Naturally alkaloids as Antimicrobial agents

Antibiotic resistance is now considered a worldwide problem that puts public health at risk. The onset of bacterial strains resistant to conventional antibiotics and the scarcity of new drugs have prompted scientific research to re-evaluate natural products as molecules with high biological and chemical potential. A class of natural compounds of significant importance is represented by alkaloids derived from higher plants.

[1]  M. Loffredo,et al.  The Revaluation of Plant-Derived Terpenes to Fight Antibiotic-Resistant Infections , 2020, Antibiotics.

[2]  M. Mori,et al.  A novel colistin adjuvant identified by virtual screening for ArnT inhibitors , 2020, The Journal of antimicrobial chemotherapy.

[3]  E. Sousa,et al.  Targeting Antimicrobial Drug Resistance with Marine Natural Products. , 2020, International journal of antimicrobial agents.

[4]  B. Lazzaro,et al.  Antimicrobial peptides: Application informed by evolution , 2020, Science.

[5]  Juan Wang,et al.  Prevalence and Therapies of Antibiotic-Resistance in Staphylococcus aureus , 2020, Frontiers in Cellular and Infection Microbiology.

[6]  M. Mori,et al.  Structural Elucidation and Antimicrobial Characterization of Novel Diterpenoids from Fabiana densa var. ramulosa. , 2020, ACS medicinal chemistry letters.

[7]  Antonia Iazzetti,et al.  The Pictet-Spengler Reaction Updates Its Habits , 2020, Molecules.

[8]  M. Loffredo,et al.  The Potential of Frog Skin Peptides for Anti-Infective Therapies: the Case of Esculentin-1a(1-21)NH2. , 2020, Current medicinal chemistry.

[9]  S. Bufo,et al.  The Biological Activity of Natural Alkaloids against Herbivores, Cancerous Cells and Pathogens , 2019, Toxins.

[10]  L. Di Marcotullio,et al.  A Smo/Gli Multitarget Hedgehog Pathway Inhibitor Impairs Tumor Growth , 2019, Cancers.

[11]  V. de Turris,et al.  Inhibition of Pseudomonas aeruginosa biofilm formation and expression of virulence genes by selective epimerization in the peptide Esculentin‐1a(1‐21)NH2 , 2019, The FEBS Journal.

[12]  B. Demoré,et al.  Fight Against Antimicrobial Resistance: We Always Need New Antibacterials but for Right Bacteria , 2019, Molecules.

[13]  A. Sleiman,et al.  Antimicrobial Activity of Polyphenols and Alkaloids in Middle Eastern Plants , 2019, Front. Microbiol..

[14]  Wen-Sen Lee,et al.  New Drugs for Multidrug-Resistant Gram-Negative Organisms: Time for Stewardship , 2019, Drugs.

[15]  F. Ungaro,et al.  Poly(lactide- co-glycolide) Nanoparticles for Prolonged Therapeutic Efficacy of Esculentin-1a-Derived Antimicrobial Peptides against Pseudomonas aeruginosa Lung Infection: in Vitro and in Vivo Studies. , 2019, Biomacromolecules.

[16]  M. Loffredo,et al.  Esculentin-1a Derived Antipseudomonal Peptides: Limited Induction of Resistance and Synergy with Aztreonam. , 2019, Protein and peptide letters.

[17]  B. Botta,et al.  Olefin metathesis reaction as a locking tool for macrocycle and mechanomolecule construction , 2018 .

[18]  D. Maiti,et al.  Role of plant alkaloids on human health: A review of biological activities , 2018, Materials Today Chemistry.

[19]  L. Di Marcotullio,et al.  Synergistic inhibition of the Hedgehog pathway by newly designed Smo and Gli antagonists bearing the isoflavone scaffold. , 2018, European journal of medicinal chemistry.

[20]  Abdullah M. Asiri,et al.  Carbonyl–olefin metathesis: a key review , 2018 .

[21]  J. Conlon,et al.  Assessment of the potential of temporin peptides from the frog Rana temporaria (Ranidae) as anti‐diabetic agents , 2018, Journal of peptide science : an official publication of the European Peptide Society.

[22]  M. Mori,et al.  Green Routes for the Production of Enantiopure Benzylisoquinoline Alkaloids , 2017, International journal of molecular sciences.

[23]  G. Morelli,et al.  Cyclic Peptides as Novel Therapeutic Microbicides: Engineering of Human Defensin Mimetics , 2017, Molecules.

[24]  S. Nabavi,et al.  Phytochemicals for human disease: An update on plant-derived compounds antibacterial activity. , 2017, Microbiological research.

[25]  T. Kirby.  New antimicrobials--lots of talk, where is the action? , 2016, The Lancet. Infectious diseases.

[26]  Bruno Botta,et al.  The Pictet-Spengler Reaction Still on Stage. , 2016, Current pharmaceutical design.

[27]  M. Mori,et al.  Occurrence of Enantioselectivity in Nature: The Case of (S)-Norcoclaurine. , 2016, Chirality.

[28]  A. Harvey,et al.  The re-emergence of natural products for drug discovery in the genomics era , 2015, Nature Reviews Drug Discovery.

[29]  M. Heinrich,et al.  Alkaloids as drug leads – A predictive structural and biodiversity-based analysis , 2014 .

[30]  G. Rossolini,et al.  Update on the antibiotic resistance crisis. , 2014, Current opinion in pharmacology.

[31]  O. Bagasra,et al.  Bacteriophage therapy: a potential solution for the antibiotic resistance crisis. , 2014, Journal of infection in developing countries.

[32]  C. Ingallina,et al.  Oxazolidin-2-ones: Antibacterial activity and chemistry , 2014 .

[33]  M. Gross.  Antibiotics in crisis , 2013, Current Biology.

[34]  M. Otto.  Community-associated MRSA: what makes them special? , 2013, International journal of medical microbiology : IJMM.

[35]  J. Lindsay.  Hospital-associated MRSA and antibiotic resistance-what have we learned from genomics? , 2013, International journal of medical microbiology : IJMM.

[36]  Paramasamy Gunasekaran,et al.  Antimicrobial Peptides: Versatile Biological Properties , 2013, International journal of peptides.

[37]  D. Savoia.  Plant-derived antimicrobial compounds: alternatives to antibiotics. , 2012, Future microbiology.

[38]  A. Boffi,et al.  Production of Bioactives Compounds: The Importance of Pictet-Spengler Reaction in the XXI Century , 2012 .

[39]  W. Evans.  Chapter 26 – Alkaloids , 2009 .

[40]  S. Martin,et al.  Ring‐Closing Metathesis as a Construct for the Synthesis of Polycyclic Alkaloids , 2006 .

[41]  V. Dembitsky.  Astonishing diversity of natural surfactants: 6. Biologically active marine and terrestrial alkaloid glycosides , 2005, Lipids.

[42]  Andrew J Lamb,et al.  Antimicrobial activity of flavonoids , 2005, International Journal of Antimicrobial Agents.

[43]  V. Tyler,et al.  Pharmacognosy and Pharmacobiotechnology , 1996 .