor Chemistry under High‐Temperature/Pressure Conditions , 2009 .
[148] J. Yoshida,et al. Generation and Reactions of α-Silyloxiranyllithium in a Microreactor , 2009 .
[149] Fabrice Renaud,et al. Facile, Fast and Safe Process Development of Nitration and Bromination Reactions Using Continuous Flow Reactors , 2009 .
[150] Jun-ichi Yoshida,et al. Photodimerization of Maleic Anhydride in a Microreactor Without Clogging , 2010 .
[151] Klavs F. Jensen,et al. Overcoming the Challenges of Solid Bridging and Constriction during Pd-Catalyzed C−N Bond Formation in Microreactors , 2010 .
[152] Klavs F. Jensen,et al. Aminolysis of Epoxides in a Microreactor System: A Continuous Flow Approach to β-Amino Alcohols , 2010 .
[153] Ron Wehrens,et al. Flash chemistry extensively optimized: high-temperature Swern-Moffatt oxidation in an automated microreactor platform. , 2010, Chemistry, an Asian journal.
[154] Cyril Aymonier,et al. Design and packaging of microreactors for high pressure and high temperature applications , 2010 .
[155] Klavs F. Jensen,et al. Synthesis and Kinetics of Highly Energetic Intermediates by Micromixers: Direct Multistep Synthesis of Sodium Nitrotetrazolate , 2010 .
[156] Fernando E. Valera,et al. Der Fluss ist das Ding …︁ oder ist er es? Ein Vergleich homogener Reaktionen in Reaktionskolben und Durchflussreaktoren , 2010 .
[157] Timothy F. Jamison,et al. Continuous flow multi-step organic synthesis , 2010 .
[158] Yolanda Schaerli,et al. Mikrotröpfchen in Mikrofluidiksystemen: eine Technik für Entdeckungen in der Chemie und Biologie , 2010 .
[159] A. Theberge,et al. Microdroplets in microfluidics: an evolving platform for discoveries in chemistry and biology. , 2010, Angewandte Chemie.
[160] Ryan L Hartman,et al. Multistep microchemical synthesis enabled by microfluidic distillation. , 2010, Angewandte Chemie.
[161] Alan Armstrong,et al. The flow's the thing..or is it? Assessing the merits of homogeneous reactions in flask and flow. , 2010, Angewandte Chemie.
[162] Daniele Vigo,et al. Reaction of Grignard reagents with carbonyl compounds under continuous flow conditions , 2010 .
[163] Jason E. Kreutz,et al. Evolution of catalysts directed by genetic algorithms in a plug-based microfluidic device tested with oxidation of methane by oxygen. , 2010, Journal of the American Chemical Society.
[164] Klavs F Jensen,et al. An integrated microreactor system for self-optimization of a Heck reaction: from micro- to mesoscale flow systems. , 2010, Angewandte Chemie.
[165] Laurent Falk,et al. Performance comparison of micromixers , 2010 .
[166] Nimisha Srivastava,et al. A unified scaling model for flow through a lattice of microfabricated posts. , 2010, Lab on a chip.
[167] John R. Goodell,et al. Reaction discovery using microfluidic-based multidimensional screening of polycyclic iminium ethers. , 2010, The Journal of organic chemistry.
[168] Klavs F Jensen,et al. Integrated microreactors for reaction automation: new approaches to reaction development. , 2010, Annual review of analytical chemistry.
[169] Klavs F. Jensen,et al. Kinetic and Scale-Up Investigations of Epoxide Aminolysis in Microreactors at High Temperatures and Pressures , 2011 .